Expression and Function of Toll-Like Receptors at the Maternal—Fetal Interface (original) (raw)
Romero R., Espinoza J., Goncalves LF, Kusanovic, JP, Friel L., Hassan S. The role of inflammation and infection in preterm birth. Semin Reprod Med. 2007;25:21–39. ArticleCASPubMedPubMed Central Google Scholar
Goldenberg RL, Hauth JC, Andrews WW Intrauterine infection and preterm delivery. N Engl J Med. 2000;342:1500–1507. ArticleCASPubMed Google Scholar
Arechavaleta-Velasco F., Gomez L., Ma Y., et al. Adverse reproductive outcomes in urban women with adeno-associated virus-2 infections in early pregnancy. Hum Reprod. 2008;23:29–36. ArticleCASPubMed Google Scholar
Medzhitov R., Janeway CA Jr. Decoding the patterns of self and nonself by the innate immune system. Science. 2002;296: 298–300. ArticleCASPubMed Google Scholar
Bulmer JN, Morrison L., Longfellow M., Ritson A., Pace D. Granulated lymphocytes in human endometrium: histochemical and immunohistochemical studies. Hum Reprod. 1991;6:791–798. ArticleCASPubMed Google Scholar
Bulmer JN, Pace D., Ritson A. Immunoregulatory cells in human decidua: morphology, immunohistochemistry and function. Reprod Nutr Dev. 1988;28:1599–1613. ArticleCASPubMed Google Scholar
Kammerer U., Schoppet M., McLellan AD, et al. Human decidua contains potent immunostimulatory CD83(+) dendritic cells. Am J Pathol. 2000;157:159–169. ArticleCASPubMedPubMed Central Google Scholar
Kammerer U., Eggert AO, Kapp M., et al. Unique appearance of proliferating antigen-presenting cells expressing DC-SIGN (CD209) in the decidua of early human pregnancy. Am J Pathol. 2003;162:887–896. ArticlePubMedPubMed Central Google Scholar
Medzhitov R., Janeway CA Jr. Innate immunity: the virtues of a nonclonal system of recognition. Cell. 1997;91:295–298. ArticleCASPubMed Google Scholar
Gordon S. Pattern recognition receptors: doubling up for the innate immune response. Cell. 2002;111:927–930. ArticleCASPubMed Google Scholar
Takeda K., Akira S. Roles of Toll-like receptors in innate immune responses. Genes Cells. 2001;6:733–742. ArticleCASPubMed Google Scholar
Zhang G., Ghosh S. Negative regulation of toll-like receptor-mediated signaling by Tollip. JBiol Chem. 2002;277:7059–7065. ArticleCAS Google Scholar
Zhang D., Zhang G., Hayden MS, et al. A toll-like receptor that prevents infection by uropathogenic bacteria. Science. 2004; 303:1522–1526. ArticleCASPubMed Google Scholar
Yarovinsky F., Zhang D., Andersen JF, et al. TLR11 activation of dendritic cells by a protozoan profilin-like protein. Science. 2005;308:1626–1629. ArticleCASPubMed Google Scholar
Poltorak A., He X., Smirnova I., et al. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science. 1998;282:2085–2088. ArticleCASPubMed Google Scholar
Aliprantis AO, Yang RB, Mark MR, et al. Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2. Science. 1999;285:736–739. ArticleCASPubMed Google Scholar
Aliprantis AO, Yang RB, Weiss DS, Godowski P., Zychlinsky A. The apoptotic signaling pathway activated by Toll-like receptor-2. EMBO J. 2000;19:3325–3336. ArticleCASPubMedPubMed Central Google Scholar
Schwandner R., Dziarski R., Wesche H., Rothe M., Kirschning CJ Peptidoglycan- and lipoteichoic acid-induced cell activation is mediated by toll-like receptor 2. J Biol Chem. 1999;274: 17406–17409. ArticleCASPubMed Google Scholar
Krutzik SR, Ochoa MT, Sieling PA, et al. Activation and regulation of Toll-like receptors 2 and 1 in human leprosy. Nat Med. 2003;9:525–532. ArticleCASPubMed Google Scholar
Triantafilou M., Gamper FG, Haston RM, et al. Membrane sorting of toll-like receptor (TLR)-2/6 and TLR2/1 heterodimers at the cell surface determines heterotypic associations with CD36 and intracellular targeting. J Biol Chem. 2006;281:31002–31011. ArticleCASPubMed Google Scholar
