Vogel, G. Studies in psychophysiology of dreams III. The dreams of narcolepsy. Arch. Gen. Psychiatry3, 421–428 (1960). ArticleCASPubMed Google Scholar
Honda, Y., Asaka, A., Tanaka, Y. & Juji, T. Discrimination of narcolepsy by using genetic markers and HLA. Sleep Res.12, 254 (1983). Google Scholar
Juji, T., Satake, M., Honda, Y. & Doi, Y. HLA antigens in Japanese patients with narcolepsy. All the patients were DR2 positive. Tissue Antigens24, 316–319 (1984). ArticleCASPubMed Google Scholar
Nishino, N., Ripley, B., Overeem, S., Lammers, G. J. & Mignot, E. Hypocretin (orexin) deficiency in human narcolepsy. Lancet355, 39–40 (2000). ArticleCASPubMed Google Scholar
American Academy of Sleep Medicine. International Classification of Sleep Disorders (ICSD-3) 3rd edn (AASM, 2014).
Juji, T., Matsuki, L., Tokunaga, K., Naohara, K. & Honda, Y. Narcolepsy and HLA in the Japanese. Ann. NY Acad. Sci.540, 106–114 (1988). ArticleCASPubMed Google Scholar
Hublin, S. et al. The prevalence of narcolepsy: an epidemiological study of the Finnish twin cohort. Ann. Neurol.35, 709–716 (1994). ArticleCASPubMed Google Scholar
Silber, M. H., Krahn, L. E., Olson, E. J. & Pankratz, V. S. The epidemiology of narcolepsy in Olmsted County, Minnesota: a population-based study. Sleep 25, (197–202 (2002). Google Scholar
Ohayon, M., Priest, R. G., Zulley, J., Smirne, S. & Paiva, T. Prevalence of narcolepsy symptomatology and diagnosis in the European general population. Neurology58, 1826–1833 (2002). ArticleCASPubMed Google Scholar
Wilner, A. et al. Narcolepsy-cataplexy in Israeli Jews is associated exclusively with the HLA DR2 haplotype. Hum. Immunol.21, 15–22 (1988). ArticleCASPubMed Google Scholar
al Rajeh, S. et al. A community survey of neurological disorders in Saudi Arabia: the Thugbah study. Neuroepidemiology12, 164–178 (1993). ArticleCASPubMed Google Scholar
Jennum, J., Ibsen, R., Petersen, E. R., Knudsen, S. & Kjellberg, J. Health, social and economic consequences of narcolepsy: a controlled national study evaluating the societal effect on patients and their partners. Sleep Med.13, 1086–1093 (2012). ArticlePubMed Google Scholar
Jennum, P., Thorstensen, E. W., Pickering, L., Ibsen, R. & Kjellberg, J. Morbidity and mortality of middle-aged and elderly narcoleptics. Sleep Med.36, 23–28 (2017). ArticlePubMed Google Scholar
Dauvilliers, Y. et al. Age at onset of narcolepsy in two large populations of patients in France and Quebec. Neurology57, 2029–2033 (2001). ArticleCASPubMed Google Scholar
Rocca, F. L., Pizza, F., Ricci, E. & Plazzi, G. Narcolepsy during childhood: an update. Neuropediatrics46, 181–198 (2015). ArticlePubMed Google Scholar
Yoss, R. & Daly, D. Narcolepsy in children. Pediatrics25, 1025–1033 (1960). CASPubMed Google Scholar
Challamel, M. J. et al. Narcolepsy in children. Sleep17, 17–20 (1994). Article Google Scholar
Guilleminault, C. & Pelayo, R. Narcolepsy in prepubertal children. Ann. Neurol.43, 135–142 (1998). ArticleCASPubMed Google Scholar
Luca, G. et al. Clinical, polysomnographic and genome-wide association analyses of narcolepsy with cataplexy: a European Narcolepsy Network study. J. Sleep Res.22, 482–495 (2013). ArticlePubMed Google Scholar
Sturzenegger, C. & Bassetti, C. L. The clinical spectrum of narcolepsy with cataplexy: a reappraisal. J. Sleep Res.13, 395–406 (2004). ArticlePubMed Google Scholar
van Dijk, J. G., Lammers, G. J. & Blansjaar, B. A. Isolated cataplexy of more than 40 years’ duration. Br. J. Psychiatry159, 719–721 (1991). ArticlePubMed Google Scholar
Trotti, L. M., Staab, B. A. & Rye, D. B. Test-retest reliability of the multiple sleep latency test in narcolepsy without cataplexy and idiopathic hypersomnia. J. Clin. Sleep Med.9, 789–785 (2013). PubMedPubMed Central Google Scholar
Lopez, R. et al. Test-retest reliability of the multiple sleep latency test in central disorders of hypersomnolence. Sleep40, 164–168 (2017). Google Scholar
Dauvilliers, Y., Abril, B., Mas, E., Michel, F. & Tafti, M. Normalization of hypocretin-1 in narcolepsy after intravenous immunoglobulin treatment. Neurology73, 1333–1334 (2009). ArticleCASPubMed Google Scholar
Symonds, C. P. Narcolepsy as a symptom of encephalitis lethargica. Lancet173, 1214–1125 (1922). Google Scholar
Mankowski, B. Zur Pathogenese kataplegisches Anfälle bei Narkolepsie (auf Grund eines Falls von Encephalitis epidemica) [German]. Monatschr. Psychiatr. Neurol.61, 340–349 (1926). Article Google Scholar
Langdon, N., Welsh, K. I., van Dam, M., Vaughan, R. W. & Parkes, D. Genetic markers in narcolepsy. Lancet2, 1178–1180 (1984). ArticleCASPubMed Google Scholar
Peyron, C. et al. A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains. Nat. Med.6, 991–997 (2000). ArticleCASPubMed Google Scholar
Crocker, A. et al. Concomitant loss of dynorphin, NARP, and orexin in narcolepsy. Neurology65, 1184–1188 (2005). ArticleCASPubMed Google Scholar
de Lecea, L. et al. The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity. Proc. Natl Acad. Sci. USA95, 322–327 (1998). ArticlePubMedPubMed Central Google Scholar
Sakurai, T. et al. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell92, 573–585 (1998). ArticleCASPubMed Google Scholar
Krahn, L. E. Reevaluating spells initially identified as cataplexy. Sleep Med.6, 537–542 (2005). ArticlePubMed Google Scholar
Broughton, R. et al. Excessive daytime sleepiness and the pathophysiology of narcolepsy-cataplexy: a laboratory perspective. Sleep9, 205–215 (1986). ArticleCASPubMed Google Scholar
Nishino, S. & Kanbayashi, T. Symptomatic narcolepsy, cataplexy, and hypersomnia, and their implications in the hypothalamic hypocretin/orexin system. Sleep Med. Rev.9, 269–310 (2005). ArticlePubMed Google Scholar
Baumann, C. R. et al. Hypocretin-1 (orexin A) deficiency in acute traumatic brain injury. Neurology65, 147–149 (2005). ArticleCASPubMed Google Scholar
Baumann, C. R., Bassetti, C. L., Hersberger, M. & Jung, H. H. Excessive daytime sleepiness in Behçet’s disease with diencephalic lesions and hypocretin dysfunction. Eur. Neurol.63, 190 (2010). ArticlePubMed Google Scholar
Mignot, E. et al. The role of cerebrospinal fluid hypocretin measurement in the diagnosis of narcolepsy and other hypersomnias. Arch. Neurol.59, 1553–1562 (2002). ArticlePubMed Google Scholar
