The distribution and targeting of neuronal voltage-gated ion channels (original) (raw)

• Hodgkin, A. L. & Huxley, A. F. Currents carried by sodium and potassium ions through the membrane of the giant axon of Loligo. J. Physiol. 116, 449–472 (1952).
  Article CAS PubMed PubMed Central Google Scholar
• Devaux, J. J., Kleopa, K. A., Cooper, E. C. & Scherer, S. S. KCNQ2 is a nodal K+ channel. J. Neurosci. 24, 1236–1244 (2004). First report that KCNQ is at the AIS and nodes of Ranvier, supported by both co-localization with markers and electrophysiological recordings.
  Article CAS PubMed PubMed Central Google Scholar
• Hille, B. Ion Channels of Excitable Membranes (Sinauer, Sunderland, Massachusetts, USA, 2001).
  Google Scholar
• Shepherd, G. M. The Synaptic Organization of the Brain (Oxford University, New York, 2004).
  Book Google Scholar
• Schwarz, J. R. et al. KCNQ channels mediate _I_Ks, a slow K+ current regulating excitability in the rat node of Ranvier. J. Physiol. 573, 17–34 (2006).
  Article CAS PubMed PubMed Central Google Scholar
• Magee, J. C. & Johnston, D. Plasticity of dendritic function. Curr. Opin. Neurobiol. 15, 334–342 (2005).
  Article CAS PubMed Google Scholar
• Magee, J. C. & Johnston, D. A synaptically controlled, associative signal for Hebbian plasticity in hippocampal neurons. Science 275, 209–213 (1997).
  Article CAS PubMed Google Scholar
• Sjostrom, P. J. & Nelson, S. B. Spike timing, calcium signals and synaptic plasticity. Curr. Opin. Neurobiol. 12, 305–314 (2002).
  Article CAS PubMed Google Scholar
• Dan, Y. & Poo, M. M. Spike timing-dependent plasticity of neural circuits. Neuron 44, 23–30 (2004).
  Article CAS PubMed Google Scholar
• Helmchen, F., Svoboda, K., Denk, W. & Tank, D. W. In vivo dendritic calcium dynamics in deep-layer cortical pyramidal neurons. Nature Neurosci. 2, 989–996 (1999).
  Article CAS PubMed Google Scholar
• Larkum, M. E. & Zhu, J. J. Signaling of layer 1 and whisker-evoked Ca2+ and Na+ action potentials in distal and terminal dendrites of rat neocortical pyramidal neurons in vitro and in vivo. J. Neurosci. 22, 6991–7005 (2002).
  Article CAS PubMed PubMed Central Google Scholar
• Schiller, J., Schiller, Y., Stuart, G. & Sakmann, B. Calcium action potentials restricted to distal apical dendrites of rat neocortical pyramidal neurons. J. Physiol. 505, 605–616 (1997).
  Article CAS PubMed PubMed Central Google Scholar
• Svoboda, K., Helmchen, F., Denk, W. & Tank, D. W. Spread of dendritic excitation in layer 2/3 pyramidal neurons in rat barrel cortex in vivo. Nature Neurosci. 2, 65–73 (1999).
  Article CAS PubMed Google Scholar
• Oakley, J. C., Schwindt, P. C. & Crill, W. E. Initiation and propagation of regenerative Ca2+-dependent potentials in dendrites of layer 5 pyramidal neurons. J. Neurophysiol. 86, 503–513 (2001).
  Article CAS PubMed Google Scholar
• Catterall, W. A., Goldin, A. L. & Waxman, S. G. International union of pharmacology. XLVII. Nomenclature and structure–function relationships of voltage-gated sodium channels. Pharmacol. Rev. 57, 397–409 (2005).
  Article CAS PubMed Google Scholar
• Goldin, A. L. et al. Nomenclature of voltage-gated sodium channels. Neuron 28, 365–368 (2000).
  Article CAS PubMed Google Scholar
• Goldin, A. L. Resurgence of sodium channel research. Annu. Rev. Physiol. 63, 871–894 (2001).
  Article CAS PubMed Google Scholar
• Yu, F. H., Yarov-Yarovoy, V., Gutman, G. A. & Catterall, W. A. Overview of molecular relationships in the voltage-gated ion channel superfamily. Pharmacol. Rev. 57, 387–395 (2005).
  Article CAS PubMed Google Scholar
• Catterall, W. A. From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels. Neuron 26, 13–25 (2000).
  Article CAS PubMed Google Scholar
• Vaughn, D. E. & Bjorkman, P. J. The (Greek) key to structures of neural adhesion molecules. Neuron 16, 261–273 (1996).
  Article CAS PubMed Google Scholar
• Gutman, G. A. et al. International union of pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. Pharmacol. Rev. 57, 473–508 (2005).
  Article CAS PubMed Google Scholar
• Gulbis, J. M., Zhou, M., Mann, S. & MacKinnon, R. Structure of the cytoplasmic β subunit–T1 assembly of voltage-dependent K+ channels. Science 289, 123–127 (2000).
  Article CAS PubMed Google Scholar
• Scannevin, R. H. et al. Two N-terminal domains of Kv4 K+ channels regulate binding to and modulation by KChIP1. Neuron 41, 587–598 (2004).
  Article CAS PubMed Google Scholar
• Kim, L. A. et al. Three-dimensional structure of Ito: Kv4.2–KChIP2 ion channels by electron microscopy at 21 Å resolution. Neuron 41, 513–519 (2004).
  Article CAS PubMed Google Scholar
• Zhou, W., Qian, Y., Kunjilwar, K., Pfaffinger, P. J. & Choe, S. Structural insights into the functional interaction of KChIP1 with Shal-type K+ channels. Neuron 41, 573–586 (2004).
  Article CAS PubMed Google Scholar
• Nadal, M. S. et al. The CD26-related dipeptidyl aminopeptidase-like protein DPPX is a critical component of neuronal A-type K+ channels. Neuron 37, 449–461 (2003).
  Article CAS PubMed Google Scholar
• Robinson, R. B. & Siegelbaum, S. A. Hyperpolarization-activated cation currents: from molecules to physiological function. Annu. Rev. Physiol. 65, 453–480 (2003).
  Article CAS PubMed Google Scholar
• Catterall, W. A. Structure and regulation of voltage-gated Ca2+ channels. Annu. Rev. Cell Dev. Biol. 16, 521–555 (2000).
  Article CAS PubMed Google Scholar
• Catterall, W. A., Perez-Reyes, E., Snutch, T. P. & Striessnig, J. International union of pharmacology. XLVIII. Nomenclature and structure–function relationships of voltage-gated calcium channels. Pharmacol. Rev. 57, 411–425 (2005).
