APP processing in Alzheimer's disease (original) (raw)
References
Levy-Lahad E, Wasco W, Poorkaj P, Romano DM, Oshima J, Pettingell WH, Yu CE, Jondro PD, Schmidt SD, Wang K, et al: Candidate gene for the chromosome 1 familial Alzheimer's disease locus. Science. 1995, 269: 973-977. 10.1126/science.7638622. CASPubMed Google Scholar
Sherrington R, Rogaev EI, Liang Y, Rogaeva EA, Levesque G, Ikeda M, Chi H, Lin C, Li G, Holman K, et al: Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature. 1995, 375: 754-760. 10.1038/375754a0. CASPubMed Google Scholar
Goate A, Chartier-Harlin MC, Mullan M, Brown J, Crawford F, Fidani L, Giuffra L, Haynes A, Irving N, James L, et al: Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease. Nature. 1991, 349: 704-706. 10.1038/349704a0. CASPubMed Google Scholar
Buee L, Bussiere T, Buee-Scherrer V, Delacourte A, Hof PR: Tau protein isoforms, phosphorylation and role in neurodegenerative disorders. Brain Res Brain Res Rev. 2000, 33: 95-130. 10.1016/S0165-0173(00)00019-9. CASPubMed Google Scholar
Gendron TF, Petrucelli L: The role of tau in neurodegeneration. Mol Neurodegener. 2009, 4: 13-10.1186/1750-1326-4-13. PubMed CentralPubMed Google Scholar
Selkoe DJ: The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer's disease. Trends Cell Biol. 1998, 8: 447-453. 10.1016/S0962-8924(98)01363-4. CASPubMed Google Scholar
Rohan de Silva HA, Jen A, Wickenden C, Jen LS, Wilkinson SL, Patel AJ: Cell-specific expression of beta-amyloid precursor protein isoform mRNAs and proteins in neurons and astrocytes. Brain Res Mol Brain Res. 1997, 47: 147-156. 10.1016/S0169-328X(97)00045-4. CASPubMed Google Scholar
Kang J, Muller-Hill B: Differential splicing of Alzheimer's disease amyloid A4 precursor RNA in rat tissues: PreA4(695) mRNA is predominantly produced in rat and human brain. Biochem Biophys Res Commun. 1990, 166: 1192-1200. 10.1016/0006-291X(90)90992-V. CASPubMed Google Scholar
Menendez-Gonzalez M, Perez-Pinera P, Martinez-Rivera M, Calatayud MT, Blazquez Menes B: APP processing and the APP-KPI domain involvement in the amyloid cascade. Neurodegener Dis. 2005, 2: 277-283. 10.1159/000092315. CASPubMed Google Scholar
Bordji K, Becerril-Ortega J, Nicole O, Buisson A: Activation of extrasynaptic, but not synaptic, NMDA receptors modifies amyloid precursor protein expression pattern and increases amyloid-ss production. J Neurosci. 2010, 30: 15927-15942. 10.1523/JNEUROSCI.3021-10.2010. CASPubMed Google Scholar
Wasco W, Bupp K, Magendantz M, Gusella JF, Tanzi RE, Solomon F: Identification of a mouse brain cDNA that encodes a protein related to the Alzheimer disease-associated amyloid beta protein precursor. Proc Natl Acad Sci USA. 1992, 89: 10758-10762. 10.1073/pnas.89.22.10758. PubMed CentralCASPubMed Google Scholar
Wasco W, Gurubhagavatula S, Paradis MD, Romano DM, Sisodia SS, Hyman BT, Neve RL, Tanzi RE: Isolation and characterization of APLP2 encoding a homologue of the Alzheimer's associated amyloid beta protein precursor. Nat Genet. 1993, 5: 95-100. 10.1038/ng0993-95. CASPubMed Google Scholar
Coulson EJ, Paliga K, Beyreuther K, Masters CL: What the evolution of the amyloid protein precursor supergene family tells us about its function. Neurochem Int. 2000, 36: 175-184. 10.1016/S0197-0186(99)00125-4. CASPubMed Google Scholar
Zheng H, Jiang M, Trumbauer ME, Sirinathsinghji DJ, Hopkins R, Smith DW, Heavens RP, Dawson GR, Boyce S, Conner MW, et al: beta-Amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity. Cell. 1995, 81: 525-531. 10.1016/0092-8674(95)90073-X. CASPubMed Google Scholar
Dawson GR, Seabrook GR, Zheng H, Smith DW, Graham S, O'Dowd G, Bowery BJ, Boyce S, Trumbauer ME, Chen HY, et al: Age-related cognitive deficits, impaired long-term potentiation and reduction in synaptic marker density in mice lacking the beta-amyloid precursor protein. Neuroscience. 1999, 90: 1-13. 10.1016/S0306-4522(98)00410-2. CASPubMed Google Scholar
von Koch CS, Zheng H, Chen H, Trumbauer M, Thinakaran G, van der Ploeg LH, Price DL, Sisodia SS: Generation of APLP2 KO mice and early postnatal lethality in APLP2/APP double KO mice. Neurobiol Aging. 1997, 18: 661-669. 10.1016/S0197-4580(97)00151-6. CASPubMed Google Scholar