Bassetti, C. L. Selective hypocretin (orexin) neuronal loss and multiple signaling deficiencies. Neurology65, 1152–1153 (2005). ArticlePubMed Google Scholar
Latorre, D. et al. T cells in patients with narcolepsy target self-antigens of hypocretin neurons. Nature562, 63–68 (2018). ArticleCASPubMed Google Scholar
Lippert, J. et al. Specific T cell activation in peripheral blood and cerebrospinal fluid in central disorders of hypersomnolence. Sleep42, zsy223 (2019). Article Google Scholar
Luo, F. et al. Autoimmunity to hypocretin and molecular mimicry to flu in type 1 narcolepsy. Proc. Natl Acad. Sci. USA115, E12323–E12332 (2018). ArticleCASPubMedPubMed Central Google Scholar
Pedersen, N. W. et al. CD8+ T cells from patients with narcolepsy and healthy controls recognize hypocretin neuron-specific antigens. Nat. Commun.10, 837 (2019). ArticlePubMedPubMed CentralCAS Google Scholar
Thannickal, T. C., Nienhuis, R. & Siegel, J. M. Localized loss of hypocretin (orexin) cells in narcolepsy without cataplexy. Sleep32, 993–998 (2009). ArticlePubMedPubMed Central Google Scholar
Valko, P. O. et al. Increase of histaminergic tuberomammillary neurons in narcolepsy. Ann. Neurol.74, 794–804 (2013). ArticleCASPubMed Google Scholar
Honda, M. et al. Absence of ubiquitinated inclusions in hypocretin neurons of patients with narcolepsy. Neurology18, 511–517 (2009). ArticleCAS Google Scholar
Gerashchenko, D. et al. Relationship between CSF hypocretin levels and hypocretin neuronal loss. Exp. Neurol.184, 1010–1016 (2003). ArticleCASPubMed Google Scholar
Khatami, R. et al. Monozygotic twins concordant for narcolepsy-cataplexy without any detectable abnormality in the hypocretin (orexin) pathway. Lancet363, 1199–1200 (2004). ArticleCASPubMed Google Scholar
Dauvilliers, Y. et al. A monozygotic twin pair discordant for narcolepsy and CSF hypocretin-1. Neurology62, 2137–2138 (2004). ArticleCASPubMed Google Scholar
Hor, H. et al. A missense mutation in myelin oligdendrocyte glycoprotein as a cause of familial narcolepsy with cataplexy. Am. J. Hum. Genet.89, 474–479 (2011). ArticleCASPubMedPubMed Central Google Scholar
Degn, M. et al. Rare missense mutations in P2RY11 in narcolepsy with cataplexy. Brain140, 1657–1668 (2017). ArticlePubMed Google Scholar
Dauvilliers, Y. et al. A narcolepsy susceptibility locus maps to a 5 Mb region of chromosome 21q. Ann. Neurol.56, 382–388 (2004). ArticleCASPubMed Google Scholar
Mignot, E. et al. Complex HLA-DR and -DQ interactions confer risk of narcolepsy-cataplexy in three ethnic groups. Am. J. Hum. Genet.68, 686–699 (2001). ArticleCASPubMedPubMed Central Google Scholar
Tafti, M. et al. DQB1 locus alone explains most of the risk and protection in narcolepsy with cataplexy in Europe. Sleep37, 19–25 (2014). ArticlePubMedPubMed Central Google Scholar
Mignot, E., Young, T., Lin, L., Finn, L. & Palta, M. Reduction of REM sleep latency associated with HLA-DQB1*0602 in normal adults. Lancet351, 727 (1998). ArticleCASPubMed Google Scholar
Han, F. et al. Genome wide analysis of narcolepsy in China implicates novel immune loci and reveals changes in association prior to versus after the 2009 H1N1 influenza pandemic. PLOS Genet.9, e1003880 (2013). ArticlePubMedPubMed CentralCAS Google Scholar
Hor, H. et al. Genome-wide association study identifies new HLA class II haplotypes strongly protective against narcolepsy. Nat. Genet.42, 786–789 (2010). ArticleCASPubMed Google Scholar
Kornum, B. R. et al. Common variants in P2RY11 are associated with narcolepsy. Nat. Genet.43, 66–71 (2011). ArticleCASPubMed Google Scholar
Singh, A. K., Mahlios, J. & Mignot, E. Genetic association, seasonal infections and autoimmune basis of narcolepsy. J. Autoimmun.43, 26–31 (2013). ArticleCASPubMedPubMed Central Google Scholar
Shimada, M., Miyagawa, T., Toyoda, H., Tokunaga, K. & Honda, M. Epigenome-wide association study of DNA methylation in narcolepsy: an integrated genetic and epigenetic approach. Sleep41, zsy019 (2018). Article Google Scholar
Pollmächer, T. et al. DR2-positive monozygotic twins discordant for narcolepsy. Sleep13, 336–343 (1990). ArticlePubMed Google Scholar
Partinen, M., Hublin, C., Kaprio, J., Koskenvuo, M. & Guilleminault, C. Twin studies in narcolepsy. Sleep17, S13–S16 (1994). ArticleCASPubMed Google Scholar
Dahmen, N. & Tonn, P. Season of birth effect in narcolepsy. Neurology61, 1016–1017 (2003). ArticlePubMed Google Scholar
Dauvilliers, Y. et al. Month of birth as a risk factor for narcolepsy. Sleep26, 663–665 (2003). ArticlePubMed Google Scholar
Picchioni, D., Mignot, E. & Harsh, J. R. The month-of-birth pattern in narcolepsy is moderated by cataplexy severity and may be independent of HLA-DQB1*0602. Sleep27, 1471–1475 (2004). ArticlePubMed Google Scholar
Donjacour, C. E., Fronczek, R., Le Cessie, Lammers, S., G. J. & Van Dijk, J. G. Month of birth is not a risk factor for narcolepsy with cataplexy in the Netherlands. J. Sleep Res.20, 522–525 (2011). ArticlePubMed Google Scholar
von Economo, C. Sleep as a problem of localization. J. Nerv. Ment. Dis.71, 249–259 (1930). Article Google Scholar
Partinen, M. et al. Narcolepsy as an autoimmune disease: the role of H1N1 infection and vaccination. Lancet Neurol.13, 600–613 (2014). ArticleCASPubMed Google Scholar
Dauvilliers, Y. et al. Increased risk of narcolepsy in children and adults after pandemic H1N1 vaccination in France. Brain136, 2486–2496 (2013). ArticlePubMed Google Scholar
Ahmed, S. S. et al. Antibodies to influenza nucleoprotein cross-react with human hypocretin receptor 2. Sci. Transl Med.7, 294ra105 (2015). ArticlePubMedCAS Google Scholar
Saariaho, A. H. et al. Autoantibodies against ganglioside GM3 are associated with narcolepsy-cataplexy developing after Pandemrix vaccination against 2009 pandemic H1N1 type influenza virus. J. Autoimmun.63, 68–75 (2015). ArticleCASPubMed Google Scholar
Han, F., Lin, L., Li, J., Dong, X. S. & Mignot, E. Decreased incidence of childhood narcolepsy 2 years after the 2009 H1N1 winter flu pandemic. Ann. Neurol.73, 560 (2013). ArticlePubMed Google Scholar
Sarkanen, T., Alakuijala, A., Julkunen, I. & Partinen, M. Narcolepsy associated with Pandemrix vaccine. Curr. Neurol. Neurosci. Rep.18, 43 (2018). ArticlePubMedCAS Google Scholar
Heyck, H. & Hess, R. Some results of clinical studies on narcolepsy. Schweiz. Arch. Neurol. Psychiatr.75, 401–402 (1955). CASPubMed Google Scholar
