- Valm, A. M. et al. Applying systems-level spectral imaging and analysis to reveal the organelle interactome. Nature 546, 162–167 (2017). By simultaneously visualizing six organelles (the ER, Golgi complex, lysosomes, peroxisomes, mitochondria and lipid droplets), this study shows how organelles make numerous contacts that affect membrane dynamics.
CAS PubMed PubMed Central Google Scholar
- Shai, N. et al. Systematic mapping of contact sites reveals tethers and a function for the peroxisome-mitochondria contact. Nat. Commun. 9, 1761 (2018). This study uses split fluorophores to systematically investigate organelle contacts in S. cerevisiae and shows that most organelles make contacts with more than one organelle.
PubMed PubMed Central Google Scholar
- Prinz, W. A. Bridging the gap: membrane contact sites in signaling, metabolism, and organelle dynamics. J. Cell. Biol. 205, 759–769 (2014).
CAS PubMed PubMed Central Google Scholar
- Helle, S. C. et al. Organization and function of membrane contact sites. Biochim. Biophys Acta 1833, 2526–2541 (2013).
CAS PubMed Google Scholar
- Cohen, S., Valm, A. M. & Lippincott-Schwartz, J. Interacting organelles. Curr. Opin. Cell. Biol. 53, 84–91 (2018).
CAS PubMed PubMed Central Google Scholar
- Scorrano, L. et al. Coming together to define membrane contact sites. Nat. Commun. 10, 1287 (2019).
PubMed PubMed Central Google Scholar
- Ma, W. & Mayr, C. A membraneless organelle associated with the endoplasmic reticulum enables 3′UTR-mediated protein-protein interactions. Cell 175, 1492–1506 (2018).
CAS PubMed PubMed Central Google Scholar
- Schorr, S. & van der Laan, M. Integrative functions of the mitochondrial contact site and cristae organizing system. Semin. Cell Dev. Biol. 76, 191–200 (2018).
CAS PubMed Google Scholar
- Fernandez-Busnadiego, R., Saheki, Y. & De Camilli, P. Three-dimensional architecture of extended synaptotagmin-mediated endoplasmic reticulum-plasma membrane contact sites. Proc. Natl Acad. Sci. USA 112, E2004–E2013 (2015).
CAS PubMed Google Scholar
- West, M., Zurek, N., Hoenger, A. & Voeltz, G. K. A 3D analysis of yeast ER structure reveals how ER domains are organized by membrane curvature. J. Cell Biol. 193, 333–346 (2011).
CAS PubMed PubMed Central Google Scholar
- Lewis, S. C., Uchiyama, L. F. & Nunnari, J. ER-mitochondria contacts couple mtDNA synthesis with mitochondrial division in human cells. Science 353, aaf5549 (2016).
PubMed PubMed Central Google Scholar
- Dickson, E. J. Endoplasmic reticulum-plasma membrane contacts regulate cellular excitability. Adv. Exp. Med. Biol. 997, 95–109 (2017).
CAS PubMed Google Scholar
- Friedman, J. R. et al. ER tubules mark sites of mitochondrial division. Science 334, 358–362 (2011). This study shows that ER-mitochondria MCS’s mark sites where mitochondrial division will subsequently occur in mammalian cells and in S. cerevisiae.
CAS PubMed PubMed Central Google Scholar
- Hoyer, M. J. et al. A novel class of ER membrane proteins regulates ER-associated endosome fission. Cell 175, 254–265 (2018).
CAS PubMed PubMed Central Google Scholar
- Besprozvannaya, M. et al. GRAM domain proteins specialize functionally distinct ER-PM contact sites in human cells. Elife 7, e31019 (2018).
PubMed PubMed Central Google Scholar
- Gonzalez Montoro, A. et al. Vps39 interacts with Tom40 to establish one of two functionally distinct vacuole-mitochondria contact sites. Dev. Cell 45, 621–636 (2018).
CAS PubMed Google Scholar
- Wang, S., Tukachinsky, H., Romano, F. B. & Rapoport, T. A. Cooperation of the ER-shaping proteins atlastin, lunapark, and reticulons to generate a tubular membrane network. Elife 5, e18605 (2016).
PubMed PubMed Central Google Scholar
- Glancy, B. et al. Power grid protection of the muscle mitochondrial reticulum. Cell Rep. 19, 487–496 (2017).
CAS PubMed PubMed Central Google Scholar
- Picard, M. et al. Trans-mitochondrial coordination of cristae at regulated membrane junctions. Nat. Commun. 6, 6259 (2015).
CAS PubMed PubMed Central Google Scholar
- Wong, Y. C., Peng, W. & Krainc, D. Lysosomal regulation of inter-mitochondrial contact fate and motility in Charcot-Marie-Tooth type 2. Dev. Cell. 50, 339–354 (2019).
CAS PubMed Google Scholar
- Wang, H. et al. Seipin is required for converting nascent to mature lipid droplets. Elife 5, e16582 (2016).
PubMed PubMed Central Google Scholar
- Xu, D. et al. Rab18 promotes lipid droplet (LD) growth by tethering the ER to LDs through SNARE and NRZ interactions. J. Cell. Biol. 217, 975–995 (2018).
CAS PubMed PubMed Central Google Scholar
- Lackner, L. L., Ping, H., Graef, M., Murley, A. & Nunnari, J. Endoplasmic reticulum-associated mitochondria-cortex tether functions in the distribution and inheritance of mitochondria. Proc. Natl Acad. Sci. USA 110, E458–E467 (2013).
CAS PubMed Google Scholar
- Hariri, H. et al. Mdm1 maintains endoplasmic reticulum homeostasis by spatially regulating lipid droplet biogenesis. J. Cell Biol. 218, 1319–1334 (2019).
CAS PubMed PubMed Central Google Scholar
- Hsu, F. et al. Rab5 and Alsin regulate stress-activated cytoprotective signaling on mitochondria. Elife 7, e32282 (2018).
PubMed PubMed Central Google Scholar
- Joshi, A. S. et al. Lipid droplet and peroxisome biogenesis occur at the same ER subdomains. Nat. Commun. 9, 2940 (2018).
PubMed PubMed Central Google Scholar
- Oikawa, K., Hayashi, M., Hayashi, Y. & Nishimura, M. Re-evaluation of physical interaction between plant peroxisomes and other organelles using live-cell imaging techniques. J. Integr. Plant Biol. 61, 836–852 (2019).
PubMed Google Scholar
- Lin, C. C. et al. Apolipoprotein J, a glucose-upregulated molecular chaperone, stabilizes core and NS5A to promote infectious hepatitis C virus virion production. J. Hepatol. 61, 984–993 (2014).
CAS PubMed Google Scholar
- Eisenberg-Bord, M., Shai, N., Schuldiner, M. & Bohnert, M. A tether is a tether is a tether: tethering at membrane contact sites. Dev. Cell 39, 395–409 (2016).
CAS PubMed Google Scholar
- Mesmin, B. et al. A four-step cycle driven by PI(4)P hydrolysis directs sterol/PI(4)P exchange by the ER-Golgi tether OSBP. Cell 155, 830–843 (2013). This study demonstrates that OSBP can use the difference in P14P levels in the ER and Golgi to drive cholesterol transport to the Golgi.
