Promises, facts and challenges for carbon nanotubes in imaging and therapeutics (original) (raw)

• Prato, M., Kostarelos, K. & Bianco, A. Functionalized carbon nanotubes in drug design and discovery. Acc. Chem. Res. 41, 60–68 (2008).
  Article CAS Google Scholar
• Boczkowski, J. & Lanone, S. Potential uses of carbon nanotubes in the medical field: how worried should patients be? Nanomedicine 2, 407–410 (2007).
  Article Google Scholar
• Itkis, M. E. et al. Comparison of analytical techniques for purity evaluation of single-walled carbon nanotubes. J. Am. Chem. Soc. 127, 3439–3448 (2005).
  Article CAS Google Scholar
• Iijima, S. & Ichihashi, T. Single-shell carbon nanotubes of 1-nm diameter. Nature 363, 603–605 (1993).
  Article CAS Google Scholar
• Iijima, S. Helical microtubules of graphitic carbon. Nature 354, 56–58 (1991).
  Article CAS Google Scholar
• Jorio, A., Dresselhaus, G. & Dresselhaus, M. S. Carbon Nanotubes: Advanced Topics in the Synthesis, Structure, Properties and Applications (Springer-Verlag, 2008).
  Book Google Scholar
• Tasis, D., Tagmatarchis, N., Bianco, A. & Prato, M. Chemistry of carbon nanotubes. Chem. Rev. 106, 1105–1136 (2006).
  Article CAS Google Scholar
• Liu, Z. et al. In vivo biodistribution and highly efficient tumour targeting of carbon nanotubes in mice. Nature Nanotech. 2, 47–52 (2007).
  Article CAS Google Scholar
• Ali-Boucetta, H. et al. Multiwalled carbon nanotube-doxorubicin supramolecular complexes for cancer therapeutics. Chem. Commun. 12, 459–461 (2008).
  Article Google Scholar
• Gannon, C. J. et al. Carbon nanotube-enhanced thermal destruction of cancer cells in a noninvasive radiofrequency field. Cancer 110, 2654–2665 (2007).
  Article CAS Google Scholar
• Zheng, M. et al. DNA-assisted dispersion and separation of carbon nanotubes. Nature Mater. 2, 338–342 (2003).
  Article CAS Google Scholar
• Kostarelos, K. et al. Cellular uptake of functionalized carbon nanotubes is independent of functional group and cell type. Nature Nanotech. 2, 108–113 (2007).
  Article CAS Google Scholar
• Podesta, J. P. et al. Antitumor activity and prolonged survival by carbon nanotube-mediated therapeutic siRNA silencing in a human lung xenograft model. Small 5, 1176–1185 (2009).
  Article CAS Google Scholar
• Liu, Z., Tabakman, S., Welsher, K. & Dai, H. Carbon nanotubes in biology and medicine: In vitro and in vivo detection, imaging and drug delivery. Nano Res. 2, 85–120 (2009).
  Article CAS Google Scholar
• De la Zerda, A. et al. Carbon nanotubes as photoacoustic molecular imaging agents in living mice. Nature Nanotech. 3, 557–562 (2008).
  Article CAS Google Scholar
• Liu, Z. et al. Drug delivery with carbon nanotubes for in vivo cancer treatment. Cancer Res. 68, 6652–6660 (2008).
  Article CAS Google Scholar
• Lacerda, L. et al. Dynamic imaging of functionalized multi-walled carbon nanotube systemic circulation and urinary excretion. Adv. Mater. 20, 225–230 (2008).
  Article CAS Google Scholar
• McDevitt, M. R. et al. PET imaging of soluble yttrium-86-labeled carbon nanotubes in mice. PLoS ONE 2, e907 (2007).
  Article Google Scholar
• Singh, R. et al. Tissue biodistribution and blood clearance rates of intravenously administered carbon nanotube radiotracers. Proc. Natl Acad. Sci. USA 103, 3357–3362 (2006).
  Article CAS Google Scholar
• Yandar, N. et al. Immunological profile of a Plasmodium vivax AMA-1 N-terminus peptide-carbon nanotube conjugate in an infected Plasmodium berghei mouse model. Vaccine 26, 5864–5873 (2008).
  Article CAS Google Scholar
• Pantarotto, D. et al. Immunization with peptide-functionalized carbon nanotubes enhances virus-specific neutralizing antibody responses. Chem. Biol. 10, 961–966 (2003).
  Article CAS Google Scholar
• McDevitt, M. R. et al. Tumor targeting with antibody-functionalized, radiolabeled carbon nanotubes. J. Nucl. Med. 48, 1180–1189 (2007).
  Article CAS Google Scholar
• Deng, X. et al. Translocation and fate of multi-walled carbon nanotubes in vivo. Carbon 45, 1419–1424 (2007).
