The receptor TREML4 amplifies TLR7-mediated signaling during antiviral responses and autoimmunity (original) (raw)

• O'Neill, L.A., Golenbock, D. & Bowie, A.G. The history of Toll-like receptors—redefining innate immunity. Nat. Rev. Immunol. 13, 453–460 (2013).
  Article CAS PubMed Google Scholar
• Barbalat, R., Ewald, S.E., Mouchess, M.L. & Barton, G.M. Nucleic acid recognition by the innate immune system. Annu. Rev. Immunol. 29, 185–214 (2011).
  CAS PubMed Google Scholar
• Gay, N.J. & Keith, F.J. Drosophila Toll and IL-1 receptor. Nature 351, 355–356 (1991).
  CAS PubMed Google Scholar
• Akira, S. & Takeda, K. Toll-like receptor signalling. Nat. Rev. Immunol. 4, 499–511 (2004).
  CAS PubMed Google Scholar
• Kono, D.H., Baccala, R. & Theofilopoulos, A.N. TLRs and interferons: a central paradigm in autoimmunity. Curr. Opin. Immunol. 25, 720–727 (2013).
  CAS PubMed PubMed Central Google Scholar
• Bouchon, A., Facchetti, F., Weigand, M.A. & Colonna, M. TREM-1 amplifies inflammation and is a crucial mediator of septic shock. Nature 410, 1103–1107 (2001).
  CAS PubMed Google Scholar
• Turnbull, I.R. et al. Cutting edge: TREM-2 attenuates macrophage activation. J. Immunol. 177, 3520–3524 (2006).
  CAS PubMed Google Scholar
• Hamerman, J.A. et al. Cutting edge: inhibition of TLR and FcR responses in macrophages by triggering receptor expressed on myeloid cells (TREM)-2 and DAP12. J. Immunol. 177, 2051–2055 (2006).
  CAS PubMed Google Scholar
• Ornatowska, M. et al. Functional genomics of silencing TREM-1 on TLR4 signaling in macrophages. Am. J. Physiol. Lung Cell. Mol. Physiol. 293, L1377–L1384 (2007).
  CAS PubMed Google Scholar
• Ford, J.W. & McVicar, D.W. TREM and TREM-like receptors in inflammation and disease. Curr. Opin. Immunol. 21, 38–46 (2009).
  CAS PubMed PubMed Central Google Scholar
• Washington, A.V. et al. TREM-like transcript-1 protects against inflammation-associated hemorrhage by facilitating platelet aggregation in mice and humans. J. Clin. Invest. 119, 1489–1501 (2009).
  CAS PubMed PubMed Central Google Scholar
• Guerreiro, R. et al. TREM2 variants in Alzheimer's disease. N. Engl. J. Med. 368, 117–127 (2013).
  CAS PubMed Google Scholar
• Jonsson, T. et al. Variant of TREM2 associated with the risk of Alzheimer's disease. N. Engl. J. Med. 368, 107–116 (2013).
  CAS PubMed Google Scholar
• Hamerman, J.A., Tchao, N.K., Lowell, C.A. & Lanier, L.L. Enhanced Toll-like receptor responses in the absence of signaling adaptor DAP12. Nat. Immunol. 6, 579–586 (2005).
  CAS PubMed PubMed Central Google Scholar
• Hemmi, H. et al. A new triggering receptor expressed on myeloid cells (Trem) family member, Trem-like 4, binds to dead cells and is a DNAX activation protein 12-linked marker for subsets of mouse macrophages and dendritic cells. J. Immunol. 182, 1278–1286 (2009).
  CAS PubMed Google Scholar
• N'Diaye, E.N. et al. TREM-2 (triggering receptor expressed on myeloid cells 2) is a phagocytic receptor for bacteria. J. Cell Biol. 184, 215–223 (2009).
  CAS PubMed PubMed Central Google Scholar
• Lövgren, T., Eloranta, M.L., Bave, U., Alm, G.V. & Ronnblom, L. Induction of interferon-alpha production in plasmacytoid dendritic cells by immune complexes containing nucleic acid released by necrotic or late apoptotic cells and lupus IgG. Arthritis Rheum. 50, 1861–1872 (2004).
  PubMed Google Scholar
• Pisitkun, P. et al. Autoreactive B cell responses to RNA-related antigens due to TLR7 gene duplication. Science 312, 1669–1672 (2006).
  CAS PubMed Google Scholar
• Subramanian, S. et al. A Tlr7 translocation accelerates systemic autoimmunity in murine lupus. Proc. Natl. Acad. Sci. USA 103, 9970–9975 (2006).
  CAS PubMed PubMed Central Google Scholar
• Deane, J.A. et al. Control of toll-like receptor 7 expression is essential to restrict autoimmunity and dendritic cell proliferation. Immunity 27, 801–810 (2007).
  CAS PubMed PubMed Central Google Scholar
• Christensen, S.R. et al. Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus. Immunity 25, 417–428 (2006).
  CAS PubMed Google Scholar
• Berland, R. et al. Toll-like receptor 7-dependent loss of B cell tolerance in pathogenic autoantibody knockin mice. Immunity 25, 429–440 (2006).