Alexopoulou L., Holt AC, Medzhitov R., Flavell RA Recognition of double-stranded RNA and activation of NFkappaB by Toll-like receptor 3. Nature. 2001;413:732–738. ArticleCASPubMed Google Scholar
Diebold SS, Kaisho T., Hemmi H., Akira S., Reis e Sousa C. Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science. 2004;303:1529–1531. ArticleCASPubMed Google Scholar
Heil F., Hemmi H., Hochrein H., et al. Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8. Science. 2004;303:1526–1529. ArticleCASPubMed Google Scholar
Hemmi H., Takeuchi O., Kawai T., et al. A Toll-like receptor recognizes bacterial DNA. Nature. 2000;408:740–745. ArticleCASPubMed Google Scholar
Hochrein H., Schlatter B., O’Keeffe M., et al. Herpes simplex virus type-1 induces IFN-alpha production via Toll-like receptor 9-dependent and -independent pathways. Proc Natl Acad Sci USA. 2004;101:11416–11421. ArticleCASPubMedPubMed Central Google Scholar
Lund J., Sato A., Akira S., Medzhitov R., Iwasaki A. Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells. J Exp Med. 2003;198:513–520. ArticleCASPubMedPubMed Central Google Scholar
Frantz S., Kelly RA, Bourcier T. Role of TLR-2 in the activation of nuclear factor kappaB by oxidative stress in cardiac myocytes. J Biol Chem. 2001;276:5197–5203. ArticleCASPubMed Google Scholar
Park JS, Svetkauskaite D., He Q., et al. Involvement of toll-like receptors 2 and 4 in cellular activation by high mobility group box 1 protein. J Biol Chem. 2004;279:7370–7377. ArticleCASPubMed Google Scholar
Guillot L., Balloy V., McCormack FX, Golenbock DT, Chignard M., Si-Tahar M. Cutting edge: the immunostimulatory activity of the lung surfactant protein-A involves Toll-like receptor 4. J Immunol. 2002;168:5989–5992. ArticleCASPubMed Google Scholar
Smiley ST, King JA, Hancock WW Fibrinogen stimulates macrophage chemokine secretion through toll-like receptor 4. J Immunol. 2001;167:2887–2894. ArticleCASPubMed Google Scholar
Okamura Y., Watari M., Jerud ES, et al. The extra domain A of fibronectin activates Toll-like receptor 4. J Biol Chem. 2001;276:10229–10233. ArticleCASPubMed Google Scholar
Termeer C., Benedix F., Sleeman J., et al. Oligosaccharides of Hyaluronan activate dendritic cells via toll-like receptor 4. J Exp Med. 2002;195:99–111. ArticleCASPubMedPubMed Central Google Scholar
Oppenheim JJ, Yang D. Alarmins: chemotactic activators of immune responses. Curr Opin Immunol. 2005;17:359–365. ArticleCASPubMed Google Scholar
Chen K., Huang J., Gong W., Iribarren P., Dunlop NM, Wang JM Toll-like receptors in inflammation, infection and cancer. Int Immunopharmacol. 2007;7:1271–1285. ArticleCASPubMed Google Scholar
Akira S., Hoshino K. Myeloid differentiation factor 88-dependent and -independent pathways in toll-like receptor signaling. J Infect Dis. 2003;187(Suppl 2):S356–S363. ArticleCASPubMed Google Scholar
Yamamoto M., Sato S., Hemmi H., et al. Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway. Science. 2003;301:640–643. ArticleCASPubMed Google Scholar
Takeuchi O., Hoshino K., Akira S. Cutting edge:TLR2-deficient and MyD88-deficient mice are highly susceptible to Staphylococcus aureus infection. J Immunol. 2000;165:5392–5396. ArticleCASPubMed Google Scholar
Klaffenbach D., Rascher W., Rollinghoff M., Dotsch J., Meissner U., Schnare M. Regulation and signal transduction of toll-like receptors in human chorioncarcinoma cell lines. Am J Reprod Immunol. 2005;53:77–84. ArticleCASPubMed Google Scholar
Mitsunari M., Yoshida S., Shoji T., et al. Macrophage-activating lipopeptide-2 induces cyclooxygenase-2 and prostaglandin E(2) via toll-like receptor 2 in human placental trophoblast cells. J Reprod Immunol. 2006;72:46–59. ArticleCASPubMed Google Scholar
Abrahams VM, Visintin I., Aldo PB, Guller S., Romero R., Mor G. A role for TLRs in the regulation of immune cell migration by first trimester trophoblast cells. J Immunol. 2005;175: 8096–8104. ArticleCASPubMed Google Scholar
