Therapy Insight: is there an imbalanced response of mineralocorticoid and glucocorticoid receptors in depression? (original) (raw)
Murray CJ and Lopez AD (1997) Alternative projections of mortality and disability by cause 1990-2020: Global Burden of Disease Study. Lancet349: 1498–1504 ArticleCASPubMed Google Scholar
Gold PW et al. (2002) Divergent endocrine abnormalities in melancholic and atypical depression: clinical and pathophysiologic implications. Endocrinol Metab Clin North Am31: 37–62 ArticleCASPubMed Google Scholar
Thakore J (Ed.; 2001) Physical Consequences of Depression. Philadelphia: Wrightson Biomedical Publishing Google Scholar
Berton O and Nestler EJ (2006) New approaches to antidepressant drug discovery: beyond monoamines. Nat Rev Neurosci7: 137–151 ArticleCASPubMed Google Scholar
Sullivan PF et al. (2000) Genetic epidemiology of major depression: review and meta-analysis. Am J Psychiatry157: 1552–1562 ArticleCASPubMed Google Scholar
Heim C and Nemeroff CB (2001) The role of childhood trauma in the neurobiology of mood and anxiety disorders: preclinical and clinical studies. Biol Psychiatry49: 1023–1039 ArticleCASPubMed Google Scholar
Rinne T et al. (2002) Hyperresponsiveness of hypothalamic-pituitary-adrenal axis to combined dexamethasone/corticotropin-releasing hormone challenge in female borderline personality disorder subjects with a history of sustained childhood abuse. Biol Psychiatry52: 1102–1112 ArticleCASPubMed Google Scholar
Caspi A et al. (2003) Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science301: 386–389 ArticleCASPubMed Google Scholar
de Kloet ER et al. (2005) Stress and the brain: from adaptation to disease. Nat Rev Neurosci6: 463–475 ArticleCASPubMed Google Scholar
Kendler S et al. (1999) Causal relationship between stressful life events and the onset of major depression. Am J Psychiatry156: 837–841 ArticleCASPubMed Google Scholar
Holsboer F (2000) The corticosteroid receptor hypothesis of depression. Neuropsychopharmacology23: 477–501 ArticleCASPubMed Google Scholar
van Praag HM et al. (2004) Stress, the Brain and Depression. Cambridge, UK: Cambridge University Press Book Google Scholar
Nemeroff CB and Vale WW (2005) The neurobiology of depression: inroads to treatment and new drug discovery. J Clin Psychiatry66: 5–13 ArticleCASPubMed Google Scholar
Modell S et al. (1998) Hormonal response patterns in the combined Dex-CRH test is stable over time in subjects at high familial risk for affective disorders. Neuropsychopharmacology18: 253–262 ArticleCASPubMed Google Scholar
Gomez RG et al. (2006) The neuropsychological profile of psychotic major depression and its relation to cortisol. Biol Psychiatry60: 472–478 ArticlePubMed Google Scholar
van der Lely AJ et al. (1991) Rapid reversal of acute psychosis in the Cushing syndrome with the cortisol-receptor antagonist mifepristone (RU 486). Ann Intern Med114: 143–144 ArticleCASPubMed Google Scholar
Schatzberg AF et al. (1984) A corticosteroid/dopamine hypothesis for psychotic depression and related states. J Psychiatr Res19: 57–64 Article Google Scholar
Binder EB et al. (2004) Polymorphism in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment. Nat Genet36: 1319–1325 ArticleCASPubMed Google Scholar
van Rossum EFC et al. (2006) Polymorphisms of the glucocorticoid receptor gene and major depression. Biol Psychiatry59: 681–688 ArticleCASPubMed Google Scholar
McEwen BS (2004) Protection and damage from acute and chronic stress: allostasis and allostatic overload and relevance to the pathophysiology of psychiatric disorders. Ann NY Acad Sci1032: 1–7 ArticlePubMed Google Scholar
Müller MB et al. (2003) Limbic corticotropin-releasing hormone receptor 1 mediates anxiety-related behavior and hormonal adaptation to stress. Nat Neurosci6: 1100–1107 ArticlePubMedCAS Google Scholar
Tomlinson JW and Stewart PM (2005) Mechanisms of disease: selective inhibition of 11β-hydroxysteroid dehydrogenase type I as a novel treatment for the metabolic syndrome. Nat Clin Pract Endocrinol Metab1: 92–99 ArticleCASPubMed Google Scholar