CAS PubMed Google Scholar
- Quon, E. et al. Endoplasmic reticulum-plasma membrane contact sites integrate sterol and phospholipid regulation. PLOS Biol. 16, e2003864 (2018).
PubMed PubMed Central Google Scholar
- Murley, A. et al. Ltc1 is an ER-localized sterol transporter and a component of ER-mitochondria and ER-vacuole contacts. J. Cell Biol. 209, 539–548 (2015).
CAS PubMed PubMed Central Google Scholar
- Kumar, N. et al. VPS13A and VPS13C are lipid transport proteins differentially localized at ER contact sites. J. Cell Biol. 217, 3625–3639 (2018).
CAS PubMed PubMed Central Google Scholar
- Munoz-Braceras, S., Tornero-Ecija, A. R., Vincent, O. & Escalante, R. VPS13A, a closely associated mitochondrial protein, is required for efficient lysosomal degradation. Dis. Model. Mech 12, dmm036681 (2019).
CAS PubMed PubMed Central Google Scholar
- Liu, L. K., Choudhary, V., Toulmay, A. & Prinz, W. A. An inducible ER-Golgi tether facilitates ceramide transport to alleviate lipotoxicity. J. Cell Biol. 216, 131–147 (2017). This study shows that yeast cells can generate MCSs that prevent the toxic accumulation of ceramide in the ER by facilitating non-vesicular ceramide exit from the ER when vesicular transport out of the ER is blocked.
CAS PubMed PubMed Central Google Scholar
- Wong, L. H., Gatta, A. T. & Levine, T. P. Lipid transfer proteins: the lipid commute via shuttles, bridges and tubes. Nat. Rev. Mol. Cell Biol. 20, 85–101 (2019).
CAS PubMed Google Scholar
- Osman, C., Voelker, D. R. & Langer, T. Making heads or tails of phospholipids in mitochondria. J. Cell Biol. 192, 7–16 (2011).
CAS PubMed PubMed Central Google Scholar
- Hanada, K. et al. Molecular machinery for non-vesicular trafficking of ceramide. Nature 426, 803–809 (2003).
CAS PubMed Google Scholar
- Funato, K. & Riezman, H. Vesicular and nonvesicular transport of ceramide from ER to the Golgi apparatus in yeast. J. Cell Biol. 155, 949–959 (2001).
CAS PubMed PubMed Central Google Scholar
- Jain, A. & Holthuis, J. C. M. Membrane contact sites, ancient and central hubs of cellular lipid logistics. Biochim. Biophys Acta. 1864, 1450–1458 (2017).
CAS Google Scholar
- John Peter, A. T. et al. Vps13-Mcp1 interact at vacuole-mitochondria interfaces and bypass ER-mitochondria contact sites. J. Cell Biol. 216, 3219–3229 (2017).
CAS PubMed PubMed Central Google Scholar
- Lang, A. B., John Peter, A. T., Walter, P. & Kornmann, B. ER-mitochondrial junctions can be bypassed by dominant mutations in the endosomal protein Vps13. J. Cell Biol. 210, 883–890 (2015).
CAS PubMed PubMed Central Google Scholar
- Elbaz-Alon, Y. et al. A dynamic interface between vacuoles and mitochondria in yeast. Dev. Cell 30, 95–102 (2014).
CAS PubMed Google Scholar
- Honscher, C. et al. Cellular metabolism regulates contact sites between vacuoles and mitochondria. Dev. Cell 30, 86–94 (2014).
PubMed Google Scholar
- de Saint-Jean, M. et al. Osh4p exchanges sterols for phosphatidylinositol 4-phosphate between lipid bilayers. J. Cell Biol. 195, 965–978 (2011).
PubMed PubMed Central Google Scholar
- Kim, Y. J., Hernandez, M. L. & Balla, T. Inositol lipid regulation of lipid transfer in specialized membrane domains. Trends Cell Biol. 23, 270–278 (2013).
CAS PubMed PubMed Central Google Scholar
- Chung, J. et al. PI4P/phosphatidylserine countertransport at ORP5- and ORP8-mediated ER-plasma membrane contacts. Science 349, 428–432 (2015).
CAS PubMed PubMed Central Google Scholar
- Moser von Filseck, J. et al. Phosphatidylserine transport by ORP/Osh proteins is driven by phosphatidylinositol 4-phosphate. Science 349, 432–436 (2015).
CAS PubMed Google Scholar
- Moser von Filseck, J., Vanni, S., Mesmin, B., Antonny, B. & Drin, G. A phosphatidylinositol-4-phosphate powered exchange mechanism to create a lipid gradient between membranes. Nat. Commun. 6, 6671 (2015).
PubMed Google Scholar
- Ghai, R. et al. ORP5 and ORP8 bind phosphatidylinositol-4, 5-biphosphate (PtdIns(4,5)P 2) and regulate its level at the plasma membrane. Nat. Commun. 8, 757 (2017).
PubMed PubMed Central Google Scholar
- Mesmin, B. et al. Sterol transfer, PI4P consumption, and control of membrane lipid order by endogenous OSBP. EMBO J. 36, 3156–3174 (2017).
CAS PubMed PubMed Central Google Scholar
- Putney, J. W. Introduction. Adv. Exp. Med. Biol. 993, 3–13 (2017).
CAS PubMed Google Scholar
- Hirve, N., Rajanikanth, V., Hogan, P. G. & Gudlur, A. Coiled-coil formation conveys a STIM1 signal from ER lumen to cytoplasm. Cell. Rep. 22, 72–83 (2018).
CAS PubMed PubMed Central Google Scholar
- Petersen, O. H., Courjaret, R. & Machaca, K. Ca2+ tunnelling through the ER lumen as a mechanism for delivering Ca2+ entering via store-operated Ca2+ channels to specific target sites. J. Physiol. 595, 2999–3014 (2017).
CAS PubMed PubMed Central Google Scholar
- Grigoriev, I. et al. STIM1 is a MT-plus-end-tracking protein involved in remodeling of the ER. Curr. Biol. 18, 177–182 (2008).
CAS PubMed PubMed Central Google Scholar
- Chang, C. L., Chen, Y. J., Quintanilla, C. G., Hsieh, T. S. & Liou, J. EB1 binding restricts STIM1 translocation to ER-PM junctions and regulates store-operated Ca2+ entry. J. Cell Biol. 217, 2047–2058 (2018).
CAS PubMed PubMed Central Google Scholar
- Giordano, F. et al. PI(4,5)P2-dependent and Ca2+-regulated ER-PM interactions mediated by the extended synaptotagmins. Cell 153, 1494–1509 (2013).
CAS PubMed PubMed Central Google Scholar
- Chang, C. L. et al. Feedback regulation of receptor-induced Ca2+ signaling mediated by e-syt1 and nir2 at endoplasmic reticulum-plasma membrane junctions. Cell Rep. 5, 813–825 (2013).