  CAS PubMed Google Scholar
• Wang, C.M. et al. Genetic variations in Toll-like receptors (TLRs 3/7/8) are associated with systemic lupus erythematosus in a Taiwanese population. Sci. Rep. 4, 3792 (2014).
  PubMed PubMed Central Google Scholar
• Luo, B. et al. Highly parallel identification of essential genes in cancer cells. Proc. Natl. Acad. Sci. USA 105, 20380–20385 (2008).
  CAS PubMed PubMed Central Google Scholar
• Moffat, J. et al. A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen. Cell 124, 1283–1298 (2006).
  CAS PubMed Google Scholar
• Ramirez-Ortiz, Z.G. et al. The scavenger receptor SCARF1 mediates the clearance of apoptotic cells and prevents autoimmunity. Nat. Immunol. 14, 917–926 (2013).
  CAS PubMed PubMed Central Google Scholar
• Hemmi, H. et al. Treml4, an Ig superfamily member, mediates presentation of several antigens to T cells in vivo, including protective immunity to HER2 protein. J. Immunol. 188, 1147–1155 (2012).
  CAS PubMed Google Scholar
• Diebold, S.S., Kaisho, T., Hemmi, H., Akira, S. & Reis e Sousa, C. Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science 303, 1529–1531 (2004).
  CAS PubMed Google Scholar
• Ramsauer, K. et al. p38 MAPK enhances STAT1-dependent transcription independently of Ser-727 phosphorylation. Proc. Natl. Acad. Sci. USA 99, 12859–12864 (2002).
  CAS PubMed PubMed Central Google Scholar
• Luu, K. et al. STAT1 plays a role in TLR signal transduction and inflammatory responses. Immunol. Cell Biol. 92, 761–769 (2014).
  CAS PubMed Google Scholar
• Ivashkiv, L.B. Cross-regulation of signaling by ITAM-associated receptors. Nat. Immunol. 10, 340–347 (2009).
  CAS PubMed PubMed Central Google Scholar
• Klesney-Tait, J., Turnbull, I.R. & Colonna, M. The TREM receptor family and signal integration. Nat. Immunol. 7, 1266–1273 (2006).
  CAS PubMed Google Scholar
• Paradowska-Gorycka, A. & Jurkowska, M. Structure, expression pattern and biological activity of molecular complex TREM-2/DAP12. Hum. Immunol. 74, 730–737 (2013).
  CAS PubMed Google Scholar
• Paloneva, J. et al. Loss-of-function mutations in TYROBP (DAP12) result in a presenile dementia with bone cysts. Nat. Genet. 25, 357–361 (2000).
  CAS PubMed Google Scholar
• Paloneva, J. et al. Mutations in two genes encoding different subunits of a receptor signaling complex result in an identical disease phenotype. Am. J. Hum. Genet. 71, 656–662 (2002).
  CAS PubMed PubMed Central Google Scholar
• Gibot, S. et al. A soluble form of the triggering receptor expressed on myeloid cells-1 modulates the inflammatory response in murine sepsis. J. Exp. Med. 200, 1419–1426 (2004).
  CAS PubMed PubMed Central Google Scholar
• Piccio, L. et al. Identification of soluble TREM-2 in the cerebrospinal fluid and its association with multiple sclerosis and CNS inflammation. Brain 131, 3081–3091 (2008).
  PubMed PubMed Central Google Scholar
• Kleinberger, G. et al. TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis. Sci Transl Med. 6, 243ra286 (2014).
  Google Scholar
• Sen, S.K. et al. Integrative DNA, RNA, and protein evidence connects TREML4 to coronary artery calcification. Am. J. Hum. Genet. 95, 66–76 (2014).
  CAS PubMed PubMed Central Google Scholar
• Silbiger, V.N. et al. Novel genes detected by transcriptional profiling from whole-blood cells in patients with early onset of acute coronary syndrome. Clin. Chim. Acta 421, 184–190 (2013).
  CAS PubMed Google Scholar
• Christensen, S.R. et al. Toll-like receptor 9 controls anti-DNA autoantibody production in murine lupus. J. Exp. Med. 202, 321–331 (2005).
  CAS PubMed PubMed Central Google Scholar
• Herlands, R.A., Christensen, S.R., Sweet, R.A., Hershberg, U. & Shlomchik, M.J. T cell-independent and toll-like receptor-dependent antigen-driven activation of autoreactive B cells. Immunity 29, 249–260 (2008).
  CAS PubMed PubMed Central Google Scholar
• Nickerson, K.M. et al. TLR9 regulates TLR7- and MyD88-dependent autoantibody production and disease in a murine model of lupus. J. Immunol. 184, 1840–1848 (2010).
  CAS PubMed Google Scholar
• Barrat, F.J., Meeker, T., Chan, J.H., Guiducci, C. & Coffman, R.L. Treatment of lupus-prone mice with a dual inhibitor of TLR7 and TLR9 leads to reduction of autoantibody production and amelioration of disease symptoms. Eur. J. Immunol. 37, 3582–3586 (2007).
  CAS PubMed Google Scholar
• Thibault, D.L. et al. IRF9 and STAT1 are required for IgG autoantibody production and B cell expression of TLR7 in mice. J. Clin. Invest. 118, 1417–1426 (2008).
  CAS PubMed PubMed Central Google Scholar