Myers, J. Development of knowledge of unity of tuberculosis and of the portals of entry of tubercle bacilli. J. Hist. Med. Allied Sci.29, 213–228 (1974). ArticleCASPubMed Google Scholar
Adams, D. O. The structure of mononuclear phagocytes differentiating in vivo. I. Sequential fine and histologic studies of the effect of Bacillus Calmette-Guerin (BCG). Am. J. Pathol.76, 17–48 (1974). CASPubMedPubMed Central Google Scholar
Cohn, Z. A. The structure and function of monocytes and macrophages. Adv. Immunol.9, 163–214 (1968). ArticleCASPubMed Google Scholar
Dannenberg, A. M. Jr. Cellular hypersensitivity and cellular immunity in the pathogensis of tuberculosis: specificity, systemic and local nature, and associated macrophage enzymes. Bacteriol. Rev.32, 85–102 (1968). ArticlePubMedPubMed Central Google Scholar
Bouley, D. M., Ghori, N., Mercer, K. L., Falkow, S. & Ramakrishnan, L. Dynamic nature of host–pathogen interactions in Mycobacterium marinum granulomas. Infect. Immun.69, 7820–7831 (2001). ArticleCASPubMedPubMed Central Google Scholar
Helming, L. & Gordon, S. The molecular basis of macrophage fusion. Immunobiology212, 785–793 (2007). ArticleCASPubMed Google Scholar
Russell, D. G., Cardona, P. J., Kim, M. J., Allain, S. & Altare, F. Foamy macrophages and the progression of the human tuberculosis granuloma. Nature Immunol.10, 943–948 (2009). ArticleCAS Google Scholar
Trogan, E. et al. Gene expression changes in foam cells and the role of chemokine receptor CCR7 during atherosclerosis regression in ApoE-deficient mice. Proc. Natl Acad. Sci. USA103, 3781–3786 (2006). ArticleCASPubMedPubMed Central Google Scholar
Weber, C., Zernecke, A. & Libby, P. The multifaceted contributions of leukocyte subsets to atherosclerosis: lessons from mouse models. Nature Rev. Immunol.8, 802–815 (2008). ArticleCAS Google Scholar
Peyron, P. et al. Foamy macrophages from tuberculous patients' granulomas constitute a nutrient-rich reservoir for M. tuberculosis persistence. PLoS Pathog.4, e1000204 (2008). ArticlePubMedPubMed CentralCAS Google Scholar
Canetti, G. The Tubercle Bacillus in the Pulmonary Lesion of Man: Histobacteriology and its Bearing on the Therapy of Pulmonary Tuberculosis (Springer, 1955). Google Scholar
Hunter, R. L. Pathology of post primary tuberculosis of the lung: an illustrated critical review. Tuberculosis91, 497–509 (2011). ArticlePubMed Google Scholar
Kumar, V., Abbas, A. K. & Fausto, N. Robbins and Cotran Pathological Basis of Disease 7th edn (Elsevier Saunders, 2005). Google Scholar
Rich, A. R. The Pathogenesis of Tuberculosis (C. C. Thomas, 1946). Google Scholar
Volkman, H. E. et al. Tuberculous granuloma induction via interaction of a bacterial secreted protein with host epithelium. Science327, 466–469 (2010). ArticleCASPubMed Google Scholar
Cosma, C. L., Sherman, D. R. & Ramakrishnan, L. The secret lives of the pathogenic mycobacteria. Annu. Rev. Microbiol.57, 641–676 (2003). ArticleCASPubMed Google Scholar
Feldman, W. H. & Baggenstoss, A. H. The residual infectivity of the primary complex of tuberculosis. Am. J. Pathol.14, 473–490 (1938). CASPubMedPubMed Central Google Scholar
Opie, E. L. & Aronson, J. D. Tubercle bacilli in latent tuberculous lesions and in lung tissue without tuberculous lesions. Arch. Pathol. Lab. Med.4, 1–21 (1927). Google Scholar
Ulrichs, T. & Kaufmann, S. H. New insights into the function of granulomas in human tuberculosis. J. Pathol.208, 261–269 (2006). ArticleCASPubMed Google Scholar
Murphy, K., Travers, P. & Walport, M. Janeway's Immunobiology 7th edn (Garland Science, 2008). Google Scholar
Mandell, G. L., Bennett, J. E. & Dolin, R. (eds) Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases 7th edn (Churchill Livingstone, 2010). Google Scholar
Schaff, H. & Zumla, A. (eds) Tuberculosis (Saunders Elsevier, 2009). Google Scholar
Longo, D. L. et al. (eds) Harrison's Principles of Internal Medicine (McGraw-Hill, 2012). Google Scholar
Rohde, K., Yates, R. M., Purdy, G. E. & Russell, D. G. Mycobacterium tuberculosis and the environment within the phagosome. Immunol. Rev.219, 37–54 (2007). ArticleCASPubMed Google Scholar
