Beta-cell differentiation from nonendocrine epithelial cells of the adult human pancreas (original) (raw)

• Shapiro, A.M. et al. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N. Engl. J. Med. 343, 230–238 (2000).
  Article CAS PubMed Google Scholar
• Hirshberg, B. et al. Benefits and risks of solitary islet transplantation for type 1 diabetes using steroid-sparing immunosuppression: the National Institutes of Health experience. Diabetes Care 26, 3288–3295 (2003).
  Article PubMed Google Scholar
• Bonner-Weir, S., Baxter, L.A., Schuppin, G.T. & Smith, F.E. A second pathway for regeneration of adult exocrine and endocrine pancreas. A possible recapitulation of embryonic development. Diabetes 42, 1715–1720 (1993).
  Article CAS PubMed Google Scholar
• Guz, Y., Nasir, I. & Teitelman, G. Regeneration of pancreatic beta cells from intra-islet precursor cells in an experimental model of diabetes. Endocrinology 142, 4956–4968 (2001).
  Article CAS PubMed Google Scholar
• Sarvetnick, N.E. & Gu, D. Regeneration of pancreatic endocrine cells in interferon-gamma transgenic mice. Adv. Exp. Med. Biol. 321, 85–89 (1992).
  Article CAS PubMed Google Scholar
• Dor, Y., Brown, J., Martinez, O.I. & Melton, D.A. Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation. Nature 429, 41–46 (2004).
  Article CAS PubMed Google Scholar
• Bonner-Weir, S. et al. In vitro cultivation of human islets from expanded ductal tissue. Proc. Natl. Acad. Sci. USA 97, 7999–8004 (2000).
  Article CAS PubMed PubMed Central Google Scholar
• Lardon, J., Huyens, N., Rooman, I. & Bouwens, L. Exocrine cell transdifferentiation in dexamethasone-treated rat pancreas. Virchows Arch. 444, 61–65 (2004).
  Article PubMed Google Scholar
• Zulewski, H. et al. Multipotential nestin-positive stem cells isolated from adult pancreatic islets differentiate ex vivo into pancreatic endocrine, exocrine, and hepatic phenotypes. Diabetes 50, 521–533 (2001).
  Article CAS PubMed Google Scholar
• Lechner, A., Leech, C.A., Abraham, E.J., Nolan, A.L. & Habener, J.F. Nestin-positive progenitor cells derived from adult human pancreatic islets of Langerhans contain side population (SP) cells defined by expression of the ABCG2 (BCRP1) ATP-binding cassette transporter. Biochem. Biophys. Res. Commun. 293, 670–674 (2002).
  Article CAS PubMed Google Scholar
• Abraham, E.J., Leech, C.A., Lin, J.C., Zulewski, H. & Habener, J.F. Insulinotropic hormone glucagon-like peptide-1 differentiation of human pancreatic islet-derived progenitor cells into insulin-producing cells. Endocrinology 143, 3152–3161 (2002).
  Article CAS PubMed Google Scholar
• Rajagopal, J., Anderson, W.J., Kume, S., Martinez, O.I. & Melton, D.A. Insulin staining of ES cell progeny from insulin uptake. Science 299, 363 (2003).
  Article PubMed Google Scholar
• Levine, F. & Mercola, M. No pancreatic endocrine stem cells? N. Engl. J. Med. 351, 1024–1026 (2004).
  Article CAS PubMed Google Scholar
• Scharfmann, R. Control of early development of the pancreas in rodents and humans: implications of signals from the mesenchyme. Diabetologia 43, 1083–1092 (2000).
  Article CAS PubMed Google Scholar
• Beattie, G.M. et al. Acid beta-galactosidase: a developmentally regulated marker of endocrine cell precursors in the human fetal pancreas. J. Clin. Endocrinol. Metab. 78, 1232–1240 (1994).
  CAS PubMed Google Scholar
• Jensen, J. Gene regulatory factors in pancreatic development. Dev. Dyn. 229, 176–200 (2004).
  Article CAS PubMed Google Scholar
• Tuch, B.E., Ng, A.B., Jones, A. & Turtle, J.R. Histologic differentiation of human fetal pancreatic explants transplanted into nude mice. Diabetes 33, 1180–1187 (1984).
  Article CAS PubMed Google Scholar
• Sandler, S. et al. Tissue culture of human fetal pancreas. Effects of human serum on development and endocrine function of isletlike cell clusters. Diabetes 36, 1401–1407 (1987).
  Article CAS PubMed Google Scholar
• Gao, R., Ustinov, J., Korsgren, O. & Otonkoski, T. In vitro neogenesis of human islets reflects the plasticity of differentiated human pancreatic cells. Diabetologia 48, 2296–2304 (2005).
  Article CAS PubMed Google Scholar
• Gao, R. et al. Characterization of endocrine progenitor cells and critical factors for their differentiation in human adult pancreatic cell culture. Diabetes 52, 2007–2015 (2003).
  Article CAS PubMed Google Scholar
• Heimberg, H. et al. Adult human pancreatic duct and islet cells exhibit similarities in expression and differences in phosphorylation and complex formation of the homeodomain protein Ipf-1. Diabetes 49, 571–579 (2000).
  Article CAS PubMed Google Scholar
• Heremans, Y. et al. Recapitulation of embryonic neuroendocrine differentiation in adult human pancreatic duct cells expressing neurogenin 3. J. Cell Biol. 159, 303–312 (2002).
