Epigenetic repression of E-cadherin expression by hepatitis B virus x antigen in liver cancer (original) (raw)

• Agami R . (2010). Micro-RNAs, RNA binding proteins and cancer. Eur J Clin Invest 40: 370–374.
  Article CAS PubMed Google Scholar
• Batlle E, Sancho E, Francí C, Domínguez D, Monfar M, Baulida J et al. (2000). The transcription factor Snail is a repressor of E-cadherin gene expression in epithelial tumour cells. Nat Cell Biol 2: 84–89.
  Article CAS PubMed Google Scholar
• Cameron EE, Bachman KE, Myöhänen S, Herman JG, Baylin SB . (1999). Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer. Nat Genet 21: 103–107.
  Article CAS PubMed Google Scholar
• Chung TW, Lee YC, Kim CH . (2004). Hepatitis B viral HBx induces MMP-9 gene expression through activation of ERK and PI-3K/AKT pathways: involvement of invasive potential. FASEB J 18: 1123–1125.
  Article CAS PubMed Google Scholar
• Endo K, Ueda T, Ueyama J, Ohta T, Terada T . (2000). Immunoreactive E-cadherin, alpha-catenin, beta-catenin, and gamma-catenin proteins in hepatocellular carcinoma: relationships with tumor grade, clinicopathological parameters, and patients’ survival. Hum Pathol 31: 558–565.
  Article CAS PubMed Google Scholar
• Feitelson MA, Millman I, Duncan GD, Blumberg BS . (1988). Presence of antibodies to the polymerase gene product(s) of hepatitis B and woodchuck hepatitis virus in natural and experimental infections. J Med Virol 24: 121–136.
  Article CAS PubMed Google Scholar
• Giroldi L, Bringuier P, de Weijert M, Jansen C, van Bokhoven A, Schalken JA . (1997). Role of E boxes in the repression of E-cadherin expression. Biochem Biophys Res Commun 241: 453–458.
  Article CAS PubMed Google Scholar
• Guarino M, Rubino B, Ballabio G . (2007). The role of epithelial-mesenchymal transition in cancer pathology. Pathology 39: 305–318.
  Article CAS PubMed Google Scholar
• Haviv I, Vaizel D, Shaul Y . (1996). pX, the HBV-encoded co-activator, interacts with components of the transcription machinery and stimulates transcription in a TAF-independent manner. EMBO J 15: 3413–3420.
  Article CAS PubMed PubMed Central Google Scholar
• He L, Hannon GJ . (2004). Micro-RNAs: small RNAs with a big role in gene regulation. Nat Rev Genet 5: 522–531.
  Article CAS PubMed Google Scholar
• Hirohashi S, Kanai Y . (2003). Cell adhesion system and human cancer morphogenesis. Cancer Sci 94: 575–581.
  Article CAS PubMed Google Scholar
• Iwatsuki M, Mimori K, Yokobori T, Ishi H, Beppu T, Nakamori S et al. (2009). Epithelial-mesenchymal transition in cancer development and its clinical significance. Cancer Sci 101: 293–299.
  Article PubMed Google Scholar
• Janowski BA, Younger ST, Hardy DB, Ram R, Huffman KE, Corey DR . (2007). Activating gene expression in mammalian cells with promoter-targeted duplex RNAs. Nat Chem Biol 3: 166–173.
  Article CAS PubMed Google Scholar
• Jiao W, Miyazaki K, Kitajima Y . (2002). Inverse correlation between E-cadherin and Snail expression in hepatocellular carcinoma cell lines in vitro and in vivo. Br J Cancer 86: 98–101.
  Article CAS PubMed PubMed Central Google Scholar
• Kanai Y, Ushijima S, Hui AM, Ochiai A, Tsuda H, Sakamoto M et al. (1997). The E-cadherin gene is silenced by CpG methylation in human hepatocellular carcinomas. Int J Cancer 71: 355–359.
  Article CAS PubMed Google Scholar
• Keasler VV, Hodgson AJ, Madden CR, Slagle BL . (2009). Hepatitis B virus HBx protein localized to the nucleus restores HBx-deficient virus replication in HepG2 cells and in vivo in hydrodynamically-injected mice. Virology 390: 122–129.
  Article CAS PubMed Google Scholar
• Kekule AS, Lauer U, Weiss L, Luber B, Hofschneider PH . (1993). Hepatitis B virus trans-activator HBx uses a tumour promoter signaling pathway. Nature 361: 742–745.
  Article CAS PubMed Google Scholar
• Lee DK, Park SH, Yi Y, Choi SG, Lee C, Parks WT et al. (2001). The hepatitis B virus encoded oncoprotein pX amplifies TGF-beta family signaling through direct interaction with Smad4: potential mechanism of HBV-induced liver fibrosis. Genes Dev 15: 455–466.
  Article CAS PubMed PubMed Central Google Scholar
• Lee JO, Kwun HJ, Jung JK, Choi KH, Min DS, Jang KL . (2005). Hepatitis B virus X protein represses E-cadherin expression via activation of DNA methyltransferase 1. Oncogene 24: 6617–6625.