Abrahams VM, Bole-Aldo P., Kim YM, et al. Divergent trophoblast responses to bacterial products mediated by TLRs. J Immunol. 2004;173:4286–4296. ArticleCASPubMed Google Scholar
Beijar EC, Mallard C., Powell TL Expression and subcellular localization of TLR-4 in term and first trimester human placenta. Placenta. 2006;27:322–326. ArticleCASPubMed Google Scholar
Mor G., Romero R., Aldo PB, Abrahams VM Is the trophoblast an immune regulator? The role of Toll-like receptors during pregnancy. Crit Rev Immunol. 2005;25:375–388. ArticleCASPubMed Google Scholar
Kumazaki K., Nakayama M., Yanagihara I., Suehara N., Wada Y. Immunohistochemical distribution of Toll-like receptor 4 in term and preterm human placentas from normal and complicated pregnancy including chorioamnionitis. Hum Pathol. 2004;35:47–54. ArticleCASPubMed Google Scholar
Ma Y., Krikun G., Abrahams VM, Mor G., Guller S. Cell type-specific expression and function of toll-like receptors 2 and 4 in human placenta: implications in fetal infection. Placenta. 2007;28:1024–1031. ArticleCASPubMedPubMed Central Google Scholar
Hirata T., Osuga Y., Hirota Y., et al. Evidence for the presence of toll-like receptor 4 system in the human endometrium. J Clin Endocrinol Metab. 2005;90:548–556. ArticleCASPubMed Google Scholar
Schaefer TM, Desouza K., Fahey JV, Beagley KW, Wira CR Toll-like receptor (TLR) expression and TLR-mediated cytokine/chemokine production by human uterine epithelial cells. Immunology. 2004;112:428–436. ArticleCASPubMedPubMed Central Google Scholar
Young SL, Lyddon TD, Jorgenson RL, Misfeldt ML Expression of Toll-like receptors in human endometrial epithelial cells and cell lines. Am J Reprod Immunol. 2004;52:67–73. ArticlePubMedPubMed Central Google Scholar
Aflatoonian R., Tuckerman E., Elliott SL, et al. Menstrual cycle-dependent changes of Toll-like receptors in endometrium. Hum Reprod. 2007;22:586–593. ArticleCASPubMed Google Scholar
Hirata T., Osuga Y., Hamasaki K., et al. Expression of toll-like receptors 2, 3, 4, and 9 genes in the human endometrium during the menstrual cycle. J Reprod Immunol. 2007;74:53–60. ArticleCASPubMed Google Scholar
Rakoff-Nahoum S., Medzhitov R. Prostaglandin-secreting cells: a portable first aid kit for tissue repair. J Clin Invest. 2007;117:83–86. ArticleCASPubMedPubMed Central Google Scholar
Krikun G., Lockwood CJ, Abrahams VM, Mor G., Paidas M., Guller S. Expression of Toll-like receptors in the human decidua. Histol Histopathol. 2007;22:847–854. CASPubMed Google Scholar
Canavan TP, Simhan HN Innate immune function of the human decidual cell at the maternal-fetal interface. J Reprod Immunol. 2007;74:46–52. ArticleCASPubMed Google Scholar
Sentman CL, Wira CR, Eriksson M. NK cell function in the human female reproductive tract. Am J Reprod Immunol. 2007;57:108–115. ArticleCASPubMed Google Scholar
Chalifour A., Jeannin P., Gauchat JF, et al. Direct bacterial protein PAMP recognition by human NK cells involves TLRs and triggers alpha-defensin production. Blood. 2004;104: 1778–1783. ArticleCASPubMed Google Scholar
Sivori S., Falco M., Della Chiesa M., et al. CpG and double-stranded RNA trigger human NK cells by Toll-like receptors: induction of cytokine release and cytotoxicity against tumors and dendritic cells. Proc Natl Acad Sci USA. 2004;101:10116–10121. ArticleCASPubMedPubMed Central Google Scholar
Hart OM, Athie-Morales V., O’Connor GM, Gardiner CM TLR7/8-mediated activation of human NK cells results in accessory cell-dependent IFN-gamma production. J Immunol. 2005;175:1636–1642. ArticleCASPubMed Google Scholar
Holmlund U., Cebers G., Dahlfors AR, et al. Expression and regulation of the pattern recognition receptors Toll-like receptor-2 and Toll-like receptor-4 in the human placenta. Immunology. 2002;107:145–151. ArticleCASPubMedPubMed Central Google Scholar
