Nonstimulatory peptides contribute to antigen-induced CD8–T cell receptor interaction at the immunological synapse (original) (raw)

References

  1. Davis, M.M. et al. Ligand recognition by αβ T cell receptors. Annu. Rev. Immunol. 16, 523–534 (1998).
    Article CAS Google Scholar
  2. Gascoigne, N.R.J., Zal, T. & Alam, S.M. T-cell receptor binding kinetics in T-cell development and activation. Exp. Rev. Mol. Med. [online] (http://www.expertreviews.org/01002502h.htm) (2001).
  3. Zamoyska, R. CD4 and CD8: Modulators of T-cell receptor recognition of antigen and of immune responses? Curr. Opin. Immunol. 10, 82–87 (1998).
    Article CAS Google Scholar
  4. Potter, T.A., Rajan, T.V., Dick, R.F., II & Bluestone, J.A. Substitution at residue 227 of H-2 class I molecules abrogates recognition by CD8-dependent, but not CD8-independent, cytotoxic T lymphocytes. Nature 337, 73–75 (1989).
    Article CAS Google Scholar
  5. Madrenas, J., Chau, L.A., Smith, J., Bluestone, J.A. & Germain, R.N. The efficiency of CD4 recruitment to ligand-engaged TCR controls the agonist/partial agonist properties of peptide-MHC molecule ligands. J. Exp. Med. 185, 219–229 (1997).
    Article CAS Google Scholar
  6. Wyer, J.R. et al. T cell receptor and coreceptor CD8αα bind peptide-MHC independently and with distinct kinetics. Immunity 10, 219–225 (1999).
    Article CAS Google Scholar
  7. Arcaro, A. et al. CD8β endows CD8 with efficient coreceptor function by coupling T cell receptor/CD3 to raft-associated CD8/p56lck complexes. J. Exp. Med. 194, 1485–1495 (2001).
    Article CAS Google Scholar
  8. Xiong, Y., Kern, P., Chang, H-C. & Reinherz, E.L. T cell receptor binding to a pMHCII ligand is kinetically distinct from and independent of CD4. J. Biol. Chem. 276, 5659–5667 (2001).
    Article CAS Google Scholar
  9. Gascoigne, N.R.J. & Zal, T. Molecular interactions at the T cell-antigen-presenting cell interface. Curr. Opin. Immunol. 16, 114–119 (2004).
    Article CAS Google Scholar
  10. Gallagher, P.F., Fazekas de St Groth, B. & Miller, J.F.A.P. CD4 and CD8 molecules can physically associate with the same T-cell receptor. Proc. Natl. Acad. Sci. USA 86, 10044–10048 (1989).
    Article CAS Google Scholar
  11. Beyers, A.D., Spruyt, L.L. & Williams, A.F. Molecular associations between the T-lymphocyte antigen receptor complex and the surface antigens CD2, CD4, or CD8 and CD5. Proc. Natl. Acad. Sci. USA 89, 2945–2949 (1992).
    Article CAS Google Scholar
  12. Suzuki, S., Kupsch, J., Eichmann, K. & Saizawa, M.K. Biochemical evidence of the physical association of the majority of CD3 δ chains with the accessory/co-receptor molecules CD4 and CD8 on nonactivated T lymphocytes. Eur. J. Immunol. 22, 2475–2479 (1992).
    Article CAS Google Scholar
  13. Doucey, M.A. et al. CD3δ establishes a functional link between the T cell receptor and CD8. J. Biol. Chem. 278, 3257–3264 (2003).
    Article CAS Google Scholar
  14. Mittler, R.S., Goldman, S.J., Spitalny, G.L. & Burakoff, S.J. T-cell receptor-CD4 physical association in a murine T-cell hybridoma: Induction by physical antigen receptor ligation. Proc. Natl. Acad. Sci. USA 86, 8531–8535 (1989).
    Article CAS Google Scholar
  15. Anel, A., Martinez-Lorenzo, M.J., Schmitt-Verhulst, A.M. & Boyer, C. Influence on CD8 of TCR/CD3-generated signals in CTL clones and CTL precursor cells. J. Immunol. 158, 19–28 (1997).