Heber S, Herms J, Gajic V, Hainfellner J, Aguzzi A, Rulicke T, von Kretzschmar H, von Koch C, Sisodia S, Tremml P, et al: Mice with combined gene knock-outs reveal essential and partially redundant functions of amyloid precursor protein family members. J Neurosci. 2000, 20: 7951-7963. CASPubMed Google Scholar
Herms J, Anliker B, Heber S, Ring S, Fuhrmann M, Kretzschmar H, Sisodia S, Muller U: Cortical dysplasia resembling human type 2 lissencephaly in mice lacking all three APP family members. Embo J. 2004, 23: 4106-4115. 10.1038/sj.emboj.7600390. PubMed CentralCASPubMed Google Scholar
Zheng H, Koo EH: The amyloid precursor protein: beyond amyloid. Mol Neurodegener. 2006, 1: 5-10.1186/1750-1326-1-5. PubMed CentralPubMed Google Scholar
Lorenzo A, Yuan M, Zhang Z, Paganetti PA, Sturchler-Pierrat C, Staufenbiel M, Mautino J, Vigo FS, Sommer B, Yankner BA: Amyloid beta interacts with the amyloid precursor protein: a potential toxic mechanism in Alzheimer's disease. Nat Neurosci. 2000, 3: 460-464. 10.1038/74833. CASPubMed Google Scholar
Ho A, Sudhof TC: Binding of F-spondin to amyloid-beta precursor protein: a candidate amyloid-beta precursor protein ligand that modulates amyloid-beta precursor protein cleavage. Proc Natl Acad Sci USA. 2004, 101: 2548-2553. 10.1073/pnas.0308655100. PubMed CentralCASPubMed Google Scholar
Lourenco FC, Galvan V, Fombonne J, Corset V, Llambi F, Muller U, Bredesen DE, Mehlen P: Netrin-1 interacts with amyloid precursor protein and regulates amyloid-beta production. Cell Death Differ. 2009, 16: 655-663. 10.1038/cdd.2008.191. PubMed CentralCASPubMed Google Scholar
Yamazaki T, Koo EH, Selkoe DJ: Cell surface amyloid beta-protein precursor colocalizes with beta 1 integrins at substrate contact sites in neural cells. J Neurosci. 1997, 17: 1004-1010. CASPubMed Google Scholar
Wang Y, Ha Y: The X-ray structure of an antiparallel dimer of the human amyloid precursor protein E2 domain. Mol Cell. 2004, 15: 343-353. 10.1016/j.molcel.2004.06.037. CASPubMed Google Scholar
Soba P, Eggert S, Wagner K, Zentgraf H, Siehl K, Kreger S, Lower A, Langer A, Merdes G, Paro R, et al: Homo- and heterodimerization of APP family members promotes intercellular adhesion. Embo J. 2005, 24: 3624-3634. 10.1038/sj.emboj.7600824. PubMed CentralCASPubMed Google Scholar
Kamal A, Stokin GB, Yang Z, Xia CH, Goldstein LS: Axonal transport of amyloid precursor protein is mediated by direct binding to the kinesin light chain subunit of kinesin-I. Neuron. 2000, 28: 449-459. 10.1016/S0896-6273(00)00124-0. CASPubMed Google Scholar
Kamal A, Almenar-Queralt A, LeBlanc JF, Roberts EA, Goldstein LS: Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP. Nature. 2001, 414: 643-648. 10.1038/414643a. CASPubMed Google Scholar
Lazarov O, Morfini GA, Lee EB, Farah MH, Szodorai A, DeBoer SR, Koliatsos VE, Kins S, Lee VM, Wong PC, et al: Axonal transport, amyloid precursor protein, kinesin-1, and the processing apparatus: revisited. J Neurosci. 2005, 25: 2386-2395. 10.1523/JNEUROSCI.3089-04.2005. CASPubMed Google Scholar
Liu Y, Zhang YW, Wang X, Zhang H, You X, Liao FF, Xu H: Intracellular trafficking of presenilin 1 is regulated by beta-amyloid precursor protein and phospholipase D1. J Biol Chem. 2009, 284: 12145-12152. 10.1074/jbc.M808497200. PubMed CentralCASPubMed Google Scholar
Satpute-Krishnan P, DeGiorgis JA, Bearer EL: Fast anterograde transport of herpes simplex virus: role for the amyloid precursor protein of alzheimer's disease. Aging Cell. 2003, 2: 305-318. 10.1046/j.1474-9728.2003.00069.x. PubMed CentralCASPubMed Google Scholar
Satpute-Krishnan P, DeGiorgis JA, Conley MP, Jang M, Bearer EL: A peptide zipcode sufficient for anterograde transport within amyloid precursor protein. Proc Natl Acad Sci USA. 2006, 103: 16532-16537. 10.1073/pnas.0607527103. PubMed CentralCASPubMed Google Scholar
Salehi A, Delcroix JD, Belichenko PV, Zhan K, Wu C, Valletta JS, Takimoto-Kimura R, Kleschevnikov AM, Sambamurti K, Chung PP, et al: Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration. Neuron. 2006, 51: 29-42. 10.1016/j.neuron.2006.05.022. CASPubMed Google Scholar
