p75NTR and the concept of cellular dependence: seeing how the other half die (original) (raw)

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• Published: 15 May 1998
• Xin Ye1,
• Andrea Tasinato1,
• Sabina Sperandio1,
• James JL Wang4,
• Nuria Assa-Munt3 &
• …
• Shahrooz Rabizadeh1,4

Cell Death & Differentiation volume 5, pages 365–371 (1998)Cite this article

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Abstract

Cells depend on specific stimuli, such as trophic factors, for survival and in the absence of such stimuli, undergo apoptosis. How do cells initiate apoptosis in response to the withdrawal of trophic factors or other dependent stimuli? Recent studies of apoptosis induction by neurotrophin withdrawal argue for a novel form of pro-apoptotic signal transduction – `negative signal transduction' – in which the absence of ligand-receptor interaction induces cell death. We have found that the prototype for this form of signaling – the common neurotrophin receptor, p75NTR – creates a state of cellular dependence (or addiction) on neurotrophins, and that this effect requires an `addiction/dependence domain' (ADD) in the intracytoplasmic region of p75NTR. We have recently found other receptors that include dependence domains, arguing that dependence receptors, and their associated dependence domains, may be involved in a rather general mechanism to create cellular states of dependence on trophic factors, cytokines, adhesion, electrical activity and other dependent stimuli.

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Authors and Affiliations

1. Program on Aging, The Burnham Institute, La Jolla, 92037, California, USA
   Dale E Bredesen, Xin Ye, Andrea Tasinato, Sabina Sperandio & Shahrooz Rabizadeh
2. Neuroscience Department, University of California, San Diego, 92093, California, USA
   Dale E Bredesen
3. Structural Biology Program, The Burnham Institute, La Jolla, 92037, California, USA
   Nuria Assa-Munt
4. Interdepartmental Program in Neuroscience, University of California, Los Angeles, 90024, California, USA
   James JL Wang & Shahrooz Rabizadeh

Authors

1. Dale E Bredesen
2. Xin Ye
3. Andrea Tasinato
4. Sabina Sperandio
5. James JL Wang
6. Nuria Assa-Munt
7. Shahrooz Rabizadeh

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Edited by G. Melino

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Bredesen, D., Ye, X., Tasinato, A. et al. p75NTR and the concept of cellular dependence: seeing how the other half die.Cell Death Differ 5, 365–371 (1998). https://doi.org/10.1038/sj.cdd.4400378

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• Received: 13 October 1997
• Revised: 29 January 1998
• Accepted: 09 February 1998
• Published: 15 May 1998
• Issue Date: 01 May 1998
• DOI: https://doi.org/10.1038/sj.cdd.4400378

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