Genealogy of the CCR5 locus and chemokine system gene variants associated with altered rates of HIV-1 disease progression (original) (raw)
Moore, J.P., Trkola, A. & Dragic, T. Co-receptors for HIV-1 entry. Curr. Opin. Immunol.9, 551–562 (1997). ArticleCAS Google Scholar
Berger, E.A. HIV entry and tropism: the chemokine receptor connection. AIDS11, S316 (1997).
Alkhatib, C. et al. CC CKR5: a RANTES, MIP-1 alpha, MIP-1 beta receptor as a fusion cofactor for macrophagetropic HIV-1. Science272, 1955–1958 (1996). ArticleCAS Google Scholar
Deng, H. et al. Identification of a major co-receptor for primary isolates of HIV-1. Nature381, 661–666 (1996). ArticleCAS Google Scholar
Dragic, T. et al. HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC- CKR-5. Nature381, 667–673 (1996). ArticleCAS Google Scholar
Doranz, B.J. et al. A dual-tropic primary HIV-1 isolate that uses fusin and the beta- chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactors. Cell85, 1149–1158 (1996). ArticleCAS Google Scholar
Feng, Y., Border, C.C., Kennedy, P.E. & Berger, E.A. HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor. Science272, 872–877 (1996). ArticleCAS Google Scholar
Bleul, C.C. et al. The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry. Nature382, 829–833 (1996). ArticleCAS Google Scholar
Oberlin, E. et al. The CXC chemokine SDF-1 is the ligand for LESTR/fusin and prevents infection by T-cell-line-adapted HIV-1. Nature382, 833–835 (1996). ArticleCAS Google Scholar
Liu, R. et al. Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection. Cell86, 367–377 (1996). ArticleCAS Google Scholar
Samson, M. et al. Resistance to HIV-1 infection in Caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene. Nature382, 722–725 (1996). ArticleCAS Google Scholar
Dean, M. et al. Genetic restriction of HIV-1 infection and progression to AIDS by a deletion allele of the CKR5 structural gene. Hemophilia Growth and Development Study, Multicenter AIDS Cohort Study, Multicenter Hemophilia Cohort Study, San Francisco City Cohort, ALIVE Study. Science273, 1856–1862 (1996). ArticleCAS Google Scholar
Moore, J.P. Coreceptors: implications for HIV pathogenesis and therapy. Science276, 51–52 (1997). ArticleCAS Google Scholar
Wu, L. et al. CCR5 levels and expression pattern correlate with infectability by macrophagetropic HIV-1, in vitro. J. Exp. Med.185, 1681–1691 (1997). ArticleCAS Google Scholar
Berger, E.A. et al. A new classification for HIV-1. Nature391, 240 (1998). ArticleCAS Google Scholar
Mummidi, S., Ahuja, S.S., McDaniel, B.L. & Ahuja, S.K., The human CC chemokine receptor 5 (CCR5) gene. Multiple transcripts with 5′-end heterogeneity, dual promoter usage, and evidence for polymorphisms within the regulatory regions and noncoding exons. J. Biol. Chem.272, 30662–30671 (1997). ArticleCAS Google Scholar
Zimmerman, P.A. et al. Inherited resistance to HIV-1 conferred by an inactivating mutation in CC chemokine receptor 5: studies in populations with contrasting clinical phenotypes, defined racial background, and quantified risk. Mol. Med.3, 23–36 (1997). ArticleCAS Google Scholar
de Roda Husman, A.M. et al. Association between CCR5 genotype and the clinical course of HIV-1 infection. Ann. Intern. Med.127, 882–890 (1997). ArticleCAS Google Scholar
Michael, N.L. et al. The role of viral phenotype and CCR-5 gene defects in HIV-1 transmission and disease progression. Nature Med.3, 338–340 (1997). ArticleCAS Google Scholar
Meyer, L. et al. Early protective effect of CCR-5 delta 32 heterozygosity on HIV-1 disease progression: relationship with viral load. The SEROCO Study Group. AIDS11, F7378 (1997).
Katzenstein, T.L. et al. HIV-infected individuals with the CCR delta32/CCR5 genotype have lower HIV RNA levels and higher CD4 cell counts in the early years of the infection than do patients with the wild type. Copenhagen AIDS Cohort Study Group. J. Acquir. Immune Defic. Syndr. Hum. Retrovirol.16, 10–14 (1997). ArticleCAS Google Scholar
Eugen-Olsen, J. et al. Heterozygosity for a deletion in the CKR-5 gene leads to prolonged AIDS- free survival and slower CD4 T-cell decline in a cohort of HIV-seropositive individuals. AIDS11, 305–310 (1997). ArticleCAS Google Scholar
Morawetz, R.A. et al. Genetic polymorphism of CCR5 gene and HIV disease: the heterozygous (CCR5/delta ccr5) genotype is neither essential nor sufficient for protection against disease progression. Swiss HIV Cohort. Eur. J. Immunol.27, 3223–3227 (1997). ArticleCAS Google Scholar
Huang, Y. et al. The role of a mutant CCR5 allele in HIV-1 transmission and disease progression. Nature Med.2, 1240–1243 (1996). ArticleCAS Google Scholar
Garred, P. Chemokine-receptor polymorphisms: clarity or confusion for HIV-1 prognosis? Lancet351, 2–3 (1998). ArticleCAS Google Scholar
Smith, M.W. et al. Contrasting genetic influence of CCR2 and CCR5 variants on HIV-1 infection and disease progression. Hemophilia Growth and Development Study (HGDS), Multicenter AIDS Cohort Study (MACS), Multicenter Hemophilia Cohort Study (MHCS), San Francisco City Cohort (SFCC), ALIVE Study. Science277, 959–965 (1997). ArticleCAS Google Scholar
Kostrikis, L.G. et al. A chemokine receptor CCR2 allele delays HIV-1 disease progression and is associated with a CCR5 promoter mutation. Nature Med.4, 350–353 (1998 ArticleCAS Google Scholar
Michael, N.L. et al. The role of CCR5 and CCR2 polymorphisms in HIV-1 transmission and disease progression. Nature Med.3, 1160–1162 (1997). ArticleCAS Google Scholar
Rizzardi, G.P. et al. CCR2 polymorphism and HIV disease. Swiss HIV Cohort. Nat Med.4, 252–253 (1998). ArticleCAS Google Scholar
Winkler, C. et al. Genetic restriction of AIDS pathogenesis by an SDF-1 chemokine gene variant. ALIVE Study, Hemophilia Growth and Development Study (HGDS), Multicenter AIDS Cohort Study (MACS), Multicenter Hemophilia Cohort Study (MHCS), San Francisco City Cohort (SFCC). Science279, 389–393 (1998). ArticleCAS Google Scholar
Weatherall, D., Clegg, J. & Kwiatkowski, D. The role of genomics in studying genetic susceptibility to infectious disease. Genome Res.7, 967–973 (1997). ArticleCAS Google Scholar
Dawson, S.J., Morris, P.J. & Latchman, D.S. A single amino acid change converts an inhibitory transcription factor into an activator.. J. Biol. Chem.271, 11631–11633 (1996). ArticleCAS Google Scholar
Kurumbail, R.G. et al. Structural basis for selective inhibition of cyclooxygenase–2 by anti– inflammatory agents.. Nature384, 644–648 (1996). ArticleCAS Google Scholar
Swofford, D.L. PAUP: Phylogenetic analysis using parsimony, Version 3.1. Computer program distributed by the Illinois Natural History Survey, Champaign, Illinois (1993).