Equils O., Lu D., Gatter M., et al. Chlamydia heat shock protein 60 induces trophoblast apoptosis through TLR4. J Immunol. 2006;177:1257–1263. ArticleCASPubMed Google Scholar
Chan G., Guilbert LJ Ultraviolet-inactivated human cytomegalovirus induces placental syncytiotrophoblast apoptosis in a Toll-like receptor-2 and tumour necrosis factor-alpha dependent manner. J Pathol. 2006;210:111–120. ArticleCASPubMed Google Scholar
Kim YM, Romero R., Oh SY, et al. Toll-like receptor 4: a potential link between “danger signals,” the innate immune system, and preeclampsia? Am J Obstet Gynecol. 2005;193:921–927. ArticleCASPubMed Google Scholar
Abrahams VM, Schaefer TM, Fahey JV, et al. Expression and secretion of antiviral factors by trophoblast cells following stimulation by the TLR-3 agonist, Poly(I: C). Hum Reprod. 2006;21:2432–2439. ArticleCASPubMed Google Scholar
Fest S., Aldo PB, Abrahams VM, et al. Trophoblast-macrophage interactions: a regulatory network for the protection of pregnancy. Am J Reprod Immunol. 2007;57:55–66. ArticlePubMed Google Scholar
Wang H., Hirsch E. Bacterially-induced preterm labor and regulation of prostaglandin-metabolizing enzyme expression in mice: the role of toll-like receptor 4. Biol Reprod. 2003; 69:1957–1963. ArticleCASPubMed Google Scholar
Elovitz MA, Wang Z., Chien EK, Rychlik DF, Phillippe M. A new model for inflammation-induced preterm birth: the role of platelet-activating factor and Toll-like receptor-4. Am J Pathol. 2003;163:2103–2111. ArticleCASPubMedPubMed Central Google Scholar
Rounioja S., Rasanen J., Ojaniemi M., Glumoff V., Autio-Harmainen H., Hallman M. Mechanism of acute fetal cardiovascular depression after maternal inflammatory challenge in mouse. Am J Pathol. 2005;166:1585–1592. ArticleCASPubMedPubMed Central Google Scholar
Murphy SP, Fast LD, Hanna NN, Sharma S. Uterine NK cells mediate inflammation-induced fetal demise in IL-10-null mice. J Immunol. 2005;175:4084–4090. ArticleCASPubMed Google Scholar
Robertson SA, Skinner RJ, Care AS Essential role for IL-10 in resistance to lipopolysaccharide-induced preterm labor in mice. J Immunol. 2006;177:4888–4896. ArticleCASPubMed Google Scholar
Elovitz MA, Mrinalini C. Can medroxyprogesterone acetate alter Toll-like receptor expression in a mouse model of intrauterine inflammation? Am J Obstet Gynecol. 2005;193:1149–1155. ArticleCASPubMed Google Scholar
Kajikawa S., Kaga N., Futamura Y., Kakinuma C., Shibutani Y. Lipoteichoic acid induces preterm delivery in mice. J Pharmacol Toxicol Methods. 1998;39:147–154. ArticleCASPubMed Google Scholar
Ilievski V., Lu SJ, Hirsch E. Activation of toll-like receptors 2 or 3 and preterm delivery in the mouse. Reprod Sci. 2007;14:315–320. ArticleCASPubMed Google Scholar
Shimada S., Iwabuchi K., Watano K., et al. Expression of allograft inflammatory factor-1 in mouse uterus and poly(I:C)-induced fetal resorption. Am J Reprod Immunol. 2003;50:104–112. ArticlePubMed Google Scholar
Lin Y., Zeng Y., Di J., Zeng S. Murine CD200+ CK7+ trophoblasts in a poly (I:C)-induced embryo resorption model. Reproduction. 2005;130:529–537. ArticleCASPubMed Google Scholar
Lin Y., Liang Z., Chen Y., Zeng Y. TLR3-involved modulation of pregnancy tolerance in double-stranded RNA-stimulated NOD/SCID mice. J Immunol. 2006;176:4147–4154. ArticleCASPubMed Google Scholar
Lin Y., Zeng Y., Zeng S., Wang T. Potential role of toll-like receptor 3 in a murine model of polyinosinic-polycytidylic acid-induced embryo resorption. Fertil Steril. 2006;85(Suppl 1):1125–1129. ArticleCASPubMed Google Scholar
Zhang J., Wei H., Wu D., Tian Z. Toll-like receptor 3 agonist induces impairment of uterine vascular remodeling and fetal losses in CBA × DBA/2 mice. J Reprod Immunol. 2007;74:61–67. ArticleCASPubMed Google Scholar
Prince LS, Dieperink HI, Okoh VO, Fierro-Perez GA, Lallone RL Toll-like receptor signaling inhibits structural development of the distal fetal mouse lung. Dev Dyn. 2005;233: 553–561. ArticleCASPubMed Google Scholar