PubMed Google Scholar
- Kumagai, K. & Hanada, K. Structure, functions and regulation of CERT, a lipid-transfer protein for the delivery of ceramide at the ER-Golgi membrane contact sites. FEBS Lett. 593, 2366–2377 (2019).
CAS PubMed Google Scholar
- Kannan, M., Lahiri, S., Liu, L. K., Choudhary, V. & Prinz, W. A. Phosphatidylserine synthesis at membrane contact sites promotes its transport out of the ER. J. Lipid Res. 58, 553–562 (2017). This study demonstrates that phospholipid synthesis at MCSs promotes non-vesicular lipid transport at MCSs.
CAS PubMed PubMed Central Google Scholar
- Kim, Y. J., Guzman-Hernandez, M. L. & Balla, T. A highly dynamic ER-derived phosphatidylinositol-synthesizing organelle supplies phosphoinositides to cellular membranes. Dev. Cell 21, 813–824 (2011).
CAS PubMed PubMed Central Google Scholar
- Maeda, K. et al. Interactome map uncovers phosphatidylserine transport by oxysterol-binding proteins. Nature 501, 257–261 (2013).
CAS PubMed Google Scholar
- Chang, C. L. et al. Spastin tethers lipid droplets to peroxisomes and directs fatty acid trafficking through ESCRT-III. J. Cell Biol. 218, 2583–2599 (2019).
CAS Google Scholar
- Schuldiner, M. & Bohnert, M. A different kind of love - lipid droplet contact sites. Biochim. Biophys Acta 1862, 1188–1196 (2017).
CAS Google Scholar
- Kerner, J. & Hoppel, C. Fatty acid import into mitochondria. Biochim. Biophys Acta. 1486, 1–17 (2000).
CAS PubMed Google Scholar
- Michaud, M. & Jouhet, J. Lipid trafficking at membrane contact sites during plant development and stress response. Front. Plant Sci. 10, 2 (2019).
PubMed PubMed Central Google Scholar
- Sheftel, A. D., Zhang, A. S., Brown, C., Shirihai, O. S. & Ponka, P. Direct interorganellar transfer of iron from endosome to mitochondrion. Blood 110, 125–132 (2007).
CAS PubMed Google Scholar
- Das, A., Nag, S., Mason, A. B. & Barroso, M. M. Endosome-mitochondria interactions are modulated by iron release from transferrin. J. Cell Biol. 214, 831–845 (2016).
CAS PubMed PubMed Central Google Scholar
- Rizzuto, R., Brini, M., Murgia, M. & Pozzan, T. Microdomains with high Ca2+ close to IP3-sensitive channels that are sensed by neighboring mitochondria. Science 262, 744–747 (1993). This study demonstrates that high Ca 2+ levels at ER–mitochondria MCSs are transiently generated next to the ER-localized Ca 2+ channel and are sensed by contacting mitochondria.
CAS PubMed Google Scholar
- Csordas, G. et al. Imaging interorganelle contacts and local calcium dynamics at the ER-mitochondrial interface. Mol. Cell 39, 121–132 (2010). This study provides direct evidence that high-Ca 2+ domains exist between the ER and mitochondria at MCSs and shows that these organelles must be tethered for Ca 2+ signalling.
CAS PubMed PubMed Central Google Scholar
- Szabadkai, G. et al. Chaperone-mediated coupling of endoplasmic reticulum and mitochondrial Ca2+ channels. J. Cell Biol. 175, 901–911 (2006).
CAS PubMed PubMed Central Google Scholar
- Csordas, G., Weaver, D. & Hajnoczky, G. Endoplasmic reticulum-mitochondrial contactology: structure and signaling functions. Trends Cell Biol. 28, 523–540 (2018).
CAS PubMed PubMed Central Google Scholar
- Zhang, X. et al. Redox signals at the ER-mitochondria interface control melanoma progression. EMBO J. 38, e100871 (2019).
PubMed PubMed Central Google Scholar
- Muallem, S., Chung, W. Y., Jha, A. & Ahuja, M. Lipids at membrane contact sites: cell signaling and ion transport. EMBO Rep. 18, 1893–1904 (2017).
CAS PubMed PubMed Central Google Scholar
- Herrera-Cruz, M. S. & Simmen, T. Over six decades of discovery and characterization of the architecture at mitochondria-associated membranes (MAMs). Adv. Exp. Med. Biol. 997, 13–31 (2017).
CAS PubMed Google Scholar
- Hirabayashi, Y. et al. ER-mitochondria tethering by PDZD8 regulates Ca2+ dynamics in mammalian neurons. Science 358, 623–630 (2017).
CAS PubMed PubMed Central Google Scholar
- Kornmann, B. et al. An ER-mitochondria tethering complex revealed by a synthetic biology screen. Science 325, 477–481 (2009). This study identifies an ER–mitochondria tethering complex in yeast that is found exclusively at these contact sites and plays a role in lipid exchange between the ER and mitochondria.
CAS PubMed PubMed Central Google Scholar
- Booth, D. M., Enyedi, B., Geiszt, M., Varnai, P. & Hajnoczky, G. Redox nanodomains are induced by and control calcium signaling at the ER-mitochondrial interface. Mol. Cell 63, 240–248 (2016). This study demonstrates how mitochondria-generated ROS participate in ER–mitochondria communication at MCSs and regulate Ca 2+ signalling and oxidative phosphorylation.
CAS PubMed PubMed Central Google Scholar
- Lock, J. T., Sinkins, W. G. & Schilling, W. P. Protein S-glutathionylation enhances Ca2+-induced Ca2+ release via the IP3 receptor in cultured aortic endothelial cells. J. Physiol. 590, 3431–3447 (2012).
CAS PubMed PubMed Central Google Scholar
- Yoboue, E. D., Sitia, R. & Simmen, T. Redox crosstalk at endoplasmic reticulum (ER) membrane contact sites (MCS) uses toxic waste to deliver messages. Cell Death. Dis. 9, 331 (2018).
PubMed PubMed Central Google Scholar
- Gordaliza-Alaguero, I., Canto, C. & Zorzano, A. Metabolic implications of organelle-mitochondria communication. EMBO Rep. 20, e47928 (2019).
PubMed Google Scholar
- Behnia, R. & Munro, S. Organelle identity and the signposts for membrane traffic. Nature 438, 597–604 (2005).
CAS PubMed Google Scholar
- Dickson, E. J. & Hille, B. Understanding phosphoinositides: rare, dynamic, and essential membrane phospholipids. Biochem. J. 476, 1–23 (2019).
CAS PubMed PubMed Central Google Scholar
- Berridge, M. J. & Irvine, R. F. Inositol trisphosphate, a novel second messenger in cellular signal transduction. Nature 312, 315–321 (1984).
CAS PubMed Google Scholar
- Balla, T. Phosphoinositides: tiny lipids with giant impact on cell regulation. Physiol. Rev. 93, 1019–1137 (2013).
CAS PubMed PubMed Central Google Scholar
- Chang, C. L. & Liou, J. Phosphatidylinositol 4,5-bisphosphate homeostasis regulated by Nir2 and Nir3 proteins at endoplasmic reticulum-plasma membrane junctions. J. Biol. Chem. 290, 14289–14301 (2015).