  Article CAS PubMed Google Scholar
• Trimmer, J. S. & Rhodes, K. J. Localization of voltage-gated ion channels in mammalian brain. Annu. Rev. Physiol. 66, 477–519 (2004).
  Article CAS PubMed Google Scholar
• Rasband, M. N. et al. Potassium channel distribution, clustering, and function in remyelinating rat axons. J. Neurosci. 18, 36–47 (1998).
  Article CAS PubMed PubMed Central Google Scholar
• Chiu, S. Y. & Ritchie, J. M. Evidence for the presence of potassium channels in the paranodal region of acutely demyelinated mammalian single nerve fibres. J. Physiol. 313, 415–437 (1981).
  Article CAS PubMed PubMed Central Google Scholar
• Rudy, B. et al. Contributions of Kv3 channels to neuronal excitability. Ann. NY Acad. Sci. 868, 304–343 (1999).
  Article CAS PubMed Google Scholar
• Baranauskas, G., Tkatch, T., Nagata, K., Yeh, J. Z. & Surmeier, D. J. Kv3.4 subunits enhance the repolarizing efficiency of Kv3.1 channels in fast-spiking neurons. Nature Neurosci. 6, 258–266 (2003).
  Article CAS PubMed Google Scholar
• Lien, C. C. & Jonas, P. Kv3 potassium conductance is necessary and kinetically optimized for high-frequency action potential generation in hippocampal interneurons. J. Neurosci. 23, 2058–2068 (2003).
  Article CAS PubMed PubMed Central Google Scholar
• Wisco, D. et al. Uncovering multiple axonal targeting pathways in hippocampal neurons. J. Cell Biol. 162, 1317–1328 (2003). Proposes mechanisms of directed targeting or transcytosis for the axonal cell adhesion molecule, NgCAM.
  Article CAS PubMed PubMed Central Google Scholar
• Sampo, B., Kaech, S., Kunz, S. & Banker, G. Two distinct mechanisms target membrane proteins to the axonal surface. Neuron 37, 611–624 (2003). Proposes a selective endocytosis mechanism for the axonal protein, VAMP2.
  Article CAS PubMed Google Scholar
• Jareb, M. & Banker, G. The polarized sorting of membrane proteins expressed in cultured hippocampal neurons using viral vectors. Neuron 20, 855–867 (1998).
  Article CAS PubMed Google Scholar
• Poyatos, I. et al. Polarized distribution of glycine transporter isoforms in epithelial and neuronal cells. Mol. Cell. Neurosci. 15, 99–111 (2000).
  Article CAS PubMed Google Scholar
• Ohno, H. et al. Interaction of tyrosine-based sorting signals with clathrin-associated proteins. Science 269, 1872–1875 (1995).
  Article CAS PubMed Google Scholar
• Owen, D. J. & Evans, P. R. A structural explanation for the recognition of tyrosine-based endocytotic signals. Science 282, 1327–1332 (1998).
  Article CAS PubMed PubMed Central Google Scholar
• Rapoport, I., Chen, Y. C., Cupers, P., Shoelson, S. E. & Kirchhausen, T. Dileucine-based sorting signals bind to the β chain of AP-1 at a site distinct and regulated differently from the tyrosine-based motif-binding site. EMBO J. 17, 2148–2155 (1998).
  Article CAS PubMed PubMed Central Google Scholar
• West, A. E., Neve, R. L. & Buckley, K. M. Identification of a somatodendritic targeting signal in the cytoplasmic domain of the transferrin receptor. J. Neurosci. 17, 6038–6047 (1997).
  Article CAS PubMed PubMed Central Google Scholar
• Stowell, J. N. & Craig, A. M. Axon/dendrite targeting of metabotropic glutamate receptors by their cytoplasmic carboxy-terminal domains. Neuron 22, 525–536 (1999).
  Article CAS PubMed Google Scholar
• Ruberti, F. & Dotti, C. G. Involvement of the proximal C terminus of the AMPA receptor subunit GluR1 in dendritic sorting. J. Neurosci. 20, RC78 (2000).
• Colbert, C. M. & Pan, E. Ion channel properties underlying axonal action potential initiation in pyramidal neurons. Nature Neurosci. 5, 533–538 (2002).
  Article CAS PubMed Google Scholar
• Westenbroek, R. E., Merrick, D. K. & Catterall, W. A. Differential subcellular localization of the RI and RII Na+ channel subtypes in central neurons. Neuron 3, 695–704 (1989).
  Article CAS PubMed Google Scholar
• Caldwell, J. H., Schaller, K. L., Lasher, R. S., Peles, E. & Levinson, S. R. Sodium channel Nav1.6 is localized at nodes of ranvier, dendrites, and synapses. Proc. Natl Acad. Sci. USA 97, 5616–5620 (2000).
  Article CAS PubMed PubMed Central Google Scholar
• Salzer, J. L. Polarized domains of myelinated axons. Neuron 40, 297–318 (2003).
  Article CAS PubMed Google Scholar
• Poliak, S. & Peles, E. The local differentiation of myelinated axons at nodes of Ranvier. Nature Rev. Neurosci. 4, 968–980 (2003).
  Article CAS Google Scholar
• Ratcliffe, C. F., Westenbroek, R. E., Curtis, R. & Catterall, W. A. Sodium channel β1 and β3 subunits associate with neurofascin through their extracellular immunoglobulin-like domain. J. Cell Biol. 154, 427–434 (2001).
  Article CAS PubMed PubMed Central Google Scholar
• Garver, T. D., Ren, Q., Tuvia, S. & Bennett, V. Tyrosine phosphorylation at a site highly conserved in the L1 family of cell adhesion molecules abolishes ankyrin binding and increases lateral mobility of neurofascin. J. Cell Biol. 137, 703–714 (1997).
  Article CAS PubMed PubMed Central Google Scholar
• Liu, C. J. et al. Direct interaction with contactin targets voltage-gated sodium channel Nav1.9/NaN to the cell membrane. J. Biol. Chem. 276, 46553–46561 (2001).
  Article CAS PubMed Google Scholar
• Kazarinova-Noyes, K. et al. Contactin associates with Na+ channels and increases their functional expression. J. Neurosci. 21, 7517–7525 (2001).
  Article CAS PubMed PubMed Central Google Scholar
• Shah, B. S. et al. Contactin associates with sodium channel Nav1.3 in native tissues and increases channel density at the cell surface. J. Neurosci. 24, 7387–7399 (2004).
