Hlx is induced by and genetically interacts with T-bet to promote heritable TH1 gene induction (original) (raw)

• Glimcher, L.H. & Murphy, K.M. Lineage commitment in the immune system: the T helper lymphocyte grows up. Genes Dev. 14, 1693–1711 (2000).
  CAS PubMed Google Scholar
• Reiner, S.L. Helper T cell differentiation, inside and out. Curr. Opin. Immunol. 13, 351–355 (2001).
  Article CAS PubMed Google Scholar
• Kurata, H., Lee, H.J., O'Garra, A. & Arai, N. Ectopic expression of activated Stat6 induces the expression of Th2-specific cytokines and transcription factors in developing Th1 cells. Immunity 11, 677–688 (1999).
  Article CAS PubMed Google Scholar
• Kurt-Jones, E.A., Hamberg, S., Ohara, J., Paul, W.E. & Abbas, A.K. Heterogeneity of helper/inducer T lymphocytes. I. Lymphokine production and lymphokine responsiveness. J. Exp. Med. 166, 1774–1787 (1987).
  Article CAS PubMed Google Scholar
• Mullen, A.C. et al. Role of T-bet in commitment of TH1 cells before IL-12-dependent selection. Science 292, 1907–1910 (2001).
  Article CAS PubMed Google Scholar
• Mullen, A.C. et al. Cell cycle controlling the silencing and functioning of mammalian activators. Curr. Biol. 11, 1695–1699 (2001).
  Article CAS PubMed Google Scholar
• Kennedy, M.K., Picha, K.S., Shanebeck, K.D., Anderson, D.M. & Grabstein, K.H. Interleukin-12 regulates the proliferation of Th1, but not Th2 or Th0, clones. Eur. J. Immunol. 24, 2271–2278 (1994).
  Article CAS PubMed Google Scholar
• Ouyang, W. et al. Inhibition of Th1 development mediated by GATA-3 through an IL-4-independent mechanism. Immunity 9, 745–755 (1998).
  Article CAS PubMed Google Scholar
• Bird, J.J. et al. Helper T cell differentiation is controlled by the cell cycle. Immunity 9, 229–237 (1998).
  Article CAS PubMed Google Scholar
• Gett, A.V. & Hodgkin, P.D. Cell division regulates the T cell cytokine repertoire, revealing a mechanism underlying immune class regulation. Proc. Natl. Acad. Sci. USA 95, 9488–9493 (1998).
  Article CAS PubMed PubMed Central Google Scholar
• Richter, A., Lohning, M. & Radbruch, A. Instruction for cytokine expression in T helper lymphocytes in relation to proliferation and cell cycle progression. J. Exp. Med. 190, 1439–1450 (1999).
  Article CAS PubMed PubMed Central Google Scholar
• Grogan, J.L. et al. Early transcription and silencing of cytokine genes underlie polarization of T helper cell subsets. Immunity 14, 205–215 (2001).
  Article CAS PubMed Google Scholar
• Tada, M. & Smith, J.C. T-targets: clues to understanding the functions of T-box proteins. Dev. Growth Differ. 43, 1–11 (2001).
  Article CAS PubMed Google Scholar
• Szabo, S.J. et al. A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell 100, 655–669 (2000).
  Article CAS PubMed Google Scholar
• Szabo, S.J. et al. Distinct effects of T-bet in TH1 lineage commitment and IFN-γ production in CD4 and CD8 T cells. Science 295, 338–342 (2002).
  Article CAS PubMed Google Scholar
• Conlon, F.L., Sedgwick, S.G., Weston, K.M. & Smith, J.C. Inhibition of Xbra transcription activation causes defects in mesodermal patterning and reveals autoregulation of Xbra in dorsal mesoderm. Development 122, 2427–2435 (1996).
  CAS PubMed Google Scholar
• Horb, M.E. & Thomsen, G.H. Tbx5 is essential for heart development. Development 126, 1739–1751 (1999).
  CAS PubMed Google Scholar
• Kispert, A., Koschorz, B. & Herrmann, B.G. The T protein encoded by Brachyury is a tissue-specific transcription factor. EMBO J. 14, 4763–4772 (1995).
  Article CAS PubMed PubMed Central Google Scholar
• Gajewski, T.F., Joyce, J. & Fitch, F.W. Antiproliferative effect of IFN-γ in immune regulation. III. Differential selection of TH1 and TH2 murine helper T lymphocyte clones using recombinant IL-2 and recombinant IFN-γ. J. Immunol. 143, 15–22 (1989).
  CAS PubMed Google Scholar
• Izon, D.J. et al. Notch1 regulates maturation of CD4+ and CD8+ thymocytes by modulating TCR signal strength. Immunity 14, 253–264 (2001).
  Article CAS PubMed Google Scholar
• DeKoter, R.P. & Singh, H. Regulation of B lymphocyte and macrophage development by graded expression of PU. 1. Science 288, 1439–1441 (2000).
  Article CAS PubMed Google Scholar
• Agarwal, S. & Rao, A. Modulation of chromatin structure regulates cytokine gene expression during T cell differentiation. Immunity 9, 765–775 (1998).
  Article CAS PubMed Google Scholar
• Solomon, M.J. & Varshavsky, A. A nuclease-hypersensitive region forms de novo after chromosome replication. Mol. Cell. Biol. 7, 3822–3825 (1987).