Hidalgo, H., Kallweit, U., Mathis, J. & Bassetti, C. L. Post Tick-borne encephalitis virus vaccination narcolepsy with cataplexy. Sleep39, 1811–1814 (2016). ArticlePubMedPubMed Central Google Scholar
Lankford, D. A., Wellmann, J. J. & O’Hara, C. Posttraumatic narcolepsy in mild to moderate closed head injury. Sleep17, S25–S28 (1994). ArticleCASPubMed Google Scholar
Silber, M. H. Narcolepsy, head injury, and the problem of causality. J. Clin. Sleep Med.1, 157–158 (2005). PubMed Google Scholar
Cvetikovic-Lopes, V. et al. Elevated Tribbles homolog-2-specific antibody levels in narcolepsy patients. J. Clin. Invest.120, 713–719 (2010). ArticleCAS Google Scholar
Bergman, H. et al. Narcolepsy patients have antibodies that stain distinct cell populations in rat brain and influence sleep patterns. Proc. Natl Acad. Sci. USA111, E3735–E3744 (2014). ArticleCASPubMedPubMed Central Google Scholar
Kallweit, U. et al. Co-existing narcolepsy (with and without cataplexy) and multiple sclerosis: six new cases and a literature review. J. Neurol.265, 2071–2078 (2018). ArticleCASPubMed Google Scholar
Ekbom, K. Familial multiple sclerosis associated with narcolepsy. Arch. Neurol.15, 337–344 (1966). ArticleCASPubMed Google Scholar
Tsutsui, K. et al. Anti-NMDA-receptor antibody detected in encephalitis, schizophrenia, and narcolepsy with psychotic features. BMC Psychiatry12, 37 (2012). ArticlePubMedPubMed Central Google Scholar
Overeem, S. et al. Hypocretin-1 CSF levels in anti-Ma2 associated encephalitis. Neurology62, 138–140 (2004). ArticleCASPubMed Google Scholar
Dauvilliers, Y. et al. Hypothalamic immunopathology in anti-Ma–associated diencephalitis with narcolepsy-cataplexy. JAMA Neurol.70, 1305–1310 (2013). PubMed Google Scholar
Peraita-Adrados, R. et al. A patient with narcolepsy with cataplexy and multiple sclerosis: two different diseases that may share pathophysiologic mechanisms? Sleep Med.14, 695–696 (2013). ArticlePubMed Google Scholar
Valko, P. O., Khatami, R., Baumann, C. R. & Bassetti, C. L. No effect of intravenous immunoglobulins in patents with narcolepsy with cataplexy. J. Neurol.255, 1900–1903 (2008). ArticlePubMed Google Scholar
Chen, W., Black, J., Call, P. & Mignot, E. Late-onset narcolepsy presenting as rapidly progressing muscle weakness: response to plasmapheresis. Ann. Neurol.58, 489–490 (2005). ArticlePubMed Google Scholar
Lecendreux, M., Maret, S., Bassetti, C., Mouren, M. C. & Tafti, M. Clinical efficacy of high-dose intravenous immunoglobulins near the onset of narcolepsy in a 10-year-old boy. J. Sleep Res.12, 347–348 (2003). ArticlePubMed Google Scholar
Black, J. L. 3rd et al. Analysis of hypocretin (orexin) antibodies in patients with narcolepsy. Sleep28, 427–431 (2005). ArticlePubMed Google Scholar
Tanaka, S., Honda, Y., Inoue, Y. & Honda, M. Detection of autoantibodies against hypocretin, HCRTR1, and HCRTR2 in narcolepsy: anti-Hcrt system antibody in narcolepsy. Sleep29, 633–638 (2006). ArticlePubMed Google Scholar
Giannoccaro, M. P. et al. Antibodies against hypocretin receptor 2 are rare in narcolepsy. Sleep40, zsw056 (2017). Article Google Scholar
Fredrikson, S., Carlander, B., Billiard, M. & Link, H. CSF immune variables in patients with narcolepsy. Acta Neurol. Scand.81, 253–254 (1990). ArticleCASPubMed Google Scholar
Hartmann, F. J. et al. High-dimensional single-cell analysis reveals the immune signature of narcolepsy. J. Exp. Med.213, 2621–2633 (2016). ArticleCASPubMedPubMed Central Google Scholar
Ramberger, M. et al. CD4+ T cell reactivity to orexin/hypocretin in patients with narcolepsy type 1. Sleep40, zsw070 (2017). Article Google Scholar
Lecendreux, M. et al. Impact of cytokine in type 1 narcolepsy: role of pandemic H1N1 vaccination? J. Autoimmun.60, 20–31 (2015). ArticleCASPubMed Google Scholar
Lecendreux, M. et al. Narcolepsy type 1 is associated with a systemic increase and activation of regulatory T cells and with a systemic activation of global T cells. PLOS ONE12, e0169836 (2017). ArticlePubMedPubMed CentralCAS Google Scholar
Khatami, R. et al. The European Narcolepsy Network (EU-NN) database. J. Sleep Res.25, 356–364 (2016). ArticlePubMed Google Scholar
Guilleminault, C., Philips, R. & Dement, W. C. A syndrome of hypersomnia with automatic behaviour. Electroencephalogr. Clin. Neurophysiol.38, 403–413 (1975). ArticleCASPubMed Google Scholar
Valko, P. O., Bassetti, C. L., Bloch, K. E., Held, U. & Baumann, C. R. Validation of the fatigue severity scale in a Swiss cohort. Sleep31, 1601–1607 (2008). ArticlePubMedPubMed Central Google Scholar
Droogleever Fortuyn, H. A. et al. Severe fatigue in narcolepsy with cataplexy. J. Sleep Res.21, 163–169 (2012). ArticlePubMed Google Scholar
Overeem, S. et al. The clinical features of cataplexy: a questionnaire study in narcolepsy patients with and without hypocretin-1 deficiency. Sleep Med.12, 12–18 (2011). ArticlePubMed Google Scholar
Pizza, F. et al. The distinguishing motor features of cataplexy: a study from video-recorded attacks. Sleep41, zsy026 (2018). Article Google Scholar
Serra, L., Montagna, P., Mignot, E., Lugaresi, E. & Plazzi, G. Cataplexy features in childhood narcolepsy. Mov. Disord.23, 858–865 (2008). ArticlePubMed Google Scholar
Barateau, L. et al. Persistence of deep-tendon reflexes during partial cataplexy. Sleep Med.45, 80–82 (2018). ArticlePubMed Google Scholar
Antelmi, E., Vandi, S., Pizza, Liguori, F., R. & Plazzi, G. Parkinsonian tremor persisting during cataplexy. Sleep Med.17, 174–176 (2016). ArticleCASPubMed Google Scholar
Poryazova, R., Siccoli, M., Werth, E. & Bassetti, C. L. Unusually prolonged rebound cataplexy after withdrawal of fluoxetine. Neurology65, 967–968 (2005). ArticlePubMed Google Scholar
Gelb, M. et al. Stability of cataplexy over several months — information for the design of therapeutic trials. Sleep17, 265–273 (1994). ArticleCASPubMed Google Scholar
Rubboli, G. et al. A video-polygraphic analysis of the cataplectic attack. Clin. Neurophysiol.111, S120–S128 (2000). ArticlePubMed Google Scholar
Plazzi, G. et al. Complex movement disorders at disease onset in childhood narcolepsy with cataplexy. Brain134, 3477–3489 (2011). ArticlePubMedPubMed Central Google Scholar
Redlich, E. Epilegomena zur Narkolepsie-Frage [German]. Z. Ges. Neurol. Psychiatr.136, 129–173 (1931). Article Google Scholar
Roth, B. Narcolepsy and Hypersomnia (Karger, 1980).