  Article CAS PubMed PubMed Central Google Scholar
• Srinivasan, J., Schachner, M. & Catterall, W. A. Interaction of voltage-gated sodium channels with the extracellular matrix molecules tenascin-C-and tenascin-R. Proc. Natl Acad. Sci. USA 95, 15753–15757 (1998).
  Article CAS PubMed PubMed Central Google Scholar
• Xiao, Z. C. et al. Tenascin-R is a functional modulator of sodium channel β subunits. J. Biol. Chem. 274, 26511–26517 (1999).
  Article CAS PubMed Google Scholar
• Ratcliffe, C. F. et al. A sodium channel signaling complex: modulation by associated receptor protein tyrosine phosphatase β. Nature Neurosci. 3, 437–444 (2000).
  Article CAS PubMed Google Scholar
• Kordeli, E., Lambert, S. & Bennett, V. AnkyrinG. A new ankyrin gene with neural-specific isoforms localized at the axonal initial segment and node of Ranvier. J. Biol. Chem. 270, 2352–2359 (1995).
  Article CAS PubMed Google Scholar
• Bennett, V. & Baines, A. J. Spectrin and ankyrin-based pathways: metazoan inventions for integrating cells into tissues. Physiol. Rev. 81, 1353–1392 (2001).
  Article CAS PubMed Google Scholar
• Jenkins, S. M. & Bennett, V. Ankyrin-G coordinates assembly of the spectrin-based membrane skeleton, voltage-gated sodium channels, and L1 CAMs at Purkinje neuron initial segments. J. Cell Biol. 155, 739–746 (2001).
  Article CAS PubMed PubMed Central Google Scholar
• Lambert, S., Davis, J. Q. & Bennett, V. Morphogenesis of the node of Ranvier: co-clusters of ankyrin and ankyrin-binding integral proteins define early developmental intermediates. J. Neurosci. 17, 7025–7036 (1997).
  Article CAS PubMed PubMed Central Google Scholar
• Zhou, D. et al. AnkyrinG is required for clustering of voltage-gated Na channels at axon initial segments and for normal action potential firing. J. Cell Biol. 143, 1295–1304 (1998).
  Article CAS PubMed PubMed Central Google Scholar
• Komada, M. & Soriano, P. βIV-spectrin regulates sodium channel clustering through ankyrin-G at axon initial segments and nodes of Ranvier. J. Cell Biol. 156, 337–348 (2002).
  Article CAS PubMed PubMed Central Google Scholar
• Lemaillet, G., Walker, B. & Lambert, S. Identification of a conserved ankyrin-binding motif in the family of sodium channel α subunits. J. Biol. Chem. 278, 27333–27339 (2003).
  Article CAS PubMed Google Scholar
• Garrido, J. J. et al. A targeting motif involved in sodium channel clustering at the axonal initial segment. Science 300, 2091–2094 (2003). Reports the identification of a motif in the II–III loop of Nav1.2 channels that is necessary and sufficient to target these channels to the AIS.
  Article CAS PubMed Google Scholar
• Srinivasan, Y., Elmer, L., Davis, J., Bennett, V. & Angelides, K. Ankyrin and spectrin associate with voltage-dependent sodium channels in brain. Nature 333, 177–180 (1988).
  Article CAS PubMed Google Scholar
• Fache, M. P. et al. Endocytotic elimination and domain-selective tethering constitute a potential mechanism of protein segregation at the axonal initial segment. J. Cell Biol. 166, 571–578 (2004).
  Article CAS PubMed PubMed Central Google Scholar
• Garrido, J. J. et al. Identification of an axonal determinant in the C-terminus of the sodium channel Nav1.2. EMBO J. 20, 5950–5961 (2001). First suggestion that Nav1.2 axonal targeting is by selective elimination in the dendrites through a di-leucine motif in the C-terminus that is associated with the clathrin endocytic pathway.
  Article CAS PubMed PubMed Central Google Scholar
• Monaghan, M. M., Trimmer, J. S. & Rhodes, K. J. Experimental localization of Kv1 family voltage-gated K+ channel α and β subunits in rat hippocampal formation. J. Neurosci. 21, 5973–5983 (2001).
  Article CAS PubMed PubMed Central Google Scholar
• Wang, H., Kunkel, D. D., Martin, T. M., Schwartzkroin, P. A. & Tempel, B. L. Heteromultimeric K+ channels in terminal and juxtaparanodal regions of neurons. Nature 365, 75–79 (1993).
  Article CAS PubMed Google Scholar
• Sheng, M., Liao, Y. J., Jan, Y. N. & Jan, L. Y. Presynaptic A-current based on heteromultimeric K+ channels detected in vivo. Nature 365, 72–75 (1993).
  Article CAS PubMed Google Scholar
• Debanne, D., Guerineau, N. C., Gahwiler, B. H. & Thompson, S. M. Action-potential propagation gated by an axonal IA-like K+ conductance in hippocampus. Nature 389, 286–289 (1997).
  Article CAS PubMed Google Scholar
• Lambe, E. K. & Aghajanian, G. K. The role of Kv1.2-containing potassium channels in serotonin-induced glutamate release from thalamocortical terminals in rat frontal cortex. J. Neurosci. 21, 9955–9963 (2001).
  Article CAS PubMed PubMed Central Google Scholar
• Wang, H., Kunkel, D. D., Schwartzkroin, P. A. & Tempel, B. L. Localization of Kv1.1 and Kv1.2, two K channel proteins, to synaptic terminals, somata, and dendrites in the mouse brain. J. Neurosci. 14, 4588–4599 (1994).
  Article CAS PubMed PubMed Central Google Scholar
• Smart, S. L. et al. Deletion of the KV1.1 potassium channel causes epilepsy in mice. Neuron 20, 809–819 (1998).
  Article CAS PubMed Google Scholar
• Fili, O. et al. Direct interaction of a brain voltage-gated K+ channel with syntaxin 1A: functional impact on channel gating. J. Neurosci. 21, 1964–1974 (2001).
  Article CAS PubMed PubMed Central Google Scholar
• Michaelevski, I. et al. Modulation of a brain voltage-gated K+ channel by syntaxin 1A requires the physical interaction of Gβγ with the channel. J. Biol. Chem. 277, 34909–34917 (2002).
  Article CAS PubMed Google Scholar
• Poliak, S. et al. Juxtaparanodal clustering of Shaker-like K+ channels in myelinated axons depends on Caspr2 and TAG-1. J. Cell Biol. 162, 1149–1160 (2003).