CAS PubMed PubMed Central Google Scholar
- Kim, Y. J., Guzman-Hernandez, M. L., Wisniewski, E. & Balla, T. Phosphatidylinositol-phosphatidic acid exchange by Nir2 at ER-PM contact sites maintains phosphoinositide signaling competence. Dev. Cell 33, 549–561 (2015).
CAS PubMed PubMed Central Google Scholar
- Lees, J. A. et al. Lipid transport by TMEM24 at ER-plasma membrane contacts regulates pulsatile insulin secretion. Science 355, eaah6171 (2017).
PubMed PubMed Central Google Scholar
- Bian, X., Saheki, Y. & De Camilli, P. Ca2+ releases E-Syt1 autoinhibition to couple ER-plasma membrane tethering with lipid transport. EMBO J. 37, 219–234 (2018).
CAS PubMed Google Scholar
- Saheki, Y. et al. Control of plasma membrane lipid homeostasis by the extended synaptotagmins. Nat. Cell Biol. 18, 504–515 (2016).
CAS PubMed PubMed Central Google Scholar
- Sohn, M. et al. PI(4,5)P2 controls plasma membrane PI4P and PS levels via ORP5/8 recruitment to ER-PM contact sites. J. Cell Biol 217, 1797–1813 (2018).
CAS PubMed PubMed Central Google Scholar
- Stuible, M. & Tremblay, M. L. In control at the ER: PTP1B and the down-regulation of RTKs by dephosphorylation and endocytosis. Trends Cell Biol. 20, 672–679 (2010).
CAS PubMed Google Scholar
- Haj, F. G. et al. Regulation of signaling at regions of cell-cell contact by endoplasmic reticulum-bound protein-tyrosine phosphatase 1B. PLOS One 7, e36633 (2012).
CAS PubMed PubMed Central Google Scholar
- Stefan, C. J. et al. Osh proteins regulate phosphoinositide metabolism at ER-plasma membrane contact sites. Cell 144, 389–401 (2011).
CAS PubMed Google Scholar
- Venditti, R. et al. The activity of Sac1 across ER-TGN contact sites requires the four-phosphate-adaptor-protein-1. J. Cell Biol. 218, 783–797 (2019).
CAS PubMed PubMed Central Google Scholar
- Zewe, J. P., Wills, R. C., Sangappa, S., Goulden, B. D. & Hammond, G. R. SAC1 degrades its lipid substrate PtdIns4P in the endoplasmic reticulum to maintain a steep chemical gradient with donor membranes. Elife 7, e35588 (2018).
PubMed PubMed Central Google Scholar
- Labbe, K., Murley, A. & Nunnari, J. Determinants and functions of mitochondrial behavior. Annu. Rev. Cell Dev. Biol. 30, 357–391 (2014).
CAS PubMed Google Scholar
- Cho, B. et al. Constriction of the mitochondrial inner compartment is a priming event for mitochondrial division. Nat. Commun. 8, 15754 (2017).
PubMed PubMed Central Google Scholar
- Murley, A. et al. ER-associated mitochondrial division links the distribution of mitochondria and mitochondrial DNA in yeast. Elife 2, e00422 (2013).
PubMed PubMed Central Google Scholar
- Korobova, F., Ramabhadran, V. & Higgs, H. N. An actin-dependent step in mitochondrial fission mediated by the ER-associated formin INF2. Science 339, 464–467 (2013).
CAS PubMed Google Scholar
- Manor, U. et al. A mitochondria-anchored isoform of the actin-nucleating spire protein regulates mitochondrial division. Elife 4, https://doi.org/10.7554/eLife.08828 (2015).
- Smirnova, E., Shurland, D. L., Ryazantsev, S. N. & van der Bliek, A. M. A human dynamin-related protein controls the distribution of mitochondria. J. Cell Biol. 143, 351–358 (1998).
CAS PubMed PubMed Central Google Scholar
- Labrousse, A. M., Zappaterra, M. D., Rube, D. A. & van der Bliek, A. M. C. elegans dynamin-related protein DRP-1 controls severing of the mitochondrial outer membrane. Mol. Cell 4, 815–826 (1999).
CAS PubMed Google Scholar
- Osellame, L. D. et al. Cooperative and independent roles of the Drp1 adaptors Mff, MiD49 and MiD51 in mitochondrial fission. J. Cell Sci. 129, 2170–2181 (2016).
CAS PubMed Google Scholar
- Arasaki, K. et al. A role for the ancient SNARE syntaxin 17 in regulating mitochondrial division. Dev. Cell 32, 304–317 (2015).
CAS PubMed Google Scholar
- Lee, J. E., Westrate, L. M., Wu, H., Page, C. & Voeltz, G. K. Multiple dynamin family members collaborate to drive mitochondrial division. Nature 540, 139–143 (2016).
CAS PubMed PubMed Central Google Scholar
- Guo, Y. et al. Visualizing intracellular organelle and cytoskeletal interactions at nanoscale resolution on millisecond timescales. Cell 175, 1430–1442 (2018).
CAS PubMed Google Scholar
- Rowland, A. A., Chitwood, P. J., Phillips, M. J. & Voeltz, G. K. ER contact sites define the position and timing of endosome fission. Cell 159, 1027–1041 (2014).
CAS PubMed PubMed Central Google Scholar
- Shcheprova, Z., Baldi, S., Frei, S. B., Gonnet, G. & Barral, Y. A mechanism for asymmetric segregation of age during yeast budding. Nature 454, 728–734 (2008). This study demonstrates that specialized ER–plasma membrane MCSs form a septin-dependent ER diffusion barrier in S. cerevisiae between mother and bud cells, which results in the asymmetric inheritance of cellular components.
CAS PubMed Google Scholar
- Clay, L. et al. A sphingolipid-dependent diffusion barrier confines ER stress to the yeast mother cell. Elife 3, e01883 (2014).
PubMed PubMed Central Google Scholar
- Luedeke, C. et al. Septin-dependent compartmentalization of the endoplasmic reticulum during yeast polarized growth. J. Cell Biol. 169, 897–908 (2005).
CAS PubMed PubMed Central Google Scholar
- Chao, J. T. et al. Polarization of the endoplasmic reticulum by ER-septin tethering. Cell 158, 620–632 (2014).
CAS PubMed Google Scholar
- Sugiyama, S. & Tanaka, M. Distinct segregation patterns of yeast cell-peripheral proteins uncovered by a method for protein segregatome analysis. Proc. Natl Acad. Sci. USA 116, 8909–8918 (2019).
CAS PubMed Google Scholar
- Perez-Sancho, J. et al. Stitching organelles: organization and function of specialized membrane contact sites in plants. Trends Cell Biol. 26, 705–717 (2016).
CAS PubMed Google Scholar
- Tilsner, J., Nicolas, W., Rosado, A. & Bayer, E. M. Staying tight: plasmodesmal membrane contact sites and the control of cell-to-cell connectivity in plants. Annu. Rev. Plant Biol. 67, 337–364 (2016).