Kaufmann, S. H. Is the development of a new tuberculosis vaccine possible? Nature Med.6, 955–960 (2000). ArticleCASPubMed Google Scholar
Lawn, S. D., Butera, S. T. & Shinnick, T. M. Tuberculosis unleashed: the impact of human immunodeficiency virus infection on the host granulomatous response to Mycobacterium tuberculosis. Microbes Infect.4, 635–646 (2002). ArticleCASPubMed Google Scholar
North, R. J. & Izzo, A. A. Granuloma formation in severe combined immunodeficient (SCID) mice in response to progressive BCG infection. Tendency not to form granulomas in the lung is associated with faster bacterial growth in this organ. Am. J. Pathol.142, 1959–1966 (1993). CASPubMedPubMed Central Google Scholar
Cooper, A. M. et al. Disseminated tuberculosis in interferon γ gene-disrupted mice. J. Exp. Med.178, 2243–2247 (1993). ArticleCASPubMed Google Scholar
Cooper, A. M., Magram, J., Ferrante, J. & Orme, I. M. Interleukin 12 (IL-12) is crucial to the development of protective immunity in mice intravenously infected with Mycobacterium tuberculosis. J. Exp. Med.186, 39–45 (1997). ArticleCASPubMedPubMed Central Google Scholar
Flynn, J. L. et al. An essential role for interferon γ in resistance to Mycobacterium tuberculosis infection. J. Exp. Med.178, 2249–2254 (1993). ArticleCASPubMed Google Scholar
Fremond, C. M. et al. IL-1 receptor-mediated signal is an essential component of MyD88-dependent innate response to Mycobacterium tuberculosis infection. J. Immunol.179, 1178–1189 (2007). ArticleCASPubMed Google Scholar
Fremond, C. M. et al. Fatal Mycobacterium tuberculosis infection despite adaptive immune response in the absence of MyD88. J. Clin. Invest.114, 1790–1799 (2004). ArticleCASPubMedPubMed Central Google Scholar
Juffermans, N. P. et al. Interleukin-1 signaling is essential for host defense during murine pulmonary tuberculosis. J. Infect. Dis.182, 902–908 (2000). ArticleCASPubMed Google Scholar
Scanga, C. A. et al. MyD88-deficient mice display a profound loss in resistance to Mycobacterium tuberculosis associated with partially impaired Th1 cytokine and nitric oxide synthase 2 expression. Infect. Immun.72, 2400–2404 (2004). ArticleCASPubMedPubMed Central Google Scholar
Sugawara, I., Yamada, H. & Mizuno, S. Relative importance of STAT4 in murine tuberculosis. J. Med. Microbiol.52, 29–34 (2003). ArticleCASPubMed Google Scholar
Clay, H., Volkman, H. E. & Ramakrishnan, L. Tumor necrosis factor signaling mediates resistance to mycobacteria by inhibiting bacterial growth and macrophage death. Immunity29, 283–294 (2008). ArticleCASPubMedPubMed Central Google Scholar
Algood, H. M., Lin, P. L. & Flynn, J. L. Tumor necrosis factor and chemokine interactions in the formation and maintenance of granulomas in tuberculosis. Clin. Infect. Dis.41, S189–S193 (2005). ArticleCASPubMed Google Scholar
Bean, A. G. et al. Structural deficiencies in granuloma formation in TNF gene-targeted mice underlie the heightened susceptibility to aerosol Mycobacterium tuberculosis infection, which is not compensated for by lymphotoxin. J. Immunol.162, 3504–3511 (1999). CASPubMed Google Scholar
Chakravarty, S. D. et al. Tumor necrosis factor blockade in chronic murine tuberculosis enhances granulomatous inflammation and disorganizes granulomas in the lungs. Infect. Immun.76, 916–926 (2008). ArticleCASPubMedPubMed Central Google Scholar
Flynn, J. L. et al. Tumor necrosis factor-α is required in the protective immune response against Mycobacterium tuberculosis in mice. Immunity2, 561–572 (1995). ArticleCASPubMed Google Scholar
Kindler, V., Sappino, A. P., Grau, G. E., Piguet, P. F. & Vassalli, P. The inducing role of tumor necrosis factor in the development of bactericidal granulomas during BCG infection. Cell56, 731–740 (1989). ArticleCASPubMed Google Scholar
Roach, D. R. et al. TNF regulates chemokine induction essential for cell recruitment, granuloma formation, and clearance of mycobacterial infection. J. Immunol.168, 4620–4627 (2002). ArticleCASPubMed Google Scholar
Dannenberg, A. M. Jr. Immunopathogenesis of pulmonary tuberculosis. Hosp. Pract.28, 51–58 (1993). Article Google Scholar