Karssen AM et al. (2005) Low doses of dexamethasone can produce a hypocorticosteroid state in the brain. Endocrinology146: 5587–5595 ArticleCASPubMed Google Scholar
de Kloet ER et al. (1999) Stress and cognition: are corticosteroids good or bad guys? Trends Neurosci22: 422–426 ArticleCASPubMed Google Scholar
Joëls M et al. (2006) Learning under stress: how does it work? Trends Cogn Sci10: 152–158 ArticlePubMed Google Scholar
Karst H et al. (2005) Mineralocorticoid receptors are indispensible for non-genomic modulation of hippocampal glutamate transmission by corticosterone. Proc Natl Acad Sci USA102: 19204–19207 ArticleCASPubMedPubMed Central Google Scholar
Di S et al. (2003) Nongenomic glucocorticoid inhibition via endocannabinoid release in the hypothalamus: a fast feedback mechanism. J Neurosci23: 4850–4857 ArticleCASPubMedPubMed Central Google Scholar
van Rossum EFC and Lamberts SW (2004) Polymorphisms in the glucocorticoid receptor gene and their associations with metabolic parameters and body composition. Recent Prog Horm Res59: 333–357 ArticleCASPubMed Google Scholar
Wüst S et al. (2004) Common polymorphisms in the glucocorticoid receptor gene are associated with adrenocortical responses to psychosocial stress. J Clin Endocrinol Metab89: 563–564 ArticleCAS Google Scholar
Kaufer D et al. (2004) Restructuring the neuronal stress response with anti-glucocorticoid gene delivery. Nat Neurosci7: 947–953 ArticleCASPubMed Google Scholar
Ridder S et al. (2005) Mice with genetically altered glucocorticoid receptor expression show altered sensitivity for stress-induced depressive reactions. J Neurosci25: 6243–6250 ArticleCASPubMedPubMed Central Google Scholar
Oitzl MS et al. (2001) Point mutation in the mouse glucocorticoid receptor preventing DNA binding impairs spatial memory. Proc Natl Acad Sci USA98: 12790–12795 ArticleCASPubMedPubMed Central Google Scholar
Boyle MP et al. (2005) Acquired deficit of forebrain glucocorticoid receptor produces depression-like changes in adrenal axis regulation and behavior. Proc Natl Acad Sci USA102: 473–478 ArticleCASPubMed Google Scholar
Tronche F et al. (1999) Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety. Nat Genet23: 99–103 ArticleCASPubMed Google Scholar
Wei Q et al. (2004) Glucocorticoid receptor overexpression in forebrain: a mouse model of increased emotional lability. Proc Natl Acad Sci USA101: 11851–11856 ArticleCASPubMedPubMed Central Google Scholar
Berger S et al. (2006) Loss of the limbic mineralocorticoid receptor impairs behavioral plasticity. Proc Natl Acad Sci USA103: 195–200 ArticleCASPubMed Google Scholar
Heim C et al. (2003) Integrating neuroscience and psychological approaches in the study of early experiences. Ann NY Acad Sci1008: 238–247 Article Google Scholar
Gunnar M (2004) Importance of studying the contributions of early adverse experience to neurobiological findings in depression. Neuropsychopharmacology29: 641–648 Article Google Scholar
Levine S (2005) Developmental determinants of sensitivity and resistance to stress. Psychoneuroendocrinology30: 939–946 ArticlePubMed Google Scholar
Liu D et al. (1997) Maternal care, hippocampal glucocorticoid receptors, and the hypothalamic-pituitary-adrenal responses to stress. Nat Neurosci277: 1659–1662 CAS Google Scholar
de Kloet ER and Oitzl MS (2003) Who cares for the stressed brain? The mother, the kid or both? Neurobiol Aging24: S61–S65 ArticlePubMed Google Scholar
Van Oers HJJ et al. (1998) Maternal deprivation effect on the infant's neural stress markers is reversed by tactile stimulation and feeding but not by suppressing corticosterone. J Neurosci18: 10171–10179 ArticleCASPubMedPubMed Central Google Scholar
Seckl JR (2004) Prenatal glucocorticoids and long-term programming. Eur J Endocrinol151: U49–U62 ArticleCASPubMed Google Scholar
Coplan JD et al. (1996) Persistent elevations of cerebrospinal fluid concentrations of corticotropin-releasing factor in adult nonhuman primates exposed to early-life stressors: implications for the pathophysiology of mood and anxiety disorders. Proc Natl Acad Sci USA93: 1619–1623 ArticleCASPubMedPubMed Central Google Scholar