  Article CAS Google Scholar
• Wang, H. et al. Biodistribution of carbon single-wall carbon nanotubes in mice. J. Nanosci. Nanotechnol. 4, 1019–1024 (2004).
  Article CAS Google Scholar
• Meng, J. et al. Carbon nanotubes conjugated to tumor lysate protein enhance the efficacy of an antitumor immunotherapy. Small 4, 1364–1370 (2008).
  Article CAS Google Scholar
• Zhang, Z. et al. Delivery of telomerase reverse transcriptase small interfering RNA in complex with positively charged single-walled carbon nanotubes suppresses tumor growth. Clin. Cancer Res. 12, 4933–4939 (2006).
  Article CAS Google Scholar
• Bhirde, A. A. et al. Targeted killing of cancer cells in vivo and in vitro with EGF-directed carbon nanotube-based drug delivery. ACS Nano 3, 307–316 (2009).
  Article CAS Google Scholar
• Ryman-Rasmussen, J. P. et al. Inhaled multiwalled carbon nanotubes potentiate airway fibrosis in murine allergic asthma. Am. J. Resp. Cell Mol. 40, 349–358 (2009).
  Article CAS Google Scholar
• Shvedova, A. A. et al. Inhalation vs. aspiration of single-walled carbon nanotubes in C57BL/6 mice: inflammation, fibrosis, oxidative stress, and mutagenesis. Am. J. Physiol. Lung C. 295, 552–565 (2008).
  Article Google Scholar
• Chou, C. C. et al. Single-walled carbon nanotubes can induce pulmonary injury in mouse model. Nano Lett. 8, 437–445 (2008).
  Article CAS Google Scholar
• Mitchell, L. A. et al. Pulmonary and systemic immune response to inhaled multiwalled carbon nanotubes. Toxicol. Sci. 100, 203–214 (2007).
  Article CAS Google Scholar
• Takagi, A. et al. Induction of mesothelioma in p53± mouse by intraperitoneal application of multi-wall carbon nanotube. J. Toxicol. Sci. 33, 105–116 (2008).
  Article CAS Google Scholar
• Poland, C. A. et al. Carbon nanotubes introduced into the abdominal cavity of mice show asbestos-like pathogenicity in a pilot study. Nature Nanotech. 3, 423–428 (2008).
  Article CAS Google Scholar
• Cherukuri, P. et al. Mammalian pharmacokinetics of carbon nanotubes using intrinsic near-infrared fluorescence. Proc. Natl Acad. Sci. USA 103, 18882–18886 (2006).
  Article CAS Google Scholar
• Yang, S. T. et al. Biodistribution of pristine single-walled carbon nanotubes in vivo. J. Phys. Chem. 111, 17761–17764 (2007).
  CAS Google Scholar
• Schipper, M. L. et al. A pilot toxicology study of single-walled carbon nanotubes in a small sample of mice. Nature Nanotech. 3, 216–221 (2008).
  Article CAS Google Scholar
• Liu, Z. et al. Circulation and long-term fate of functionalized, biocompatible single-walled carbon nanotubes in mice probed by Raman spectroscopy. Proc. Natl Acad. Sci. USA 105, 1410–1415 (2008).
  Article CAS Google Scholar
• Yang, S. T. et al. Long-term accumulation and low toxicity of single-walled carbon nanotubes in intravenously exposed mice. Toxicol. Lett. 181, 182–189 (2008).
  Article CAS Google Scholar
• Kostarelos, K. The long and short of carbon nanotube toxicity. Nature Biotechnol. 26, 774–776 (2008).
  Article CAS Google Scholar
• Lacerda, L. et al. Carbon-nanotube shape and individualization critical for renal excretion. Small 4, 1130–1132 (2008).
  Article CAS Google Scholar
• Lacerda, L. et al. Tissue histology and physiology following intravenous administration of different types of functionalized multiwalled carbon nanotubes. Nanomedicine 3, 149–161 (2008).
  Article CAS Google Scholar
• Keefer, E. W. et al. Carbon nanotube coating improves neuronal recordings. Nature Nanotech. 3, 434–439 (2008).
  Article CAS Google Scholar
• Sitharaman, B. et al. In vivo biocompatibility of ultra-short single-walled carbon nanotube/biodegradable polymer nanocomposites for bone tissue engineering. Bone 43, 362–370 (2008).
  Article CAS Google Scholar
• Khang, D., Park, G. E. & Webster, T. J. Enhanced chondrocyte densities on carbon nanotube composites: the combined role of nanosurface roughness and electrical stimulation. J. Biomed. Mater. Res. A 86, 253–260 (2008).
  Article Google Scholar
• Heller, D. A. et al. Multimodal optical sensing and analyte specificity using single-walled carbon nanotubes. Nature Nanotech. 4, 114–120 (2009).
  Article CAS Google Scholar