The multidrug-resistant human pathogen Clostridium difficile has a highly mobile, mosaic genome (original) (raw)
References
McDonald, L.C. et al. An epidemic, toxin gene-variant strain of Clostridium difficile . N. Engl. J. Med.353, 2433–2441 (2005). ArticleCASPubMed Google Scholar
Loo, V.G. et al. A predominantly clonal multi-institutional outbreak of _Clostridium difficile_-associated diarrhea with high morbidity and mortality. N. Engl. J. Med.353, 2442–2449 (2005). ArticleCASPubMed Google Scholar
Voth, D.E. & Ballard, J.D. Clostridium difficile toxins: mechanism of action and role in disease. Clin. Microbiol. Rev.18, 247–263 (2005). ArticleCASPubMedPubMed Central Google Scholar
Wust, J., Sullivan, N.M., Hardegger, U. & Wilkins, T.D. Investigation of an outbreak of antibiotic-associated colitis by various typing methods. J. Clin. Microbiol.16, 1096–1101 (1982). CASPubMedPubMed Central Google Scholar
Nolling, J. et al. Genome sequence and comparative analysis of the solvent-producing bacterium Clostridium acetobutylicum . J. Bacteriol.183, 4823–4838 (2001). ArticleCASPubMedPubMed Central Google Scholar
Shimizu, T. et al. Complete genome sequence of Clostridium perfringens, an anaerobic flesh-eater. Proc. Natl. Acad. Sci. USA99, 996–1001 (2002). ArticleCASPubMedPubMed Central Google Scholar
Bruggemann, H. et al. The genome sequence of Clostridium tetani, the causative agent of tetanus disease. Proc. Natl. Acad. Sci. USA100, 1316–1321 (2003). ArticleCASPubMedPubMed Central Google Scholar
Farrow, K.A., Lyras, D. & Rood, J.I. Genomic analysis of the erythromycin resistance element Tn_5398_ from Clostridium difficile . Microbiology147, 2717–2728 (2001). ArticleCASPubMed Google Scholar
Haraldsen, J.D. & Sonenshein, A.L. Efficient sporulation in Clostridium difficile requires disruption of the sigmaK gene. Mol. Microbiol.48, 811–821 (2003). ArticleCASPubMed Google Scholar
Braun, V. et al. A chimeric ribozyme in Clostridium difficile combines features of group I introns and insertion elements. Mol. Microbiol.36, 1447–1459 (2000). ArticleCASPubMed Google Scholar
Burrus, V., Pavlovic, G., Decaris, B. & Guedon, G. Conjugative transposons: the tip of the iceberg. Mol. Microbiol.46, 601–610 (2002). ArticleCASPubMed Google Scholar
Mullany, P. et al. Genetic analysis of a tetracycline resistance element from Clostridium difficile and its conjugal transfer to and from Bacillus subtilis . J. Gen. Microbiol.136, 1343–1349 (1990). ArticleCASPubMed Google Scholar
Wang, H. et al. Characterization of the ends and target sites of the novel conjugative transposon Tn_5397_ from Clostridium difficile: excision and circularization is mediated by the large resolvase, TndX. J. Bacteriol.182, 3775–3783 (2000). ArticleCASPubMedPubMed Central Google Scholar
Franke, A.E. & Clewell, D.B. Evidence for a chromosome-borne resistance transposon (Tn_916_) in Streptococcus faecalis that is capable of “conjugal” transfer in the absence of a conjugative plasmid. J. Bacteriol.145, 494–502 (1981). CASPubMedPubMed Central Google Scholar
Roberts, A.P., Johanesen, P.A., Lyras, D., Mullany, P. & Rood, J.I. Comparison of Tn_5397_ from Clostridium difficile, Tn_916_ from Enterococcus faecalis and the CW459tet(M) element from Clostridium perfringens shows that they have similar conjugation regions but different insertion and excision modules. Microbiology147, 1243–1251 (2001). ArticleCASPubMed Google Scholar
