Medullary thymic epithelial cells expressing Aire represent a unique lineage derived from cells expressing claudin (original) (raw)

• van Ewijk, W. et al. Thymic microenvironments, 3-D versus 2-D? Semin. Immunol. 11, 57–64 (1999).
  Article CAS Google Scholar
• Gill, J. et al. Thymic generation and regeneration. Immunol. Rev. 195, 28–50 (2003).
  Article CAS Google Scholar
• Blackburn, C.C. & Manley, N.R. Developing a new paradigm for thymus organogenesis. Nat. Rev. Immunol. 4, 278–289 (2004).
  Article CAS Google Scholar
• Anderson, G., Owen, J.J., Moore, N.C. & Jenkinson, E.J. Thymic epithelial cells provide unique signals for positive selection of CD4+CD8+ thymocytes in vitro. J. Exp. Med. 179, 2027–2031 (1994).
  Article CAS Google Scholar
• Petrie, H.T. Cell migration and the control of post-natal T-cell lymphopoiesis in the thymus. Nat. Rev. Immunol. 3, 859–866 (2003).
  Article CAS Google Scholar
• Takahama, Y. Journey through the thymus: stromal guides for T-cell development and selection. Nat. Rev. Immunol. 6, 127–135 (2006).
  Article CAS Google Scholar
• Kyewski, B. & Klein, L. A central role for central tolerance. Annu. Rev. Immunol. 24, 571–606 (2006).
  Article CAS Google Scholar
• Farr, A.G., Dooley, J.L. & Erickson, M. Organization of thymic medullary epithelial heterogeneity: implications for mechanisms of epithelial differentiation. Immunol. Rev. 189, 20–27 (2002).
  Article CAS Google Scholar
• Anderson, M.S. et al. Projection of an immunological self shadow within the thymus by the aire protein. Science 298, 1395–1401 (2002).
  Article CAS Google Scholar
• Derbinski, J. et al. Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels. J. Exp. Med. 202, 33–45 (2005).
  Article CAS Google Scholar
• Bennett, A.R. et al. Identification and characterization of thymic epithelial progenitor cells. Immunity 16, 803–814 (2002).
  Article CAS Google Scholar
• Gill, J., Malin, M., Hollander, G.A. & Boyd, R. Generation of a complete thymic microenvironment by MTS24+ thymic epithelial cells. Nat. Immunol. 3, 635–642 (2002).
  Article CAS Google Scholar
• Rossi, S.W., Jenkinson, W.E., Anderson, G. & Jenkinson, E.J. Clonal analysis reveals a common progenitor for thymic cortical and medullary epithelium. Nature 441, 988–991 (2006).
  Article CAS Google Scholar
• Gillard, G.O. & Farr, A.G. Contrasting models of promiscuous gene expression by thymic epithelium. J. Exp. Med. 202, 15–19 (2005).
  Article CAS Google Scholar
• Hollander, G.A. et al. Developmental control point in induction of thymic cortex regulated by a subpopulation of prothymocytes. Nature 373, 350–353 (1995).
  Article CAS Google Scholar
• van Ewijk, W., Hollander, G., Terhorst, C. & Wang, B. Stepwise development of thymic microenvironments in vivo is regulated by thymocyte subsets. Development 127, 1583–1591 (2000).
  CAS PubMed Google Scholar
• Itoi, M., Kawamoto, H., Katsura, Y. & Amagai, T. Two distinct steps of immigration of hematopoietic progenitors into the early thymus anlage. Int. Immunol. 13, 1203–1211 (2001).
  Article CAS Google Scholar
• Gordon, J. et al. Functional evidence for a single endodermal origin for the thymic epithelium. Nat. Immunol. 5, 546–553 (2004).
  Article CAS Google Scholar
• Tsukita, S., Furuse, M. & Itoh, M. Multifunctional strands in tight junctions. Nat. Rev. Mol. Cell Biol. 2, 285–293 (2001).
  Article CAS Google Scholar
• Klug, D.B. et al. Interdependence of cortical thymic epithelial cell differentiation and T-lineage commitment. Proc. Natl. Acad. Sci. USA 95, 11822–11827 (1998).
  Article CAS Google Scholar
• Sonoda, N. et al. Clostridium perfringens enterotoxin fragment removes specific claudins from tight junction strands: Evidence for direct involvement of claudins in tight junction barrier. J. Cell Biol. 147, 195–204 (1999).
  Article Google Scholar
• Kajiura, F. et al. NF-κB-inducing kinase establishes self-tolerance in a thymic stroma-dependent manner. J. Immunol. 172, 2067–2075 (2004).
  Article CAS Google Scholar
• Akiyama, T. et al. Dependence of self-tolerance on TRAF6-directed development of thymic stroma. Science 308, 248–251 (2005).
  Article CAS Google Scholar
• Derbinski, J., Schulte, A., Kyewski, B. & Klein, L. Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self. Nat. Immunol. 2, 1032–1039 (2001).
  Article CAS Google Scholar
• Kyewski, B. & Derbinski, J. Self-representation in the thymus: an extended view. Nat. Rev. Immunol. 4, 688–698 (2004).
  Article CAS Google Scholar
• Aaltonen, J. et al. An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains. Nat. Genet. 17, 399–403 (1997).
