Interleukin-35 induces regulatory B cells that suppress autoimmune disease (original) (raw)
Edwards, J.C. et al. Efficacy of B cell–targeted therapy with rituximab in patients with rheumatoid arthritis. N. Engl. J. Med.350, 2572–2581 (2004). ArticleCAS Google Scholar
Hu, C.Y. et al. Treatment with CD20-specific antibody prevents and reverses autoimmune diabetes in mice. J. Clin. Invest.117, 3857–3867 (2007). ArticleCAS Google Scholar
Yanaba, K. et al. B-lymphocyte contributions to human autoimmune disease. Immunol. Rev.223, 284–299 (2008). ArticleCAS Google Scholar
Bouaziz, J.D. et al. Therapeutic B cell depletion impairs adaptive and autoreactive CD4+ T cell activation in mice. Proc. Natl. Acad. Sci. USA104, 20878–20883 (2007). ArticleCAS Google Scholar
Hamaguchi, Y. Molecular mechanisms of B lymphocyte depletion by CD20 immunotherapy. Nihon Rinsho Meneki Gakkai Kaishi32, 29–34 (2009). ArticleCAS Google Scholar
Pers, J.O. et al. B cell depletion and repopulation in autoimmune diseases. Clin. Rev. Allergy Immunol.34, 50–55 (2008). ArticleCAS Google Scholar
Bouaziz, J.D., Yanaba, K. & Tedder, T.F. Regulatory B cells as inhibitors of immune responses and inflammation. Immunol. Rev.224, 201–214 (2008). ArticleCAS Google Scholar
Yanaba, K. et al. A regulatory B cell subset with a unique CD1dhiCD5+ phenotype controls T cell–dependent inflammatory responses. Immunity28, 639–650 (2008). ArticleCAS Google Scholar
Mauri, C. & Bosma, A. Immune regulatory function of B cells. Annu. Rev. Immunol.30, 221–241 (2012). ArticleCAS Google Scholar
Tadmor, T., Zhang, Y., Cho, H.M., Podack, E.R. & Rosenblatt, J.D. The absence of B lymphocytes reduces the number and function of T-regulatory cells and enhances the anti-tumor response in a murine tumor model. Cancer Immunol. Immunother.60, 609–619 (2011). ArticleCAS Google Scholar
Schioppa, T. et al. B regulatory cells and the tumor-promoting actions of TNF-a during squamous carcinogenesis. Proc. Natl. Acad. Sci. USA108, 10662–10667 (2011). ArticleCAS Google Scholar
Mauri, C. & Ehrenstein, M.R. The 'short' history of regulatory B cells. Trends Immunol.29, 34–40 (2008). ArticleCAS Google Scholar
Berthelot, J.M. et al. Regulatory B cells play a key role in immune system balance. Joint Bone Spine80, 18–22 (2013). ArticleCAS Google Scholar
Yoshizaki, A. et al. Regulatory B cells control T cell autoimmunity through IL-21–dependent cognate interactions. Nature491, 264–268 (2012). ArticleCAS Google Scholar
Rafei, M. et al. A granulocyte-macrophage colony-stimulating factor and interleukin-15 fusokine induces a regulatory B cell population with immune suppressive properties. Nat. Med.15, 1038–1045 (2009). ArticleCAS Google Scholar
Collison, L.W. et al. The inhibitory cytokine IL-35 contributes to regulatory T cell function. Nature450, 566–569 (2007). ArticleCAS Google Scholar
Collison, L.W. et al. IL-35–mediated induction of a potent regulatory T cell population. Nat. Immunol.11, 1093–1101 (2010). ArticleCAS Google Scholar
Hunter, C.A. New IL-12-family members: IL-23 and IL-27, cytokines with divergent functions. Nat. Rev. Immunol.5, 521–531 (2005). ArticleCAS Google Scholar
Devergne, O., Birkenbach, M. & Kieff, E. Epstein-Barr virus–induced gene 3 and the p35 subunit of interleukin 12 form a novel heterodimeric hematopoietin. Proc. Natl. Acad. Sci. USA94, 12041–12046 (1997). ArticleCAS Google Scholar
Niedbala, W. et al. IL-35 is a novel cytokine with therapeutic effects against collagen-induced arthritis through the expansion of regulatory T cells and suppression of Th17 cells. Eur. J. Immunol.37, 3021–3029 (2007). ArticleCAS Google Scholar
Caspi, R.R. A look at autoimmunity and inflammation in the eye. J. Clin. Invest.120, 3073–3083 (2010). ArticleCAS Google Scholar
Fillatreau, S., Gray, D. & Anderton, S.M. Not always the bad guys: B cells as regulators of autoimmune pathology. Nat. Rev. Immunol.8, 391–397 (2008). ArticleCAS Google Scholar
Carter, N.A. et al. Mice lacking endogenous IL-10–producing regulatory B cells develop exacerbated disease and present with an increased frequency of Th1/Th17 but a decrease in regulatory T cells. J. Immunol.186, 5569–5579 (2011). ArticleCAS Google Scholar
Ding, Q. et al. Regulatory B cells are identified by expression of TIM-1 and can be induced through TIM-1 ligation to promote tolerance in mice. J. Clin. Invest.121, 3645–3656 (2011). ArticleCAS Google Scholar
