- Chambers, C. A. & Allison, J. P. Costimulatory regulation of T cell function. Curr. Opin. Cell Biol. 11, 203–210 (1999).
Article CAS PubMed Google Scholar
- Keane, M. M., Rivero-Lezcano, O. M., Mitchell, J. A., Robbins, K. C. & Lipkowitz, S. Cloning and characterization of cbl-b: a SH3 binding protein with homology to the c-cbl proto-oncogene. Oncogene 10, 2367–2377 (1995).
CAS PubMed Google Scholar
- Thien, C. B. & Langdon, W. Y. Cbl: many adaptations to regulate protein tyrosine kinases. Nature Rev. Mol. Cell Biol. 2, 294–307 (2001).
Article CAS Google Scholar
- Bachmaier, K. et al. Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b. Nature 403, 211–216 (2000).
Article CAS PubMed Google Scholar
- Chiang, Y. J. et al. Cbl-b regulates the CD28 dependence of T-cell activation. Nature 403, 216–220 (2000).
Article CAS PubMed Google Scholar
- Krawczyk, C. et al. Cbl-b is a negative regulator of receptor clustering and raft aggregation in T cells. Immunity 13, 463–473 (2000).
Article CAS PubMed Google Scholar
- Miyake, S., Lupher, M. L. Jr, Druker, B. & Band, H. The tyrosine kinase regulator Cbl enhances the ubiquitination and degradation of the platelet-derived growth factor receptor α. Proc. Natl Acad. Sci. USA 95, 7927–7932 (1998).
Article CAS PubMed PubMed Central Google Scholar
- Lee, P. S. et al. The Cbl protooncoprotein stimulates CSF-1 receptor multiubiquitination and endocytosis, and attenuates macrophage proliferation. EMBO J. 18, 3616–3628 (1999).
Article CAS PubMed PubMed Central Google Scholar
- Levkowitz, G. et al. Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1. Mol. Cell 4, 1029–1040 (1999).
Article CAS PubMed Google Scholar
- Joazeiro, C. A. et al. The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase. Science 286, 309–312 (1999).
Article CAS PubMed Google Scholar
- Yokouchi, M. et al. Ligand-induced ubiquitination of the epidermal growth factor receptor involves the interaction of the c-Cbl RING finger and UbcH7. J. Biol. Chem. 274, 31707–31712 (1999).
Article CAS PubMed Google Scholar
- Zheng, N., Wang, P., Jeffrey, P. D. & Pavletich, N. P. Structure of a c-Cbl-UbcH7 complex: RING domain function in ubiquitin-protein ligases. Cell 102, 533–539 (2000).
Article CAS PubMed Google Scholar
- Hochstrasser, M. Ubiquitin-dependent protein degradation. Annu. Rev. Genet. 30, 405–439 (1996).
Article CAS PubMed Google Scholar
- Hershko, A. & Ciechanover, A. The ubiquitin system. Annu. Rev. Biochem. 67, 425–479 (1998).
Article CAS PubMed Google Scholar
- Fang, D. et al. Cbl-b, a RING-type E3 ubiquitin ligase, targets phosphatidylinositol 3-kinase for ubiquitination in T cells. J. Biol. Chem. 276, 4872–4878 (2001).
Article CAS PubMed Google Scholar
- Han, J. et al. Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav. Science 279, 558–560 (1998).
Article CAS PubMed Google Scholar
- Scheffner, M., Huibregtse, J. M., Vierstra, R. D. & Howley, P. M. The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53. Cell 75, 495–505 (1993).
Article CAS PubMed Google Scholar
- Dhand, R. et al. PI 3-kinase: structural and functional analysis of intersubunit interactions. EMBO J. 13, 511–521 (1994).
Article CAS PubMed PubMed Central Google Scholar
- Hu, P. & Schlessinger, J. Direct association of p110β phosphatidylinositol 3-kinase with p85 is mediated by an N-terminal fragment of p110β. Mol. Cell. Biol. 14, 2577–2583 (1994).
Article CAS PubMed PubMed Central Google Scholar
- Rameh, L. E. & Cantley, L. C. The role of phosphoinositide 3-kinase lipid products in cell function. J. Biol. Chem. 274, 8347–8350 (1999).