Hagberg H., Peebles D., Mallard C. Models of white matter injury: comparison of infectious, hypoxic-ischemic, and excitotoxic insults. Ment Retard Dev Disabil Res Rev. 2002;8:30–38. ArticlePubMed Google Scholar
Shi L., Fatemi SH, Sidwell RW, Patterson PH Maternal influenza infection causes marked behavioral and pharmacological changes in the offspring. J Neurosci. 2003;23:297–302. ArticlePubMedPubMed Central Google Scholar
Patterson PH Neuroscience. Maternal effects on schizophrenia risk. Science. 2007;318:576–577. ArticleCASPubMed Google Scholar
Ciaranello AL, Ciaranello RD The neurobiology of infantile autism. Annu Rev Neurosci. 1995;18:101–128. ArticleCASPubMed Google Scholar
Gilmore JH, Jarskog LF, Vadlamudi S. Maternal poly I:C exposure during pregnancy regulates TNF alpha, BDNF, and NGF expression in neonatal brain and the maternal-fetal unit of the rat. J Neuroimmunol. 2005;159:106–112. ArticleCASPubMed Google Scholar
Kim YM, Romero R., Chaiworapongsa T., Espinoza J., Mor G., Kim CJ Dermatitis as a component of the fetal inflammatory response syndrome is associated with activation of Toll-like receptors in epidermal keratinocytes. Histopathology. 2006;49: 506–514. ArticleCASPubMedPubMed Central Google Scholar
Lotz M., Gutle D., Walther S., Menard S., Bogdan C., Hornef MW Postnatal acquisition of endotoxin tolerance in intestinal epithelial cells. J Exp Med. 2006;203:973–984. ArticleCASPubMedPubMed Central Google Scholar
Manimtim WM, Hasday JD, Hester L., Fairchild KD, Lovchik JC, Viscardi RM Ureaplasma urealyticum modulates endotoxin-induced cytokine release by human monocytes derived from preterm and term newborns and adults. Infect Immun. 2001;69:3906–3915. ArticleCASPubMedPubMed Central Google Scholar
Kim YM, Romero R., Chaiworapongsa T., et al. Toll-like receptor- 2 and -4 in the chorioamniotic membranes in spontaneous labor at term and in preterm parturition that are associated with chorioamnionitis. Am J Obstet Gynecol. 2004;191:1346–1355. ArticleCASPubMed Google Scholar
Rindsjo E., Holmlund U., Sverremark-Ekstrom E., Papadogiannakis N., Scheynius A. Toll-like receptor-2 expression in normal and pathologic human placenta. Hum Pathol. 2007;38:468–473. ArticlePubMedCAS Google Scholar
Adams KM, Lucas J., Kapur RP, Stevens AM LPS induces translocation of TLR4 in amniotic epithelium. Placenta. 2007;28:477–481. ArticleCASPubMed Google Scholar
Wang X., Athayde N., Trudinger B. Placental vascular disease and toll-like receptor 4 gene expression. Am J Obstet Gynecol. 2005;192:961–966. ArticleCASPubMed Google Scholar
Holmlund U., Wahamaa H., Bachmayer N., Bremme K., Sverremark-Ekstrom E., Palmblad K. The novel inflammatory cytokine high mobility group box protein 1 (HMGB1) is expressed by human term placenta. Immunology. 2007;122: 430–437. ArticleCASPubMedPubMed Central Google Scholar
Krediet TG, Wiertsema SP, Vossers MJ, et al. Toll-like receptor 2 polymorphism is associated with preterm birth. Pediatr Res. 2007;62:474–476. ArticleCASPubMed Google Scholar
Lorenz E., Hallman M., Marttila R., Haataja R., Schwartz DA Association between the Asp299Gly polymorphisms in the Toll-like receptor 4 and premature births in the Finnish population. Pediatr Res. 2002;52:373–376. ArticleCASPubMed Google Scholar
Goepfert AR, Varner M., Ward K., et al. Differences in inflammatory cytokine and Toll-like receptor genes and bacterial vaginosis in pregnancy. Am J Obstet Gynecol. 2005;193:1478–1485. ArticleCASPubMed Google Scholar
Genc MR, Vardhana S., Delaney ML, et al. Relationship between a toll-like receptor-4 gene polymorphism, bacterial vaginosisrelated flora and vaginal cytokine responses in pregnant women. Eur J Obstet Gynecol Reprod Biol. 2004;116:152–156. ArticleCASPubMed Google Scholar