RETRACTED ARTICLE: Tissue plasminogen activator neurovascular toxicity is controlled by activated protein C (original) (raw)
Wang, Y.F. et al. Tissue plasminogen activator (tPA) increases neuronal damage after focal cerebral ischemia in wild-type and tPA-deficient mice. Nat. Med.4, 228–231 (1998). ArticleCASPubMed Google Scholar
Nicole, O. et al. The proteolytic activity of tissue-plasminogen activator enhances NMDA receptor-mediated signaling. Nat. Med.7, 59–64 (2001). ArticleCASPubMed Google Scholar
Yepes, M. et al. Regulation of seizure spreading by neuroserpin and tissue-type plasminogen activator is plasminogen-independent. J. Clin. Invest.109, 1571–1578 (2002). ArticleCASPubMedPubMed Central Google Scholar
Matys, T. & Strickland, S. Tissue plasminogen activator and NMDA receptor cleavage. Nat. Med.9, 371–373 (2003). ArticleCASPubMed Google Scholar
Chen, Z.L. & Strickland, S. Neuronal death in the hippocampus is promoted by plasmin-catalyzed degradation of laminin. Cell91, 917–925 (1997). ArticleCASPubMed Google Scholar
Plesnila, N., et al. BID mediates neuronal cell death after oxygen/glucose deprivation and focal cerebral ischemia. Proc. Natl. Acad. Sci. USA98, 15318–15323 (2001). ArticleCASPubMedPubMed Central Google Scholar
Griffin, J.H. et al. Activated protein C and ischemic stroke. Crit. Care Med.32, S247–S253 (2004). ArticleCASPubMed Google Scholar
Shibata, M. et al. Anti-inflammatory, antithrombotic, and neuroprotective effects of activated protein C in a murine model of focal ischemic stroke. Circulation103, 1799–1805 (2001). ArticleCASPubMed Google Scholar
Cheng, T. et al. Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective. Nat. Med.9, 338–342 (2003). ArticleCASPubMed Google Scholar
Joyce, D.E., Gelbert, L., Ciaccia, A., DeHoff, B. & Grinnell, B.W. Gene expression profile of antithrombotic protein C defines new mechanisms modulating inflammation and apoptosis. J. Biol. Chem.276, 11199–11203 (2001). ArticleCASPubMed Google Scholar
Riewald, M., Petrovan, R.J., Donner, A., Mueller, B.M. & Ruf, W. Activation of endothelial cell protease activated receptor 1 by the protein C pathway. Science296, 1880–1882 (2002). ArticleCASPubMed Google Scholar
Guo, H. et al. Activated protein C prevents neuronal apoptosis via protease activated receptors 1 and 3. Neuron42, 563–572 (2004). Article Google Scholar
Lo, E.H., Broderick, J.P. & Moskowitz, M.A. tPA and proteolysis in the neurovascular unit. Stroke35, 354–356 (2004). ArticlePubMed Google Scholar
Sharp, C.D., et al. Glutamate causes a loss in human cerebral endothelial barrier integrity through activation of NMDA receptor. Am. Physiol. Heart Circ. Physiol.285, H2592–H2598 (2003). ArticleCAS Google Scholar
Budd, S.L., Tenneti, L., Lishnak, T. & Lipton, S.A. Mitochondrial and extramitochondrial apoptotic signaling pathways in cerebrocortical neurons. Proc. Natl. Acad. Sci. USA97, 6161–6166 (2000). ArticleCASPubMedPubMed Central Google Scholar
Stennicke, H.R., et al. Pro-caspase-3 is a major physiologic target of caspase-8. J. Biol. Chem.273, 27084–90 (1998). ArticleCASPubMed Google Scholar
Zhang, W., et al. Fundamental role of the Rip2/caspase-1 pathway in hypoxia and ischemia-induced neuronal cell death. Proc. Natl. Acad. Sci. USA100, 16012–16017 (2003). ArticleCASPubMedPubMed Central Google Scholar
Du, Y.S., et al. Activation of a caspase 3-related cysteine protease is required for glutamate-mediated apoptosis of cultured cerebellar granule neurons. Proc. Natl. Acad. Sci. USA94, 11657–11662 (1997). ArticleCASPubMedPubMed Central Google Scholar
Okamoto, S., et al. Dominant – interfering forms of MEF2 generated by caspase cleavage contribute to NMDA-induced neuronal apoptosis. Proc. Natl. Acad. Sci. USA99, 3974–3979 (2002). ArticleCASPubMedPubMed Central Google Scholar
Penninger, J.M. and Kroemer, G. Mitochondria, AIF and caspases–rivaling for cell death execution. Nat. Cell Biol.5, 97–99 (2003). ArticleCASPubMed Google Scholar
Yu, S., et al. Mediation of poly (APD-Ribose) polymerase-1-dependent cell death by apoptosis-inducing factor. Science297, 259–263 (2002). ArticleCASPubMed Google Scholar
Tabrizi, P. et al. Tissue plasminogen activator (tPA) deficiency exacerbates cerebrovascular fibrin deposition and brain injury in murine stroke model: studies in tPA-deficient mice and wild-type mice on a matched genetic background. Arterioscler. Thromb. Vasc. Biol.19, 2801–2806 (1999). ArticleCASPubMed Google Scholar
Jiang, Q. et al. Magnetic resonance imaging indexes of therapeutic efficacy of recombinant tissue plasminogen activator treatment of rat at 1 and 4 hours after embolic stroke. J. Cereb. Blood Flow Metab.20, 21–27 (2000). ArticleCASPubMed Google Scholar
Pichiule, P. & LaManna, J.C. Angiopoietin-2 and rat brain capillary remodeling during adaptation and deadaptation to prolonged mild hypoxia. J. Appl. Physiol.93, 1131–1139 (2002). ArticleCASPubMed Google Scholar
Tibbetts, M.D., Zheng, L. & Lenardo, M.J. The death effector domain protein family: regulators of cellular homeostasis. Nat. Immunol.4, 404–409 (2003). ArticleCASPubMed Google Scholar