  Article CAS PubMed PubMed Central Google Scholar
• Gu, C., Jan, Y. N. & Jan, L. Y. A conserved domain in axonal targeting of Kv1 (Shaker) voltage-gated potassium channels. Science 301, 646–649 (2003). Reports that the T1 domain of Kv1 channels is necessary and sufficient to target to the axons that depend on proper association with Kvβ.
  Article CAS PubMed Google Scholar
• Rivera, J. F., Chu, P. J. & Arnold, D. B. The T1 domain of Kv1.3 mediates intracellular targeting to axons. Eur. J. Neurosci. 22, 1853–1862 (2005).
  Article PubMed Google Scholar
• Pongs, O. et al. Functional and molecular aspects of voltage-gated K+ channel β subunits. Ann. NY Acad. Sci. 868, 344–355 (1999).
  Article CAS PubMed Google Scholar
• Rhodes, K. J. et al. Association and colocalization of the Kvβ1 and Kvβ2 β-subunits with Kv1 α-subunits in mammalian brain K+ channel complexes. J. Neurosci. 17, 8246–8258 (1997).
  Article CAS PubMed PubMed Central Google Scholar
• Gulbis, J. M., Mann, S. & MacKinnon, R. Structure of a voltage-dependent K+ channel β subunit. Cell 97, 943–952 (1999).
  Article CAS PubMed Google Scholar
• Campomanes, C. R. et al. Kv β subunit oxidoreductase activity and Kv1 potassium channel trafficking. J. Biol. Chem. 277, 8298–8305 (2002).
  Article CAS PubMed Google Scholar
• Shi, G. et al. β subunits promote K+ channel surface expression through effects early in biosynthesis. Neuron 16, 843–852 (1996).
  Article CAS PubMed Google Scholar
• Li, D., Takimoto, K. & Levitan, E. S. Surface expression of Kv1 channels is governed by a C-terminal motif. J. Biol. Chem. 275, 11597–11602 (2000).
  Article CAS PubMed Google Scholar
• Manganas, L. N. & Trimmer, J. S. Subunit composition determines Kv1 potassium channel surface expression. J. Biol. Chem. 275, 29685–29693 (2000).
  Article CAS PubMed Google Scholar
• Manganas, L. N. et al. Identification of a trafficking determinant localized to the Kv1 potassium channel pore. Proc. Natl Acad. Sci. USA 98, 14055–14059 (2001).
  Article CAS PubMed PubMed Central Google Scholar
• Manganas, L. N. et al. Episodic ataxia type-1 mutations in the Kv1.1 potassium channel display distinct folding and intracellular trafficking properties. J. Biol. Chem. 276, 49427–49434 (2001).
  Article CAS PubMed Google Scholar
• Hattan, D., Nesti, E., Cachero, T. G. & Morielli, A. D. Tyrosine phosphorylation of Kv1.2 modulates its interaction with the actin-binding protein cortactin. J. Biol. Chem. 277, 38596–38606 (2002).
  Article CAS PubMed Google Scholar
• Manganas, L. N. & Trimmer, J. S. Calnexin regulates mammalian Kv1 channel trafficking. Biochem. Biophys. Res. Commun. 322, 577–584 (2004).
  Article CAS PubMed Google Scholar
• Tiffany, A. M. et al. PSD-95 and SAP97 exhibit distinct mechanisms for regulating K+ channel surface expression and clustering. J. Cell Biol. 148, 147–158 (2000).
  Article CAS PubMed PubMed Central Google Scholar
• Kim, E., Niethammer, M., Rothschild, A., Jan, Y. N. & Sheng, M. Clustering of Shaker-type K+ channels by interaction with a family of membrane-associated guanylate kinases. Nature 378, 85–88 (1995).
  Article CAS PubMed Google Scholar
• Jugloff, D. G., Khanna, R., Schlichter, L. C. & Jones, O. T. Internalization of the Kv1.4 potassium channel is suppressed by clustering interactions with PSD-95. J. Biol. Chem. 275, 1357–1364 (2000).
  Article CAS PubMed Google Scholar
• Hsueh, Y. P., Kim, E. & Sheng, M. Disulfide-linked head-to-head multimerization in the mechanism of ion channel clustering by PSD-95. Neuron 18, 803–814 (1997).
  Article CAS PubMed Google Scholar
• Hsueh, Y. P. & Sheng, M. Requirement of N-terminal cysteines of PSD-95 for PSD-95 multimerization and ternary complex formation, but not for binding to potassium channel Kv1.4. J. Biol. Chem. 274, 532–536 (1999).
  Article CAS PubMed Google Scholar
• Topinka, J. R. & Bredt, D. S. N-terminal palmitoylation of PSD-95 regulates association with cell membranes and interaction with K+ channel Kv1.4. Neuron 20, 125–134 (1998).
  Article CAS PubMed Google Scholar
• Kim, E. & Sheng, M. Differential K+ channel clustering activity of PSD-95 and SAP97, two related membrane-associated putative guanylate kinases. Neuropharmacology 35, 993–1000 (1996).
  Article CAS PubMed Google Scholar
• Arnold, D. B. & Clapham, D. E. Molecular determinants for subcellular localization of PSD-95 with an interacting K+ channel. Neuron 23, 149–157 (1999).
  Article CAS PubMed Google Scholar
• Kim, E. & Sheng, M. PDZ domain proteins of synapses. Nature Rev. Neurosci. 5, 771–781 (2004).
  Article CAS Google Scholar
• Rasband, M. N. et al. Clustering of neuronal potassium channels is independent of their interaction with PSD-95. J. Cell Biol. 159, 663–672 (2002).
  Article CAS PubMed PubMed Central Google Scholar
• Wang, H. S. et al. KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channel. Science 282, 1890–1893 (1998).
  Article CAS PubMed Google Scholar
• Castaldo, P. et al. Benign familial neonatal convulsions caused by altered gating of KCNQ2/KCNQ3 potassium channels. J. Neurosci. 22, RC199 (2002).
  Article PubMed PubMed Central Google Scholar
• Dedek, K. et al. Myokymia and neonatal epilepsy caused by a mutation in the voltage sensor of the KCNQ2 K+ channel. Proc. Natl Acad. Sci. USA 98, 12272–12277 (2001).
  Article CAS PubMed PubMed Central Google Scholar
• Arroyo, E. J. et al. Genetic dysmyelination alters the molecular architecture of the nodal region. J. Neurosci. 22, 1726–1737 (2002).
  Article CAS PubMed PubMed Central Google Scholar
• Pan, Z. et al. A common ankyrin-G-based mechanism retains KCNQ and Nav channels at electrically active domains of the axon. J. Neurosci. 26, 2599–2603 (2006).
