Common neuropeptide Y2 receptor gene variant is protective against obesity among Swedish men (original) (raw)

• World Health Organization. Obesity: Preventing and Managing the Global Epidemic Report 894. World Health Organization, Geneva, Switzerland, 1998.
• Barsh GS, Farooqi IS, O’Rahilly S . Genetics of body-weight regulation. Nature 2000; 404: 644–651.
  Article CAS Google Scholar
• Friedman JM . Modern science versus the stigma of obesity. Nat Med 2004; 10: 563–569.
  Article CAS Google Scholar
• Small CJ, Bloom SR . Gut hormones and the control of appetite. Trends Endocrinol Metab 2004; 15: 259–263.
  Article CAS Google Scholar
• Wynne K, Stanley S, Bloom S . The gut and regulation of body weight. J Clin Endocrinol Metab 2004; 89: 2576–2582.
  Article CAS Google Scholar
• Tatemoto K, Mutt V . Isolation of two novel candidate hormones using a chemical method for finding naturally occurring peptides. Nature 1980; 285: 417–418.
  Article CAS Google Scholar
• Batterham RL, Cowley MA, Small CJ, Herzog H, Cohen MA, Dakin CL et al. Gut hormone PYY (3–36) physiologically inhibits food intake. Nature 2002; 418: 650–654.
  Article CAS Google Scholar
• Batterham RL, Bloom SR . The gut hormone peptide YY regulates appetite. Ann NY Acad Sci 2003; 994: 162–168.
  Article CAS Google Scholar
• Adrian TE, Ferri GL, Bacarese-Hamilton AJ, Fuessl HS, Polak JM, Bloom SR . Human distribution and release of a putative new gut hormone, peptide YY. Gastroenterology 1985; 89: 1070–1077.
  Article CAS Google Scholar
• Grandt D, Schimiczek M, Beglinger C, Layer P, Goebell H, Eysselein VE et al. Two molecular forms of peptide YY (PYY) are abundant in human blood: characterization of a radioimmunoassay recognizing PYY1–36, and PYY3–36. Regul Peptides 1994; 51: 151–159.
  Article CAS Google Scholar
• Mentlein R, Dahms P, Grandt D, Kruger R . Proteolytic processing of neuropeptide Y and peptide YY by dipeptidyl peptidase IV. Regul Peptides 1993; 49: 133–144.
  Article CAS Google Scholar
• Grandt D, Schimiczek M, Rascher W, Feth F, Shively J, Lee TD et al. Neuropeptide Y 3–36 is an endogenous ligand selective for Y2 receptors. Regul Peptides 1996; 67: 33–37.
  Article CAS Google Scholar
• Keire DA, Mannon P, Kobayashi M, Walsh JH, Solomon TE, Reeve Jr JR . Primary structures of PYY, [Pro(34)]PYY, and PYY-(3–36) confer different conformations and receptor selectivity. Am J Physiol Gastrointest Liver Physiol 2000; 279: G126–G131.
  Article CAS Google Scholar
• Ingenhoven N, Eckard CP, Gehlert DR, Beck-Sickinger AG . Molecular characterization of the human neuropeptide Y Y2-receptor. Biochemistry 1999; 38: 6897–6902.
  Article CAS Google Scholar
• Broberger C, Landry M, Wong H, Walsh JN, Hokfelt T . Subtypes Y1 and Y2 of the neuropeptide Y receptor are respectively expressed in pro-opiomelanocortin- and neuropeptide-Y-containing neurons of the rat hypothalamic arcuate nucleus. Neuroendocrinology 1997; 66: 393–408.
  Article CAS Google Scholar
• Batterham RL, Cowley MA, Small CJ, Herzog H, Cohen MA, Dakin CL et al. Comment on: Physiology: does gut hormone PYY3–36 decrease food intake in rodents? Nature 2004; 430: 3–4.
  Article Google Scholar
• Batterham RL, Cohen MA, Ellis SM, Le Roux CW, Withers DJ, Frost GS et al. Inhibition of food intake in obese subjects by peptide YY3–36. N Engl J Med 2003b; 349: 941–948.
  Article CAS Google Scholar
• Hung CC, Pirie F, Luan J, Lank E, Motala A, Yeo GSH et al. Studies of the peptide YY and neuropeptide Y2 receptor genes in relation to human obesity and obesity-related traits. Diabetes 2004; 53: 2461–2466.
  Article CAS Google Scholar
• Cerdá-Reverter JM, Larhammar D . Neuropeptide Y family of peptides: structure, anatomical expression, function, and molecular evolution. Biochem Cell Biol 2000; 78: 371–392.
  Article Google Scholar
• Guo SW, Thompson EA . Performing the exact test of Hardy–Weinberg proportions for multiple alleles. Biometrics 1992; 48: 361–372.
  Article CAS Google Scholar
• Altschul SF, Madden TL, Schäffer AA, Zhang J, Zhang Z, Miller W et al. Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucl Acids Res 1997; 25: 3389–3402.