  Article CAS PubMed Google Scholar
• Li LC, Okino ST, Zhao H, Pookot D, Place RF, Urakami S et al. (2006). Small dsRNAs induce transcriptional activation in human cells. Proc Natl Acad Sci USA 103: 17337–17342.
  Article CAS PubMed PubMed Central Google Scholar
• Lian Z, Liu J, Li L, Li X, Clayton M, Wu MC et al. (2006). Enhanced cell survival of Hep3B cells by the hepatitis B x antigen effector, URG11, is associated with upregulation of beta-catenin. Hepatology 43: 415–424.
  Article CAS PubMed Google Scholar
• Lian Z, Pan J, Liu J, Zhang S, Zhu M, Arbuthnot P et al. (1999). The translation initiation factor, hu-Sui1 may be a target of hepatitis B X antigen in hepatocarcinogenesis. Oncogene 18: 1677–1587.
  Article CAS PubMed Google Scholar
• Liu J, Lian Z, Han S, Waye MM, Wang H, Wu MC et al. (2006). Downregulation of E-cadherin by hepatitis B virus X antigen in hepatocellullar carcinoma. Oncogene 25: 1008–1017.
  Article CAS PubMed Google Scholar
• Lupberger J, Hildt E . (2007). Hepatitis B virus-induced oncogenesis. World J Gastroenterol 13: 74–81.
  Article CAS PubMed PubMed Central Google Scholar
• MacPherson MR, Molina P, Souchelnytskyi S, Wernstedt C, Martin-Pérez J, Portillo F et al. (2010). Phosphorylation of serine 11 and serine 92 as new positive regulators of human Snail1 function: potential involvement of casein kinase-2 and the cAMP-activated protein kinase A. Mol Biol Cell 21: 244–253.
  Article CAS PubMed PubMed Central Google Scholar
• Moustakas A, Heldin CH . (2007). Signaling networks guiding epithelial-mesenchymal transitions during embryogenesis and cancer progression. Cancer Sci 98: 1512–1520.
  Article CAS PubMed Google Scholar
• Nomura T, Lin Y, Dorjsuren D, Ohno S, Yamashita T, Murakami S et al. (1999). Human hepatitis B virus X protein is detectable in nuclei of transfected cells, and is active for transactivation. Biochim Biophys Acta 1453: 330–340.
  Article CAS PubMed Google Scholar
• Osada T, Sakamoto M, Ino Y, Iwamatsu A, Matsuno Y, Muto T et al. (1996). E-cadherin is involved in the intrahepatic metastasis of hepatocellular carcinoma. Hepatology 24: 1460–1467.
  Article CAS PubMed Google Scholar
• Ou JN, Torrisani J, Unterberger A, Provençal N, Shikimi K, Karimi M et al. (2007). Histone deacetylase inhibitor Trichostatin A induces global and gene-specific DNA demethylation in human cancer cell lines. Biochem Pharmacol 73: 1297–1307.
  Article CAS PubMed Google Scholar
• Pan J, Clayton M, Feitelson MA . (2004). Hepatitis B virus X antigen promotes TGF-beta1 activity by up-regulation of TGF-beta1 and down-regulation of alpha2-macroglobulin. J Gen Virol 85 (Part 2): 275–282.
  Article CAS PubMed Google Scholar
• Park IY, Sohn BH, Yu E, Suh DJ, Chung YH, Lee JH et al. (2007). Aberrant epigenetic modifications in hepatocarcinogenesis induced by hepatitis B virus X protein. Gastroenterology 132: 1476–1494.
  Article CAS PubMed Google Scholar
• Park NH, Song IH, Chung YH . (2006). Chronic hepatitis B in hepatocarcinogenesis. Postgrad Med J 82: 507–515.
  Article CAS PubMed PubMed Central Google Scholar
• Peinado H, Ballestar E, Esteller M, Cano A . (2004). Snail mediates E-cadherin repression by the recruitment of the Sin3A/HDAC1/HDAC2 complex. Mol Cell Biol 24: 306–319.
  Article CAS PubMed PubMed Central Google Scholar
• Peinado H, Quintanilla M, Cano A . (2003). TGFβ-1 induces snail transcription factor in epithelial cell lines: mechanisms for epithelial mesenchymal transitions. J Biol Chem 278: 113–123.
  Article Google Scholar
• Perl AK, Wilgenbus P, Dahl U, Semb H, Christofori G . (1998). A causal role for E-cadherin in the transition from adenoma to carcinoma. Nature 392: 190–193.
  Article CAS PubMed Google Scholar
• Place R, Li L, Pookot D, Noonan EJ, Dahiya R . (2008). MicroRNA-373 induces expression of genes with complementary promoter sequences. Proc Natl Acad Sci USA 105: 1608–1613.