Rüther, E., Meier-Ewert, K. & Gallitz, A. Zur Symptomatologie des narkoleptischen syndroms [German]. Nervenarzt43, 640–643 (1972). PubMed Google Scholar
Attarian, H. P., Schenck, C. H. & Mahowald, M. W. Presumed REM sleep behavior disorder arising from cataplexy and wakeful dreaming. Sleep Med.1, 131–133 (2000). ArticleCASPubMed Google Scholar
Poryazova, R., Khatami, R., Werth, E. & Bassetti, C. L. Weak with sex: sexual intercourse as a trigger for cataplexy. J. Sex. Med.6, 2271–2277 (2009). ArticlePubMed Google Scholar
Parkes, J. D., Chen, S. Y., Clift, S. J., Dahlitz, M. J. & Dunn, G. The clinical diagnosis of the narcoleptic syndrome. J. Sleep Res.7, 41–52 (1997). Article Google Scholar
Vgontzas, A. N., Sollenberger, S. E., Kales, A., Bixler, E. O. & Vela-Bueno, A. Narcolepsy-cataplexy and loss of sphincter control. Postgrad. Med. J.72, 493–494 (1996). ArticleCASPubMedPubMed Central Google Scholar
Fortuyn, H. A. et al. Psychotic symptoms in narcolepsy: phenomenology and a comparison with schizophrenia. Gen. Hosp. Psychiatry31, 146–154 (2009). ArticlePubMed Google Scholar
Wamsley, E., Donjacour, C. E., Scammell, T. E., Lammers, G. J. & Stickgold, R. Delusional confusion of dreaming and reality in narcolepsy. Sleep37, 419–422 (2014). ArticlePubMedPubMed Central Google Scholar
Gudden, H. Die physiologische und pathologische Schlaftrunkenheit [German]. Arch. Psychiat.40, 989–1015 (1905). Article Google Scholar
Mullington, J. & Broughton, R. Daytime sleep inertia in narcolepsy-cataplexy. Sleep17, 69–76 (1994). CASPubMed Google Scholar
Broughton, R., Dunham, W., Weisskopf, M. & Rivers, M. Night sleep does not predict day sleep in narcolepsy. Electroencephalogr. Clin. Neurophysiol.91, 67–70 (1994). ArticleCASPubMed Google Scholar
Harsh, J., Peszka, J., Hartwig, G. & Mitler, M. Night-time sleep and daytime sleepiness in narcolepsy. J. Sleep Res.9, 309–316 (2000). ArticleCASPubMed Google Scholar
Mayer, G. & Meier-Ewert, K. Motor dyscontrol in sleep of narcoleptic patients (a lifelong development?). J. Sleep Res.2, 143–148 (1993). ArticleCASPubMed Google Scholar
Nevsimalova, S., Prihodova, I., Kemlink, D., Lin, L. & Mignot, E. REM behavior disorder (RBD) can be one of the first symptoms of childhood narcolepsy. Sleep Med.8, 784–786 (2007). ArticlePubMed Google Scholar
Pizza, F., Tartarotti, S., Poryazova, R., Baumann, C. R. & Bassetti, C. L. Sleep-disordered breathing and periodic limb movements in narcolepsy with cataplexy: a systematic analysis of 35 consecutive patients. Eur. Neurol.70, 22–26 (2013). ArticlePubMed Google Scholar
Knudsen, S., Gammeltoft, S. & Jennum, P. J. Rapid eye movement sleep behaviour disorder in patients with narcolepsy is associated with hypocretin-1 deficiency. Brain133, 568–579 (2010). ArticlePubMed Google Scholar
Dauvilliers, Y. et al. Periodic leg movements during sleep and wakefulness in narcolepsy. J. Sleep Res.16, 333–339 (2007). ArticlePubMed Google Scholar
Franceschini, C. et al. Motor events during REM sleep in patients with narcolepsy-cataplexy: a video-polysomnographic pilot study. Sleep Med.12, S59–S63 (2011). ArticlePubMed Google Scholar
Nightingale, S. et al. The association between narcolepsy and REM behavior disorder (RBD). Sleep Med.6, 253–258 (2005). ArticleCASPubMed Google Scholar
Orellana, C. et al. Life events in the year preceding the onset of narcolepsy. Sleep17, S50–S53 (1994). ArticleCASPubMed Google Scholar
Broughton, R. et al. Life effects of narcolepsy in 180 patients from North America, Asia and Europe compared to matched controls. Can. J. Neurol. Sci.8, 299–304 (1981). ArticleCASPubMed Google Scholar
Roth, B. & Nevsimalova, S. Depression in narcolepsy and hypersomnia. Schweiz. Arch. Neurol. Neurochir. Psychiatr.116, 291–300 (1975). CASPubMed Google Scholar
Vourdas, A. et al. Narcolepsy and psychopathology: is there an association? Sleep Med.3, 353–360 (2002). ArticleCASPubMed Google Scholar
Ohayon, M. M. Narcolepsy is complicated by high medical and psychiatric comorbidities: a comparison with the general population. Sleep Med.14, 488–492 (2013). ArticlePubMed Google Scholar
Ruoff, C. M. et al. High rates of psychiatric comorbidity in narcolepsy: findings from the Burden of Narcolepsy Disease (BOND) study of 9,312 patients in the United States. J. Clin. Psychiatry78, 171–176 (2017). ArticlePubMed Google Scholar
Cohen, A., Mandrekar, J., St Louis, E. K., Silber, M. H. & Kotagal, S. Comorbidities in a community sample of narcolepsy. Sleep Med.43, 14–18 (2018). ArticlePubMed Google Scholar
Fortuyn, H. A., Mulders, P. C., Renier, Buitelaar, W. O., J. K. & Overeem, S. Narcolepsy and psychiatry: an evolving association of increasing interest. Sleep Med.12, 714–719 (2011). ArticlePubMed Google Scholar
Rosenthal, C. Über das Auftreten von halluzinatorisch-kataplektischen Angstsyndrom, Wachanfällen und ähnlichen Störungen bei Schizophrenen [German]. Monatschr. Psychiatr. Neurol.102, 11–38 (1939). Article Google Scholar
Nissen, C. et al. Transient narcolepsy-cataplexy syndrome after discontinuation of the antidepressant venlafaxine. J. Sleep Res.14, 207–208 (2005). ArticlePubMed Google Scholar
Plazzi, G., Khatami, R., Serra, Pizza, L., F. & Bassetti, C. L. Pseudocataplexy in narcolepsy-cataplexy. Sleep Med.11, 591–594 (2010). ArticlePubMed Google Scholar
Krahn, L. E., Hansen, M. R. & Shepard, J. W. Pseudocataplexy. Psychosomatics42, 356–358 (2001). ArticleCASPubMed Google Scholar
Ponz, A. et al. Abnormal activitiy in reward brain circuits in human narcolepsy with cataplexy. Ann. Neurol.67, 190–200 (2010). ArticlePubMed Google Scholar
Ponz, A. et al. Reduced amygdala activity during aversive conditioning in human narcolepsy. Ann. Neurol.67, 394–398 (2010). ArticlePubMed Google Scholar
Georgescu, D. et al. Involvement of the lateral hypothalamic peptide orexin in morphine dependence and withdrawal. J. Neurosci.23, 3106–3111 (2003). ArticleCASPubMedPubMed Central Google Scholar
Broughton, R. J., Guberman, A. & Roberts, J. Comparison of the psychosocial effects of epilepsy and narcolepsy/cataplexy: a controlled study. Epilepsia25, 423–433 (1984). ArticleCASPubMed Google Scholar
Blackwell, J. E., Alammar, H. A., Weighall, A. R., Kellar, I. & Nash, H. M. A systematic review of cognitive function and psychosocial well-being in school-age children with narcolepsy. Sleep Med. Rev.34, 82–93 (2017). ArticlePubMed Google Scholar
Szakacs, Z., Hallbook, T., Tideman, P., Darin, N. & Wentz, E. Psychiatric comorbidity and cognitive profile in children with narcolepsy with or without association to the H1N1 influenza vaccnination. Sleep38, 615–621 (2015). ArticlePubMedPubMed Central Google Scholar
Goswami, M. The influence of clinical symptoms on quality of life in patients with narcolepsy. Neurology50, S31–S36 (1998). ArticleCASPubMed Google Scholar