CAS PubMed Google Scholar
- Nicolas, W. J. et al. Architecture and permeability of post-cytokinesis plasmodesmata lacking cytoplasmic sleeves. Nat. Plants 3, 17082 (2017).
CAS PubMed Google Scholar
- Kvam, E. & Goldfarb, D. S. Nucleus-vacuole junctions in yeast: anatomy of a membrane contact site. Biochem. Soc. Trans 34, 340–342 (2006).
CAS PubMed Google Scholar
- Dawaliby, R. & Mayer, A. Microautophagy of the nucleus coincides with a vacuolar diffusion barrier at nuclear-vacuolar junctions. Mol. Biol. Cell 21, 4173–4183 (2010).
CAS PubMed PubMed Central Google Scholar
- Graef, M., Friedman, J. R., Graham, C., Babu, M. & Nunnari, J. ER exit sites are physical and functional core autophagosome biogenesis components. Mol. Biol. Cell 24, 2918–2931 (2013).
CAS PubMed PubMed Central Google Scholar
- Suzuki, K., Akioka, M., Kondo-Kakuta, C., Yamamoto, H. & Ohsumi, Y. Fine mapping of autophagy-related proteins during autophagosome formation in Saccharomyces cerevisiae. J. Cell Sci. 126, 2534–2544 (2013).
CAS PubMed Google Scholar
- Ktistakis, N. T. ER platforms mediating autophagosome generation. Biochim. Biophys Acta https://doi.org/10.1016/j.bbalip.2019.03.005 (2019).
- Okumura, K. et al. Norepinephrine-induced 1,2-diacylglycerol accumulation and change in its fatty acid composition in the isolated perfused rat heart. Mol. Cell Biochem. 93, 173–178 (1990).
CAS PubMed Google Scholar
- Nascimbeni, A. C. et al. ER-plasma membrane contact sites contribute to autophagosome biogenesis by regulation of local PI3P synthesis. EMBO J. 36, 2018–2033 (2017).
CAS PubMed PubMed Central Google Scholar
- Zhao, Y. G. et al. The ER contact proteins vapa/b interact with multiple autophagy proteins to modulate autophagosome biogenesis. Curr. Biol. 28, 1234–1245 (2018). This study identifies proteins that link the ER and autophagosomal regulators at contact sites within growing autophagosomes.
CAS PubMed Google Scholar
- Zachari, M. & Ganley, I. G. The mammalian ULK1 complex and autophagy initiation. Essays Biochem. 61, 585–596 (2017).
PubMed PubMed Central Google Scholar
- Zhao, Y. G. et al. The ER-localized transmembrane protein EPG-3/VMP1 regulates SERCA activity to control ER-isolation membrane contacts for autophagosome formation. Mol. Cell 67, 974–989 (2017).
CAS PubMed Google Scholar
- Tabara, L. C. & Escalante, R. VMP1 Establishes er-microdomains that regulate membrane contact sites and autophagy. PLOS One 11, e0166499 (2016).
PubMed PubMed Central Google Scholar
- Nishimura, T. et al. Autophagosome formation is initiated at phosphatidylinositol synthase-enriched ER subdomains. EMBO J. 36, 1719–1735 (2017).
CAS PubMed PubMed Central Google Scholar
- Valverde, D. P. et al. ATG2 transports lipids to promote autophagosome biogenesis. J. Cell Biol. 218, 1787–1798 (2019).
CAS PubMed Google Scholar
- Hayashi-Nishino, M. et al. A subdomain of the endoplasmic reticulum forms a cradle for autophagosome formation. Nat. Cell Biol. 11, 1433–1437 (2009).
CAS PubMed Google Scholar
- Yla-Anttila, P., Vihinen, H., Jokitalo, E. & Eskelinen, E. L. 3D tomography reveals connections between the phagophore and endoplasmic reticulum. Autophagy 5, 1180–1185 (2009).
PubMed Google Scholar
- Biazik, J., Yla-Anttila, P., Vihinen, H., Jokitalo, E. & Eskelinen, E. L. Ultrastructural relationship of the phagophore with surrounding organelles. Autophagy 11, 439–451 (2015).
PubMed PubMed Central Google Scholar
- Elkin, S. R., Lakoduk, A. M. & Schmid, S. L. Endocytic pathways and endosomal trafficking: a primer. Wien Med Wochenschr 166, 196–204 (2016).
PubMed PubMed Central Google Scholar
- Eden, E. R., White, I. J., Tsapara, A. & Futter, C. E. Membrane contacts between endosomes and ER provide sites for PTP1B-epidermal growth factor receptor interaction. Nat. Cell Biol. 12, 267–272 (2010). This study shows that, at MCSs, PTP1B in the ER acts in trans on epidermal growth factor in endosomes.
CAS PubMed Google Scholar
- Stuible, M. et al. PTP1B targets the endosomal sorting machinery: dephosphorylation of regulatory sites on the endosomal sorting complex required for transport component STAM2. J. Biol. Chem. 285, 23899–23907 (2010).
CAS PubMed PubMed Central Google Scholar
- Dong, R. et al. Endosome-ER contacts control actin nucleation and retromer function through VAP-dependent regulation of PI4P. Cell 166, 408–423 (2016).
CAS PubMed PubMed Central Google Scholar
- Allison, R. et al. Defects in er-endosome contacts impact lysosome function in hereditary spastic paraplegia. J. Cell Biol. 216, 1337–1355 (2017).
CAS PubMed PubMed Central Google Scholar
- Salogiannis, J., Egan, M. J. & Reck-Peterson, S. L. Peroxisomes move by hitchhiking on early endosomes using the novel linker protein PxdA. J. Cell Biol. 212, 289–296 (2016). This study shows that peroxisomes can be transported in cells by being linked at MCSs to early endosomes, which are themselves moved by microtubule-dependent motors.
CAS PubMed PubMed Central Google Scholar
- Friedman, J. R., Webster, B. M., Mastronarde, D. N., Verhey, K. J. & Voeltz, G. K. ER sliding dynamics and ER-mitochondrial contacts occur on acetylated microtubules. J. Cell Biol. 190, 363–375 (2010).
CAS PubMed PubMed Central Google Scholar
- Jongsma, M. L. et al. An ER-associated pathway defines endosomal architecture for controlled cargo transport. Cell 166, 152–166 (2016).
CAS PubMed PubMed Central Google Scholar
- Rocha, N. et al. Cholesterol sensor ORP1L contacts the ER protein VAP to control Rab7-RILP-p150 glued and late endosome positioning. J. Cell Biol. 185, 1209–1225 (2009). This study shows that late endosomes can be attached to the ER via MCSs or to motor proteins by a cholesterol-regulated switch.
CAS PubMed PubMed Central Google Scholar
- Raiborg, C. et al. Repeated ER-endosome contacts promote endosome translocation and neurite outgrowth. Nature 520, 234–238 (2015). This study shows that ER–late endosome MCSs regulate loading of the microtubule-dependent motor kinesin 1 onto the late endosomes, controlling their movement to the plasma membrane and, as a result, neurite outgrowth.