Wolf, A. J. et al. Mycobacterium tuberculosis infects dendritic cells with high frequency and impairs their function in vivo. J. Immunol.179, 2509–2519 (2007). This study presents a comprehensive temporal analysis of the immune cells arriving at the site of granuloma formation in the lungs ofM. tuberculosis-infected mice. ArticleCASPubMed Google Scholar
Wolf, A. J. et al. Initiation of the adaptive immune response to Mycobacterium tuberculosis depends on antigen production in the local lymph node, not the lungs. J. Exp. Med.205, 105–115 (2008). This study implicates delayed migration of DCs to the draining lymph nodes, where effective antigen responses are generated, in the unchecked mycobacterial proliferation that occurs in the forming granuloma. ArticleCASPubMedPubMed Central Google Scholar
Ramakrishnan, L. Images in clinical medicine. Mycobacterium marinum infection of the hand. N. Engl. J. Med.337, 612 (1997). ArticleCASPubMed Google Scholar
Swaim, L. E. et al. Mycobacterium marinum infection of adult zebrafish causes caseating granulomatous tuberculosis and is moderated by adaptive immunity. Infect. Immun.74, 6108–6117 (2006). ArticleCASPubMedPubMed Central Google Scholar
Andersen, P. Host responses and antigens involved in protective immunity to Mycobacterium tuberculosis. Scand. J. Immunol.45, 115–131 (1997). ArticleCASPubMed Google Scholar
Saunders, B. M. & Cooper, A. M. Restraining mycobacteria: role of granulomas in mycobacterial infections. Immunol. Cell Biol.78, 334–341 (2000). ArticleCASPubMed Google Scholar
Davis, J. M. & Ramakrishnan, L. The role of the granuloma in expansion and dissemination of early tuberculous infection. Cell136, 37–49 (2009). This study shows how the early tuberculous granuloma expands infection and disseminates it within the host. ArticleCASPubMedPubMed Central Google Scholar
Volkman, H. E. et al. Tuberculous granuloma formation is enhanced by a mycobacterium virulence determinant. PLoS Biol.2, e367 (2004). References 23 and 65 together show that the mycobacterial protein ESAT6, which is secreted through ESX-1, enhances macrophage migration to granulomas through the induction of MMP9 in surrounding epithelial cells. This provides a mechanistic understanding of the clinical findings in references 92–95. ArticlePubMedPubMed CentralCAS Google Scholar
Davis, J. M. et al. Real-time visualization of mycobacterium–macrophage interactions leading to initiation of granuloma formation in zebrafish embryos. Immunity17, 693–702 (2002). This study shows that tuberculous granuloma formation can occur in the sole context of innate immunity. ArticleCASPubMed Google Scholar
Castellino, F. et al. Chemokines enhance immunity by guiding naive CD8+ T cells to sites of CD4+ T cell–dendritic cell interaction. Nature440, 890–895 (2006). ArticleCASPubMed Google Scholar
Okada, T. et al. Antigen-engaged B cells undergo chemotaxis toward the T zone and form motile conjugates with helper T cells. PLoS Biol.3, e150 (2005). ArticlePubMedPubMed CentralCAS Google Scholar
Kahnert, A. et al. Mycobacterium tuberculosis triggers formation of lymphoid structure in murine lungs. J. Infect. Dis.195, 46–54 (2007). ArticleCASPubMed Google Scholar
Ulrichs, T. et al. Human tuberculous granulomas induce peripheral lymphoid follicle-like structures to orchestrate local host defence in the lung. J. Pathol.204, 217–228 (2004). References 69 and 70 describe tertiary lymphoid structures in human and mouse tuberculous granulomas. ArticlePubMed Google Scholar
Stoll, S., Delon, J., Brotz, T. M. & Germain, R. N. Dynamic imaging of T cell–dendritic cell interactions in lymph nodes. Science296, 1873–1876 (2002). ArticlePubMed Google Scholar
Egen, J. G. et al. Macrophage and T cell dynamics during the development and disintegration of mycobacterial granulomas. Immunity28, 271–284 (2008). This study reveals the dynamic nature of mouse tuberculous granulomas through three-dimensional time-lapse microscopy and shows activated T cells entering and moving throughout the granuloma. ArticleCASPubMedPubMed Central Google Scholar
Egen, J. G. et al. Intravital imaging reveals limited antigen presentation and T cell effector function in mycobacterial granulomas. Immunity34, 807–819 (2011). ArticleCASPubMedPubMed Central Google Scholar