    CAS PubMed Google Scholar
  16. Osono, E., Sato, N., Yokomuro, K. & Saizawa, M.K. Changes in arrangement and in conformation of molecular components of peripheral T-cell antigen receptor complex after ligand binding: analyses by co-precipitation profiles. Scand. J. Immunol. 45, 487–493 (1997).
    Article CAS Google Scholar
  17. Block, M.S., Johnson, A.J., Mendez-Fernandez, Y. & Pease, L.R. Monomeric class I molecules mediate TCR/CD3ε/CD8 interaction on the surface of T cells. J. Immunol. 167, 821–826 (2001).
    Article CAS Google Scholar
  18. Takada, S. & Engleman, E.G. Evidence for an association between CD8 molecules and the T cell receptor complex on cytotoxic T cells. J. Immunol. 139, 3231–3235 (1987).
    CAS PubMed Google Scholar
  19. Anderson, P., Blue, M-L., Schlossman, S.F. & Comodulation of CD3 and CD4 Evidence for a specific association between CD4 and approximately 5% of the CD3:T cell receptor complexes on helper T lymphocytes. J. Immunol. 140, 1732–1737 (1988).
    CAS PubMed Google Scholar
  20. Rojo, J.M., Saizawa, K. & Janeway, C.A., Jr. Physical association of CD4 and the T-cell receptor can be induced by anti-T-cell receptor antibodies. Proc. Natl. Acad. Sci. USA 86, 3311–3315 (1989).
    Article CAS Google Scholar
  21. Kwan Lim, G.E., McNeill, L., Whitley, K., Becker, D.L. & Zamoyska, R. Co-capping studies reveal CD8/TCR interactions after capping CD8β polypeptides and intracellular associations of CD8 with p56lck. Eur. J. Immunol. 28, 745–754 (1998).
    Article CAS Google Scholar
  22. Montixi, C. et al. Engagement of T cell receptor triggers its recruitment to low-density detergent-insoluble membrane domains. EMBO J. 17, 5334–5348 (1998).
    Article CAS Google Scholar
  23. Xavier, R., Brennan, T., Li, Q.Q., McCormack, C. & Seed, B. Membrane compartmentation is required for efficient T cell activation. Immunity 8, 723–732 (1998).
    Article CAS Google Scholar
  24. Bromley, S.K. et al. The immunological synapse. Annu. Rev. Immunol. 19, 375–396 (2001).
    Article CAS Google Scholar
  25. Krummel, M.F., Sjaastad, M.D., Wülfing, C. & Davis, M.M. Differential clustering of CD4 and CD3ζ during T cell recognition. Science 289, 1349–1352 (2000).
    Article CAS Google Scholar
  26. Zal, T., Zal, M.A. & Gascoigne, N.R.J. Inhibition of T-cell receptor-coreceptor interactions by antagonist ligands visualized by live FRET imaging of the T-hybridoma immunological synapse. Immunity 16, 521–534 (2002).
    Article CAS Google Scholar
  27. Purbhoo, M.A., Irvine, D.J., Huppa, J.B. & Davis, M.M. T cell killing does not require the formation of a stable mature immunological synapse. Nat. Immunol. 5, 524–530 (2004).
    Article CAS Google Scholar
  28. Potter, T.A., Grebe, K., Freiberg, B. & Kupfer, A. Formation of supramolecular activation clusters on fresh ex vivo CD8+ T cells after engagement of the T cell antigen receptor and CD8 by antigen-presenting cells. Proc. Natl. Acad. Sci. USA 98, 12624–12629 (2001).
    Article CAS Google Scholar
  29. Revy, P., Sospedra, M., Barbour, B. & Trautmann, A. Functional antigen-independent synapses formed between T cells and dendritic cells. Nat. Immunol. 2, 925–931 (2001).
    Article CAS Google Scholar
  30. Wulfing, C. et al. Costimulation and endogenous MHC ligands contribute to T cell recognition. Nat. Immunol. 3, 42–47 (2002).
    Article CAS Google Scholar
  31. Krogsgaard, M. et al. Agonist/endogenous peptide-MHC heterodimers drive T cell activation and sensitivity. Nature 434, 238–243 (2005).