Wang B, Yang L, Wang Z, Zheng H: Amyolid precursor protein mediates presynaptic localization and activity of the high-affinity choline transporter. Proc Natl Acad Sci USA. 2007, 104: 14140-14145. 10.1073/pnas.0704070104. PubMed CentralCASPubMed Google Scholar
Xu H, Sweeney D, Wang R, Thinakaran G, Lo AC, Sisodia SS, Greengard P, Gandy S: Generation of Alzheimer beta-amyloid protein in the trans-Golgi network in the apparent absence of vesicle formation. Proc Natl Acad Sci USA. 1997, 94: 3748-3752. 10.1073/pnas.94.8.3748. PubMed CentralCASPubMed Google Scholar
Hartmann T, Bieger SC, Bruhl B, Tienari PJ, Ida N, Allsop D, Roberts GW, Masters CL, Dotti CG, Unsicker K, et al: Distinct sites of intracellular production for Alzheimer's disease A beta40/42 amyloid peptides. Nat Med. 1997, 3: 1016-1020. 10.1038/nm0997-1016. CASPubMed Google Scholar
Greenfield JP, Tsai J, Gouras GK, Hai B, Thinakaran G, Checler F, Sisodia SS, Greengard P, Xu H: Endoplasmic reticulum and trans-Golgi network generate distinct populations of Alzheimer beta-amyloid peptides. Proc Natl Acad Sci USA. 1999, 96: 742-747. 10.1073/pnas.96.2.742. PubMed CentralCASPubMed Google Scholar
Sisodia SS: Beta-amyloid precursor protein cleavage by a membrane-bound protease. Proc Natl Acad Sci USA. 1992, 89: 6075-6079. 10.1073/pnas.89.13.6075. PubMed CentralCASPubMed Google Scholar
Nordstedt C, Caporaso GL, Thyberg J, Gandy SE, Greengard P: Identification of the Alzheimer beta/A4 amyloid precursor protein in clathrin-coated vesicles purified from PC12 cells. J Biol Chem. 1993, 268: 608-612. CASPubMed Google Scholar
Caporaso GL, Takei K, Gandy SE, Matteoli M, Mundigl O, Greengard P, De Camilli P: Morphologic and biochemical analysis of the intracellular trafficking of the Alzheimer beta/A4 amyloid precursor protein. J Neurosci. 1994, 14: 3122-3138. CASPubMed Google Scholar
Haass C, Hung AY, Schlossmacher MG, Teplow DB, Selkoe DJ: beta-Amyloid peptide and a 3-kDa fragment are derived by distinct cellular mechanisms. J Biol Chem. 1993, 268: 3021-3024. CASPubMed Google Scholar
Haass C, Hung AY, Schlossmacher MG, Oltersdorf T, Teplow DB, Selkoe DJ: Normal cellular processing of the beta-amyloid precursor protein results in the secretion of the amyloid beta peptide and related molecules. Ann N Y Acad Sci. 1993, 695: 109-116. 10.1111/j.1749-6632.1993.tb23037.x. CASPubMed Google Scholar
Furukawa K, Sopher BL, Rydel RE, Begley JG, Pham DG, Martin GM, Fox M, Mattson MP: Increased activity-regulating and neuroprotective efficacy of alpha-secretase-derived secreted amyloid precursor protein conferred by a C-terminal heparin-binding domain. J Neurochem. 1996, 67: 1882-1896. 10.1046/j.1471-4159.1996.67051882.x. CASPubMed Google Scholar
Mattson MP: Cellular actions of beta-amyloid precursor protein and its soluble and fibrillogenic derivatives. Physiol Rev. 1997, 77: 1081-1132. CASPubMed Google Scholar
Han P, Dou F, Li F, Zhang X, Zhang YW, Zheng H, Lipton SA, Xu H, Liao FF: Suppression of cyclin-dependent kinase 5 activation by amyloid precursor protein: a novel excitoprotective mechanism involving modulation of tau phosphorylation. J Neurosci. 2005, 25: 11542-11552. 10.1523/JNEUROSCI.3831-05.2005. CASPubMed Google Scholar
Roberts SB, Ripellino JA, Ingalls KM, Robakis NK, Felsenstein KM: Non-amyloidogenic cleavage of the beta-amyloid precursor protein by an integral membrane metalloendopeptidase. J Biol Chem. 1994, 269: 3111-3116. CASPubMed Google Scholar
Black RA, Rauch CT, Kozlosky CJ, Peschon JJ, Slack JL, Wolfson MF, Castner BJ, Stocking KL, Reddy P, Srinivasan S, et al: A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells. Nature. 1997, 385: 729-733. 10.1038/385729a0. CASPubMed Google Scholar
Buxbaum JD, Liu KN, Luo Y, Slack JL, Stocking KL, Peschon JJ, Johnson RS, Castner BJ, Cerretti DP, Black RA: Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor. J Biol Chem. 1998, 273: 27765-27767. 10.1074/jbc.273.43.27765. CASPubMed Google Scholar