Sherman, D. R. et al. Mycobacterium tuberculosis H37Rv:ΔRD1 is more virulent than M. bovis bacille Calmette-Guerin in long-term murine infection. J. Infect. Dis.190, 123–126 (2004). ArticlePubMed Google Scholar
Cosma, C. L., Humbert, O. & Ramakrishnan, L. Superinfecting mycobacteria home to established tuberculous granulomas. Nature Immunol.5, 828–835 (2004). ArticleCAS Google Scholar
Dannenberg, A. M. Jr. Macrophage turnover, division and activation within developing, peak and “healed” tuberculous lesions produced in rabbits by BCG. Tuberculosis83, 251–260 (2003). References 75 and 76 show that the mature tuberculous granuloma, including its necrotic centre, is not secluded but is continuously populated by both infected and uninfected macrophages. ArticlePubMed Google Scholar
Savill, J. & Fadok, V. Corpse clearance defines the meaning of cell death. Nature407, 784–788 (2000). ArticleCASPubMed Google Scholar
Taylor, R. C., Cullen, S. P. & Martin, S. J. Apoptosis: controlled demolition at the cellular level. Nature Rev. Mol. Cell Biol.9, 231–241 (2008). ArticleCAS Google Scholar
Clay, H. et al. Dichotomous role of the macrophage in early Mycobacterium marinum infection of the zebrafish. Cell Host Microbe2, 29–39 (2007). ArticleCASPubMedPubMed Central Google Scholar
Ray, J. C., Flynn, J. L. & Kirschner, D. E. Synergy between individual TNF-dependent functions determines granuloma performance for controlling Mycobacterium tuberculosis infection. J. Immunol.182, 3706–3717 (2009). ArticleCASPubMed Google Scholar
Lin, P. L. et al. Tumor necrosis factor neutralization results in disseminated disease in acute and latent Mycobacterium tuberculosis infection with normal granuloma structure in a cynomolgus macaque model. Arthritis Rheum.62, 340–350 (2010). ArticleCASPubMedPubMed Central Google Scholar
Garcia Vidal, C. et al. Paradoxical response to antituberculous therapy in infliximab-treated patients with disseminated tuberculosis. Clin. Infect. Dis.40, 756–759 (2005). ArticlePubMed Google Scholar
Iliopoulos, A., Psathakis, K., Aslanidis, S., Skagias, L. & Sfikakis, P. P. Tuberculosis and granuloma formation in patients receiving anti-TNF therapy. Int. J. Tuberc. Lung Dis.10, 588–590 (2006). CASPubMed Google Scholar
Van den Steen, P. E. et al. Biochemistry and molecular biology of gelatinase B or matrix metalloproteinase-9 (MMP-9). Crit. Rev. Biochem. Mol. Biol.37, 375–536 (2002). ArticleCASPubMed Google Scholar
Banaiee, N., Kincaid, E. Z., Buchwald, U., Jacobs, W. R. Jr & Ernst, J. D. Potent inhibition of macrophage responses to IFN-γ by live virulent Mycobacterium tuberculosis is independent of mature mycobacterial lipoproteins but dependent on TLR2. J. Immunol.176, 3019–3027 (2006). ArticleCASPubMed Google Scholar
Fortune, S. M. et al. Mycobacterium tuberculosis inhibits macrophage responses to IFN-γ through myeloid differentiation factor 88-dependent and -independent mechanisms. J. Immunol.172, 6272–6280 (2004). ArticleCASPubMed Google Scholar
Kincaid, E. Z. & Ernst, J. D. Mycobacterium tuberculosis exerts gene-selective inhibition of transcriptional responses to IFN-γ without inhibiting STAT1 function. J. Immunol.171, 2042–2049 (2003). ArticleCASPubMed Google Scholar
Ting, L. M., Kim, A. C., Cattamanchi, A. & Ernst, J. D. Mycobacterium tuberculosis inhibits IFN-γ transcriptional responses without inhibiting activation of STAT1. J. Immunol.163, 3898–3906 (1999). CASPubMed Google Scholar
Stockhammer, O. W., Zakrzewska, A., Hegedus, Z., Spaink, H. P. & Meijer, A. H. Transcriptome profiling and functional analyses of the zebrafish embryonic innate immune response to Salmonella infection. J. Immunol.182, 5641–5653 (2009). ArticleCASPubMed Google Scholar
Tobin, D. M. et al. The lta4h locus modulates susceptibility to mycobacterial infection in zebrafish and humans. Cell140, 717–730 (2010). ArticleCASPubMedPubMed Central Google Scholar
Taylor, J. L. et al. Role for matrix metalloproteinase 9 in granuloma formation during pulmonary Mycobacterium tuberculosis infection. Infect. Immun.74, 6135–6144 (2006). ArticleCASPubMedPubMed Central Google Scholar