Oosterloo, M., Lammers, G. J., Overeem, S., de Noord, I. & Kooij, J. J. Possible confusion between primary hypersomnia and adult attention-deficit/hyperactivity disorder. Psychiatry Res.143, 293–297 (2006). ArticlePubMed Google Scholar
Filardi, M. et al. Attention impairments and ADHD symptoms in adult narcoleptic patients with and without hypocretin deficiency. PLOS ONE12, e0182085 (2017). ArticlePubMedPubMed CentralCAS Google Scholar
Naumann, A., Bellebaum, C. & Daum, I. Cognitive deficits in narcolepsy. J. Sleep Res.15, 329–338 (2006). ArticleCASPubMed Google Scholar
Zamarian, L. et al. Subjective deficits of attention, cognition and depression in patients with narcolepsy. Sleep Med.16, 45–51 (2015). ArticlePubMed Google Scholar
Jennum, J. et al. Cerebrospinal fluid biomarkers of neurodegeneration are decreased or normal in narcolepsy. Sleep40, zsw006 (2017). Google Scholar
Economou, N. T., Manconi, M., Ghika, J., Raimondi, M. & Bassetti, C. L. Development of Parkinson and Alzheimer diseases in two cases of narcolepsy-cataplexy. Eur. Neurol.67, 48–50 (2012). ArticlePubMed Google Scholar
Roberts, H. J. Obesity due to the syndrome of narcolepsy and diabetogenic hyperinsulinism: clinical and therapeutic observations on 252 patients. J. Am. Geriatr. Soc.15, 721–743 (1967). ArticleCAS Google Scholar
Schuld, A., Hebebrand, J., Geller, F. & Pöllmächer, T. Increased body mass index in patients with narcolepsy. Lancet355, 1274–1275 (2000). ArticleCASPubMed Google Scholar
Kok, S. W. et al. Reduction of plasma leptin levels and loss of its circadian rhythmicity in hypocretin (orexin)-deficient narcoleptic humans. J. Clin. Endocrinol. Metab.87, 805–809 (2002). ArticleCASPubMed Google Scholar
Donjacour, C. E. et al. Glucose and fat metabolism in narcolepsy and the effect of sodium oxybate: a hyperinsulinemic-euglycemic clamp study. Sleep37, 795–801 (2014). ArticlePubMedPubMed Central Google Scholar
Poli, F. et al. High prevalence of precocious puberty and obesity in childhood narcolepsy with cataplexy. Sleep36, 175–181 (2013). ArticlePubMedPubMed Central Google Scholar
van Holst, R. J. et al. Aberrant food choices after satiation in human orexin-deficient narcolepsy type 1. Sleep39, 1951–1959 (2016). ArticlePubMedPubMed Central Google Scholar
Nishino, S. et al. Low cerebrospinal fluid hypocretin (orexin) and altered energy homeostasis in human narcolepsy. Ann. Neurol.50, 381–388 (2001). ArticleCASPubMed Google Scholar
Kok, S. W. et al. Altered setting of the pituitary-thyroid ensemble in hypocretin-deficient narcoleptic men. Am. J. Physiol. Endocrinol. Metab.288, E892–E899 (2005). ArticleCASPubMed Google Scholar
Plazzi, G. et al. Autonomic disturbances in narcolepsy. Sleep Med. Rev.15, 187–196 (2011). ArticlePubMed Google Scholar
Stiasny-Kolster, K. et al. Combination of ‘idiopathic’ REM sleep behaviour disorder and olfactory dysfunction as possible indicator for alpha-synucleinopathy demonstrated by dopamine transporter FP-CIT-SPECT. Brain128, 126–137 (2005). ArticleCASPubMed Google Scholar
Bayard, S. et al. Olfactory dysfunction in narcolepsy with cataplexy. Sleep Med.11, 876–881 (2010). ArticlePubMed Google Scholar
Black, J. et al. Medical comorbidity in narcolepsy: findings from the Burden of Narcolepsy Disease (BOND) study. Sleep Med.33, 13–18 (2017). ArticleCASPubMed Google Scholar
Lecendreux, M. Pediatric narcolepsy: clinical and therapeutical approach. Handb. Clin. Neurol.112, 839–845 (2013). Article Google Scholar
Vandi, S. et al. A standardized test to document cataplexy. Sleep Med.53, 197–204 (2017). ArticlePubMed Google Scholar
Baumann, C. R., Khatami, R., Werth, E. & Bassetti, C. L. Hypocretin (orexin) deficiency predicts severe objective excessive daytime sleepiness in narcolepsy with cataplexy. J. Neurol. Neurosurg. Psychiatry77, 402–404 (2006). ArticleCASPubMedPubMed Central Google Scholar
Gerashchenko, D. et al. Hypocretin-2-saporin lesions of the lateral hypothalamus produce narcoleptic-like sleep behavior in the rat. J. Neurosci.21, 7273–7283 (2001). ArticleCASPubMedPubMed Central Google Scholar
Baumann, C. R. & Bassetti, C. L. Hypocretins (orexins) and sleep-wake disorders. Lancet Neurol.10, 673–682 (2005). Article Google Scholar
Baumann, C. R., Dauvilliers, Y., Mignot, E. & Bassetti, C. L. Normal CSF hypocretin-1 (orexin-A) levels in dementia with Lewy bodies. Eur. Neurol.52, 73–76 (2004). ArticleCASPubMed Google Scholar
Sakai, N., Matsumura, M., Lin, L., Mignot, E. & Nishino, S. HLPC analysis of CSF hypocretin-1 in type 1 and 2 narcolepsy. Sci. Rep.9, 477 (2019). ArticlePubMedPubMed CentralCAS Google Scholar
Mignot, E. et al. Correlates of sleep-onset REM periods during the Multiple Sleep Latency Test in community adults. Brain129, 1609–1623 (2006). ArticlePubMed Google Scholar
Zhang, Z. et al. Exploring the clinical features of narcolepsy type 1 versus narcolepsy type 2 from European Narcolepsy Network database with machine learning. Sci. Rep.8, 10628 (2018). ArticlePubMedPubMed CentralCAS Google Scholar
Bassetti, C. & Aldrich, M. S. Idiopathic hypersomnia. A series of 42 patients. Brain120, 1423–1435 (1997). ArticlePubMed Google Scholar
Berti Ceroni, G., Coccagna, G., Gambi, D. & Lugaresi, E. Considerazioni clinico-poligrafiche sulla narcolessia essenziale “a sonno lento” [Italian]. Sist. Nerv.2, 81–89 (1967). Google Scholar
Hishikawa, Y. et al. The nature of sleep attack and other symptoms of narcolepsy. Electroencephalogr. Clin. Neurophysiol.24, 1–10 (1968). ArticleCASPubMed Google Scholar
Melberg, A. et al. Autosomal dominant cerebellar ataxia deafness and narcolepsy. J. Neurol. Sci.134, 119–129 (1995). ArticleCASPubMed Google Scholar
Moghadam, K. K. et al. Narcolepsy is a common phenotype in HSAN IE and ADCA-DN. Brain137, 1643–1655 (2014). ArticlePubMed Google Scholar
D’Cruz, O. F., Vaughn, B. V., Gold, S. H. & Greenwood, R. S. Symptomatic cataplexy in pontomedullary lesions. Neurology44, 2189–2191 (1994). ArticlePubMed Google Scholar
Kanbayashi, T. Symptomatic narcolepsy in patients with neuromyelitis optica and multiple sclerosis: new neurochemical and immunological implications. Arch. Neurol.66, 1563–1566 (2009). ArticlePubMed Google Scholar
Mathis, J., Hess, C. W. & Bassetti, C. Isolated mediotegmental lesion causing narcolepsy and rapid eye movement sleep behaviour disorder: a case evidencing a common pathway in narcolepsy and rapid eye movement sleep behaviour disorder. J. Neurol. Neurosurg. Psychiatry78, 427–429 (2007). ArticleCASPubMedPubMed Central Google Scholar
Schwartz, W. J., Stakes, J. W. & Hobson, J. A. Transient cataplexy after removal of a craniopharyngioma. Neurology34, 1372–1375 (1984). ArticleCASPubMed Google Scholar
Bonduelle, M. & Degos, C. in Narcolepsy: Proceedings of the First International Symposium on Narcolepsy (eds Guilleminault, C. et al.) 313–332 (Spectrum, 1976).