Blacker M, Noe MC, Carty TJ, Goodyer CG, LeBlanc AC: Effect of tumor necrosis factor-alpha converting enzyme (TACE) and metalloprotease inhibitor on amyloid precursor protein metabolism in human neurons. J Neurochem. 2002, 83: 1349-1357. 10.1046/j.1471-4159.2002.01228.x. CASPubMed Google Scholar
Kuhn PH, Wang H, Dislich B, Colombo A, Zeitschel U, Ellwart JW, Kremmer E, Rossner S, Lichtenthaler SF: ADAM10 is the physiologically relevant, constitutive alpha-secretase of the amyloid precursor protein in primary neurons. Embo J. 2010, 29: 3020-3032. 10.1038/emboj.2010.167. PubMed CentralCASPubMed Google Scholar
Merlos-Suarez A, Ruiz-Paz S, Baselga J, Arribas J: Metalloprotease-dependent protransforming growth factor-alpha ectodomain shedding in the absence of tumor necrosis factor-alpha-converting enzyme. J Biol Chem. 2001, 276: 48510-48517. CASPubMed Google Scholar
Koike H, Tomioka S, Sorimachi H, Saido TC, Maruyama K, Okuyama A, Fujisawa-Sehara A, Ohno S, Suzuki K, Ishiura S: Membrane-anchored metalloprotease MDC9 has an alpha-secretase activity responsible for processing the amyloid precursor protein. Biochem J. 1999, 343 (Pt 2): 371-375. 10.1042/0264-6021:3430371. PubMed CentralCASPubMed Google Scholar
Lopez-Perez E, Zhang Y, Frank SJ, Creemers J, Seidah N, Checler F: Constitutive alpha-secretase cleavage of the beta-amyloid precursor protein in the furin-deficient LoVo cell line: involvement of the pro-hormone convertase 7 and the disintegrin metalloprotease ADAM10. J Neurochem. 2001, 76: 1532-1539. 10.1046/j.1471-4159.2001.00180.x. CASPubMed Google Scholar
Lammich S, Kojro E, Postina R, Gilbert S, Pfeiffer R, Jasionowski M, Haass C, Fahrenholz F: Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease. Proc Natl Acad Sci USA. 1999, 96: 3922-3927. 10.1073/pnas.96.7.3922. PubMed CentralCASPubMed Google Scholar
Jorissen E, Prox J, Bernreuther C, Weber S, Schwanbeck R, Serneels L, Snellinx A, Craessaerts K, Thathiah A, Tesseur I, et al: The disintegrin/metalloproteinase ADAM10 is essential for the establishment of the brain cortex. J Neurosci. 2010, 30: 4833-4844. 10.1523/JNEUROSCI.5221-09.2010. PubMed CentralCASPubMed Google Scholar
Colciaghi F, Borroni B, Pastorino L, Marcello E, Zimmermann M, Cattabeni F, Padovani A, Di Luca M: [alpha]-Secretase ADAM10 as well as [alpha]APPs is reduced in platelets and CSF of Alzheimer disease patients. Mol Med. 2002, 8: 67-74. PubMed CentralCASPubMed Google Scholar
Tyler SJ, Dawbarn D, Wilcock GK, Allen SJ: alpha- and beta-secretase: profound changes in Alzheimer's disease. Biochem Biophys Res Commun. 2002, 299: 373-376. 10.1016/S0006-291X(02)02635-9. CASPubMed Google Scholar
Caille I, Allinquant B, Dupont E, Bouillot C, Langer A, Muller U, Prochiantz A: Soluble form of amyloid precursor protein regulates proliferation of progenitors in the adult subventricular zone. Development. 2004, 131: 2173-2181. 10.1242/dev.01103. CASPubMed Google Scholar
Ohsawa I, Takamura C, Morimoto T, Ishiguro M, Kohsaka S: Amino-terminal region of secreted form of amyloid precursor protein stimulates proliferation of neural stem cells. Eur J Neurosci. 1999, 11: 1907-1913. 10.1046/j.1460-9568.1999.00601.x. CASPubMed Google Scholar
Ma T, Zhao Y, Kwak YD, Yang Z, Thompson R, Luo Z, Xu H, Liao FF: Statin's excitoprotection is mediated by sAPP and the subsequent attenuation of calpain-induced truncation events, likely via rho-ROCK signaling. J Neurosci. 2009, 29: 11226-11236. 10.1523/JNEUROSCI.6150-08.2009. PubMed CentralCASPubMed Google Scholar
Marcade M, Bourdin J, Loiseau N, Peillon H, Rayer A, Drouin D, Schweighoffer F, Desire L: Etazolate, a neuroprotective drug linking GABA(A) receptor pharmacology to amyloid precursor protein processing. J Neurochem. 2008, 106: 392-404. 10.1111/j.1471-4159.2008.05396.x. CASPubMed Google Scholar
Levites Y, Amit T, Mandel S, Youdim MB: Neuroprotection and neurorescue against Abeta toxicity and PKC-dependent release of nonamyloidogenic soluble precursor protein by green tea polyphenol (-)-epigallocatechin-3-gallate. Faseb J. 2003, 17: 952-954. CASPubMed Google Scholar