CAS PubMed Google Scholar
- Knoblach, B. et al. An ER-peroxisome tether exerts peroxisome population control in yeast. EMBO J. 32, 2439–2453 (2013).
CAS PubMed PubMed Central Google Scholar
- Knoblach, B. & Rachubinski, R. A. Transport and retention mechanisms govern lipid droplet inheritance in Saccharomyces cerevisiae. Traffic 16, 298–309 (2015).
CAS PubMed Google Scholar
- Swayne, T. C. et al. Role for cER and Mmr1p in anchorage of mitochondria at sites of polarized surface growth in budding yeast. Curr. Biol. 21, 1994–1999 (2011).
CAS PubMed PubMed Central Google Scholar
- Pernice, W. M., Vevea, J. D. & Pon, L. A. A role for Mfb1p in region-specific anchorage of high-functioning mitochondria and lifespan in Saccharomyces cerevisiae. Nat. Commun. 7, 10595 (2016).
CAS PubMed PubMed Central Google Scholar
- Eisenberg-Bord, M. et al. Identification of seipin-linked factors that act as determinants of a lipid droplet subpopulation. J. Cell Biol 217, 269–282 (2018).
CAS PubMed PubMed Central Google Scholar
- Teixeira, V. et al. Regulation of lipid droplets by metabolically controlled Ldo isoforms. J. Cell Biol. 217, 127–138 (2018).
CAS PubMed PubMed Central Google Scholar
- Benador, I. Y. et al. Mitochondria bound to lipid droplets have unique bioenergetics, composition, and dynamics that support lipid droplet expansion. Cell Metab. 27, 869–885 (2018). This study demonstrates that, in brown adipose tissue, mitochondria that from contacts with lipid droplets are metabolically different from those that do not.
CAS PubMed PubMed Central Google Scholar
- Bravo, R. et al. Increased ER-mitochondrial coupling promotes mitochondrial respiration and bioenergetics during early phases of ER stress. J. Cell Sci. 124, 2143–2152 (2011).
CAS PubMed PubMed Central Google Scholar
- Gutierrez, T. & Simmen, T. Endoplasmic reticulum chaperones tweak the mitochondrial calcium rheostat to control metabolism and cell death. Cell Calcium. 70, 64–75 (2018).
CAS PubMed Google Scholar
- Michaud, M., Prinz, W. A. & Jouhet, J. Glycerolipid synthesis and lipid trafficking in plant mitochondria. FEBS J. 284, 376–390 (2017).
CAS PubMed Google Scholar
- Michaud, M. et al. AtMic60 is involved in plant mitochondria lipid trafficking and is part of a large complex. Curr. Biol. 26, 627–639 (2016).
CAS PubMed PubMed Central Google Scholar
- Listenberger, L. L. et al. Triglyceride accumulation protects against fatty acid-induced lipotoxicity. Proc. Natl Acad. Sci. USA 100, 3077–3082 (2003).
CAS PubMed Google Scholar
- Garbarino, J. et al. Sterol and diacylglycerol acyltransferase deficiency triggers fatty acid-mediated cell death. J. Biol. Chem. 284, 30994–31005 (2009).
CAS PubMed PubMed Central Google Scholar
- Olzmann, J. A. & Carvalho, P. Dynamics and functions of lipid droplets. Nat. Rev. Mol. Cell Biol. 20, 137–155 (2018).
Google Scholar
- Hariri, H. et al. Lipid droplet biogenesis is spatially coordinated at ER-vacuole contacts under nutritional stress. EMBO Rep. 19, 57–72 (2018).
CAS PubMed Google Scholar
- Henne, W. M. et al. Mdm1/Snx13 is a novel ER-endolysosomal interorganelle tethering protein. J. Cell Biol. 210, 541–551 (2015).
CAS PubMed PubMed Central Google Scholar
- Nguyen, T. B. et al. DGAT1-dependent lipid droplet biogenesis protects mitochondrial function during starvation-induced autophagy. Dev. Cell 42, 9–21 (2017).
CAS PubMed PubMed Central Google Scholar
- Roelants, F. M. et al. TOR complex 2-regulated protein kinase Ypk1 controls sterol distribution by inhibiting StARkin domain-containing proteins located at plasma membrane-endoplasmic reticulum contact sites. Mol. Biol. Cell 29, 2128–2136 (2018).
CAS PubMed PubMed Central Google Scholar
- Omnus, D. J., Manford, A. G., Bader, J. M., Emr, S. D. & Stefan, C. J. Phosphoinositide kinase signaling controls ER-PM cross-talk. Mol. Biol. Cell 27, 1170–1180 (2016).
CAS PubMed PubMed Central Google Scholar
- Perez-Sancho, J. et al. The Arabidopsis synaptotagmin1 is enriched in endoplasmic reticulum-plasma membrane contact sites and confers cellular resistance to mechanical stresses. Plant Physiol. 168, 132–143 (2015).
CAS PubMed PubMed Central Google Scholar
- Lee, E. et al. Ionic stress enhances ER-PM connectivity via phosphoinositide-associated SYT1 contact site expansion in Arabidopsis. Proc. Natl Acad. Sci. USA 116, 1420–1429 (2019).
CAS PubMed Google Scholar
- Schapire, A. L. et al. Arabidopsis synaptotagmin 1 is required for the maintenance of plasma membrane integrity and cell viability. Plant Cell 20, 3374–3388 (2008).
CAS PubMed PubMed Central Google Scholar
- Yamazaki, T., Kawamura, Y., Minami, A. & Uemura, M. Calcium-dependent freezing tolerance in Arabidopsis involves membrane resealing via synaptotagmin SYT1. Plant Cell 20, 3389–3404 (2008).
CAS PubMed PubMed Central Google Scholar
- Bockler, S. & Westermann, B. Mitochondrial ER contacts are crucial for mitophagy in yeast. Dev. Cell 28, 450–458 (2014).
PubMed Google Scholar
- Kawano, S. et al. Structure-function insights into direct lipid transfer between membranes by Mmm1-Mdm12 of ERMES. J. Cell Biol. 217, 959–974 (2018).
CAS PubMed PubMed Central Google Scholar
- Wu, W. et al. FUNDC1 regulates mitochondrial dynamics at the ER-mitochondrial contact site under hypoxic conditions. EMBO J. 35, 1368–1384 (2016).
CAS PubMed PubMed Central Google Scholar
- Missiroli, S. et al. PML at mitochondria-associated membranes is critical for the repression of autophagy and cancer development. Cell Rep. 16, 2415–2427 (2016).
CAS PubMed PubMed Central Google Scholar
- Liu, X., Wen, X. & Klionsky, D. J. ER-mitochondria contacts are required for pexophagy in Saccharomyces cerevisiae. Contact (Thousand Oaks) 2, https://journals.sagepub.com/doi/10.1177/2515256418821584 (2018).
- Mattiazzi Usaj, M. et al. Genome-wide localization study of yeast Pex11 identifies peroxisome-mitochondria interactions through the ERMES complex. J. Mol. Biol. 427, 2072–2087 (2015).