Garnier, F., Taourit, S., Glaser, P., Courvalin, P. & Galimand, M. Characterization of transposon Tn_1549_, conferring VanB-type resistance in Enterococcus spp. Microbiology146, 1481–1489 (2000). ArticleCASPubMed Google Scholar
Jansen, R., Embden, J.D., Gaastra, W. & Schouls, L.M. Identification of genes that are associated with DNA repeats in prokaryotes. Mol. Microbiol.43, 1565–1575 (2002). ArticleCASPubMed Google Scholar
Mojica, F.J., Diez-Villasenor, C., Garcia-Martinez, J. & Soria, E. Intervening sequences of regularly spaced prokaryotic repeats derive from foreign genetic elements. J. Mol. Evol.60, 174–182 (2005). ArticleCASPubMed Google Scholar
Makarova, K.S., Grishin, N.V., Shabalina, S.A., Wolf, Y.I. & Koonin, E.V. A putative RNA-interference-based immune system in prokaryotes: computational analysis of the predicted enzymatic machinery, functional analogies with eukaryotic RNAi, and hypothetical mechanisms of action. Biol. Direct1, 7 (2006). ArticlePubMedPubMed Central Google Scholar
Calabi, E. et al. Molecular characterization of the surface layer proteins from Clostridium difficile . Mol. Microbiol.40, 1187–1199 (2001). ArticleCASPubMed Google Scholar
Wright, A. et al. Proteomic analysis of cell surface proteins from Clostridium difficile . Proteomics5, 2443–2452 (2005). ArticleCASPubMed Google Scholar
Waligora, A.J. et al. Characterization of a cell surface protein of Clostridium difficile with adhesive properties. Infect. Immun.69, 2144–2153 (2001). ArticleCASPubMedPubMed Central Google Scholar
Savariau-Lacomme, M.P., Lebarbier, C., Karjalainen, T., Collignon, A. & Janoir, C. Transcription and analysis of polymorphism in a cluster of genes encoding surface-associated proteins of Clostridium difficile . J. Bacteriol.185, 4461–4470 (2003). ArticleCASPubMedPubMed Central Google Scholar
Hennequin, C., Janoir, C., Barc, M.C., Collignon, A. & Karjalainen, T. Identification and characterization of a fibronectin-binding protein from Clostridium difficile . Microbiology149, 2779–2787 (2003). ArticleCASPubMed Google Scholar
Poilane, I., Karjalainen, T., Barc, M.C., Bourlioux, P. & Collignon, A. Protease activity of Clostridium difficile strains. Can. J. Microbiol.44, 157–161 (1998). ArticleCASPubMed Google Scholar
Dramsi, S., Trieu-Cuot, P. & Bierne, H. Sorting sortases: a nomenclature proposal for the various sortases of Gram-positive bacteria. Res. Microbiol.156, 289–297 (2005). ArticleCASPubMed Google Scholar
Mazmanian, S.K., Ton-That, H., Su, K. & Schneewind, O. An iron-regulated sortase anchors a class of surface protein during Staphylococcus aureus pathogenesis. Proc. Natl. Acad. Sci. USA99, 2293–2298 (2002). ArticleCASPubMedPubMed Central Google Scholar
Borriello, S.P., Welch, A.R., Barclay, F.E. & Davies, H.A. Mucosal association by Clostridium difficile in the hamster gastrointestinal tract. J. Med. Microbiol.25, 191–196 (1988). ArticleCASPubMed Google Scholar
Davies, H.A. & Borriello, S.P. Detection of capsule in strains of Clostridium difficile of varying virulence and toxigenicity. Microb. Pathog.9, 141–146 (1990). ArticleCASPubMed Google Scholar
Depardieu, F., Bonora, M.G., Reynolds, P.E. & Courvalin, P. The vanG glycopeptide resistance operon from Enterococcus faecalis revisited. Mol. Microbiol.50, 931–948 (2003). ArticleCASPubMed Google Scholar