Ring S, Weyer SW, Kilian SB, Waldron E, Pietrzik CU, Filippov MA, Herms J, Buchholz C, Eckman CB, Korte M, et al: The secreted beta-amyloid precursor protein ectodomain APPs alpha is sufficient to rescue the anatomical, behavioral, and electrophysiological abnormalities of APP-deficient mice. J Neurosci. 2007, 27: 7817-7826. 10.1523/JNEUROSCI.1026-07.2007. CASPubMed Google Scholar
Sinha S, Anderson JP, Barbour R, Basi GS, Caccavello R, Davis D, Doan M, Dovey HF, Frigon N, Hong J, et al: Purification and cloning of amyloid precursor protein beta-secretase from human brain. Nature. 1999, 402: 537-540. 10.1038/990114. CASPubMed Google Scholar
Vassar R, Bennett BD, Babu-Khan S, Kahn S, Mendiaz EA, Denis P, Teplow DB, Ross S, Amarante P, Loeloff R, et al: Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Science. 1999, 286: 735-741. 10.1126/science.286.5440.735. CASPubMed Google Scholar
Yan R, Bienkowski MJ, Shuck ME, Miao H, Tory MC, Pauley AM, Brashier JR, Stratman NC, Mathews WR, Buhl AE, et al: Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity. Nature. 1999, 402: 533-537. 10.1038/990107. CASPubMed Google Scholar
Lau KF, McLoughlin DM, Standen C, Miller CC: X11 alpha and x11 beta interact with presenilin-1 via their PDZ domains. Mol Cell Neurosci. 2000, 16: 557-565. 10.1006/mcne.2000.0898. CASPubMed Google Scholar
Cai H, Wang Y, McCarthy D, Wen H, Borchelt DR, Price DL, Wong PC: BACE1 is the major beta-secretase for generation of Abeta peptides by neurons. Nat Neurosci. 2001, 4: 233-234. 10.1038/85064. CASPubMed Google Scholar
Creemers JW, Ines Dominguez D, Plets E, Serneels L, Taylor NA, Multhaup G, Craessaerts K, Annaert W, De Strooper B: Processing of beta-secretase by furin and other members of the proprotein convertase family. J Biol Chem. 2001, 276: 4211-4217. 10.1074/jbc.M006947200. CASPubMed Google Scholar
Bennett BD, Denis P, Haniu M, Teplow DB, Kahn S, Louis JC, Citron M, Vassar R: A furin-like convertase mediates propeptide cleavage of BACE, the Alzheimer's beta-secretase. J Biol Chem. 2000, 275: 37712-37717. 10.1074/jbc.M005339200. CASPubMed Google Scholar
Walter J, Fluhrer R, Hartung B, Willem M, Kaether C, Capell A, Lammich S, Multhaup G, Haass C: Phosphorylation regulates intracellular trafficking of beta-secretase. J Biol Chem. 2001, 276: 14634-14641. 10.1074/jbc.M011116200. CASPubMed Google Scholar
Huse JT, Pijak DS, Leslie GJ, Lee VM, Doms RW: Maturation and endosomal targeting of beta-site amyloid precursor protein-cleaving enzyme. The Alzheimer's disease beta-secretase. J Biol Chem. 2000, 275: 33729-33737. 10.1074/jbc.M004175200. CASPubMed Google Scholar
Huse JT, Liu K, Pijak DS, Carlin D, Lee VM, Doms RW: Beta-secretase processing in the trans-Golgi network preferentially generates truncated amyloid species that accumulate in Alzheimer's disease brain. J Biol Chem. 2002, 277: 16278-16284. 10.1074/jbc.M111141200. CASPubMed Google Scholar
He W, Lu Y, Qahwash I, Hu XY, Chang A, Yan R: Reticulon family members modulate BACE1 activity and amyloid-beta peptide generation. Nat Med. 2004, 10: 959-965. 10.1038/nm1088. CASPubMed Google Scholar
Murayama KS, Kametani F, Saito S, Kume H, Akiyama H, Araki W: Reticulons RTN3 and RTN4-B/C interact with BACE1 and inhibit its ability to produce amyloid beta-protein. Eur J Neurosci. 2006, 24: 1237-1244. 10.1111/j.1460-9568.2006.05005.x. PubMed Google Scholar
Shi Q, Prior M, He W, Tang X, Hu X, Yan R: Reduced amyloid deposition in mice overexpressing RTN3 is adversely affected by preformed dystrophic neurites. J Neurosci. 2009, 29: 9163-9173. 10.1523/JNEUROSCI.5741-08.2009. PubMed CentralCASPubMed Google Scholar
He X, Li F, Chang WP, Tang J: GGA proteins mediate the recycling pathway of memapsin 2 (BACE). J Biol Chem. 2005, 280: 11696-11703. 10.1074/jbc.M411296200. CASPubMed Google Scholar
Tesco G, Koh YH, Kang EL, Cameron AN, Das S, Sena-Esteves M, Hiltunen M, Yang SH, Zhong Z, Shen Y, et al: Depletion of GGA3 stabilizes BACE and enhances beta-secretase activity. Neuron. 2007, 54: 721-737. 10.1016/j.neuron.2007.05.012. PubMed CentralCASPubMed Google Scholar
Wahle T, Prager K, Raffler N, Haass C, Famulok M, Walter J: GGA proteins regulate retrograde transport of BACE1 from endosomes to the trans-Golgi network. Mol Cell Neurosci. 2005, 29: 453-461. 10.1016/j.mcn.2005.03.014. CASPubMed Google Scholar