CAS PubMed PubMed Central Google Scholar
- Roberts, P. et al. Piecemeal microautophagy of nucleus in Saccharomyces cerevisiae. Mol. Biol. Cell 14, 129–141 (2003).
CAS PubMed PubMed Central Google Scholar
- Datta, S., Liu, Y., Hariri, H., Bowerman, J. & Henne, W. M. Cerebellar ataxia disease-associated Snx14 promotes lipid droplet growth at ER-droplet contacts. J. Cell Biol. 218, 1335–1351 (2019).
CAS PubMed PubMed Central Google Scholar
- Murley, A. et al. Sterol transporters at membrane contact sites regulate TORC1 and TORC2 signaling. J. Cell Biol. 216, 2679–2689 (2017).
CAS PubMed PubMed Central Google Scholar
- Liu, Z. W. et al. Protein kinase RNA-like endoplasmic reticulum kinase (PERK) signaling pathway plays a major role in reactive oxygen species (ROS)-mediated endoplasmic reticulum stress-induced apoptosis in diabetic cardiomyopathy. Cardiovasc. Diabetol. 12, 158 (2013).
PubMed PubMed Central Google Scholar
- Verfaillie, T. et al. PERK is required at the ER-mitochondrial contact sites to convey apoptosis after ROS-based ER stress. Cell Death Differ. 19, 1880–1891 (2012).
CAS PubMed PubMed Central Google Scholar
- Raturi, A. et al. TMX1 determines cancer cell metabolism as a thiol-based modulator of ER-mitochondria Ca2+ flux. J. Cell Biol. 214, 433–444 (2016).
CAS PubMed PubMed Central Google Scholar
- Gilady, S. Y. et al. Ero1alpha requires oxidizing and normoxic conditions to localize to the mitochondria-associated membrane (MAM). Cell Stress Chaperones 15, 619–629 (2010).
CAS PubMed PubMed Central Google Scholar
- Marino, M. et al. SEPN1, an endoplasmic reticulum-localized selenoprotein linked to skeletal muscle pathology, counteracts hyperoxidation by means of redox-regulating SERCA2 pump activity. Hum. Mol. Genet. 24, 1843–1855 (2015).
CAS PubMed Google Scholar
- Debattisti, V., Gerencser, A. A., Saotome, M., Das, S. & Hajnoczky, G. ROS control mitochondrial motility through p38 and the motor adaptor Miro/Trak. Cell Rep. 21, 1667–1680 (2017).
CAS PubMed PubMed Central Google Scholar
- Arruda, A. P. et al. Chronic enrichment of hepatic endoplasmic reticulum-mitochondria contact leads to mitochondrial dysfunction in obesity. Nat. Med. 20, 1427–1435 (2014).
CAS PubMed PubMed Central Google Scholar
- Eisenberg-Bord, M. et al. The endoplasmic reticulum-mitochondria encounter structure complex coordinates coenzyme Q biosynthesis. Contact (Thousand Oaks) 2, https://doi.org/10.1177/2515256418825409 (2019).
Article Google Scholar
- Mourier, A. et al. Mitofusin 2 is required to maintain mitochondrial coenzyme Q levels. J. Cell Biol. 208, 429–442 (2015).
CAS PubMed PubMed Central Google Scholar
- Subramanian, K. et al. Coenzyme Q biosynthetic proteins assemble in a substrate-dependent manner into domains at ER-mitochondria contacts. J. Cell Biol. 218, 1353–1369 (2019).
PubMed PubMed Central Google Scholar
- Simmen, T. & Herrera-Cruz, M. S. Plastic mitochondria-endoplasmic reticulum (ER) contacts use chaperones and tethers to mould their structure and signaling. Curr. Opin. Cell Biol. 53, 61–69 (2018).
CAS PubMed Google Scholar
- Orrenius, S., Zhivotovsky, B. & Nicotera, P. Regulation of cell death: the calcium-apoptosis link. Nat. Rev. Mol. Cell Biol. 4, 552–565 (2003).
CAS PubMed Google Scholar
- Lynes, E. M. et al. Palmitoylation is the switch that assigns calnexin to quality control or ER Ca2+ signaling. J. Cell Sci. 126, 3893–3903 (2013).
CAS PubMed Google Scholar
- Eckenrode, E. F., Yang, J., Velmurugan, G. V., Foskett, J. K. & White, C. Apoptosis protection by Mcl-1 and Bcl-2 modulation of inositol 1,4,5-trisphosphate receptor-dependent Ca2+ signaling. J. Biol. Chem. 285, 13678–13684 (2010).
CAS PubMed PubMed Central Google Scholar
- Xu, L. et al. Bcl-2 overexpression reduces cisplatin cytotoxicity by decreasing ER-mitochondrial Ca2+ signaling in SKOV3 cells. Oncol. Rep. 39, 985–992 (2018).
CAS PubMed Google Scholar
- Mebratu, Y. A. et al. Bik reduces hyperplastic cells by increasing Bak and activating DAPk1 to juxtapose ER and mitochondria. Nat. Commun. 8, 803 (2017).
PubMed PubMed Central Google Scholar
- Giorgi, C. et al. p53 at the endoplasmic reticulum regulates apoptosis in a Ca2+-dependent manner. Proc. Natl Acad. Sci. USA 112, 1779–1784 (2015).
CAS PubMed Google Scholar
- Giorgi, C. et al. PML regulates apoptosis at endoplasmic reticulum by modulating calcium release. Science 330, 1247–1251 (2010).
CAS PubMed PubMed Central Google Scholar
- Doghman-Bouguerra, M. et al. FATE1 antagonizes calcium- and drug-induced apoptosis by uncoupling ER and mitochondria. EMBO Rep. 17, 1264–1280 (2016).
CAS PubMed PubMed Central Google Scholar
- Chami, M. et al. Role of SERCA1 truncated isoform in the proapoptotic calcium transfer from ER to mitochondria during ER stress. Mol. Cell 32, 641–651 (2008).
CAS PubMed PubMed Central Google Scholar
- van Vliet, A. R. et al. The ER stress sensor PERK coordinates ER-plasma membrane contact site formation through interaction with filamin-A and F-actin remodeling. Mol. Cell 65, 885–899 (2017).
PubMed Google Scholar
- Philpott, C. C. & Jadhav, S. The ins and outs of iron: escorting iron through the mammalian cytosol. Free. Radic. Biol. Med. 133, 112–117 (2019).
CAS PubMed Google Scholar
- Kambe, T., Matsunaga, M. & Takeda, T. A. Understanding the contribution of zinc transporters in the function of the early secretory pathway. Int. J. Mol. Sci. 18, E2179 (2017).
PubMed Google Scholar
- Williamson, C. D. & Colberg-Poley, A. M. Access of viral proteins to mitochondria via mitochondria-associated membranes. Rev. Med. Virol. 19, 147–164 (2009).
CAS PubMed PubMed Central Google Scholar
- Levy, A., Zheng, J. Y. & Lazarowitz, S. G. Synaptotagmin SYTA forms ER-plasma membrane junctions that are recruited to plasmodesmata for plant virus movement. Curr. Biol. 25, 2018–2025 (2015).