  Article CAS PubMed PubMed Central Google Scholar
• Chung, H. J., Jan, Y. N. & Jan, L. Y. Polarized axonal surface expression of neuronal KCNQ channels is mediated by multiple signals in the KCNQ2 and KCNQ3 C-terminal domains. Proc. Natl Acad. Sci. USA 30 May 2006 (doi: 10.1073/pnas.0603376103).
• Devaux, J. et al. Kv3.1b is a novel component of CNS nodes. J. Neurosci. 23, 4509–4518 (2003). First report that Kv3.1b is at the nodes of Ranvier.
  Article CAS PubMed PubMed Central Google Scholar
• Goldberg, E. M. et al. Specific functions of synaptically localized potassium channels in synaptic transmission at the neocortical GABAergic fast-spiking cell synapse. J. Neurosci. 25, 5230–5235 (2005).
  Article CAS PubMed PubMed Central Google Scholar
• Matsukawa, H., Wolf, A. M., Matsushita, S., Joho, R. H. & Knopfel, T. Motor dysfunction and altered synaptic transmission at the parallel fiber–Purkinje cell synapse in mice lacking potassium channels Kv3.1 and Kv3.3. J. Neurosci. 23, 7677–7684 (2003).
  Article CAS PubMed PubMed Central Google Scholar
• Magee, J. C. & Johnston, D. Characterization of single voltage-gated Na+ and Ca2+ channels in apical dendrites of rat CA1 pyramidal neurons. J. Physiol. 487, 67–90 (1995).
  Article CAS PubMed PubMed Central Google Scholar
• Johnston, D., Magee, J. C., Colbert, C. M. & Cristie, B. R. Active properties of neuronal dendrites. Annu. Rev. Neurosci. 19, 165–186 (1996).
  Article CAS PubMed Google Scholar
• Magee, J., Hoffman, D., Colbert, C. & Johnston, D. Electrical and calcium signaling in dendrites of hippocampal pyramidal neurons. Annu. Rev. Physiol. 60, 327–346 (1998).
  Article CAS PubMed Google Scholar
• Hoffman, D. A., Magee, J. C., Colbert, C. M. & Johnston, D. K+ channel regulation of signal propagation in dendrites of hippocampal pyramidal neurons. Nature 387, 869–875 (1997).
  Article CAS PubMed Google Scholar
• Johnston, D. et al. Dendritic potassium channels in hippocampal pyramidal neurons. J. Physiol. 525, 75–81 (2000).
  Article CAS PubMed PubMed Central Google Scholar
• Jinno, S., Jeromin, A. & Kosaka, T. Postsynaptic and extrasynaptic localization of Kv4.2 channels in the mouse hippocampal region, with special reference to targeted clustering at gabaergic synapses. Neuroscience 134, 483–494 (2005).
  Article CAS PubMed Google Scholar
• Strassle, B. W., Menegola, M., Rhodes, K. J. & Trimmer, J. S. Light and electron microscopic analysis of KChIP and Kv4 localization in rat cerebellar granule cells. J. Comp. Neurol. 484, 144–155 (2005).
  Article PubMed Google Scholar
• Chen, X. & Johnston, D. Properties of single voltage-dependent K+ channels in dendrites of CA1 pyramidal neurones of rat hippocampus. J. Physiol. 559, 187–203 (2004).
  Article CAS PubMed PubMed Central Google Scholar
• Notomi, T. & Shigemoto, R. Immunohistochemical localization of Ih channel subunits, HCN1–4, in the rat brain. J. Comp. Neurol. 471, 241–276 (2004).
  Article CAS PubMed Google Scholar
• Lorincz, A., Notomi, T., Tamas, G., Shigemoto, R. & Nusser, Z. Polarized and compartment-dependent distribution of HCN1 in pyramidal cell dendrites. Nature Neurosci. 5, 1185–1193 (2002).
  Article CAS PubMed Google Scholar
• Kole, M. H., Hallermann, S. & Stuart, G. J. Single Ih channels in pyramidal neuron dendrites: properties, distribution, and impact on action potential output. J. Neurosci. 26, 1677–1687 (2006).
  Article CAS PubMed PubMed Central Google Scholar
• Wang, Z., Xu, N. L., Wu, C. P., Duan, S. & Poo, M. M. Bidirectional changes in spatial dendritic integration accompanying long-term synaptic modifications. Neuron 37, 463–472 (2003).
  Article CAS PubMed Google Scholar
• Fan, Y. et al. Activity-dependent decrease of excitability in rat hippocampal neurons through increases in Ih . Nature Neurosci. 8, 1542–1551 (2005).
  Article CAS PubMed Google Scholar
• Pape, H. C. Queer current and pacemaker: the hyperpolarization-activated cation current in neurons. Annu. Rev. Physiol. 58, 299–327 (1996).
  Article CAS PubMed Google Scholar
• Poolos, N. P., Migliore, M. & Johnston, D. Pharmacological upregulation of h-channels reduces the excitability of pyramidal neuron dendrites. Nature Neurosci. 5, 767–774 (2002).
  Article CAS PubMed Google Scholar
• Berger, T., Senn, W. & Luscher, H. R. Hyperpolarization-activated current Ih disconnects somatic and dendritic spike initiation zones in layer V pyramidal neurons. J. Neurophysiol. 90, 2428–2437 (2003).
  Article PubMed Google Scholar
• Williams, S. R. & Stuart, G. J. Role of dendritic synapse location in the control of action potential output. Trends Neurosci. 26, 147–154 (2003).
  Article CAS PubMed Google Scholar
• Williams, S. R. & Stuart, G. J. Voltage- and site-dependent control of the somatic impact of dendritic IPSPs. J. Neurosci. 23, 7358–7367 (2003).
  Article CAS PubMed PubMed Central Google Scholar
• Williams, S. R. & Stuart, G. J. Site independence of EPSP time course is mediated by dendritic Ih in neocortical pyramidal neurons. J. Neurophysiol. 83, 3177–3182 (2000).
  Article CAS PubMed Google Scholar
• Magee, J. C. Dendritic _I_h normalizes temporal summation in hippocampal CA1 neurons. Nature Neurosci. 2, 848 (1999). Reports that the HCN current density gradient maintains temporal resolution of synaptic potentials.
  Article CAS PubMed Google Scholar
• Migliore, M. & Shepherd, G. M. Emerging rules for the distributions of active dendritic conductances. Nature Rev. Neurosci. 3, 362–370 (2002).
