Generation of orthotopic and heterotopic human pancreatic cancer xenografts in immunodeficient mice (original) (raw)
Jones, S. et al. Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science321, 1801–1806 (2008). ArticleCAS Google Scholar
Sharpless, N.E. & Depinho, R.A. The mighty mouse: genetically engineered mouse models in cancer drug development. Nat. Rev. Drug Discov.5, 741–754 (2006). ArticleCAS Google Scholar
Frese, K.K. & Tuveson, D.A. Maximizing mouse cancer models. Nat. Rev. Cancer7, 645–658 (2007). ArticleCAS Google Scholar
Olive, K.P. & Tuveson, D.A. The use of targeted mouse models for preclinical testing of novel cancer therapeutics. Clin. Cancer Res.12, 5277–5287 (2006). ArticleCAS Google Scholar
Rangarajan, A. & Weinberg, R.A. Opinion: comparative biology of mouse versus human cells: modelling human cancer in mice. Nat. Rev. Cancer3, 952–959 (2003). ArticleCAS Google Scholar
Fu, X., Guadagni, F. & Hoffman, R.M. A metastatic nude-mouse model of human pancreatic cancer constructed orthotopically with histologically intact patient specimens. Proc. Natl. Acad. Sci. USA89, 5645–5649 (1992). ArticleCAS Google Scholar
Loukopoulos, P. et al. Orthotopic transplantation models of pancreatic adenocarcinoma derived from cell lines and primary tumors and displaying varying metastatic activity. Pancreas29, 193–203 (2004). ArticleCAS Google Scholar
Rubio-Viqueira, B. et al. An in vivo platform for translational drug development in pancreatic cancer. Clin. Cancer Res.12, 4652–4661 (2006). ArticleCAS Google Scholar
Rubio-Viqueira, B. & Hidalgo, M. Direct in vivo xenograft tumor model for predicting chemotherapeutic drug response in cancer patients. Clin. Pharmacol. Ther.85, 217–221 (2009). ArticleCAS Google Scholar
Flanagan, S.P. 'Nude', a new hairless gene with pleiotropic effects in the mouse. Genet. Res.8, 295–309 (1966). ArticleCAS Google Scholar
Trevino, J.G. et al. Inhibition of SRC expression and activity inhibits tumor progression and metastasis of human pancreatic adenocarcinoma cells in an orthotopic nude mouse model. Am. J. Pathol.168, 962–972 (2006). ArticleCAS Google Scholar
Gray, M.J. et al. Neuropilin-1 suppresses tumorigenic properties in a human pancreatic adenocarcinoma cell line lacking neuropilin-1 coreceptors. Cancer Res.65, 3664–3670 (2005). ArticleCAS Google Scholar
Bosma, G.C., Custer, R.P. & Bosma, M.J. A severe combined immunodeficiency mutation in the mouse. Nature301, 527–530 (1983). ArticleCAS Google Scholar
Ito, M. et al. NOD/SCID/gamma(c)(null) mouse: an excellent recipient mouse model for engraftment of human cells. Blood100, 3175–3182 (2002). ArticleCAS Google Scholar
Quintana, E. et al. Efficient tumour formation by single human melanoma cells. Nature456, 593–598 (2008). ArticleCAS Google Scholar
Voskoglou-Nomikos, T., Pater, J.L. & Seymour, L. Clinical predictive value of the in vitro cell line, human xenograft, and mouse allograft preclinical cancer models. Clin. Cancer Res.9, 4227–4239 (2003). Google Scholar
Johnson, J.I. et al. Relationships between drug activity in NCI preclinical in vitro and in vivo models and early clinical trials. Br. J. Cancer84, 1424–1431 (2001). ArticleCAS Google Scholar
End, D.W. et al. Characterization of the antitumor effects of the selective farnesyl protein transferase inhibitor R115777 in vivo and in vitro . Cancer Res.61, 131–137 (2001). CAS Google Scholar
Van Cutsem, E. et al. Phase III trial of gemcitabine plus tipifarnib compared with gemcitabine plus placebo in advanced pancreatic cancer. J. Clin. Oncol.22, 1430–1438 (2004). ArticleCAS Google Scholar
Garber, K. From human to mouse and back: 'tumorgraft' models surge in popularity. J. Natl. Cancer Inst.101, 6–8 (2009). Article Google Scholar
Fichtner, I. et al. Establishment of patient-derived non-small cell lung cancer xenografts as models for the identification of predictive biomarkers. Clin. Cancer Res.14, 6456–6468 (2008). ArticleCAS Google Scholar
Houghton, P.J. et al. The pediatric preclinical testing program: description of models and early testing results. Pediatr. Blood Cancer49, 928–940 (2007). Article Google Scholar
Peterson, J.K. & Houghton, P.J. Integrating pharmacology and in vivo cancer models in preclinical and clinical drug development. Eur. J. Cancer40, 837–844 (2004). ArticleCAS Google Scholar
Hoffman, R.M. Orthotopic metastatic mouse models for anticancer drug discovery and evaluation: a bridge to the clinic. Invest. New Drugs17, 343–359 (1999). ArticleCAS Google Scholar
Li, C. et al. Identification of pancreatic cancer stem cells. Cancer Res.67, 1030–1037 (2007). ArticleCAS Google Scholar
Al-Hajj, M., Wicha, M.S., Benito-Hernandez, A., Morrison, S.J. & Clarke, M.F. Prospective identification of tumorigenic breast cancer cells. Proc. Natl. Acad. Sci. USA100, 3983–3988 (2003). ArticleCAS Google Scholar
O'Brien, C.A., Pollett, A., Gallinger, S. & Dick, J.E. A human colon cancer cell capable of initiating tumour growth in immunodeficient mice. Nature445, 106–110 (2007). ArticleCAS Google Scholar
Kim, M.P., Gallick, G.E., Evans, D.B., Wang, H.M. & Fleming, J.B. Effect of preoperative therapy on engraftment of pancreatic adenocarcinoma tumor in mice after pancreatectomy. Proceedings of the 2009 American Society of Clinical Oncology—Gastrointestinal Cancers Symposium, 15–17 January 2009, San Francisco, CA. Abstract no. 165, p 142.
Kim, M.P., Fleming, J.B., Evans, D.B., Wang, H.M. & Gallick, G.E. Pancreatic cancer xenografts contain distinct populations of cells expressing the cancer stem cell marker CD133. Proceedings of the 2009 American Society of Clinical Oncology—Gastrointestinal Cancers Symposium, 15–17 January 2009, San Francisco, CA. Abstract no. 150, p 135.
Bruns, C.J., Harbison, M.T., Kuniyasu, H., Eue, I. & Fidler, I.J. In vivo selection and characterization of metastatic variants from human pancreatic adenocarcinoma by using orthotopic implantation in nude mice. Neoplasia1, 50–62 (1999). ArticleCAS Google Scholar
Khanbolooki, S. et al. Nuclear factor-kappaB maintains TRAIL resistance inhuman pancreatic cancer cells. Mol. Cancer Ther.5, 2251–2260 (2006). ArticleCAS Google Scholar
Nawrocki, S.T., Sweeney-Gotsch, B., Takamori, R. & McConkey, D.J. The proteasome inhibitor bortezomib enhances the activity of docetaxel in orthotopic human pancreatic tumor xenografts. Mol. Cancer Ther.3, 59–70 (2004). CASPubMed Google Scholar