Luo Y, Bolon B, Kahn S, Bennett BD, Babu-Khan S, Denis P, Fan W, Kha H, Zhang J, Gong Y, et al: Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation. Nat Neurosci. 2001, 4: 231-232. 10.1038/85059. CASPubMed Google Scholar
Ohno M, Sametsky EA, Younkin LH, Oakley H, Younkin SG, Citron M, Vassar R, Disterhoft JF: BACE1 deficiency rescues memory deficits and cholinergic dysfunction in a mouse model of Alzheimer's disease. Neuron. 2004, 41: 27-33. 10.1016/S0896-6273(03)00810-9. CASPubMed Google Scholar
Ohno M, Cole SL, Yasvoina M, Zhao J, Citron M, Berry R, Disterhoft JF, Vassar R: BACE1 gene deletion prevents neuron loss and memory deficits in 5XFAD APP/PS1 transgenic mice. Neurobiol Dis. 2007, 26: 134-145. 10.1016/j.nbd.2006.12.008. PubMed CentralCASPubMed Google Scholar
Yang LB, Lindholm K, Yan R, Citron M, Xia W, Yang XL, Beach T, Sue L, Wong P, Price D, et al: Elevated beta-secretase expression and enzymatic activity detected in sporadic Alzheimer disease. Nat Med. 2003, 9: 3-4. 10.1038/nm0103-3. CASPubMed Google Scholar
Johnston JA, Liu WW, Todd SA, Coulson DT, Murphy S, Irvine GB, Passmore AP: Expression and activity of beta-site amyloid precursor protein cleaving enzyme in Alzheimer's disease. Biochem Soc Trans. 2005, 33: 1096-1100. 10.1042/BST20051096. CASPubMed Google Scholar
Dominguez D, Tournoy J, Hartmann D, Huth T, Cryns K, Deforce S, Serneels L, Camacho IE, Marjaux E, Craessaerts K, et al: Phenotypic and biochemical analyses of BACE1- and BACE2-deficient mice. J Biol Chem. 2005, 280: 30797-30806. 10.1074/jbc.M505249200. CASPubMed Google Scholar
Hu X, Hicks CW, He W, Wong P, Macklin WB, Trapp BD, Yan R: Bace1 modulates myelination in the central and peripheral nervous system. Nat Neurosci. 2006, 9: 1520-1525. 10.1038/nn1797. CASPubMed Google Scholar
Willem M, Garratt AN, Novak B, Citron M, Kaufmann S, Rittger A, DeStrooper B, Saftig P, Birchmeier C, Haass C: Control of peripheral nerve myelination by the beta-secretase BACE1. Science. 2006, 314: 664-666. 10.1126/science.1132341. CASPubMed Google Scholar
Vassar R, Kovacs DM, Yan R, Wong PC: The beta-secretase enzyme BACE in health and Alzheimer's disease: regulation, cell biology, function, and therapeutic potential. J Neurosci. 2009, 29: 12787-12794. 10.1523/JNEUROSCI.3657-09.2009. PubMed CentralCASPubMed Google Scholar
Solans A, Estivill X, de La Luna S: A new aspartyl protease on 21q22.3, BACE2, is highly similar to Alzheimer's amyloid precursor protein beta-secretase. Cytogenet Cell Genet. 2000, 89: 177-184. 10.1159/000015608. CASPubMed Google Scholar
Hussain I, Powell DJ, Howlett DR, Chapman GA, Gilmour L, Murdock PR, Tew DG, Meek TD, Chapman C, Schneider K, et al: ASP1 (BACE2) cleaves the amyloid precursor protein at the beta-secretase site. Mol Cell Neurosci. 2000, 16: 609-619. 10.1006/mcne.2000.0884. CASPubMed Google Scholar
Bennett BD, Babu-Khan S, Loeloff R, Louis JC, Curran E, Citron M, Vassar R: Expression analysis of BACE2 in brain and peripheral tissues. J Biol Chem. 2000, 275: 20647-20651. 10.1074/jbc.M002688200. CASPubMed Google Scholar
Yan R, Munzner JB, Shuck ME, Bienkowski MJ: BACE2 functions as an alternative alpha-secretase in cells. J Biol Chem. 2001, 276: 34019-34027. 10.1074/jbc.M105583200. CASPubMed Google Scholar
Hook V, Toneff T, Bogyo M, Greenbaum D, Medzihradszky KF, Neveu J, Lane W, Hook G, Reisine T: Inhibition of cathepsin B reduces beta-amyloid production in regulated secretory vesicles of neuronal chromaffin cells: evidence for cathepsin B as a candidate beta-secretase of Alzheimer's disease. Biol Chem. 2005, 386: 931-940. 10.1515/BC.2005.108. CASPubMed Google Scholar
Hook VY, Kindy M, Reinheckel T, Peters C, Hook G: Genetic cathepsin B deficiency reduces beta-amyloid in transgenic mice expressing human wild-type amyloid precursor protein. Biochem Biophys Res Commun. 2009, 386: 284-288. 10.1016/j.bbrc.2009.05.131. PubMed CentralCASPubMed Google Scholar
Nikolaev A, McLaughlin T, O'Leary DD, Tessier-Lavigne M: APP binds DR6 to trigger axon pruning and neuron death via distinct caspases. Nature. 2009, 457: 981-989. 10.1038/nature07767. PubMed CentralCASPubMed Google Scholar
