CXCR4 acts as a costimulator during thymic β-selection (original) (raw)
Kruisbeek, A.M. et al. Branching out to gain control: how the pre-TCR is linked to multiple functions. Immunol. Today21, 637–644 (2000). ArticleCASPubMed Google Scholar
Wiest, D.L., Berger, M.A. & Carleton, M. Control of early thymocyte development by the pre-T cell receptor complex: A receptor without a ligand? Semin. Immunol.11, 251–262 (1999). ArticleCASPubMed Google Scholar
von Boehmer, H. Unique features of the pre-T-cell receptor α-chain: not just a surrogate. Nat. Rev. Immunol.5, 571–577 (2005). ArticleCASPubMed Google Scholar
Petrie, H.T. & Zúñiga-Pflücker, J.C. Zoned out: functional mapping of stromal signaling microenvironments in the thymus. Annu. Rev. Immunol.25, 649–679 (2007). ArticleCASPubMed Google Scholar
Hollander, G. et al. Cellular and molecular events during early thymus development. Immunol. Rev.209, 28–46 (2006). ArticleCASPubMed Google Scholar
Takahama, Y. Journey through the thymus: stromal guides for T-cell development and selection. Nat. Rev. Immunol.6, 127–135 (2006). ArticleCASPubMed Google Scholar
Zou, Y.R., Kottmann, A.H., Kuroda, M., Taniuchi, I. & Littman, D.R. Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development. Nature393, 595–599 (1998). ArticleCASPubMed Google Scholar
Nagasawa, T. et al. Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1. Nature382, 635–638 (1996). ArticleCASPubMed Google Scholar
Tachibana, K. et al. The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract. Nature393, 591–594 (1998). ArticleCASPubMed Google Scholar
Ceradini, D.J. et al. Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1. Nat. Med.10, 858–864 (2004). ArticleCASPubMed Google Scholar
Kumar, A. et al. CXCR4 physically associates with the T cell receptor to signal in T cells. Immunity25, 213–224 (2006). ArticleCASPubMed Google Scholar
Molon, B. et al. T cell costimulation by chemokine receptors. Nat. Immunol.6, 465–471 (2005). ArticleCASPubMed Google Scholar
Plotkin, J., Prockop, S.E., Lepique, A. & Petrie, H.T. Critical role for CXCR4 signaling in progenitor localization and T cell differentiation in the postnatal thymus. J. Immunol.171, 4521–4527 (2003). ArticleCASPubMed Google Scholar
Aifantis, I., Mandal, M., Sawai, K., Ferrando, A. & Vilimas, T. Regulation of T-cell progenitor survival and cell-cycle entry by the pre-T-cell receptor. Immunol. Rev.209, 159–169 (2006). ArticleCASPubMed Google Scholar
Ciofani, M. & Zúñiga-Pflücker, J.C. The thymus as an inductive site for T lymphopoiesis. Annu. Rev. Cell Dev. Biol.23, 463–493 (2007). ArticleCASPubMed Google Scholar
Ciofani, M. et al. Obligatory role for cooperative signaling by pre-TCR and Notch during thymocyte differentiation. J. Immunol.172, 5230–5239 (2004). ArticleCASPubMed Google Scholar
Haks, M.C., Krimpenfort, P., van den Brakel, J.H. & Kruisbeek, A.M. Pre-TCR signaling and inactivation of p53 induces crucial cell survival pathways in pre-T cells. Immunity11, 91–101 (1999). ArticleCASPubMed Google Scholar
Opferman, J.T. & Korsmeyer, S.J. Apoptosis in the development and maintenance of the immune system. Nat. Immunol.4, 410–415 (2003). ArticleCASPubMed Google Scholar
Voll, R.E. et al. NF-κB activation by the pre-T cell receptor serves as a selective survival signal in T lymphocyte development. Immunity13, 677–689 (2000). ArticleCASPubMed Google Scholar
Lind, E.F., Prockop, S.E., Porritt, H.E. & Petrie, H.T. Mapping precursor movement through the postnatal thymus reveals specific microenvironments supporting defined stages of early lymphoid development. J. Exp. Med.194, 127–134 (2001). ArticleCASPubMedPubMed Central Google Scholar
Sierro, F. et al. Disrupted cardiac development but normal hematopoiesis in mice deficient in the second CXCL12/SDF-1 receptor, CXCR7. Proc. Natl. Acad. Sci. USA104, 14759–14764 (2007). ArticleCASPubMedPubMed Central Google Scholar
Schols, D. et al. Inhibition of T-tropic HIV strains by selective antagonization of the chemokine receptor CXCR4. J. Exp. Med.186, 1383–1388 (1997). ArticleCASPubMedPubMed Central Google Scholar
Nie, Y. et al. The role of CXCR4 in maintaining peripheral B cell compartments and humoral immunity. J. Exp. Med.200, 1145–1156 (2004). ArticleCASPubMedPubMed Central Google Scholar