  Article CAS PubMed PubMed Central Google Scholar
• Wolffe, A.P. & Brown, D.D. DNA replication in vitro erases a Xenopus 5S RNA gene transcription complex. Cell 47, 217–227 (1986).
  Article CAS PubMed Google Scholar
• Lamolet, B. et al. A pituitary cell-restricted T box factor, Tpit, activates POMC transcription in cooperation with Pitx homeoproteins. Cell 104, 849–859 (2001).
  Article CAS PubMed Google Scholar
• Liu, J. et al. Tbx19, a tissue-selective regulator of POMC gene expression. Proc. Natl. Acad. Sci. USA 98, 8674–8679 (2001).
  Article CAS PubMed PubMed Central Google Scholar
• Hiroi, Y. et al. Tbx5 associates with Nkx2-5 and synergistically promotes cardiomyocyte differentiation. Nature Genet. 28, 276–280 (2001).
  Article CAS PubMed Google Scholar
• Bruneau, B.G. et al. A murine model of Holt-Oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and disease. Cell 106, 709–721 (2001).
  Article CAS PubMed Google Scholar
• Lipshutz, R.J., Fodor, S.P., Gingeras, T.R. & Lockhart, D.J. High density synthetic oligonucleotide arrays. Nature Genet. 21, 20–24 (1999).
  Article CAS PubMed Google Scholar
• Allen, J.D. et al. Novel murine homeo box gene on chromosome 1 expressed in specific hematopoietic lineages and during embryogenesis. Genes Dev. 5, 509–520 (1991).
  Article CAS PubMed Google Scholar
• Deguchi, Y. et al. Cloning of a human homeobox gene that resembles a diverged Drosophila homeobox gene and is expressed in activated lymphocytes. New Biol. 3, 353–363 (1991).
  CAS PubMed Google Scholar
• Hentsch, B. et al. Hlx homeo box gene is essential for an inductive tissue interaction that drives expansion of embryonic liver and gut. Genes Dev. 10, 70–79 (1996).
  Article CAS PubMed Google Scholar
• Kaplan, M.H., Sun, Y.L., Hoey, T. & Grusby, M.J. Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice. Nature 382, 174–177 (1996).
  Article CAS PubMed Google Scholar
• Horcher, M., Souabni, A. & Busslinger, M. Pax5/BSAP maintains the identity of B cells in late B lymphopoiesis. Immunity 14, 779–790 (2001).
  Article CAS PubMed Google Scholar
• Tanigaki, K. et al. Notch-RBP-J signaling is involved in cell fate determination of marginal zone B cells. Nature Immunol. 3, 443–450 (2002).
  Article CAS Google Scholar
• Reimold, A.M. et al. Plasma cell differentiation requires the transcription factor XBP-1. Nature 412, 300–307 (2001).
  Article CAS PubMed Google Scholar
• Calfon, M. et al. IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA. Nature 415, 92–96 (2002).
  Article CAS PubMed Google Scholar
• Agarwal, S., Avni, O. & Rao, A. Cell-type-restricted binding of the transcription factor NFAT to a distal IL-4 enhancer in vivo. Immunity 12, 643–652 (2000).
  Article CAS PubMed Google Scholar
• Bird, A. DNA methylation patterns and epigenetic memory. Genes Dev. 16, 6–21 (2002).
  Article CAS PubMed Google Scholar
• Yang, J., Zhu, H., Murphy, T.L., Ouyang, W. & Murphy, K.M., IL-18-stimulated GADD45β required in cytokine-induced, but not TCR-induced, IFN-γ production. Nature Immunol. 2, 157–164 (2001).
  Article CAS Google Scholar
• Lee, H.J. et al. GATA-3 induces T helper cell type 2 (Th2) cytokine expression and chromatin remodeling in committed Th1 cells. J. Exp. Med. 192, 105–115 (2000).
  Article CAS PubMed PubMed Central Google Scholar
• Zhang, D.H., Yang, L. & Ray, A. Differential responsiveness of the IL-5 and IL-4 genes to transcription factor GATA-3. J. Immunol. 161, 3817–382 (1998).
  CAS PubMed Google Scholar
• Cirillo, L.A. et al. Opening of compacted chromatin by early developmental transcription factors HNF3 (FoxA) and GATA-4. Mol. Cell 9, 279–289 (2002).
  Article CAS PubMed Google Scholar
• Lighvani, A.A. et al. T-bet is rapidly induced by interferon-γ in lymphoid and myeloid cells. Proc. Natl. Acad. Sci. USA 98, 15137–15142 (2001).
  Article CAS PubMed PubMed Central Google Scholar
• Kozak, M. Compilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAs. Nucl. Acids Res. 12, 857–872 (1984).
  Article CAS PubMed PubMed Central Google Scholar
• Pear, W.S., Nolan, G.P., Scott, M.L. & Baltimore, D. Production of high-titer helper-free retroviruses by transient transfection. Proc. Natl. Acad. Sci. USA 90, 8392–8396 (1993).
  Article CAS PubMed PubMed Central Google Scholar
• Fitzpatrick, D.R. et al. Distinct methylation of the interferon γ (IFN-γ) and interleukin 3 (IL-3) genes in newly activated primary CD8+ T lymphocytes: regional IFN-γ promoter demethylation and mRNA expression are heritable in CD44highCD8+ T cells. J. Exp. Med. 188, 103–117 (1998).
  Article CAS PubMed PubMed Central Google Scholar