Li H, Wang B, Wang Z, Guo Q, Tabuchi K, Hammer RE, Sudhof TC, Zheng H: Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APP. Proc Natl Acad Sci USA. 2010, 107: 17362-17367. 10.1073/pnas.1012568107. PubMed CentralCASPubMed Google Scholar
Yankner BA, Dawes LR, Fisher S, Villa-Komaroff L, Oster-Granite ML, Neve RL: Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer's disease. Science. 1989, 245: 417-420. 10.1126/science.2474201. CASPubMed Google Scholar
Oster-Granite ML, McPhie DL, Greenan J, Neve RL: Age-dependent neuronal and synaptic degeneration in mice transgenic for the C terminus of the amyloid precursor protein. J Neurosci. 1996, 16: 6732-6741. CASPubMed Google Scholar
Zhao G, Mao G, Tan J, Dong Y, Cui MZ, Kim SH, Xu X: Identification of a new presenilin-dependent zeta-cleavage site within the transmembrane domain of amyloid precursor protein. J Biol Chem. 2004, 279: 50647-50650. 10.1074/jbc.C400473200. CASPubMed Google Scholar
Zhao G, Tan J, Mao G, Cui MZ, Xu X: The same gamma-secretase accounts for the multiple intramembrane cleavages of APP. J Neurochem. 2007, 100: 1234-1246. 10.1111/j.1471-4159.2006.04302.x. CASPubMed Google Scholar
Sastre M, Steiner H, Fuchs K, Capell A, Multhaup G, Condron MM, Teplow DB, Haass C: Presenilin-dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch. EMBO Rep. 2001, 2: 835-841. 10.1093/embo-reports/kve180. PubMed CentralCASPubMed Google Scholar
Weidemann A, Eggert S, Reinhard FB, Vogel M, Paliga K, Baier G, Masters CL, Beyreuther K, Evin G: A novel epsilon-cleavage within the transmembrane domain of the Alzheimer amyloid precursor protein demonstrates homology with Notch processing. Biochemistry. 2002, 41: 2825-2835. 10.1021/bi015794o. CASPubMed Google Scholar
Kimberly WT, LaVoie MJ, Ostaszewski BL, Ye W, Wolfe MS, Selkoe DJ: Gamma-secretase is a membrane protein complex comprised of presenilin, nicastrin, Aph-1, and Pen-2. Proc Natl Acad Sci USA. 2003, 100: 6382-6387. 10.1073/pnas.1037392100. PubMed CentralCASPubMed Google Scholar
Takasugi N, Tomita T, Hayashi I, Tsuruoka M, Niimura M, Takahashi Y, Thinakaran G, Iwatsubo T: The role of presenilin cofactors in the gamma-secretase complex. Nature. 2003, 422: 438-441. 10.1038/nature01506. CASPubMed Google Scholar
Kim J, Schekman R: The ins and outs of presenilin 1 membrane topology. Proc Natl Acad Sci USA. 2004, 101: 905-906. 10.1073/pnas.0307297101. PubMed CentralCASPubMed Google Scholar
Borchelt DR, Thinakaran G, Eckman CB, Lee MK, Davenport F, Ratovitsky T, Prada CM, Kim G, Seekins S, Yager D, et al: Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo. Neuron. 1996, 17: 1005-1013. 10.1016/S0896-6273(00)80230-5. CASPubMed Google Scholar
Li YM, Lai MT, Xu M, Huang Q, DiMuzio-Mower J, Sardana MK, Shi XP, Yin KC, Shafer JA, Gardell SJ: Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state. Proc Natl Acad Sci USA. 2000, 97: 6138-6143. 10.1073/pnas.110126897. PubMed CentralCASPubMed Google Scholar
Ahn K, Shelton CC, Tian Y, Zhang X, Gilchrist ML, Sisodia SS, Li YM: Activation and intrinsic {gamma}-secretase activity of presenilin 1. Proc Natl Acad Sci USA. 2010 Google Scholar
Luo WJ, Wang H, Li H, Kim BS, Shah S, Lee HJ, Thinakaran G, Kim TW, Yu G, Xu H: PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1. J Biol Chem. 2003, 278: 7850-7854. 10.1074/jbc.C200648200. CASPubMed Google Scholar
Francis R, McGrath G, Zhang J, Ruddy DA, Sym M, Apfeld J, Nicoll M, Maxwell M, Hai B, Ellis MC, et al: aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation. Dev Cell. 2002, 3: 85-97. 10.1016/S1534-5807(02)00189-2. CASPubMed Google Scholar
Goutte C, Tsunozaki M, Hale VA, Priess JR: APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos. Proc Natl Acad Sci USA. 2002, 99: 775-779. 10.1073/pnas.022523499. PubMed CentralCASPubMed Google Scholar
Edbauer D, Winkler E, Regula JT, Pesold B, Steiner H, Haass C: Reconstitution of gamma-secretase activity. Nat Cell Biol. 2003, 5: 486-488. 10.1038/ncb960. CASPubMed Google Scholar