  Article CAS Google Scholar
• Zhang, W. & Linden, D. J. The other side of the engram: experience-driven changes in neuronal intrinsic excitability. Nature Rev. Neurosci. 4, 885–900 (2003).
  Article CAS Google Scholar
• Frick, A. & Johnston, D. Plasticity of dendritic excitability. J. Neurobiol. 64, 100–115 (2005).
  Article CAS PubMed Google Scholar
• Bernard, C. et al. Acquired dendritic channelopathy in temporal lobe epilepsy. Science 305, 532–535 (2004).
  Article CAS PubMed Google Scholar
• Ludwig, A. et al. Absence epilepsy and sinus dysrhythmia in mice lacking the pacemaker channel HCN2. EMBO J. 22, 216–224 (2003).
  Article CAS PubMed PubMed Central Google Scholar
• Shah, M. M., Anderson, A. E., Leung, V., Lin, X. & Johnston, D. Seizure-induced plasticity of h channels in entorhinal cortical layer III pyramidal neurons. Neuron 44, 495–508 (2004).
  Article CAS PubMed PubMed Central Google Scholar
• Chen, K., Aradi, I., Santhakumar, V. & Soltesz, I. H-channels in epilepsy: new targets for seizure control? Trends Pharmacol. Sci. 23, 552–557 (2002).
  Article PubMed Google Scholar
• Brewster, A. L., Bernard, J. A., Gall, C. M. & Baram, T. Z. Formation of heteromeric hyperpolarization-activated cyclic nucleotide-gated (HCN) channels in the hippocampus is regulated by developmental seizures. Neurobiol. Dis. 19, 200–207 (2005).
  Article CAS PubMed PubMed Central Google Scholar
• Chen, S., Wang, J. & Siegelbaum, S. A. Properties of hyperpolarization-activated pacemaker current defined by coassembly of HCN1 and HCN2 subunits and basal modulation by cyclic nucleotide. J. Gen. Physiol. 117, 491–504 (2001).
  Article CAS PubMed PubMed Central Google Scholar
• Proenza, C. et al. Different roles for the cyclic nucleotide binding domain and amino terminus in assembly and expression of hyperpolarization-activated, cyclic nucleotide-gated channels. J. Biol. Chem. 277, 29634–29642 (2002).
  Article CAS PubMed Google Scholar
• Tran, N. et al. A conserved domain in the NH2 terminus important for assembly and functional expression of pacemaker channels. J. Biol. Chem. 277, 43588–43592 (2002).
  Article CAS PubMed Google Scholar
• Zagotta, W. N. et al. Structural basis for modulation and agonist specificity of HCN pacemaker channels. Nature 425, 200–205 (2003).
  Article CAS PubMed Google Scholar
• Akhavan, A. et al. Identification of the cyclic-nucleotide-binding domain as a conserved determinant of ion-channel cell-surface localization. J. Cell Sci. 118, 2803–2812 (2005).
  Article CAS PubMed Google Scholar
• Magee, J. C. Dendritic hyperpolarization-activated currents modify the integrative properties of hippocampal CA1 pyramidal neurons. J. Neurosci. 18, 7613–7624 (1998). Reports an increase in current density of I h using cell-attached patch from the soma to the dendrites in hippocampal CA1 pyramidal neurons.
  Article CAS PubMed PubMed Central Google Scholar
• Nolan, M. F. et al. A behavioral role for dendritic integration: HCN1 channels constrain spatial memory and plasticity at inputs to distal dendrites of CA1 pyramidal neurons. Cell 119, 719–732 (2004).
  CAS PubMed Google Scholar
• Nolan, M. F. et al. The hyperpolarization-activated HCN1 channel is important for motor learning and neuronal integration by cerebellar Purkinje cells. Cell 115, 551–564 (2003).
  Article CAS PubMed Google Scholar
• Qu, J. et al. MiRP1 modulates HCN2 channel expression and gating in cardiac myocytes. J. Biol. Chem. 279, 43497–43502 (2004).
  Article CAS PubMed Google Scholar
• Santoro, B., Wainger, B. J. & Siegelbaum, S. A. Regulation of HCN channel surface expression by a novel C-terminal protein–protein interaction. J. Neurosci. 24, 10750–10762 (2004).
  Article CAS PubMed PubMed Central Google Scholar
• Gravante, B. et al. Interaction of the pacemaker channel HCN1 with filamin A. J. Biol. Chem. 279, 43847–43853 (2004).
  Article CAS PubMed Google Scholar
• Kimura, K., Kitano, J., Nakajima, Y. & Nakanishi, S. Hyperpolarization-activated, cyclic nucleotide-gated HCN2 cation channel forms a protein assembly with multiple neuronal scaffold proteins in distinct modes of protein–protein interaction. Genes Cells 9, 631–640 (2004).
  Article CAS PubMed Google Scholar
• Murakoshi, H. & Trimmer, J. S. Identification of the Kv2.1 K+ channel as a major component of the delayed rectifier K+ current in rat hippocampal neurons. J. Neurosci. 19, 1728–1735 (1999).
  Article CAS PubMed PubMed Central Google Scholar
• Malin, S. A. & Nerbonne, J. M. Delayed rectifier K+ currents, _I_K, are encoded by Kv2 α-subunits and regulate tonic firing in mammalian sympathetic neurons. J. Neurosci. 22, 10094–10105 (2002).
  Article CAS PubMed PubMed Central Google Scholar
• Misonou, H. et al. Regulation of ion channel localization and phosphorylation by neuronal activity. Nature Neurosci. 7, 711–718 (2004). Seminal paper describing the activity-dependent phosphorylation of Kv2.1 leading to clustering of these channels at somatodendritic membranes, which thereby changes the current properties of the neuron.
  Article CAS PubMed Google Scholar
• Misonou, H., Mohapatra, D. P., Menegola, M. & Trimmer, J. S. Calcium- and metabolic state-dependent modulation of the voltage-dependent Kv2.1 channel regulates neuronal excitability in response to ischemia. J. Neurosci. 25, 11184–11193 (2005).
  Article CAS PubMed PubMed Central Google Scholar
• Misonou, H., Mohapatra, D. P. & Trimmer, J. S. Kv2.1: a voltage-gated K+ channel critical to dynamic control of neuronal excitability. Neurotoxicology 26, 743–752 (2005).
  Article CAS PubMed Google Scholar
• Lim, S. T., Antonucci, D. E., Scannevin, R. H. & Trimmer, J. S. A novel targeting signal for proximal clustering of the Kv2.1 K+ channel in hippocampal neurons. Neuron 25, 385–397 (2000).