  Article CAS PubMed PubMed Central Google Scholar
• Rikimaru T, Taketomi A, Yamashita Y, Shirabe K, Hamatsu T, Shimada M et al. (2007). Clinical significance of histone deacetylase 1 expression in patients with hepatocellular carcinoma. Oncology 72: 69–74.
  Article CAS PubMed Google Scholar
• Ropero S, Esteller M . (2007). The role of histone deacetylases (HDACs) in human cancer. Mol Oncol 1: 19–25.
  Article CAS PubMed PubMed Central Google Scholar
• Shon JK, Shon BH, Park IY, Lee SU, Fa L, Chang KY et al. (2009). Hepatitis B virus-X protein recruits histone deacetylase 1 to repress insulin-like growth factor binding protein 3 transcription. Virus Res 139: 14–21.
  Article CAS PubMed Google Scholar
• Sirma H, Weil R, Rosmorduc O, Urban S, Israël A, Kremsdorf D et al. (1998). Cytosol is the prime compartment of hepatitis B virus X protein where it co-localizes with the proteasome. Oncogene 16: 2051–2063.
  Article CAS PubMed Google Scholar
• Sugimachi K, Tanaka S, Kameyama T, Taguchi K, Aishima S, Shimada M et al. (2003). Transcriptional repressor Snail and progression of human hepatocellular carcinoma. Clin Cancer Res 9: 2657–2664.
  CAS PubMed Google Scholar
• Takeichi M . (1991). Cadherin cell adhesion receptors as a morphogenetic regulator. Science 251: 1451–1455.
  Article CAS PubMed Google Scholar
• Takeno S, Noguchi T, Fumoto S, Kimura Y, Shibata T, Kawahara K . (2004). E-cadherin expression in patients with esophageal squamous cell carcinoma: Promoter hypermethylation, Snail overexpression, and clinico-pathologic implications. Am J Clin Pathol 122: 78–84.
  Article CAS PubMed Google Scholar
• van Roy F, Berx G . (2008). The cell-cell adhesion molecule E-cadherin. Cell Mol Life Sci 65: 3756–3788.
  Article CAS PubMed Google Scholar
• Wadia JS, Stan RV, Dowdy SF . (2004). Transducible TAT-HA fusogenic peptide enhances escape of TAT-fusion proteins after lipid raft macropinocytosis. Nat Med 1: 310–315.
  Article Google Scholar
• Wang W, London WT, Feitelson MA . (1991a). Hepatitis B x antigen in hepatitis B virus carrier patients with liver cancer. Cancer Res 51: 4971–4977.
  CAS PubMed Google Scholar
• Wang W, London WT, Lega L, Feitelson MA . (1991b). HBxAg in liver from carrier patients with chronic hepatitis and cirrhosis. Hepatology 14: 29–37.
  Article CAS PubMed Google Scholar
• Waris G, Huh KW, Siddiqui A . (2001). Mitochondrially associated hepatitis B virus X protein constitutively activates transcription factors STAT-3 and NF-kB via oxidative stress. Mol Cell Biol 21: 7721–7730.
  Article CAS PubMed PubMed Central Google Scholar
• Weil R, Sirma H, Giannini C, Kremsdorf D, Bessia C, Dargemont C et al. (1999). Direct association and nuclear import of the hepatitis B virus X protein with the NF-kB inhibitor IkBa. Mol Cell Biol 19: 6345–6354.
  Article CAS PubMed PubMed Central Google Scholar
• Xu J, Lamouille S, Derynck R . (2009). TGF-beta-induced epithelial to mesenchymal transition. Cell Res 19: 156–172.
  Article CAS PubMed Google Scholar
• Yoo YD, Ueda H, Park K, Flanders KC, Lee YI, Jay G et al. (1996). Regulation of TGF-beta 1 expression by the hepatitis B virus (HBV) X transactivator. Role in HBV pathogenesis. J Clin Invest 97: 388–395.
  Article CAS PubMed PubMed Central Google Scholar
• Yoo YG, Na TY, Seo HW, Seong JK, Park CK, Shin YK et al. (2008). Hepatitis B virus X protein induces the expression of MTA1 and HDAC1, which enhances hypoxia signaling in hepatocellular carcinoma cells. Oncogene 27: 3405–3413.
  Article CAS PubMed Google Scholar
• Zeng PY, Vakoc CR, Chen ZC, Blobel GA, Berger SL . (2006). In vivo dual cross-linking for identification of indirect DNA-associated proteins by chromatin immunoprecipitation. Biotechniques 41: 694–698.
  Article CAS PubMed Google Scholar
• Zheng DL, Zhang L, Cheng N, Xu X, Deng Q, Teng XM et al. (2009). Epigenetic modification induced by hepatitis B virus X protein via interaction with de novo DNA methyltransferase DNMT3A. J Hepatol 50: 377–387.
  Article CAS PubMed Google Scholar
• Zhou H, Wu S, Joo JY, Zhu S, Han DW, Lin T et al. (2009). Generation of induced pluripotent stem cells using recombinant proteins. Cell Stem Cell 4: 381–384.
  Article CAS PubMed Google Scholar