Park, K. J. et al. Expression of matrix metalloproteinase-9 in pleural effusions of tuberculosis and lung cancer. Respiration72, 166–175 (2005). ArticleCASPubMed Google Scholar
Price, N. M. et al. Identification of a matrix-degrading phenotype in human tuberculosis in vitro and in vivo. J. Immunol.166, 4223–4230 (2001). ArticleCASPubMed Google Scholar
Sheen, P. et al. High MMP-9 activity characterises pleural tuberculosis correlating with granuloma formation. Eur. Respir. J.33, 134–141 (2009). ArticleCASPubMed Google Scholar
Elkington, P. T. et al. Synergistic up-regulation of epithelial cell matrix metalloproteinase-9 secretion in tuberculosis. Am. J. Respir. Cell Mol. Biol.37, 431–437 (2007). ArticleCASPubMed Google Scholar
Adams, K. N. et al. Drug tolerance in replicating mycobacteria mediated by a macrophage-induced efflux mechanism. Cell145, 39–53 (2011). This study reveals that granulomas can increase the number of infected macrophages containing antibiotic-tolerant bacteria during chemotherapy and can also promote the dissemination of these macrophages. This provides an explanation for the clinical observations in references 103 and 104 that lesions containing genetically drug-sensitive bacteria appear in new locations during tuberculosis treatment. ArticleCASPubMedPubMed Central Google Scholar
Hernandez-Pando, R. et al. Persistence of DNA from Mycobacterium tuberculosis in superficially normal lung tissue during latent infection. Lancet356, 2133–2138 (2000). ArticleCASPubMed Google Scholar
Balasubramanian, V., Wiegeshaus, E. H., Taylor, B. T. & Smith, D. W. Pathogenesis of tuberculosis: pathway to apical localization. Tuber. Lung Dis.75, 168–178 (1994). ArticleCASPubMed Google Scholar
Chackerian, A. A., Alt, J. M., Perera, T. V., Dascher, C. C. & Behar, S. M. Dissemination of Mycobacterium tuberculosis is influenced by host factors and precedes the initiation of T-cell immunity. Infect. Immun.70, 4501–4509 (2002). ArticleCASPubMedPubMed Central Google Scholar
Schreiber, H. A. et al. Inflammatory dendritic cells migrate in and out of transplanted chronic mycobacterial granulomas in mice. J. Clin. Invest.121, 3902–3913 (2011). This study complements reference 64 and shows that inflammatory DCs exit mouse tuberculous granulomas to disseminate widely and prime immune responses. ArticleCASPubMedPubMed Central Google Scholar
Welsh, K. J., Risin, S. A., Actor, J. K. & Hunter, R. L. Immunopathology of postprimary tuberculosis: increased T-regulatory cells and DEC-205-positive foamy macrophages in cavitary lesions. Clin. Dev. Immunol.2011, 307631 (2011). ArticlePubMed Google Scholar
Akira, M., Sakatani, M. & Ishikawa, H. Transient radiographic progression during initial treatment of pulmonary tuberculosis: CT findings. J. Comput. Assist. Tomogr.24, 426–431 (2000). ArticleCASPubMed Google Scholar
Bobrowitz, I. D. Reversible roentgenographic progression in the initial treatment of pulmonary tuberculosis. Am. Rev. Respir. Dis.121, 735–742 (1980). CASPubMed Google Scholar
Cree, I. A., Nurbhai, S., Milne, G. & Beck, J. S. Cell death in granulomata: the role of apoptosis. J. Clin. Pathol.40, 1314–1319 (1987). ArticleCASPubMedPubMed Central Google Scholar
Keane, J. et al. Infection by Mycobacterium tuberculosis promotes human alveolar macrophage apoptosis. Infect. Immun.65, 298–304 (1997). ArticleCASPubMedPubMed Central Google Scholar
Fayyazi, A. et al. Apoptosis of macrophages and T cells in tuberculosis associated caseous necrosis. J. Pathol.191, 417–425 (2000). ArticleCASPubMed Google Scholar
Tobin, D. et al. Host genotype-specific therapies can optimize the inflammatory response to mycobacterial infections. Cell148, 434–446 (2012). ArticleCASPubMedPubMed Central Google Scholar
Chen, M. et al. Lipid mediators in innate immunity against tuberculosis: opposing roles of PGE2 and LXA4 in the induction of macrophage death. J. Exp. Med.205, 2791–2801 (2008). References 90, 107 and 108 together show that virulent mycobacteria induce the production of host lipoxins, which are anti-inflammatory eicosanoids that induce the necrosis of granuloma macrophages through TNF suppression. ArticleCASPubMedPubMed Central Google Scholar