  Article CAS PubMed Google Scholar
• Du, J., Haak, L. L., Phillips-Tansey, E., Russell, J. T. & McBain, C. J. Frequency-dependent regulation of rat hippocampal somato-dendritic excitability by the K+ channel subunit Kv2.1. J. Physiol. 522, 19–31 (2000).
  Article CAS PubMed PubMed Central Google Scholar
• Rhodes, K. J. et al. KChIPs and Kv4 α subunits as integral components of A-type potassium channels in mammalian brain. J. Neurosci. 24, 7903–7915 (2004).
  Article CAS PubMed PubMed Central Google Scholar
• An, W. F. et al. Modulation of A-type potassium channels by a family of calcium sensors. Nature 403, 553–556 (2000).
  Article CAS PubMed Google Scholar
• Johnston, D. et al. Active dendrites, potassium channels and synaptic plasticity. Phil. Trans. R. Soc. Lond. B 358, 667–674 (2003).
  Article CAS Google Scholar
• Cai, X. et al. Unique roles of SK and Kv4.2 potassium channels in dendritic integration. Neuron 44, 351–364 (2004).
  Article CAS PubMed Google Scholar
• Yuan, W., Burkhalter, A. & Nerbonne, J. M. Functional role of the fast transient outward K+ current IA in pyramidal neurons in (rat) primary visual cortex. J. Neurosci. 25, 9185–9194 (2005).
  Article CAS PubMed PubMed Central Google Scholar
• Alonso, G. & Widmer, H. Clustering of KV4.2 potassium channels in postsynaptic membrane of rat supraoptic neurons: an ultrastructural study. Neuroscience 77, 617–621 (1997).
  Article CAS PubMed Google Scholar
• Shibasaki, K. et al. Mossy fibre contact triggers the targeting of Kv4.2 potassium channels to dendrites and synapses in developing cerebellar granule neurons. J. Neurochem. 89, 897–907 (2004).
  Article CAS PubMed Google Scholar
• Frick, A., Magee, J. & Johnston, D. LTP is accompanied by an enhanced local excitability of pyramidal neuron dendrites. Nature Neurosci. 7, 126–135 (2004).
  Article CAS PubMed Google Scholar
• Petrecca, K., Miller, D. M. & Shrier, A. Localization and enhanced current density of the Kv4.2 potassium channel by interaction with the actin-binding protein filamin. J. Neurosci. 20, 8736–8744 (2000).
  Article CAS PubMed PubMed Central Google Scholar
• Rivera, J. F., Ahmad, S., Quick, M. W., Liman, E. R. & Arnold, D. B. An evolutionarily conserved dileucine motif in Shal K+ channels mediates dendritic targeting. Nature Neurosci. 6, 243–250 (2003). Reports a C-terminal di-leucine motif that is necessary and sufficient for dendritic targeting of Kv4.2.
  Article CAS PubMed Google Scholar
• Chu, P. J., Rivera, J. F. & Arnold, D. B. A role for Kif17 in transport of Kv4.2. J. Biol. Chem. 281, 365–373 (2006).
  Article CAS PubMed Google Scholar
• Ren, X., Hayashi, Y., Yoshimura, N. & Takimoto, K. Transmembrane interaction mediates complex formation between peptidase homologues and Kv4 channels. Mol. Cell. Neurosci. 29, 320–332 (2005).
  Article CAS PubMed Google Scholar
• Jerng, H. H., Kunjilwar, K. & Pfaffinger, P. J. Multiprotein assembly of Kv4.2, KChIP3 and DPP10 produces ternary channel complexes with ISA-like properties. J. Physiol. 568, 767–788 (2005).
  Article CAS PubMed PubMed Central Google Scholar
• Zagha, E. et al. DPP10 modulates Kv4-mediated A-type potassium channels. J. Biol. Chem. 280, 18853–18861 (2005).
  Article CAS PubMed Google Scholar
• Strop, P., Bankovich, A. J., Hansen, K. C., Garcia, K. C. & Brunger, A. T. Structure of a human A-type potassium channel interacting protein DPPX, a member of the dipeptidyl aminopeptidase family. J. Mol. Biol. 343, 1055–1065 (2004).
  Article CAS PubMed Google Scholar
• Jerng, H. H., Qian, Y. & Pfaffinger, P. J. Modulation of Kv4.2 channel expression and gating by dipeptidyl peptidase 10 (DPP10). Biophys. J. 87, 2380–2396 (2004).
  Article CAS PubMed PubMed Central Google Scholar
• Shibata, R. et al. A fundamental role for KChIPs in determining the molecular properties and trafficking of Kv4.2 potassium channels. J. Biol. Chem. 278, 36445–36454 (2003).
  Article CAS PubMed Google Scholar
• Hasdemir, B., Fitzgerald, D. J., Prior, I. A., Tepikin, A. V. & Burgoyne, R. D. Traffic of Kv4 K+ channels mediated by KChIP1 is via a novel post-ER vesicular pathway. J. Cell Biol. 171, 459–469 (2005). Describes that KChIP1 can increase surface expression of Kv4.2 by a pathway that is COPII independent.
  Article CAS PubMed PubMed Central Google Scholar
• Deng, Q. et al. A C-terminal domain directs Kv3.3 channels to dendrites. J. Neurosci. 25, 11531–11541 (2005).
  Article CAS PubMed PubMed Central Google Scholar
• Martina, M., Yao, G. L. & Bean, B. P. Properties and functional role of voltage-dependent potassium channels in dendrites of rat cerebellar Purkinje neurons. J. Neurosci. 23, 5698–5707 (2003).
  Article CAS PubMed PubMed Central Google Scholar
• Ozaita, A. et al. A unique role for Kv3 voltage-gated potassium channels in starburst amacrine cell signaling in mouse retina. J. Neurosci. 24, 7335–7343 (2004).
  Article CAS PubMed PubMed Central Google Scholar
• Euler, T., Detwiler, P. B. & Denk, W. Directionally selective calcium signals in dendrites of starburst amacrine cells. Nature 418, 845–852 (2002).
  Article CAS PubMed Google Scholar
• Parameshwaran-Iyer, S., Carr, C. E. & Perney, T. M. Localization of KCNC1 (Kv3.1) potassium channel subunits in the avian auditory nucleus magnocellularis and nucleus laminaris during development. J. Neurobiol. 55, 165–178 (2003).
  Article CAS PubMed PubMed Central Google Scholar
• Hell, J. W. et al. Identification and differential subcellular localization of the neuronal class C and class D L-type calcium channel α1 subunits. J. Cell Biol. 123, 949–962 (1993).
