DNMT1 knockout delivers a strong blow to genome stability and cell viability (original) (raw)

Nature Genetics volume 39, pages 289–290 (2007)Cite this article

The DNA methyltransferase DNMT1 is essential for cell viability in various mouse models, but gene targeting in human tumor cells results in a viable line. This dilemma has now been resolved using a new human DNMT1 knockout line, although new questions arise as to the full extent of DNMT1 function in maintaining genome integrity.

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Figure 1: Phenotypic effects stemming from variable DNMT1 expression in mammalian cells.

Katie Ris

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Authors and Affiliations

  1. Kevin D. Brown and Keith D. Robertson are in the Department of Biochemistry and Molecular Biology and the University of Florida–Shands Cancer Center, University of Florida, Box 100245, 1600 S.W. Archer Rd., Gainesville, Florida 32610, USA. keithr@ufl.edu,
    Kevin D Brown & Keith D Robertson

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  1. Kevin D Brown
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  2. Keith D Robertson
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Brown, K., Robertson, K. DNMT1 knockout delivers a strong blow to genome stability and cell viability.Nat Genet 39, 289–290 (2007). https://doi.org/10.1038/ng0307-289

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