Behar, S. M. et al. Apoptosis is an innate defense function of macrophages against Mycobacterium tuberculosis. Mucosal Immunol.4, 279–287 (2011). ArticleCASPubMedPubMed Central Google Scholar
Fratazzi, C., Arbeit, R. D., Carini, C. & Remold, H. G. Programmed cell death of Mycobacterium avium serovar 4-infected human macrophages prevents the mycobacteria from spreading and induces mycobacterial growth inhibition by freshly added, uninfected macrophages. J. Immunol.158, 4320–4327 (1997). CASPubMed Google Scholar
Gan, H. et al. Mycobacterium tuberculosis blocks crosslinking of annexin-1 and apoptotic envelope formation on infected macrophages to maintain virulence. Nature Immunol.9, 1189–1197 (2008). ArticleCAS Google Scholar
Keane, J., Shurtleff, B. & Kornfeld, H. TNF-dependent BALB/c murine macrophage apoptosis following Mycobacterium tuberculosis infection inhibits bacillary growth in an IFN-γ independent manner. Tuberculosis82, 55–61 (2002). ArticleCASPubMed Google Scholar
Oddo, M. et al. Fas ligand-induced apoptosis of infected human macrophages reduces the viability of intracellular Mycobacterium tuberculosis. J. Immunol.160, 5448–5454 (1998). CASPubMed Google Scholar
Gao, L. Y. et al. A mycobacterial virulence gene cluster extending RD1 is required for cytolysis, bacterial spreading and ESAT-6 secretion. Mol. Microbiol.53, 1677–1693 (2004). ArticleCASPubMed Google Scholar
Guinn, K. M. et al. Individual RD1-region genes are required for export of ESAT-6/CFP-10 and for virulence of Mycobacterium tuberculosis. Mol. Microbiol.51, 359–370 (2004). ArticleCASPubMedPubMed Central Google Scholar
Choi, H. H. et al. Endoplasmic reticulum stress response is involved in Mycobacterium tuberculosis protein ESAT-6-mediated apoptosis. FEBS Lett.584, 2445–2454 (2010). ArticleCASPubMed Google Scholar
Derrick, S. C. & Morris, S. L. The ESAT6 protein of Mycobacterium tuberculosis induces apoptosis of macrophages by activating caspase expression. Cell. Microbiol.9, 1547–1555 (2007). ArticleCASPubMed Google Scholar
Mishra, B. B. et al. Mycobacterium tuberculosis protein ESAT-6 is a potent activator of the NLRP3/ASC inflammasome. Cell. Microbiol.12, 1046–1063 (2010). ArticleCASPubMed Google Scholar
Molloy, A., Laochumroonvorapong, P. & Kaplan, G. Apoptosis, but not necrosis, of infected monocytes is coupled with killing of intracellular bacillus Calmette-Guerin. J. Exp. Med.180, 1499–1509 (1994). ArticleCASPubMed Google Scholar
Lammas, D. A. et al. ATP-induced killing of mycobacteria by human macrophages is mediated by purinergic P2Z(P2X7) receptors. Immunity7, 433–444 (1997). ArticleCASPubMed Google Scholar
Briken, V. & Miller, J. L. Living on the edge: inhibition of host cell apoptosis by Mycobacterium tuberculosis. Future Microbiol.3, 415–422 (2008). ArticleCASPubMed Google Scholar
Hinchey, J. et al. Enhanced priming of adaptive immunity by a proapoptotic mutant of Mycobacterium tuberculosis. J. Clin. Invest.117, 2279–2288 (2007). ArticleCASPubMedPubMed Central Google Scholar
Jayakumar, D., Jacobs, W. R. Jr & Narayanan, S. Protein kinase E of Mycobacterium tuberculosis has a role in the nitric oxide stress response and apoptosis in a human macrophage model of infection. Cell. Microbiol.10, 365–374 (2008). CASPubMed Google Scholar
Velmurugan, K. et al. Mycobacterium tuberculosis nuoG is a virulence gene that inhibits apoptosis of infected host cells. PLoS Pathog.3, e110 (2007). ArticlePubMedPubMed CentralCAS Google Scholar
Miller, J. L., Velmurugan, K., Cowan, M. J. & Briken, V. The type I NADH dehydrogenase of Mycobacterium tuberculosis counters phagosomal NOX2 activity to inhibit TNF-α-mediated host cell apoptosis. PLoS Pathog.6, e1000864 (2010). ArticlePubMedPubMed CentralCAS Google Scholar
Divangahi, M., Desjardins, D., Nunes-Alves, C., Remold, H. G. & Behar, S. M. Eicosanoid pathways regulate adaptive immunity to Mycobacterium tuberculosis. Nature Immunol.11, 751–758 (2010). ArticleCAS Google Scholar
Divangahi, M. et al. Mycobacterium tuberculosis evades macrophage defenses by inhibiting plasma membrane repair. Nature Immunol.10, 899–906 (2009). ArticleCAS Google Scholar