Parker KJ et al. (2006) Maternal mediation, stress inoculation, and the development of neuroendocrine stress resistance in primates. Proc Natl Acad Sci USA103: 3000–3005 ArticleCASPubMedPubMed Central Google Scholar
Szyf M et al. (2005) Maternal programming of steroid receptor expression and phenotype through DNA methylation in the rat. Front Neuroendocrinol26: 139–162 ArticleCASPubMed Google Scholar
Karten YJ et al. (1999) Long term exposure to high corticosterone levels attenuates serotonin responses in rat hippocampal CA1 neurones. Proc Natl Acad Sci USA96: 13456–13461 ArticleCASPubMedPubMed Central Google Scholar
Magarinos AM et al. (2006) Chronic stress alters synaptic terminal structure in hippocampus. Proc Natl Acad Sci USA94: 14002–14008 Article Google Scholar
Sandi C (2005) Stress, cognitive impairment and cell adhesion molecules. Nat Neurosci5: 917–930 ArticleCAS Google Scholar
Vyas A et al. (2002) Chronic stress induces contrasting patterns of dendritic remodeling in hippocampal and amygdaloid neurons. J Neurosci22: 6810–6818 ArticleCASPubMedPubMed Central Google Scholar
Revsin Y et al. (2005) Neuronal and astroglial alterations in the hippocampus of a mouse model for type 1 diabetes. Brain Res1038: 22–31 ArticleCASPubMed Google Scholar
Magarinos AM and McEwen BS (2000) Experimental diabetes in rats causes hippocampal dendritic and synaptic reorganization and increased glucocorticoid reactivity to stress. Proc Natl Acad Sci USA97: 11056–11061 ArticleCASPubMedPubMed Central Google Scholar
Westenbroek C et al. (2004) Chronic stress and social housing differentially affect neurogenesis in male and female rats. Brain Res Bull64: 303–308 ArticlePubMed Google Scholar
McEwen BS (2005) Glucocorticoids, depression, and mood disorders: structural remodeling in the brain. Metabolism54: 20–23 ArticleCASPubMed Google Scholar
Sheline YI et al. (1999) Depression duration but not age predicts hippocampal volume loss in medically healthy woman with recurrent major depression. J Neurosci19: 5034–5043 ArticleCASPubMedPubMed Central Google Scholar
Lucassen PJ et al. (2001) Hippocampal apoptosis in major depression is a minor event and absent from subareas predicted to be at risk for glucocorticoid overexposure. Am J Pathol158: 453–468 ArticleCASPubMedPubMed Central Google Scholar
Gilbertson MW et al. (2002) Smaller hippocampal volume predicts pathologic vulnerability to psychological trauma. Nat Neurosci5: 1242–1247 ArticleCASPubMedPubMed Central Google Scholar
Holsboer F (2001) Stress, hypercortisolism and corticosteroid receptors in depression: implications for therapy. J Affect Disord62: 77–91 ArticleCASPubMed Google Scholar
Wolkowitz OM et al. (2001) Stress hormone-related psychopathology: pathophysiological and treatment implications. World J Biol Psychiatry2: 115–143 ArticleCASPubMed Google Scholar
Thakore JH and Dinan TG (1995) Cortisol synthesis inhibition: a new treatment strategy for the clinical and endocrine manifestations of depression. Biol Psychiatry37: 364–368 ArticleCASPubMed Google Scholar
Jahn H et al. (2004) Methyrapone as additive treatment in major depression. Arch Gen Psychiatry61: 1235–1244 ArticleCASPubMed Google Scholar
Arana GW et al. (1995) Dexamethasone for the treatment of depression: a randomized, placebo-controlled, double-blind trial. Am J Psychiatry152: 265–267 ArticleCASPubMed Google Scholar
Bodani M et al. (1999) The use of dexamethasone in elderly patients with antidepressant-resistant depressive illness. J Psychopharmacol13: 196–197 ArticleCASPubMed Google Scholar
De Battista CJ and Belanoff J (2006) The use of mifepristone in the treatment of neuropsychiatric disorders. Trends Endocrinol Metab17: 117–121 ArticleCAS Google Scholar
Young AH et al. (2004) Improvements in neurocognitive function and mood following adjunctive treatment with mifepristone (RU-486) in bipolar disorder. Neuropsychopharmacology29: 1528–1545 Google Scholar