Arthur, M., Depardieu, F., Molinas, C., Reynolds, P. & Courvalin, P. The vanZ gene of Tn_1546_ from Enterococcus faecium BM4147 confers resistance to teicoplanin. Gene154, 87–92 (1995). ArticleCASPubMed Google Scholar
Champion, O.L. et al. Comparative phylogenomics of the food-borne pathogen Campylobacter jejuni reveals genetic markers predictive of infection source. Proc. Natl. Acad. Sci. USA102, 16043–16048 (2005). ArticleCASPubMedPubMed Central Google Scholar
Selmer, T. & Andrei, P.I. p-Hydroxyphenylacetate decarboxylase from Clostridium difficile. A novel glycyl radical enzyme catalysing the formation of p-cresol. Eur. J. Biochem.268, 1363–1372 (2001). ArticleCASPubMed Google Scholar
Elsden, S.R., Hilton, M.G. & Waller, J.M. The end products of the metabolism of aromatic amino acids by clostridia. Arch. Microbiol.107, 283–288 (1976). ArticleCASPubMed Google Scholar
Begley, M., Gahan, C.G. & Hill, C. The interaction between bacteria and bile. FEMS Microbiol. Rev.29, 625–651 (2005). ArticleCASPubMed Google Scholar
Sleator, R.D., Wemekamp-Kamphuis, H.H., Gahan, C.G., Abee, T. & Hill, C.A. PrfA-regulated bile exclusion system (BilE) is a novel virulence factor in Listeria monocytogenes . Mol. Microbiol.55, 1183–1195 (2005). ArticleCASPubMed Google Scholar
Paredes, C.J., Alsaker, K.V. & Papoutsakis, E.T. A comparative genomic view of clostridial sporulation and physiology. Nat. Rev. Microbiol.3, 969–978 (2005). ArticleCASPubMed Google Scholar
Moir, A., Corfe, B.M. & Behravan, J. Spore germination. Cell. Mol. Life Sci.59, 403–409 (2002). ArticleCASPubMed Google Scholar
Broussolle, V. et al. Molecular and physiological characterisation of spore germination in Clostridium botulinum and C. sporogenes . Anaerobe8, 89–100 (2002). ArticleCAS Google Scholar
Carter, G.P., Purdy, D., Williams, P. & Minton, N.P. Quorum sensing in Clostridium difficile: analysis of a luxS-type signalling system. J. Med. Microbiol.54, 119–127 (2005). ArticleCASPubMed Google Scholar
Lee, A.S. & Song, K.P. LuxS/autoinducer-2 quorum sensing molecule regulates transcriptional virulence gene expression in Clostridium difficile . Biochem. Biophys. Res. Commun.335, 659–666 (2005). ArticleCASPubMed Google Scholar
Ohtani, K., Hayashi, H. & Shimizu, T. The luxS gene is involved in cell-cell signalling for toxin production in Clostridium perfringens . Mol. Microbiol.44, 171–179 (2002). ArticleCASPubMed Google Scholar
Lyon, G.J. & Novick, R.P. Peptide signaling in Staphylococcus aureus and other Gram-positive bacteria. Peptides25, 1389–1403 (2004). ArticleCASPubMed Google Scholar
van Schaik, W. & Abee, T. The role of sigmaB in the stress response of Gram-positive bacteria–targets for food preservation and safety. Curr. Opin. Biotechnol.16, 218–224 (2005). ArticleCASPubMed Google Scholar
de Vries, Y.P. et al. Deletion of sigB in Bacillus cereus affects spore properties. FEMS Microbiol. Lett.252, 169–173 (2005). ArticleCASPubMed Google Scholar
Wilson, K.H. Efficiency of various bile salt preparations for stimulation of Clostridium difficile spore germination. J. Clin. Microbiol.18, 1017–1019 (1983). CASPubMedPubMed Central Google Scholar
Bell, K.S. et al. Genome sequence of the enterobacterial phytopathogen Erwinia carotovora subsp. atroseptica and characterization of virulence factors. Proc. Natl. Acad. Sci. USA101, 11105–11110 (2004). ArticleCASPubMedPubMed Central Google Scholar
Rutherford, K. et al. Artemis: sequence visualization and annotation. Bioinformatics16, 944–945 (2000). ArticleCASPubMed Google Scholar