  Article Google Scholar
• Nagamine, K. et al. Positional cloning of the APECED gene. Nat. Genet. 17, 393–398 (1997).
  Article CAS Google Scholar
• Ramsey, C. et al. Aire deficient mice develop multiple features of APECED phenotype and show altered immune response. Hum. Mol. Genet. 11, 397–409 (2002).
  Article CAS Google Scholar
• Kuroda, N. et al. Development of autoimmunity against transcriptionally unrepressed target antigen in the thymus of Aire-deficient mice. J. Immunol. 174, 1862–1870 (2005).
  Article CAS Google Scholar
• Zhang, M. et al. T cell tolerance to a neo-self antigen expressed by thymic epithelial cells: the soluble form is more effective than the membrane-bound form. J. Immunol. 170, 3954–3962 (2003).
  Article CAS Google Scholar
• Gallegos, A.M. & Bevan, M.J. Central tolerance to tissue-specific antigens mediated by direct and indirect antigen presentation. J. Exp. Med. 200, 1039–1049 (2004).
  Article CAS Google Scholar
• Gillard, G.O. & Farr, A.G. Features of medullary thymic epithelium implicate postnatal development in maintaining epithelial heterogeneity and tissue-restricted antigen expression. J. Immunol. 176, 5815–5824 (2006).
  Article CAS Google Scholar
• Furuse, M. et al. Claudin-based tight junctions are crucial for the mammalian epidermal barrier: a lesson from claudin-1-deficient mice. J. Cell Biol. 156, 1099–1111 (2002).
  Article CAS Google Scholar
• Tsukita, S. & Furuse, M. Claudin-based barrier in simple and stratified cellular sheets. Curr. Opin. Cell Biol. 14, 531–536 (2002).
  Article CAS Google Scholar
• Rodewald, H.R., Paul, S., Haller, C., Bluethmann, H. & Blum, C. Thymus medulla consisting of epithelial islets each derived from a single progenitor. Nature 414, 763–768 (2001).
  Article CAS Google Scholar
• Bleul, C.C. et al. Formation of a functional thymus initiated by a postnatal epithelial progenitor cell. Nature 441, 992–996 (2006).
  Article CAS Google Scholar
• Chin, R.K. et al. Lymphotoxin pathway directs thymic Aire expression. Nat. Immunol. 4, 1121–1127 (2003).
  Article CAS Google Scholar
• Boehm, T., Scheu, S., Pfeffer, K. & Bleul, C.C. Thymic medullary epithelial cell differentiation, thymocyte emigration, and the control of autoimmunity require lympho-epithelial cross talk via LTβR. J. Exp. Med. 198, 757–769 (2003).
  Article CAS Google Scholar
• Zuklys, S. et al. Normal thymic architecture and negative selection are associated with Aire expression, the gene defective in the autoimmune-polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED). J. Immunol. 165, 1976–1983 (2000).
  Article CAS Google Scholar
• Burkly, L. et al. Expression of relB is required for the development of thymic medulla and dendritic cells. Nature 373, 531–536 (1995).
  Article CAS Google Scholar
• Weih, F. et al. Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-κB/Rel family. Cell 80, 331–340 (1995).
  Article CAS Google Scholar
• Furuse, M., Sasaki, H., Fujimoto, K. & Tsukita, S. A single gene product, claudin-1 or -2, reconstitutes tight junction strands and recruits occludin in fibroblasts. J. Cell Biol. 143, 391–401 (1998).
  Article CAS Google Scholar
• Kobayashi, T. et al. TRAF6 is a critical factor for dendritic cell maturation and development. Immunity 19, 353–363 (2003).
  Article CAS Google Scholar
• Ishida, M. et al. Differential expression of PD-L1 and PD-L2, ligands for an inhibitory receptor PD-1, in the cells of lymphohematopoietic tissues. Immunol. Lett. 84, 57–62 (2002).
  Article CAS Google Scholar
• Niki, S. et al. Alteration of intra-pancreatic target-organ specificity by abrogation of Aire in NOD mice. J. Clin. Invest. 116, 1292–1301 (2006).
  Article CAS Google Scholar
• Liston, A. et al. Gene dosage–limiting role of Aire in thymic expression, clonal deletion, and organ-specific autoimmunity. J. Exp. Med. 200, 1015–1026 (2004).
  Article CAS Google Scholar
• Katahira, J., Inoue, N., Horiguchi, Y., Matsuda, M. & Sugimoto, N. Molecular cloning and functional characterization of the receptor for Clostridium perfringens enterotoxin. J. Cell Biol. 136, 1239–1247 (1997).
  Article CAS Google Scholar
• Gray, D.H., Chidgey, A.P. & Boyd, R.L. Analysis of thymic stromal cell populations using flow cytometry. J. Immunol. Methods 260, 15–28 (2002).
  Article CAS Google Scholar
• Hamazaki, Y., Itoh, M., Sasaki, H., Furuse, M. & Tsukita, S. Multi-PDZ domain protein 1 (MUPP1) is concentrated at tight junctions through its possible interaction with claudin-1 and junctional adhesion molecule. J. Biol. Chem. 277, 455–461 (2002).
  Article CAS Google Scholar