CAS PubMed PubMed Central Google Scholar
- Derre, I., Swiss, R. & Agaisse, H. The lipid transfer protein CERT interacts with the Chlamydia inclusion protein IncD and participates to ER-Chlamydia inclusion membrane contact sites. PLOS Pathog. 7, e1002092 (2011). This study shows how the intracellular pathogen Chlamydia trachomatis generates MCSs between the ER and the membrane of the inclusion that the bacteria propagate in, by hijacking CERT and other host MCS proteins.
CAS PubMed PubMed Central Google Scholar
- Elwell, C. A. et al. Chlamydia trachomatis co-opts GBF1 and CERT to acquire host sphingomyelin for distinct roles during intracellular development. PLOS Pathog. 7, e1002198 (2011).
CAS PubMed PubMed Central Google Scholar
- Stoica, R. et al. ER-mitochondria associations are regulated by the VAPB-PTPIP51 interaction and are disrupted by ALS/FTD-associated TDP-43. Nat. Commun. 5, 3996 (2014). This study shows that TDP-43, which is linked to amyotrophic lateral sclerosis, regulates ER–mitochondria MCSs and cellular Ca 2+ homeostasis.
CAS PubMed PubMed Central Google Scholar
- Bernard-Marissal, N., Medard, J. J., Azzedine, H. & Chrast, R. Dysfunction in endoplasmic reticulum-mitochondria crosstalk underlies SIGMAR1 loss of function mediated motor neuron degeneration. Brain 138, 875–890 (2015).
PubMed Google Scholar
- Nishimura, A. L. et al. A mutation in the vesicle-trafficking protein VAPB causes late-onset spinal muscular atrophy and amyotrophic lateral sclerosis. Am. J. Hum. Genet. 75, 822–831 (2004).
CAS PubMed PubMed Central Google Scholar
- Area-Gomez, E. et al. Presenilins are enriched in endoplasmic reticulum membranes associated with mitochondria. Am. J. Pathol. 175, 1810–1816 (2009).
CAS PubMed PubMed Central Google Scholar
- Area-Gomez, E. et al. Upregulated function of mitochondria-associated ER membranes in Alzheimer disease. EMBO J. 31, 4106–4123 (2012).
CAS PubMed PubMed Central Google Scholar
- Zampese, E. et al. Presenilin 2 modulates endoplasmic reticulum (ER)-mitochondria interactions and Ca2+ cross-talk. Proc. Natl Acad. Sci. USA 108, 2777–2782 (2011).
CAS PubMed Google Scholar
- Lim, Y., Cho, I. T., Schoel, L. J., Cho, G. & Golden, J. A. Hereditary spastic paraplegia-linked REEP1 modulates endoplasmic reticulum/mitochondria contacts. Ann. Neurol. 78, 679–696 (2015).
CAS PubMed PubMed Central Google Scholar
- Rampoldi, L. et al. A conserved sorting-associated protein is mutant in chorea-acanthocytosis. Nat. Genet. 28, 119–120 (2001).
CAS PubMed Google Scholar
- Ueno, S. et al. The gene encoding a newly discovered protein, chorein, is mutated in chorea-acanthocytosis. Nat. Genet. 28, 121–122 (2001).
CAS PubMed Google Scholar
- Guardia-Laguarta, C. et al. -Synuclein is localized to mitochondria-associated ER membranes. J. Neurosci. 34, 249–259 (2014).
CAS PubMed PubMed Central Google Scholar
- Cali, T., Ottolini, D., Negro, A. & Brini, M. α-Synuclein controls mitochondrial calcium homeostasis by enhancing endoplasmic reticulum-mitochondria interactions. J. Biol. Chem. 287, 17914–17929 (2012).
CAS PubMed PubMed Central Google Scholar
- Lesage, S. et al. Loss of VPS13C function in autosomal-recessive Parkinsonism causes mitochondrial dysfunction and increases PINK1/Parkin-dependent mitophagy. Am. J. Hum. Genet. 98, 500–513 (2016).
CAS PubMed PubMed Central Google Scholar
- Sano, R. et al. GM1-ganglioside accumulation at the mitochondria-associated ER membranes links ER stress to Ca2+-dependent mitochondrial apoptosis. Mol. Cell 36, 500–511 (2009). This study emonstrates that accumulation of the ganglioside monosialotetrahexosylganglioside at ER–mitochondria MCSs induces Ca 2+ -mediated apoptotic signalling that links ER stress and apoptosis in neurons.
CAS PubMed PubMed Central Google Scholar
- Szado, T. et al. Phosphorylation of inositol 1,4,5-trisphosphate receptors by protein kinase B/Akt inhibits Ca2+ release and apoptosis. Proc. Natl Acad. Sci. USA 105, 2427–2432 (2008).
CAS PubMed Google Scholar
- Marchi, S. et al. Selective modulation of subtype III IP(3)R by Akt regulates ER Ca(2)(+) release and apoptosis. Cell Death Dis. 3, e304 (2012).
CAS PubMed PubMed Central Google Scholar
- Scorrano, L. et al. BAX and BAK regulation of endoplasmic reticulum Ca2+: a control point for apoptosis. Science 300, 135–139 (2003).
CAS PubMed Google Scholar
- Anelli, T. et al. Ero1alpha regulates Ca2+ fluxes at the endoplasmic reticulum-mitochondria interface (MAM). Antioxid. Redox Signal. 16, 1077–1087 (2012).
CAS PubMed Google Scholar
- Kakihana, T., Nagata, K. & Sitia, R. Peroxides and peroxidases in the endoplasmic reticulum: integrating redox homeostasis and oxidative folding. Antioxid. Redox Signal. 16, 763–771 (2012).
CAS PubMed Google Scholar
- Betz, C. et al. mTOR complex 2-Akt signaling at mitochondria-associated endoplasmic reticulum membranes (MAM) regulates mitochondrial physiology. Proc. Natl Acad. Sci. USA 110, 12526–12534 (2013).
CAS PubMed Google Scholar
- Bononi, A. et al. Identification of PTEN at the ER and MAMs and its regulation of Ca2+ signaling and apoptosis in a protein phosphatase-dependent manner. Cell Death Differ. 20, 1631–1643 (2013).
CAS PubMed PubMed Central Google Scholar
- Avalle, L. et al. STAT3 localizes to the ER, acting as a gatekeeper for ER-mitochondrion Ca2+ fluxes and apoptotic responses. Cell Death Differ. 26, 932–942 (2019).
CAS PubMed Google Scholar
- Tubbs, E. et al. Mitochondria-associated endoplasmic reticulum membrane (MAM) integrity is required for insulin signaling and is implicated in hepatic insulin resistance. Diabetes 63, 3279–3294 (2014).
CAS PubMed Google Scholar
- Thoudam, T. et al. PDK4 augments ER-mitochondria contact to dampen skeletal muscle insulin signaling during obesity. Diabetes 68, 571–586 (2019).
CAS PubMed Google Scholar
- Saxena, R. et al. Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. Nat. Genet. 42, 142–148 (2010).
CAS PubMed PubMed Central Google Scholar