Flores BH et al. (2006) Clinical and biological effects of mifepristone treatment for psychotic depression. Neuropsychopharmacology31: 628–636 ArticleCASPubMed Google Scholar
Keller J et al. (2006) Cortisol circadian rhythm alterations in psychotic major depression. Biol Psychiatry60: 275–281 ArticleCASPubMed Google Scholar
van Haarst AD et al. (1996) Chronic brain glucocorticoid receptor blockade enhances the rise in circadian and stress-induced pituitary-adrenal activity. Endocrinology137: 4935–4943 ArticleCASPubMed Google Scholar
Oitzl MS et al. (1998) Continuous blockade of brain glucocorticoid receptors facilitates spatial learning and memory in rats. Eur J Neurosci10: 3759–3766 ArticleCASPubMed Google Scholar
Crown A and Lightman S (2005) Management of patients with glucocorticoid deficiency. Nat Clin Pract Endocrinol Metab1: 62–63 ArticlePubMed Google Scholar
Bohus B and de Kloet ER (1981) Adrenal steroids and extinction behavior: antagonism by progesterone, deoxycorticosterone and dexamethasone of a specific effect of corticosterone. Life Sci28: 433–440 ArticleCASPubMed Google Scholar
Schelling G et al. (2004) Stress doses of hydrocortisone, traumatic memories, and symptoms of posttraumatic stress disorder in patients after cardiac surgery: a randomized study. Biol Psychiatry55: 627–633 ArticleCASPubMed Google Scholar
Morsink MC et al. (2006) Acute activation of hippocampal glucocorticoid receptors results in different waves of gene expression throughout time. J Neuroendocrinol18: 239–252 ArticleCASPubMed Google Scholar
Dallman MF (2005) Fast glucocorticoid actions on brain: back to the future. Front Neuroendocrinol26: 103–108 ArticleCASPubMed Google Scholar
Kruk MR et al. (2005) Fast positive feedback between the adrenocortical stress response and a brain mechanism involved in aggressive behavior. Behav Neurosci118: 1062–1070 ArticleCAS Google Scholar
Revest JM et al. (2006) The MAPK pathway and Egr-1 mediate stress-related behavioral effects of glucocorticoids. Nat Neurosci8: 664–672 ArticleCAS Google Scholar
Carroll BJ and Rubin RT (2006) Is mifepristone useful in psychotic depression? Neuropsychopharmacology31: 2793–2794 ArticleCASPubMed Google Scholar
Keller J and Schatzberg AF (2006) Reply: clinical and biological effects of mifepristone treatment for psychotic treatment. Neuropsychopharmacology31: 2795–2797 ArticleCAS Google Scholar
Chu JW et al. (2001) Successful long-term treatment of refractory Cushing's disease with high-dose mifepristone (RU 486). J Clin Endocrinol Metab86: 3568–3573 CASPubMed Google Scholar
Debattista C et al. (2006) Mifepristone versus placebo in the treatment of psychosis in patients with psychotic major depression. Biol Psychiatry [doi: 10.1016/j.biopsych.2006.05.034]
Wong EY and Herbert J (2005) Roles of mineralocorticoid and glucocorticoid receptors in the regulation of progenitor proliferation in the adult hippocampus. Eur J Neurosci22: 785–792 ArticlePubMedPubMed Central Google Scholar
Mayer JL et al. (2006) Brief treatment with the glucocorticoid receptor antagonist mifepristone normalises the corticosterone-induced reduction of adult hippocampal neurogenesis. J Neuroendocrinol18: 629–631 ArticleCASPubMed Google Scholar
Wong EY and Herbert J (2006) Raised corticosterone inhibits neuronal differentiation of progenitor cells in the adult hippocampus. Neuroscience137: 83–92 ArticleCASPubMed Google Scholar
DeRijk RH et al. (2006) A common polymorphism in the mineralocorticoid receptor modulates stress responsiveness. J Clin Endocrinol Metab91: 5083–5089 ArticleCASPubMed Google Scholar
Kuningas M et al. (2006) Mental performance in old age is dependent on cortisol and genetic variance in the mineralocorticoid and glucocorticoid receptors. Neuropsychopharmacology [doi:10.1038/sj.npp.1301260]
Herman JP et al. (2003) Central mechanisms of stress integration: hierarchical circuitry controlling hypothalamo-pituitary-adrenocortical responsiveness. Front Neuroendocrinol24: 151–180 ArticleCASPubMed Google Scholar