Stahl, S. M., Layzer, R. B., Aminoff, M. J., Townsend, J. J. & Feldon, S. Continuous cataplexy in a patient with a midbrain tumor: the limp man syndrome. Neurology30, 1115–1118 (1980). ArticleCASPubMed Google Scholar
Fernandez, J. M., Sadaba, F., Villaverde, F. J., Alvaro, L. C. & Cortina, C. Cataplexy associated with midbrain lesion. Neurology45, 393–394 (1995). ArticleCASPubMed Google Scholar
Roehrs, T., Zorick, F., Sicklesteel, J., Wittig, R. & Roth, T. Excessive daytime sleepiness associated with insufficient sleep. Sleep6, 319–325 (1983). ArticleCASPubMed Google Scholar
Baumann, C., Ferini-Strambi, L., Waldvogel, D., Werth, E. & Bassetti, C. L. Parkinsonism with excessive daytime sleepiness — a narcolepsy-like disorder? J. Neurol.252, 139–145 (2005). ArticlePubMed Google Scholar
Kaplan, K. A. & Harvey, A. G. Hypersomnia across mood disorders: a review and synthesis. Sleep Med. Rev.13, 275–285 (2009). ArticlePubMed Google Scholar
McLeod, S., Ferrie, C. & Zuberi, S. M. Symptoms of narcolepsy in children misinterpreted as epilepsy. Epileptic Disord.7, 13–17 (2005). Google Scholar
Paskind, H. A. Effect of laughter on muscle tone. Arch. Neurol. Psychiatry28, 623–628 (1932). Article Google Scholar
Partinen, M. Sleeping habits and sleep disorders of Finnish men before, during and after military service. Ann. Med. Milit. Fenn.57 (Suppl. 1), 1–96 (1982). Google Scholar
Kim, L. J. et al. Frequencies and associations of narcolepsy-related symptoms: a cross-sectional study. J. Clin. Sleep Med.11, 1377–1384 (2015). ArticlePubMedPubMed Central Google Scholar
Parkes, J. D. Genetic factors in human sleep disorders with special reference to Norrie disease, Prader–Willi syndrome and Moebius syndrome. J. Sleep Res.8 (Suppl. 1), 14–22 (1999). ArticlePubMed Google Scholar
Iranzo, A. & Santamaria, J. Hyperkalemic periodic paralysis associated with multiple sleep onset REM periods. Sleep22, 1123–1124 (1999). ArticleCASPubMed Google Scholar
Hartse, K. M., Zorick, F., Sicklesteel, J. & Roth, T. Isolated cataplexy: a familial study. Henry Ford Hosp. Med. J.36, 24–27 (1988). CASPubMed Google Scholar
Kishi, Y. et al. Schizophrenia and narcolepsy: a review with a case report. Psychiatry Clin. Neurosci.58, 117–124 (2004). ArticlePubMed Google Scholar
Bassetti, C. L. in Handbook of Clinical Neurology 169–190 (Elsevier, 2014).
Antelmi, E., Pizza, F., Vandi, S. & Plazzi, G. Stereotyped episodes of aphasia and immobility: how cataplexy mimics stroke in an elderly patient. Sleep Med.36, 122–124 (2017). ArticleCASPubMed Google Scholar
Leu-Semenscu, S. et al. Hallucinations in narcolepsy with and without cataplexy: contrasts with Parkinson’s disease. Sleep Med.12, 497–504 (2011). Article Google Scholar
Cheyne, J. A., Newby-Clark, I. R. & Rueffer, S. D. Relations among hypnagogic and hypnopompic experiences associated with sleep paralysis. J. Sleep Res.8, 313–318 (1999). ArticleCASPubMed Google Scholar
Dahmen, N., Kasten, M., Müller, M. J. & Mittag, K. Frequency and dependence on body posture of hallucinations and sleep paralysis in a community sample. J. Sleep Res.11, 179–180 (2002). ArticlePubMed Google Scholar
Ohayon, M. M. & Smirne, S. Prevalence and consequences of insomnia disorders in the general population of Italy. Sleep Med.3, 115–120 (2002). ArticlePubMed Google Scholar
Kallweit, U., Schmidt, M. & Bassetti, C. L. Patient-reported measures of narcolepsy: the need for better assessment. J. Clin. Sleep Med.13, 737–744 (2017). ArticlePubMedPubMed Central Google Scholar
Sturzenegger, C. et al. Swiss Narcolepsy Scale: a simple screening tool for hypocretin-deficient narcolepsy with cataplexy. Clin. Transl Neurosci.2, 1–5 (2018). Article Google Scholar
Aldrich, M. S., Chervin, R. D. & Malow, B. A. Value of the multiple sleep latency test (MSLT) for the diagnosis of narcolepsy. Sleep20, 620–629 (1997). CASPubMed Google Scholar
Dauvilliers, Y. et al. Effect of age on MSLT results in patients with narcolepsy-cataplexy. Neurology62, 46–50 (2004). ArticleCASPubMed Google Scholar
Singh, M., Drake, C. L. & Roth, T. The prevalence of multiple sleep-onset REM periods in a population-based sample. Sleep29, 890–895 (2016). Article Google Scholar
Huang, Y. S. et al. Multiple sleep latency test in narcolepsy type 1 and narcolepsy type 2: a 5-year follow-up study. J. Sleep Res.27, e12700 (2018). ArticlePubMed Google Scholar
Marti, I., Valko, P. O., Khatami, R., Bassetti, C. L. & Baumann, C. R. Multiple sleep latency measures in narcolepsy and behaviourally insufficient sleep syndrome. Sleep Med.10, 1146–1150 (2009). ArticlePubMed Google Scholar
Drakatos, P. et al. First rapid eye movement sleep periods and sleep-onset rapid eye movement periods in sleep-stage sequencing of hypersomnias. Sleep Med.14, 897–901 (2013). ArticlePubMed Google Scholar
Cairns, A. & Bogan, R. Prevalence and clinical correlates of a short onset REM period (SOREMP) during routine PSG. Sleep38, 1575–1581 (2015). ArticlePubMedPubMed Central Google Scholar
Pizza, F. et al. Spectral electroencephalography profile of rapid eye movement sleep at sleep onset in narcolepsy type 1. Eur. J. Neurol.24, 334–340 (2017). ArticleCASPubMed Google Scholar
Sakai, N., Mastsumura, M., Lin, L., Mignot, E. & Nishino, S. HPLC analysis of CSF hypocretin-1 in type 1 and 2 narcolepsy. Sci. Rep.9, 477 (2019). ArticlePubMedPubMed CentralCAS Google Scholar
Bassetti, C., Aldrich, M. S. & Quint, D. J. MRI findings in narcolepsy. Sleep20, 630–631 (1997). ArticleCASPubMed Google Scholar
Kaufmann, C., Schuld, A., Pöllmächer, T. & Auer, D. P. Reduced cortical gray matter in narcolepsy: preliminary findings with voxel-based morphometry. Neurology58, 1852–1855 (2002). ArticlePubMed Google Scholar
Overeem, S. et al. Voxel-based morphometry in hypocretin-deficient narcolepsy. Sleep26, 44–46 (2003). PubMed Google Scholar
Poryazova, R. et al. Magnetic resonance spectroscopy in narcolepsy [abstract]. Sleep29, A222 (2006). Google Scholar
Schaer, M., Poryazova, R., Schwartz, S., Bassetti, C. L. & Baumann, C. R. Cortical morphometry in narcolepsy with cataplexy. J. Sleep Res.21, 487–494 (2012). ArticlePubMed Google Scholar
Schwartz, S. et al. Abnormal activity in hypothalamus and amygdala during humour processing in human narcolepsy with cataplexy. Brain131, 514–522 (2008). ArticlePubMed Google Scholar
Siegel, J. M. et al. Neuronal-activity in narcolepsy: Identification of cataplexy-related cells in the medial medulla. Science252, 1315–1318 (1991). ArticleCASPubMedPubMed Central Google Scholar
Apergis-Schoute, J. et al. Optogenetic evidence for inhibitory signaling from orexin to MCH neurons via local microcircuits. J. Neurosci.35, 5435–5441 (2015). ArticleCASPubMedPubMed Central Google Scholar