  Article CAS Google Scholar
• Apweiler R, Bairoch A, Wu CH, Barker WC, Boeckmann B, Ferro S et al. UniProt: the universal protein knowledgebase. Nucl Acids Res 2004; 32: D115–D119.
  Article CAS Google Scholar
• Rice P, Longden I, Bleasby A . EMBOSS: The European Molecular Biology Open Software Suite. Trends Genet 2000; 16: 276–277.
  Article CAS Google Scholar
• Clark JT, Kalra PS, Crowley WR, Kalra SP . Neuropeptide Y and human pancreatic polypeptide stimulate feeding behavior in rats. Endocrinology 1984; 115: 427–429.
  Article CAS Google Scholar
• Goumain M, Voisin T, Lorinet AM, Laburthe M . Identification and distribution of mRNA encoding the Y1, Y2, Y4, and Y5 receptors for peptides of the PP-fold family in the rat intestine and colon. Biochem Biophys Res Commun 1998; 247: 52–56.
  Article CAS Google Scholar
• Pheng LH, Fournier A, Dumont Y, Quirion R, Regoli D . The dog saphenous vein: a sensitive and selective preparation for the Y2 receptor of neuropeptide Y. Eur J Pharmacol 1997; 327: 163–167.
  Article CAS Google Scholar
• Rose PM, Fernandes P, Lynch JS, Frazier ST, Fisher SM, Kodukula K et al. Cloning and functional expression of a cDNA encoding a human type 2 neuropeptide Y receptor. J Biol Chem 1995; 270: 22661–22664.
  Article CAS Google Scholar
• Zukowska-Grojec Z, Karwatowska-Prokopczuk E, Rose W, Rone J, Movafagh S, Ji H et al. Neuropeptide Y: a novel angiogenic factor from the sympathetic nerves and endothelium. Circ Res 1998; 83: 187–195.
  Article CAS Google Scholar
• Michel MC, Beck-Sickinger A, Cox H, Doods HN, Herzog H, Larhammar D et al. XVI International Union of pharmacology recommendations for the nomenclature of neuropeptide Y, peptide YY, and pancreatic polypeptide receptors. Pharmacol Rev 1998; 50: 143–150.
  CAS PubMed Google Scholar
• Csiffary A, Gorcs TJ, Palkovits M . Neuropeptide Y innervation of ACTH-immunoreactive neurons in the arcuate nucleus of rats: a correlated light and electron microscopic double immunolabeling study. Brain Res 1990; 506: 215–222.
  Article CAS Google Scholar
• Cowley MA, Smart JL, Rubinstein M, Cerdan MG, Diano S, Horvath TL et al. Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus. Nature 2001; 411: 480–484.
  Article CAS Google Scholar
• Roseberry AG, Liu H, Jackson AC, Cai X, Friedman JM . Neuropeptide Y-mediated inhibition of proopiomelanocortin neurons in the arcuate nucleus shows enhanced desensitization in ob/ob mice. Neuron 2004; 41: 711–722.
  Article CAS Google Scholar
• Naveilhan P, Hassani H, Canals JM, Ekstrand AJ, Larefalk A, Chhajlani V et al. Normal feeding behavior, body weight and leptin response require the neuropeptide Y Y2 receptor. Nat Med 1999; 5: 1188–1193.
  Article CAS Google Scholar
• Sainsbury A, Schwarzer C, Couzens M, Fetissov S, Furtinger S, Jenkins A et al. Important role of hypothalamic Y2 receptors in body weight regulation revealed in conditional knockout mice. Proc Natl Acad Sci USA 2002; 99: 8938–8943.
  Article CAS Google Scholar
• Herzog H . Neuropeptide Y and energy homeostasis: insights from Y receptor knockout models. Eur J Pharmacol 2003; 480: 21–29.
  Article CAS Google Scholar
• Dumont Y, Martel JC, Fournier A, St-Pierre S, Quirion R . Neuropeptide Y and neuropeptide Y receptor subtypes in brain and peripheral tissues. Prog Neurobiol 1992; 38: 125–167.
  Article CAS Google Scholar
• Narváez JA, Aguirre JA, Fuxe K . Subpicomolar amounts of NPY(13–36) injected into the nucleus tractus solitarius of the rat counteract the cardiovascular responses to L-glutamate. Neurosci Lett 1993; 151: 182–186.
  Article Google Scholar
• Schwertfeger E, Klein T, Vonend O, Oberhauser V, Stegbauer J, Rump LC . Neuropeptide Y inhibits acetylcholine release in human heart atrium by activation of Y2-receptors. Naunyn Schmiedebergs Arch Pharmacol 2004; 369: 455–461.
  Article CAS Google Scholar
• Cartegni L, Wang J, Zhu Z, Zhang MQ, Krainer AR . ESEfinder: a web resource to identify exonic splicing enhancers. Nucl Acids Res 2003; 31: 3568–3571.
  Article CAS Google Scholar
• Snyder EE, Walts B, Pérusse L, Chagnon YC, Weisnagel SJ, Rankinen T et al. The human obesity gene map: the 2003 update. Obes Res 2004; 12: 369–439.
  Article CAS Google Scholar