Nussenblatt, R.B. Proctor Lecture. Experimental autoimmune uveitis: mechanisms of disease and clinical therapeutic indications. Invest. Ophthalmol. Vis. Sci.32, 3131–3141 (1991). CASPubMed Google Scholar
Caspi, R.R. et al. A new model of autoimmune disease. Experimental autoimmune uveoretinitis induced in mice with two different retinal antigens. J. Immunol.140, 1490–1495 (1988). CASPubMed Google Scholar
Vasconcellos, R., Carter, N.A., Rosser, E.C. & Mauri, C. IL-12p35 subunit contributes to autoimmunity by limiting IL-27–driven regulatory responses. J. Immunol.187, 3402–3412 (2011). ArticleCAS Google Scholar
Collison, L.W. et al. The composition and signaling of the IL-35 receptor are unconventional. Nat. Immunol.13, 290–299 (2012). ArticleCAS Google Scholar
Tarrant, T.K., Silver, P.B., Chan, C.C., Wiggert, B. & Caspi, R.R. Endogenous IL-12 is required for induction and expression of experimental autoimmune uveitis. J. Immunol.161, 122–127 (1998). CASPubMed Google Scholar
Egwuagu, C.E., Charukamnoetkanok, P. & Gery, I. Thymic expression of autoantigens correlates with resistance to autoimmune disease. J. Immunol.159, 3109–3112 (1997). CASPubMed Google Scholar
Shen, P. et al. IL-35–producing B cells are critical regulators of immunity during autoimmune and infectious diseases. Nature507, 366–370 (2014). ArticleCAS Google Scholar
Vignali, D.A. & Kuchroo, V.K. IL-12 family cytokines: immunological playmakers. Nat. Immunol.13, 722–728 (2012). ArticleCAS Google Scholar
Wang, R.X., Yu, C.R., Mahdi, R.M. & Egwuagu, C.E. Novel IL27p28/IL12p40 cytokine suppressed experimental autoimmune uveitis by inhibiting autoreactive Th1/Th17 cells and promoting expansion of regulatory T cells. J. Biol. Chem.287, 36012–36021 (2012). ArticleCAS Google Scholar
Stumhofer, J.S. et al. A role for IL-27p28 as an antagonist of gp130-mediated signaling. Nat. Immunol.11, 1119–1126 (2010). ArticleCAS Google Scholar
Nussenblatt, R.B. Bench to bedside: new approaches to the immunotherapy of uveitic disease. Int. Rev. Immunol.21, 273–289 (2002). Article Google Scholar
Olkhanud, P.B. et al. Tumor-evoked regulatory B cells promote breast cancer metastasis by converting resting CD4 T cells to T-regulatory cells. Cancer Res.71, 3505–3515 (2011). ArticleCAS Google Scholar
Liu, X., Lee, Y.S., Yu, C.R. & Egwuagu, C.E. Loss of STAT3 in CD4+ T cells prevents development of experimental autoimmune diseases. J. Immunol.180, 6070–6076 (2008). ArticleCAS Google Scholar
Takase, H. et al. Induction of suppressors of cytokine signaling (SOCS) in the retina during experimental autoimmune uveitis (EAU): potential neuroprotective role of SOCS proteins. J. Neuroimmunol.168, 118–127 (2005). ArticleCAS Google Scholar
Oh, H.M. et al. Autoreactive memory CD4+ T lymphocytes that mediate chronic uveitis reside in the bone marrow through STAT3-dependent mechanisms. J. Immunol.187, 3338–3346 (2011). ArticleCAS Google Scholar
Fillatreau, S., Sweenie, C.H., McGeachy, M.J., Gray, D. & Anderton, S.M. B cells regulate autoimmunity by provision of IL-10. Nat. Immunol.3, 944–950 (2002). ArticleCAS Google Scholar
Paques, M. et al. Panretinal, high-resolution color photography of the mouse fundus. Invest. Ophthalmol. Vis. Sci.48, 2769–2774 (2007). Article Google Scholar
Xu, H. et al. A clinical grading system for retinal inflammation in the chronic model of experimental autoimmune uveoretinitis using digital fundus images. Exp. Eye Res.87, 319–326 (2008). ArticleCAS Google Scholar
Chan, C.C. et al. Pathology of experimental autoimmune uveoretinitis in mice. J. Autoimmun.3, 247–255 (1990). ArticleCAS Google Scholar
Amadi-Obi, A. et al. TH17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27/STAT1. Nat. Med.13, 711–718 (2007). ArticleCAS Google Scholar
Yu, C.R., Lee, Y.S., Mahdi, R.M., Surendran, N. & Egwuagu, C.E. Therapeutic targeting of STAT3 (signal transducers and activators of transcription 3) pathway inhibits experimental autoimmune uveitis. PLoS ONE7, e29742 (2012). ArticleCAS Google Scholar
Li, W., Nagineni, C.N., Hooks, J.J., Chepelinsky, A.B. & Egwuagu, C.E. Interferon-g signaling in human retinal pigment epithelial cells mediated by STAT1, ICSBP, and IRF-1 transcription factors. Invest. Ophthalmol. Vis. Sci.40, 976–982 (1999). CASPubMed Google Scholar
Oh, H.M. et al. STAT3 protein promotes T cell survival and inhibits interleukin-2 production through up-regulation of class O Forkhead transcription factors. J. Biol. Chem.286, 30888–30897 (2011). ArticleCAS Google Scholar