  Article CAS PubMed PubMed Central Google Scholar
• Bouwens, L., Lu, W.G. & De Krijger, R. Proliferation and differentiation in the human fetal endocrine pancreas. Diabetologia 40, 398–404 (1997).
  Article CAS PubMed Google Scholar
• Street, C.N. et al. Enriched human pancreatic ductal cultures obtained from selective death of acinar cells express pancreatic and duodenal homeobox gene-1 age-dependently. The Review of Diabetic Studies 1, 66–79 (2004).
  Article PubMed PubMed Central Google Scholar
• Bogdani, M. et al. Formation of insulin-positive cells in implants of human pancreatic duct cell preparations from young donors. Diabetologia 46, 830–838 (2003).
  Article CAS PubMed Google Scholar
• Halban, P.A. Cellular sources of new pancreatic beta cells and therapeutic implications for regenerative medicine. Nat. Cell Biol. 6, 1021–1025 (2004).
  Article CAS PubMed Google Scholar
• Halaban, R. & Alfano, F.D. Selective elimination of fibroblasts from cultures of normal human melanocytes. In Vitro 20, 447–450 (1984).
  Article CAS PubMed Google Scholar
• Klein, T. et al. Nestin is expressed in vascular endothelial cells in the adult human pancreas. J. Histochem. Cytochem. 51, 697–706 (2003).
  Article CAS PubMed Google Scholar
• Lardon, J., Rooman, I. & Bouwens, L. Nestin expression in pancreatic stellate cells and angiogenic endothelial cells. Histochem. Cell Biol. 117, 535–540 (2002).
  Article CAS PubMed Google Scholar
• Humphrey, R.K. et al. Characterization and isolation of promoter-defined nestin-positive cells from the human fetal pancreas. Diabetes 52, 2519–2525 (2003).
  Article CAS PubMed Google Scholar
• Esni, F., Stoffers, D.A., Takeuchi, T. & Leach, S.D. Origin of exocrine pancreatic cells from nestin-positive precursors in developing mouse pancreas. Mech. Dev. 121, 15–25 (2004).
  Article CAS PubMed Google Scholar
• Delacour, A., Nepote, V., Trumpp, A. & Herrera, P.L. Nestin expression in pancreatic exocrine cell lineages. Mech. Dev. 121, 3–14 (2004).
  Article CAS PubMed Google Scholar
• Leibowitz, G. et al. Gene transfer to human pancreatic endocrine cells using viral vectors. Diabetes 48, 745–753 (1999).
  Article CAS PubMed Google Scholar
• Lechner, A. et al. No evidence for significant transdifferentiation of bone marrow into pancreatic beta-cells in vivo. Diabetes 53, 616–623 (2004).
  Article CAS PubMed Google Scholar
• Wang, X. et al. Cell fusion is the principal source of bone-marrow-derived hepatocytes. Nature 422, 897–901 (2003).
  Article CAS PubMed Google Scholar
• Wurmser, A.E. & Gage, F.H. Stem cells: cell fusion causes confusion. Nature 416, 485–487 (2002).
  Article CAS PubMed Google Scholar
• Wurmser, A.E. et al. Cell fusion-independent differentiation of neural stem cells to the endothelial lineage. Nature 430, 350–356 (2004).
  Article CAS PubMed Google Scholar
• Boyer, B., Tucker, G.C., Valles, A.M., Franke, W.W. & Thiery, J.P. Rearrangements of desmosomal and cytoskeletal proteins during the transition from epithelial to fibroblastoid organization in cultured rat bladder carcinoma cells. J. Cell Biol. 109, 1495–1509 (1989).
  Article CAS PubMed Google Scholar
• Gershengorn, M.C. et al. Epithelial-to-mesenchymal transition generates proliferative human islet precursor cells. Science 306, 2261–2264 (2004).
  Article CAS PubMed Google Scholar
• Halvorsen, T.L., Beattie, G.M., Lopez, A.D., Hayek, A. & Levine, F. Accelerated telomere shortening and senescence in human pancreatic islet cells stimulated to divide in vitro. J. Endocrinol. 166, 103–109 (2000).
  Article CAS PubMed Google Scholar
• Finegood, D.T., Scaglia, L. & Bonner-Weir, S. Dynamics of beta-cell mass in the growing rat pancreas. Estimation with a simple mathematical model. Diabetes 44, 249–256 (1995).
  Article CAS PubMed Google Scholar
• Tyrberg, B., Andersson, A. & Borg, L.A. Species differences in susceptibility of transplanted and cultured pancreatic islets to the β-cell toxin alloxan. Gen. Comp. Endocrinol. 122, 238–251 (2001).
  Article CAS PubMed Google Scholar
• Butler, A.E. et al. Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. Diabetes 52, 102–110 (2003).
  Article CAS PubMed Google Scholar
• Beattie, G.M., Rubin, J.S., Mally, M.I., Otonkoski, T. & Hayek, A. Regulation of proliferation and differentiation of human fetal pancreatic islet cells by extracellular matrix, hepatocyte growth factor, and cell-cell contact. Diabetes 45, 1223–1228 (1996).
  Article CAS PubMed Google Scholar
• Wang, S. et al. Isolation and characterization of a cell line from the epithelial cells of the human fetal pancreas. Cell Transplant. 6, 59–67 (1997).
  Article CAS PubMed Google Scholar
• Beattie, G.M., Butler, C. & Hayek, A. Morphology and function of cultured human fetal pancreatic cells transplanted into athymic mice: a longitudinal study. Cell Transplant. 3, 421–425 (1994).
  Article CAS PubMed Google Scholar