Schöne, C., Apergis-Schoute, J., Sakurai, T., Adamantidis, A. & Burdakov, D. Coreleased orexin and glutamate evoke nonredundant spike outputs and computations in histamine neurons. Cell Rep.7, 697–704 (2014). ArticlePubMedPubMed CentralCAS Google Scholar
van den Top, M., Lee, K., Whyment, A. D., Blanks, A. M. & Spanswick, D. Orexigen-sensitive NPY/AgRP pacemaker neurons in the hypothalamic arcuate nucleus. Nat. Neurosci.7, 493–494 (2004). ArticlePubMedCAS Google Scholar
Belle, M. D. et al. Acute suppressive and long-term phase modulation actions of orexin on the mammalian circadian clock. J. Neurosci.34, 3607–3621 (2014). ArticleCASPubMedPubMed Central Google Scholar
Lee, M. G., Hassani, O. K. & Jones, B. E. Discharge of identified orexin/hypocretin neurons across the sleep-waking cycle. J. Neurosci.25, 6716–6720 (2005). ArticleCASPubMedPubMed Central Google Scholar
Chemelli, R. M. et al. Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation. Cell98, 437–451 (1999). ArticleCASPubMed Google Scholar
Lin, L. et al. The sleep disorder of canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene. Cell98, 365–376 (1999). ArticleCASPubMed Google Scholar
Hasegawa, E., Yanagisawa, M., Sakurai, T. & Mieda, M. Orexin neurons suppress narcolepsy via 2 distinct efferent pathways. J. Clin. Invest.124, 604–616 (2014). ArticleCASPubMedPubMed Central Google Scholar
Irukayama-Tomobe, Y. et al. Nonpeptide orexin type-2 receptor agonist ameliorates narcolepsy-cataplexy symptoms in mouse models. Proc. Natl Acad. Sci. USA114, 5731–5736 (2017). ArticleCASPubMedPubMed Central Google Scholar
Kaushik, M. K. et al. Continuous intrathecal orexin delivery inhibits cataplexy in a murine model of narcolepsy. Proc. Natl Acad. Sci. USA115, 6046–6051 (2018). ArticleCASPubMedPubMed Central Google Scholar
Black, S. W. et al. Partial ablation of the orexin field induces a sub-narcoleptic phenotype in a conditional mouse model of orexin neurodegeneration. Sleep41, zsy116 (2018). Article Google Scholar
Lin, J. S. Brain structures and mechanisms involved in the control of cortical activation and wakefulness, with emphasis on posterior hypothalamus and histaminergic neurons. Sleep Med. Rev.4, 471–503 (2000). ArticleCASPubMed Google Scholar
Kanbayashi, T. et al. CSF histamine contents in narcolepsy, idiopathic hypersomnia and obstructive sleep apnea syndrome. Sleep32, 181–187 (2009). ArticlePubMedPubMed Central Google Scholar
Nishino, S. et al. Decreased CSF histamine in narcolepsy with and without low CSF hypocretin-1 in comparison to healthy controls. Sleep32, 175–180 (2009). ArticlePubMedPubMed Central Google Scholar
Bassetti, C. L. et al. Cerebrospinal fluid histamine levels are decreased in patients with narcolepsy and excessive daytime sleepiness of other origin. J. Sleep Res.19, 620–623 (2010). ArticlePubMed Google Scholar
Dauvilliers, Y. et al. Normal cerebrospinal fluid histamine and tele-methylhistamine levels in hypersomnia conditions. Sleep35, 1359–1366 (2012). ArticlePubMedPubMed Central Google Scholar
Lin, J. S. et al. An inverse agonist of the histamine H3 receptor improves wakefulnesss in narcolepsy: studies in orexin−/− mice and patients. Neurobiol. Dis.30, 74–83 (2008). ArticlePubMedCAS Google Scholar
Jordan, W. et al. Prostaglandin D synthase (beta-trace) in healthy human sleep. Sleep27, 867–874 (2004). ArticlePubMed Google Scholar
Jordan, W. et al. Narcolepsy increased L-PGDS (beta-trace) levels correlate with excessive daytime sleepiness but not with cataplexy. J. Neurol.252, 1372–1378 (2005). ArticleCASPubMed Google Scholar
Bassetti, C. L., Hersberger, M. & Baumann, C. R. CSF prostaglandin D synthase is reduced in excessive daytime sleepiness. J. Neurol.253, 1030–1033 (2006). ArticleCASPubMed Google Scholar
Boissard, R. et al. The rat ponto-medullary network responsible for paradoxical sleep onset and maintenance: a combined microinjection and functional neuroanatomical study. Eur. J. Neurosci.16, 1959–1973 (2002). ArticlePubMed Google Scholar
Lu, J., Sherman, D., Devor, M. & Saper, C. B. A putative flip-flop switch for control of REM sleep. Nature441, 589–594 (2006). ArticleCASPubMed Google Scholar
Okura, M., Riehl, J., Mignot, E. & Nishino, S. Sulpiride, a D2/D3 blocker reduces cataplexy but not REM sleep in canine narcolepsy. Neuropsychopharmacology23, 528–538 (2000). ArticleCASPubMed Google Scholar
Vu, M. H., Hurni, C., Mathis, J., Roth, C. & Bassetti, C. L. Selective REM sleep deprivation in narcolepsy. J. Sleep Res.20, 50–56 (2011). ArticlePubMed Google Scholar
Overeem, S., Lammers, G. J. & van Dijk, J. G. Cataplexy: ‘tonic immobility’ rather than ‘REM-sleep atonia’? Sleep Med.3, 471–477 (2002). ArticlePubMed Google Scholar
Hishikawa, Y. et al. Characteristics of REM sleep accompanied by sleep paralysis and hypnagogic hallucinations in narcoleptic patients. Waking Sleeping2, 113–123 (1978). Google Scholar
Terzaghi, M., Ratti, P. L., Manni, F. & Manni, R. Sleep paralysis in narcolepsy: more than just a motor dissociative phenomenon? Neurol. Sci.33, 169–172 (2012). ArticlePubMed Google Scholar
Mahoney, C. E., Agostinelli, L. J., Brooks, J. N., Lowell, B. B. & Scammell, T. E. GABAergic neurons of the central amygdala promote cataplexy. J. Neurosci.37, 3995–4006 (2017). ArticleCASPubMedPubMed Central Google Scholar
Gulyani, S., Wu, M. F., Nienhuis, R., John, J. & Siegel, J. M. Cataplexy-related neurons in the amygdala of the narcoleptic dog. Neuroscience112, 355–365 (2002). ArticleCASPubMed Google Scholar
Burgess, C. R., Oishi, Y., Mochizuki, T., Peever, J. H. & Scammell, T. E. Amygdala lesions reduce cataplexy in orexin knock-out mice. J. Neurosci.33, 9734–9742 (2013). ArticleCASPubMedPubMed Central Google Scholar
Hong, S. B., Tae, W. S. & Joo, E. Y. Cerebral perfusion changes during cataplexy in narcolepsy patients. Neurology66, 1747–1749 (2006). ArticlePubMed Google Scholar
Tucci, V. et al. Emotional information processing in patients with narcolepsy: a psychophysiologic investigation. Sleep26, 558–564 (2003). ArticlePubMed Google Scholar
Khatami, R., Birkmann, S. & Bassetti, C. L. Amygdala dysfunction in narcolepsy-cataplexy. J. Sleep Res.16, 226–229 (2007). ArticlePubMed Google Scholar
Vassalli, A. et al. Electroencephalogram paroxysmal θ characterizes cataplexy in mice and children. Brain136, 1592–1608 (2013). ArticlePubMed Google Scholar
van der Heide, A. et al. Comparing treatment effect measurements in narcolepsy: the sustained attention to response task, Epworth sleepiness scale and maintenance of wakefulness test. Sleep38, 1051–1058 (2015). ArticlePubMedPubMed Central Google Scholar
Bogan, R. et al. Evaluation of quality of life in patients with narcolepsy treated with sodium oxybate: use of the 36-item short-form health survey in a clinical trial. Neurol. Ther.5, 203–213 (2016). ArticlePubMedPubMed Central Google Scholar