Lee, P.P. et al. A critical role for Dnmt1 and DNA methylation in T cell development, function, and survival. Immunity15, 763–774 (2001). ArticleCASPubMed Google Scholar
Kabashima, K. et al. CXCR4 engagement promotes dendritic cell survival and maturation. Biochem. Biophys. Res. Commun.361, 1012–1016 (2007). ArticleCASPubMed Google Scholar
Suzuki, Y., Rahman, M. & Mitsuya, H. Diverse transcriptional response of CD4+ T cells to stromal cell-derived factor (SDF)-1: cell survival promotion and priming effects of SDF-1 on CD4+ T cells. J. Immunol.167, 3064–3073 (2001). ArticleCASPubMed Google Scholar
Schmitt, T.M. & Zúñiga-Pflücker, J.C. Induction of T cell development from hematopoietic progenitor cells by delta-like-1 in vitro. Immunity17, 749–756 (2002). ArticleCASPubMed Google Scholar
Ciofani, M. & Zúñiga-Pflücker, J.C. A survival guide to early T cell development. Immunol. Res.34, 117–132 (2006). ArticleCASPubMed Google Scholar
Yang, L. et al. Blocking CXCR4-mediated cyclic AMP suppression inhibits brain tumor growth in vivo. Cancer Res.67, 651–658 (2007). ArticleCASPubMed Google Scholar
Shinkai, Y. et al. RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement. Cell68, 855–867 (1992). ArticleCASPubMed Google Scholar
Shinkai, Y. et al. Restoration of T cell development in RAG-2-deficient mice by functional TCR transgenes. Science259, 822–825 (1993). ArticleCASPubMed Google Scholar
Aifantis, I., Gounari, F., Scorrano, L., Borowski, C. & von Boehmer, H. Constitutive pre-TCR signaling promotes differentiation through Ca2+ mobilization and activation of NF-κB and NFAT. Nat. Immunol.2, 403–409 (2001). ArticleCASPubMed Google Scholar
Sotsios, Y., Whittaker, G.C., Westwick, J. & Ward, S.G. The CXC chemokine stromal cell-derived factor activates a Gi-coupled phosphoinositide 3-kinase in T lymphocytes. J. Immunol.163, 5954–5963 (1999). CASPubMed Google Scholar
Kelemen, B.R., Hsiao, K. & Goueli, S.A. Selective in vivo inhibition of mitogen-activated protein kinase activation using cell-permeable peptides. J. Biol. Chem.277, 8741–8748 (2002). ArticleCASPubMed Google Scholar
Alsayed, Y. et al. Mechanisms of regulation of CXCR4/SDF-1 (CXCL12)-dependent migration and homing in multiple myeloma. Blood109, 2708–2717 (2007). CASPubMedPubMed Central Google Scholar
Kremer, K.N., Humphreys, T.D., Kumar, A., Qian, N.X. & Hedin, K.E. Distinct role of ZAP-70 and Src homology 2 domain-containing leukocyte protein of 76 kDa in the prolonged activation of extracellular signal-regulated protein kinase by the stromal cell-derived factor-1α/CXCL12 chemokine. J. Immunol.171, 360–367 (2003). ArticleCASPubMed Google Scholar
Trampont, P., Zhang, L. & Ravichandran, K.S. ShcA mediates the dominant pathway to extracellular signal-regulated kinase activation during early thymic development. Mol. Cell. Biol.26, 9035–9044 (2006). ArticleCASPubMedPubMed Central Google Scholar
Zhang, L., Camerini, V., Bender, T.P. & Ravichandran, K.S. A nonredundant role for the adapter protein Shc in thymic T cell development. Nat. Immunol.3, 749–755 (2002). ArticleCASPubMed Google Scholar
Patrussi, L. et al. p52Shc is required for CXCR4-dependent signaling and chemotaxis in T cells. Blood110, 1730–1738 (2007). ArticleCASPubMed Google Scholar
von Boehmer, H. et al. Crucial function of the pre-T-cell receptor (TCR) in TCR beta selection, TCR beta allelic exclusion and αβ versus γδ lineage commitment. Immunol. Rev.165, 111–119 (1998). ArticleCASPubMed Google Scholar
Espert, L. et al. Autophagy is involved in T cell death after binding of HIV-1 envelope proteins to CXCR4. J. Clin. Invest.116, 2161–2172 (2006). ArticleCASPubMedPubMed Central Google Scholar
Brooks, D.G., Kitchen, S.G., Kitchen, C.M., Scripture-Adams, D.D. & Zack, J.A. Generation of HIV latency during thymopoiesis. Nat. Med.7, 459–464 (2001). ArticleCASPubMed Google Scholar
Yoder, A. et al. HIV envelope-CXCR4 signaling activates cofilin to overcome cortical actin restriction in resting CD4 T cells. Cell134, 782–792 (2008). ArticleCASPubMedPubMed Central Google Scholar
Broxmeyer, H.E. et al. Transgenic expression of stromal cell-derived factor-1/CXC chemokine ligand 12 enhances myeloid progenitor cell survival/antiapoptosis in vitro in response to growth factor withdrawal and enhances myelopoiesis in vivo. J. Immunol.170, 421–429 (2003). ArticleCASPubMed Google Scholar