Saunders, B. M., Frank, A. A., Orme, I. M. & Cooper, A. M. CD4 is required for the development of a protective granulomatous response to pulmonary tuberculosis. Cell. Immunol.216, 65–72 (2002). ArticleCASPubMed Google Scholar
van Rie, A. et al. Exogenous reinfection as a cause of recurrent tuberculosis after curative treatment. New Engl. J. Med.341, 1174–1179 (1999). ArticleCASPubMed Google Scholar
Verver, S. et al. Rate of reinfection tuberculosis after successful treatment is higher than rate of new tuberculosis. Am. J. Respir. Crit. Care Med.171, 1430–1435 (2005). ArticlePubMed Google Scholar
Caminero, J. A. et al. Exogenous reinfection with tuberculosis on a European island with a moderate incidence of disease. Am. J. Respir. Crit. Care Med.163, 717–720 (2001). ArticleCASPubMed Google Scholar
Kaufmann, S. H. How can immunology contribute to the control of tuberculosis? Nature Rev. Immunol.1, 20–30 (2001). ArticleCAS Google Scholar
Cosma, C. L., Humbert, O., Sherman, D. R. & Ramakrishnan, L. Trafficking of superinfecting Mycobacterium organisms into established granulomas occurs in mammals and is independent of the Erp and ESX-1 mycobacterial virulence loci. J. Infect. Dis.198, 1851–1855 (2008). ArticlePubMed Google Scholar
Gallegos, A. M., Pamer, E. G. & Glickman, M. S. Delayed protection by ESAT-6-specific effector CD4+ T cells after airborne M. tuberculosis infection. J. Exp. Med.205, 2359–2368 (2008). This study highlights the poor responsiveness of infected macrophages to T cell help that should ordinarily be expected to increase their microbicidal capacity. ArticleCASPubMedPubMed Central Google Scholar
Gill, W. P. et al. A replication clock for Mycobacterium tuberculosis. Nature Med.15, 211–214 (2009). ArticleCASPubMed Google Scholar
Shafiani, S., Tucker-Heard, G., Kariyone, A., Takatsu, K. & Urdahl, K. B. Pathogen-specific regulatory T cells delay the arrival of effector T cells in the lung during early tuberculosis. J. Exp. Med.207, 1409–1420 (2010). ArticleCASPubMedPubMed Central Google Scholar
Khader, S. A. et al. IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge. Nature Immunol.8, 369–377 (2007). ArticleCAS Google Scholar
Scott-Browne, J. P. et al. Expansion and function of Foxp3-expressing T regulatory cells during tuberculosis. J. Exp. Med.204, 2159–2169 (2007). ArticleCASPubMedPubMed Central Google Scholar
Kursar, M. et al. Cutting edge: regulatory T cells prevent efficient clearance of Mycobacterium tuberculosis. J. Immunol.178, 2661–2665 (2007). References 137, 139 and 140 together document the detrimental effect of TRegcells present in lymphoid areas of lung tuberculous granulomas. These cells delay the arrival of specific effector T cells to the granuloma. ArticleCASPubMed Google Scholar
Redford, P. S. et al. Enhanced protection to Mycobacterium tuberculosis infection in IL-10-deficient mice is accompanied by early and enhanced Th1 responses in the lung. Eur. J. Immunol.40, 2200–2210 (2010). ArticleCASPubMedPubMed Central Google Scholar
Pancholi, P., Mirza, A., Bhardwaj, N. & Steinman, R. M. Sequestration from immune CD4+ T cells of mycobacteria growing in human macrophages. Science260, 984–986 (1993). ArticleCASPubMed Google Scholar
Bold, T. D., Banaei, N., Wolf, A. J. & Ernst, J. D. Suboptimal activation of antigen-specific CD4+ effector cells enables persistence of M. tuberculosis in vivo. PLoS Pathog.7, e1002063 (2011). References 73 and 143 together show that there is limited activation of and antigen recognition by T cells in tuberculous granulomas. ArticleCASPubMedPubMed Central Google Scholar
Nagabhushanam, V. et al. Innate inhibition of adaptive immunity: _Mycobacterium tuberculosis_-induced IL-6 inhibits macrophage responses to IFN-γ. J. Immunol.171, 4750–4757 (2003). ArticleCASPubMed Google Scholar
Beatty, W. L. et al. Trafficking and release of mycobacterial lipids from infected macrophages. Traffic1, 235–247 (2000). ArticleCASPubMed Google Scholar
Desvignes, L. & Ernst, J. D. Interferon-γ-responsive nonhematopoietic cells regulate the immune response to Mycobacterium tuberculosis. Immunity31, 974–985 (2009). ArticleCASPubMedPubMed Central Google Scholar