Filardi, M. et al. Physical activity and sleep/wake behavior, anthropometric, and metabolic profile in pediatric narcolepsy type 1. Front. Neurol.9, 707 (2018). ArticlePubMedPubMed Central Google Scholar
Hishikawa, Y., Ida, H., Nakai, K. & Kaneko, Z. Treatment of narcolepsy with imipramine (tofranil) and desmethylimipramine (pertofran). J. Neurol. Sci.3, 453–461 (1966). ArticleCASPubMed Google Scholar
Frey, J. & Darbonne, C. Fluoxetine suppresses human cataplexy: a pilot study. Neurology44, 707–709 (1994). ArticleCASPubMed Google Scholar
Kallweit, U. & Bassetti, C. L. Pharmacological management of narcolepsy with and without cataplexy. Expert Opin. Pharmacother.18, 809–817 (2017). ArticleCASPubMed Google Scholar
Broughton, R. et al. Randomized, double blind, placebo-controlled cross-over trial of modafinil in the treatment of excessive daytime sleepiness in narcolepsy. Neurology49, 444–451 (1997). ArticleCASPubMed Google Scholar
US Modafinil in Narcolepsy Multicenter Study Group. Randomized trial of modafinil for the treatment of pathological somnolence in narcolepsy. Ann. Neurol.43, 88–97 (1998). Article Google Scholar
US Xyrem Multicenter Study Group. Sodium oxybate demonstrates long-term efficacy for the treatment of cataplexy in patients with narcolepsy. Sleep Med.5, 119–123 (2004). Article Google Scholar
US Xyrem Multicenter Study Group. A 12-month, open-label, multicenter extension trial of orally administered sodium oxybate for the treatment of narcolepsy. Sleep26, 31–35 (2003). Google Scholar
Dauvilliers, Y. et al. Pitolisant versus placebo or modafinil in patients with narcolepsy: a double-blind, randomised trial. Lancet Neurol.12, 1068–1075 (2013). ArticleCASPubMed Google Scholar
Szakacs, Z. et al. Safety and efficacy of pitolisant on cataplexy in patients with narcolepsy: a randomised, double-blind, placebo-controlled trial. Lancet Neurol.16, 200–207 (2017). ArticleCASPubMed Google Scholar
Thannickal, T. C. et al. Opiates increase the number of hypocretin-producing cells in human and mouse brain and reverse cataplexy in a mouse model of narcolepsy. Sci. Transl Med.10, eaao4953 (2018). ArticlePubMedCASPubMed Central Google Scholar
Harper, J. M. Gelineau’s narcolepsy relieved by opiates. Lancet10, 92 (1981). Article Google Scholar
Fry, J. M., Pressman, M. R., DiPhilippo, M. A. & Forst-Paulus, M. Treatment of narcolepsy with codeine. Sleep9, 269–274 (1986). ArticleCASPubMed Google Scholar
Billiard, M. et al. EFNS guidelines on management of narcolepsy. Eur. J. Neurol.13, 1035–1048 (2006). ArticleCASPubMed Google Scholar
Bogan, R. K., Roth, T., Schwartz, J. & Miloslavsky, M. Time to response with sodium oxybate for the treatment if excessive daytime sleepiness and cataplexy in patients with narcolepsy. J. Clin. Sleep Med.11, 427–432 (2015). PubMedPubMed Central Google Scholar
Ruoff, C. et al. Effect of oral JZP-110 (ADX-N05) on wakefulness and sleepiness in adults with narcolepsy: a phase 2b study. Sleep39, 1379–1387 (2016). ArticlePubMedPubMed Central Google Scholar
Mitler, M. M., Hajdukovic, R. & Erman, M. K. Treatment of narcolepsy with methamphetamine. Sleep16, 306–317 (1993). ArticleCASPubMed Google Scholar
Lehert, P. & Falissard, B. Multiple treatment comparison in narcolepsy: a network meta-analysis. Sleep41, zsy185 (2018). ArticlePubMed Central Google Scholar
Roth, T. et al. Effect of sodium oxybate on disrupted nighttime sleep in patients with narcolepsy. J. Sleep Res.26, 407–414 (2016). ArticlePubMed Google Scholar
Plazzi, G. et al. Treatment of paediatric narcolepsy with sodium oxybate: a double-blind, placebo-controlled, randomised-withdrawal multicentre study and open-label investigation. Lancet Child Adolesc. Health2, 483–494 (2018). ArticlePubMed Google Scholar
Calvo-Ferrandiz, E. & Peraita-Adrados, R. Narcolepsy with cataplexy and pregnancy: a case–control study. J. Sleep Res.27, 268–272 (2017). PubMed Google Scholar
Maurovich-Horvat, E. et al. Narcolepsy and pregnancy: a retrospective European evaluation of 249 pregnancies. J. Sleep Res.22, 496–512 (2013). ArticlePubMed Google Scholar
Dauvilliers, Y., Carlander, B., Rivier, F., Touchon, J. & Tafti, M. Successful management of cataplexy with intravenous immunoglobulins at narcolepsy onset. Ann. Neurol.56, 905–908 (2004). ArticleCASPubMed Google Scholar
Miyata, R., Hayashi, M., Kohyama, J. & Honda, M. Steroid therapy ameliorated cataplexy in three children with recent-onset of narcolepsy. Sleep Med.29, 86–87 (2017). ArticlePubMed Google Scholar
Donjacur, C. E. & Lammers, G. J. A remarkable effect of alemtuzumab in a patient suffering from narcolepsy with cataplexy. J. Sleep Res.21, 479–480 (2012). Article Google Scholar
Liblau, R. S., Vassalli, A., Seifinejad, A. & Tafti, M. Hypocretin (orexin) biology and the pathophysiology of narcolepsy with cataplexy. Lancet Neurol.14, 318–328 (2015). ArticleCASPubMed Google Scholar
Bernard-Valnet, R. et al. CD8 T cell-mediated killing of orexinergic neurons induces a narcolepsy-like phenotype in mice. Proc. Natl Acad. Sci. USA113, 10956–10961 (2016). ArticleCASPubMedPubMed Central Google Scholar
Krahn, L. E., Boeve, B. F., Olson, E. J., Herold, D. L. & Silber, M. H. A standardized test for cataplexy. Sleep Med.1, 125–130 (2000). ArticleCASPubMed Google Scholar
Olsen, A. V. et al. Diagnostic value of sleep stage dissociation as visualized on a 2-dimensional sleep state space in human narcolepsy. J. Neurosci. Methods282, 9–19 (2017). ArticlePubMed Google Scholar
Hirtz, C. et al. From radioimmunoassay to mass spectrometry: a new method to quantify orexin-A (hypocretin-1) in cerebrospinal fluid. Sci. Rep.6, 25162 (2016). ArticleCASPubMedPubMed Central Google Scholar
Stephansen, J. B. et al. Neural network analysis of sleep stages enables efficient diagnosis of narcolepsy. Nat. Commun.9, 5229 (2018). ArticlePubMedPubMed CentralCAS Google Scholar
Rosenberg, R. & Kim, A. Y. The AWAKEN survey: knowledge of narcolepsy among physicians and the general population. Postgrad. Med.126, 78–86 (2014). ArticlePubMed Google Scholar
Maski, K. et al. Listening to the patient voice in narcolepsy: diagnostic delay, disease burden, and treatment efficacy. J. Clin. Sleep Med.13, 419–425 (2017). ArticlePubMedPubMed Central Google Scholar
Chaplin, J. E., Szakács, A. & Hallböök, Darin, T. N. The development of a health-related quality-of-life instrument for young people with narcolepsy: NARQoL-21. Health Qual. Life Outcomes15, 135 (2017). ArticlePubMedPubMed Central Google Scholar
Dauvilliers, Y. et al. Measurement of narcolepsy symptoms: the Narcolepsy Severity Scale. Neurology88, 1358–1365 (2017). ArticlePubMed Google Scholar