Article CAS PubMed Google Scholar
- Cai, Y.-C. et al. Selective CD28pYMNM mutations implicate phophatidylinositol 3-kinase in CD86-CD28-mediated costimulation. Immunity 3, 417–426 (1995).
Article CAS PubMed Google Scholar
- Exley, M., Varticovski, L., Peter, M., Sancho, J. & Terhorst, C. Association of phosphatidylinositol 3-kinase with a specific sequence of the T cell receptor ζ chain is dependent on T cell activation. J. Biol. Chem. 269, 15140–15146 (1994).
CAS PubMed Google Scholar
- Shahinian, A. et al. Differential T cell costimulatory requirements in CD28-deficient mice. Science 261, 609–612 (1993).
Article CAS PubMed Google Scholar
- Green, J. M. et al. Absence of B7-dependent responses in CD28-deficient mice. Immunity 1, 501–508 (1994).
Article CAS PubMed Google Scholar
- Kaiser, P., Flick, K., Wittenberg, C. & Reed, S. I. Regulation of transcription by ubiquitination without proteolysis: Cdc34/SCF(Met30)-mediated inactivation of the transcription factor Met4. Cell 102, 303–314 (2000).
Article CAS PubMed Google Scholar
- Hoppe, T. et al. Activation of a membrane-bound transcription factor by regulated ubiquitin/proteasome-dependent processing. Cell 102, 577–586 (2000).
Article CAS PubMed Google Scholar
- de Aos, I. et al. Tyrosine phosphorylation of the CD3ɛ subunit of the T cell antigen receptor mediates enhanced association with phosphatidylinositol 3-kinase in Jurkat T cells. J. Biol. Chem. 272, 25310–25318 (1997).
Article CAS PubMed Google Scholar
- Wulfing, C. & Davis, M. M. A receptor-cytoskeletal movement triggered by costimulation during T cell activation. Science 282, 2266–2269 (1998).
Article CAS PubMed Google Scholar
- Viola, A., Schroeder, S., Sakakibara, Y. & Lanzavecchia, A. T lymphocyte costimulation mediated by reorganization of membrane microdomains. Science 283, 680–682 (1999).
Article CAS PubMed Google Scholar
- Kane, L. P., Andres, P. G., Howland, K. C., Abbas, A. K. & Weiss, A. Akt provides the CD28 costimulatory signal for up-regulation of IL-2 and IFN-γ but not Th2 cytokines. Nature Immunol. 2, 37–44 (2001).
Article CAS Google Scholar
- Zhang, W., Sloan-Lancaster, J., Kitchen, J., Trible, R. P. & Samelson, L. E. LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation. Cell 92, 83–92 (1998).
Article CAS PubMed Google Scholar
- Okada, T., Maeda, A., Iwamatsu, A., Gotoh, K. & Kurosaki, T. BCAP: the tyrosine kinase substrate that connects B cell receptor to phosphoinositide 3-kinase activation. Immunity 13, 817–827 (2000).
Article CAS PubMed Google Scholar
- Murphy, M. A. et al. Tissue hyperplasia and enhanced T-cell signalling via ZAP-70 in c-Cbl-deficient mice. Mol. Cell. Biol. 18, 487–4882 (1998).
Article Google Scholar
- Naramura, M., Kole, H. K., Hu, R.-J. & Gu, H. Altered thymic positive selection and intracellular signals in Cbl-deficient mice. Proc. Natl Acad. Sci. USA 95, 15547–15552 (1998).
Article CAS PubMed PubMed Central Google Scholar
- Wang, H. Y. et al. Cbl promotes ubiquitination of the T cell receptor ζ through an adaptor function of Zap-70. J. Biol. Chem. 276, 26004–26011 (2001).
Article CAS PubMed Google Scholar
- Elly, C. et al. Tyrosine phosphorylation and complex formation of Cbl-b upon T cell receptor stimulation. Oncogene 18, 1153–1162 (1999).
Article Google Scholar
- Qiu, L. et al. Recognition and ubiquitination of Notch by Itch, a Hect-type E3 ubiquitin ligase. J. Biol. Chem. 275, 35734–35737 (2000).
Article CAS PubMed Google Scholar