  Article CAS PubMed Google Scholar
• Westenbroek, R. E. et al. Biochemical properties and subcellular distribution of an N-type calcium channel α1 subunit. Neuron 9, 1099–1115 (1992).
  Article CAS PubMed Google Scholar
• Castillo, P. E., Weisskopf, M. G. & Nicoll, R. A. The role of Ca2+ channels in hippocampal mossy fiber synaptic transmission and long-term potentiation. Neuron 12, 261–269 (1994).
  Article CAS PubMed Google Scholar
• Dietrich, D. et al. Functional specialization of presynaptic Cav2.3 Ca2+ channels. Neuron 39, 483–496 (2003).
  Article CAS PubMed Google Scholar
• Yasuda, R., Sabatini, B. L. & Svoboda, K. Plasticity of calcium channels in dendritic spines. Nature Neurosci. 6, 948–955 (2003).
  Article CAS PubMed Google Scholar
• Magee, J. C., Avery, R. B., Christie, B. R. & Johnston, D. Dihydropyridine-sensitive, voltage-gated Ca2+ channels contribute to the resting intracellular Ca2+ concentration of hippocampal CA1 pyramidal neurons. J. Neurophysiol. 76, 3460–3470 (1996).
  Article CAS PubMed Google Scholar
• Bichet, D. et al. The I–II loop of the Ca2+ channel α1 subunit contains an endoplasmic reticulum retention signal antagonized by the β subunit. Neuron 25, 177–190 (2000).
  Article CAS PubMed Google Scholar
• Leroy, J. et al. Interaction via a key tryptophan in the I–II linker of N-type calcium channels is required for β1 but not for palmitoylated β2, implicating an additional binding site in the regulation of channel voltage-dependent properties. J. Neurosci. 25, 6984–6996 (2005).
  Article CAS PubMed PubMed Central Google Scholar
• Takahashi, S. X., Miriyala, J., Tay, L. H., Yue, D. T. & Colecraft, H. M. A CaVβ SH3/guanylate kinase domain interaction regulates multiple properties of voltage-gated Ca2+ channels. J. Gen. Physiol. 126, 365–377 (2005).
  Article CAS PubMed PubMed Central Google Scholar
• Viard, P. et al. PI3K promotes voltage-dependent calcium channel trafficking to the plasma membrane. Nature Neurosci. 7, 939–946 (2004).
  Article CAS PubMed Google Scholar
• Cornet, V. et al. Multiple determinants in voltage-dependent P/Q calcium channels control their retention in the endoplasmic reticulum. Eur. J. Neurosci. 16, 883–895 (2002).
  Article PubMed Google Scholar
• Altier, C. et al. Trafficking of L-type calcium channels mediated by the postsynaptic scaffolding protein AKAP79. J. Biol. Chem. 277, 33598–33603 (2002).
  Article CAS PubMed Google Scholar
• Canti, C. et al. The metal-ion-dependent adhesion site in the Von Willebrand factor-A-domain of α2δ subunits is key to trafficking voltage-gated Ca2+ channels. Proc. Natl Acad. Sci. USA 102, 11230–11235 (2005).
  Article CAS PubMed PubMed Central Google Scholar
• Carr, C. E., Soares, D., Parameshwaran, S. & Perney, T. Evolution and development of time coding systems. Curr. Opin. Neurobiol. 11, 727–733 (2001).
  Article CAS PubMed Google Scholar
• Jentsch, T. J., Neagoe, I. & Scheel, O. CLC chloride channels and transporters. Curr. Opin. Neurobiol. 15, 319–325 (2005).
  Article CAS PubMed Google Scholar
• Scheel, O., Zdebik, A. A., Lourdel, S. & Jentsch, T. J. Voltage-dependent electrogenic chloride/proton exchange by endosomal CLC proteins. Nature 436, 424–427 (2005).
  Article CAS PubMed Google Scholar
• Boiko, T. et al. Functional specialization of the axon initial segment by isoform-specific sodium channel targeting. J. Neurosci. 23, 2306–2313 (2003). Reports the differential expression of Nav1.2 and Nav1.6 during development at the axon initial segment and that the appearance of Nav1.6 coincides with repetitive firing in retinal ganglion cells.
  Article CAS PubMed PubMed Central Google Scholar
• Boiko, T. et al. Compact myelin dictates the differential targeting of two sodium channel isoforms in the same axon. Neuron 30, 91–104 (2001). Describes the differential expression of Nav1.2 and Nav1.6 during development at the nodes of Ranvier.
  Article CAS PubMed Google Scholar
• Wang, G. Y., Ratto, G., Bisti, S. & Chalupa, L. M. Functional development of intrinsic properties in ganglion cells of the mammalian retina. J. Neurophysiol. 78, 2895–2903 (1997).
  Article CAS PubMed Google Scholar
• Grinspan, J. B., Coulalaglou, M., Beesley, J. S., Carpio, D. F. & Scherer, S. S. Maturation-dependent apoptotic cell death of oligodendrocytes in myelin-deficient rats. J. Neurosci. Res. 54, 623–634 (1998).
  Article CAS PubMed Google Scholar
• Kaplan, M. R. et al. Induction of sodium channel clustering by oligodendrocytes. Nature 386, 724–728 (1997).
  Article CAS PubMed Google Scholar
• Henry, E. W. & Sidman, R. L. Long lives for homozygous trembler mutant mice despite virtual absence of peripheral nerve myelin. Science 241, 344–346 (1988).
  Article CAS PubMed Google Scholar
• Baba, H. et al. Completion of myelin compaction, but not the attachment of oligodendroglial processes triggers K+ channel clustering. J. Neurosci. Res. 58, 752–764 (1999).
  Article CAS PubMed Google Scholar
• Kaplan, M. R. et al. Differential control of clustering of the sodium channels Nav1.2 and Nav1.6 at developing CNS nodes of Ranvier. Neuron 30, 105–119 (2001). Reports the changing distribution of Nav1.2 and Nav1.6 channels in a myelinating culture system.
  Article CAS PubMed Google Scholar
• Rasband, M. N., Trimmer, J. S., Peles, E., Levinson, S. R. & Shrager, P. K+ channel distribution and clustering in developing and hypomyelinated axons of the optic nerve. J. Neurocytol. 28, 319–331 (1999).
  Article CAS PubMed Google Scholar
• Rasband, M. N. & Shrager, P. Ion channel sequestration in central nervous system axons. J. Physiol. 525, 63–73 (2000).
  Article CAS PubMed PubMed Central Google Scholar