    Article CAS Google Scholar
  32. Zal, T. & Gascoigne, N.R.J. Using live FRET imaging to reveal early protein-protein interactions during T cell activation. Curr. Opin. Immunol. 16, 418–427 (2004).
    Article CAS Google Scholar
  33. Alam, S.M. et al. T cell receptor affinity and thymocyte positive selection. Nature 381, 616–620 (1996).
    Article CAS Google Scholar
  34. Stotz, S.H., Bolliger, L., Carbone, F.R. & Palmer, E. T cell receptor (TCR) antagonism without a negative signal: Evidence from T cell hybridomas expressing two independent TCRs. J. Exp. Med. 189, 253–263 (1999).
    Article CAS Google Scholar
  35. Gorman, S.D., Sun, Y.H., Zamoyska, R. & Parnes, J.R. Molecular linkage of the Ly-3 and Ly-2 genes. Requirement of Ly-2 for Ly-3 surface expression. J. Immunol. 140, 3646–3653 (1988).
    CAS Google Scholar
  36. Holmberg, K., Mariathasan, S., Ohteki, T., Ohashi, P.S. & Gascoigne, N.R.J. TCR binding kinetics measured with MHC class I tetramers reveal a positive selecting peptide with relatively high affinity for TCR. J. Immunol. 171, 2427–2434 (2003).
    Article CAS Google Scholar
  37. Monks, C.R.F., Freiberg, B.A., Kupfer, H., Sciaky, N. & Kupfer, A. Three-dimensional segregation of supramolecular activation clusters in T cells. Nature 395, 82–86 (1998).
    Article CAS Google Scholar
  38. Zal, T. & Gascoigne, N.R.J. Photobleaching-corrected FRET efficiency imaging of live cells. Biophys. J. 86, 3923–3939 (2004).
    Article CAS Google Scholar
  39. Freiberg, B.A. et al. Staging and resetting T cell activation in SMACs. Nat. Immunol. 3, 911–917 (2002).
    Article CAS Google Scholar
  40. Porgador, A., Yewdell, J.W., Deng, Y., Bennink, J.R. & Germain, R.N. Localization, quantitation, and in situ detection of specific peptide–MHC class I complexes using a monoclonal antibody. Immunity 6, 715–726 (1997).
    Article CAS Google Scholar
  41. Santori, F.R. et al. Rare, structurally homologous self-peptides promote thymocyte positive selection. Immunity 17, 131–142 (2002).
    Article CAS Google Scholar
  42. Kupfer, A., Singer, S.J., Janeway, C.A., Jr & Swain, S.L. Coclustering of CD4 (L3T4) molecule with the T cell receptor is induced by specific direct interaction of helper T cells and antigen-presenting cells. Proc. Natl. Acad. Sci. USA 84, 5888–5892 (1987).
    Article CAS Google Scholar
  43. O'Rourke, A.M., Rogers, J. & Mescher, M.F. Activated CD8 binding to class I protein mediated by the T cell receptor results in signalling. Nature 346, 187–189 (1990).
    Article CAS Google Scholar
  44. Sporri, R. & Reis e Sousa, C. Self peptide/MHC class I complexes have a negligible effect on the response of some CD8+ T cells to foreign antigen. Eur. J. Immunol. 32, 3161–3170 (2002).
    Article CAS Google Scholar
  45. van der Merwe, P.A. & Davis, S.J. Molecular interactions mediating T cell antigen recognition. Annu. Rev. Immunol. 21, 659–684 (2003).
    Article CAS Google Scholar
  46. Irvine, D.J., Purbhoo, M.A., Krogsgaard, M. & Davis, M.M. Direct observation of ligand recognition by T cells. Nature 419, 845–849 (2002).
    Article CAS Google Scholar
  47. Li, Q.J. et al. CD4 enhances T cell sensitivity to antigen by coordinating Lck accumulation at the immunological synapse. Nat. Immunol. 5, 791–799 (2004).
    Article CAS Google Scholar
  48. Ljunggren, H.G. et al. Empty MHC class I molecules come out in the cold. Nature 346, 476–480 (1990).
    Article CAS Google Scholar
  49. Altman, J.D. et al. Phenotypic analysis of antigen-specific T lymphocytes. Science 274, 94–96 (1996).
    Article CAS Google Scholar

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