MacMicking, J. D., Taylor, G. A. & McKinney, J. D. Immune control of tuberculosis by IFN-γ-inducible LRG-47. Science302, 654–659 (2003). ArticleCASPubMed Google Scholar
MacMicking, J. D. et al. Identification of nitric oxide synthase as a protective locus against tuberculosis. Proc. Natl Acad. Sci. USA94, 5243–5248 (1997). ArticleCASPubMedPubMed Central Google Scholar
Nandi, B. & Behar, S. M. Regulation of neutrophils by interferon-γ limits lung inflammation during tuberculosis infection. J. Exp. Med.208, 2251–2262 (2011). ArticleCASPubMedPubMed Central Google Scholar
Narui, K. et al. Anti-infectious activity of tryptophan metabolites in the L-tryptophan–L-kynurenine pathway. Biol. Pharm. Bull.32, 41–44 (2009). ArticleCASPubMed Google Scholar
Schneider, B. E. et al. A role for IL-18 in protective immunity against Mycobacterium tuberculosis. Eur. J. Immunol.40, 396–405 (2010). ArticleCASPubMedPubMed Central Google Scholar
Cruz, A. et al. Pathological role of interleukin 17 in mice subjected to repeated BCG vaccination after infection with Mycobacterium tuberculosis. J. Exp. Med.207, 1609–1616 (2010). ArticleCASPubMedPubMed Central Google Scholar
Russell, D. G. Who puts the tubercle in tuberculosis? Nature Rev. Microbiol.5, 39–47 (2007). ArticleCAS Google Scholar
Brunet, L. R., Finkelman, F. D., Cheever, A. W., Kopf, M. A. & Pearce, E. J. IL-4 protects against TNF-α-mediated cachexia and death during acute schistosomiasis. J. Immunol.159, 777–785 (1997). CASPubMed Google Scholar
Fallon, P. G. & Dunne, D. W. Tolerization of mice to Schistosoma mansoni egg antigens causes elevated type 1 and diminished type 2 cytokine responses and increased mortality in acute infection. J. Immunol.162, 4122–4132 (1999). CASPubMed Google Scholar
Fallon, P. G., Richardson, E. J., Smith, P. & Dunne, D. W. Elevated type 1, diminished type 2 cytokines and impaired antibody response are associated with hepatotoxicity and mortalities during Schistosoma mansoni infection of CD4-depleted mice. Eur. J. Immunol.30, 470–480 (2000). ArticleCASPubMed Google Scholar
Amiri, P. et al. Tumour necrosis factor α restores granulomas and induces parasite egg-laying in schistosome-infected SCID mice. Nature356, 604–607 (1992). ArticleCASPubMed Google Scholar
Bjerkeli, V. et al. Expression of matrix metalloproteinases in patients with Wegener's granulomatosis. Ann. Rheum. Dis.63, 1659–1663 (2004). ArticleCASPubMedPubMed Central Google Scholar
Fireman, E., Kraiem, Z., Sade, O., Greif, J. & Fireman, Z. Induced sputum-retrieved matrix metalloproteinase 9 and tissue metalloproteinase inhibitor 1 in granulomatous diseases. Clin. Exp. Immunol.130, 331–337 (2002). ArticleCASPubMedPubMed Central Google Scholar
Piotrowski, W., Górski, P., Pietras, T., Fendler, W. & Szemraj, J. The selected genetic polymorphisms of metalloproteinases MMP2, 7, 9 and MMP inhibitor TIMP2 in sarcoidosis. Med. Sci. Monit.10, CR598–CR607 (2011). Google Scholar
Relman, D. A., Schmidt, T. M., MacDermott, R. P. & Falkow, S. Identification of the uncultured bacillus of Whipple's disease. N. Engl. J. Med.327, 293–301 (1992). ArticleCASPubMed Google Scholar
Dolan, M. J. et al. Syndrome of Rochalimaea henselae adenitis suggesting cat scratch disease. Ann. Intern. Med.118, 331–336 (1993). ArticleCASPubMed Google Scholar
Villemin, J. A. Etudes Sur La Tuberculosis (J.-B. Balliere et fils, 1868). Google Scholar
Flynn, J. L. Lessons from experimental Mycobacterium tuberculosis infections. Microbes Infect.8, 1179–1188 (2006). ArticleCASPubMed Google Scholar
Pichugin, A. V., Yan, B. S., Sloutsky, A., Kobzik, L. & Kramnik, I. Dominant role of the sst1 locus in pathogenesis of necrotizing lung granulomas during chronic tuberculosis infection and reactivation in genetically resistant hosts. Am. J. Pathol.174, 2190–2201 (2009). ArticleCASPubMedPubMed Central Google Scholar
Tobin, D. M. & Ramakrishnan, L. Comparative pathogenesis of Mycobacterium marinum and Mycobacterium tuberculosis. Cell. Microbiol.10, 1027–1039 (2008). ArticleCASPubMed Google Scholar
Ramakrishnan, L., Federspiel, N. A. & Falkow, S. Granuloma-specific expression of Mycobacterium virulence proteins from the glycine-rich PE-PGRS family. Science288, 1436–1439 (2000). ArticleCASPubMed Google Scholar