Greenfield JP, Xu H, Greengard P, Gandy S, Seeger M: Generation of the amyloid-beta peptide N terminus in Saccharomyces cerevisiae expressing human Alzheimer's amyloid-beta precursor protein. J Biol Chem. 1999, 274: 33843-33846. 10.1074/jbc.274.48.33843. CASPubMed Google Scholar
Zhou S, Zhou H, Walian PJ, Jap BK: CD147 is a regulatory subunit of the gamma-secretase complex in Alzheimer's disease amyloid beta-peptide production. Proc Natl Acad Sci USA. 2005, 102: 7499-7504. 10.1073/pnas.0502768102. PubMed CentralCASPubMed Google Scholar
Chen F, Hasegawa H, Schmitt-Ulms G, Kawarai T, Bohm C, Katayama T, Gu Y, Sanjo N, Glista M, Rogaeva E, et al: TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity. Nature. 2006, 440: 1208-1212. 10.1038/nature04667. CASPubMed Google Scholar
Vetrivel KS, Gong P, Bowen JW, Cheng H, Chen Y, Carter M, Nguyen PD, Placanica L, Wieland FT, Li YM, et al: Dual roles of the transmembrane protein p23/TMP21 in the modulation of amyloid precursor protein metabolism. Mol Neurodegener. 2007, 2: 4-10.1186/1750-1326-2-4. PubMed CentralPubMed Google Scholar
He G, Luo W, Li P, Remmers C, Netzer WJ, Hendrick J, Bettayeb K, Flajolet M, Gorelick F, Wennogle LP, et al: Gamma-secretase activating protein is a therapeutic target for Alzheimer's disease. Nature. 2010, 467: 95-98. 10.1038/nature09325. PubMed CentralCASPubMed Google Scholar
Cupers P, Bentahir M, Craessaerts K, Orlans I, Vanderstichele H, Saftig P, De Strooper B, Annaert W: The discrepancy between presenilin subcellular localization and gamma-secretase processing of amyloid precursor protein. J Cell Biol. 2001, 154: 731-740. 10.1083/jcb.200104045. PubMed CentralCASPubMed Google Scholar
Kovacs DM, Fausett HJ, Page KJ, Kim TW, Moir RD, Merriam DE, Hollister RD, Hallmark OG, Mancini R, Felsenstein KM, et al: Alzheimer-associated presenilins 1 and 2: neuronal expression in brain and localization to intracellular membranes in mammalian cells. Nat Med. 1996, 2: 224-229. 10.1038/nm0296-224. CASPubMed Google Scholar
Haass C, De Strooper B: The presenilins in Alzheimer's disease--proteolysis holds the key. Science. 1999, 286: 916-919. 10.1126/science.286.5441.916. CASPubMed Google Scholar
Wang R, Tang P, Wang P, Boissy RE, Zheng H: Regulation of tyrosinase trafficking and processing by presenilins: partial loss of function by familial Alzheimer's disease mutation. Proc Natl Acad Sci USA. 2006, 103: 353-358. 10.1073/pnas.0509822102. PubMed CentralCASPubMed Google Scholar
Vetrivel KS, Zhang YW, Xu H, Thinakaran G: Pathological and physiological functions of presenilins. Mol Neurodegener. 2006, 1: 4-10.1186/1750-1326-1-4. PubMed CentralPubMed Google Scholar
Tarassishin L, Yin YI, Bassit B, Li YM: Processing of Notch and amyloid precursor protein by gamma-secretase is spatially distinct. Proc Natl Acad Sci USA. 2004, 101: 17050-17055. 10.1073/pnas.0408007101. PubMed CentralCASPubMed Google Scholar
Kopan R, Schroeter EH, Weintraub H, Nye JS: Signal transduction by activated mNotch: importance of proteolytic processing and its regulation by the extracellular domain. Proc Natl Acad Sci USA. 1996, 93: 1683-1688. 10.1073/pnas.93.4.1683. PubMed CentralCASPubMed Google Scholar
Sardi SP, Murtie J, Koirala S, Patten BA, Corfas G: Presenilin-dependent ErbB4 nuclear signaling regulates the timing of astrogenesis in the developing brain. Cell. 2006, 127: 185-197. 10.1016/j.cell.2006.07.037. CASPubMed Google Scholar
Baek SH, Ohgi KA, Rose DW, Koo EH, Glass CK, Rosenfeld MG: Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein. Cell. 2002, 110: 55-67. 10.1016/S0092-8674(02)00809-7. CASPubMed Google Scholar
Kim HS, Kim EM, Lee JP, Park CH, Kim S, Seo JH, Chang KA, Yu E, Jeong SJ, Chong YH, et al: C-terminal fragments of amyloid precursor protein exert neurotoxicity by inducing glycogen synthase kinase-3beta expression. Faseb J. 2003, 17: 1951-1953. CASPubMed Google Scholar
Pardossi-Piquard R, Petit A, Kawarai T, Sunyach C, Alves da Costa C, Vincent B, Ring S, D'Adamio L, Shen J, Muller U, et al: Presenilin-dependent transcriptional control of the Abeta-degrading enzyme neprilysin by intracellular domains of betaAPP and APLP. Neuron. 2005, 46: 541-554. 10.1016/j.neuron.2005.04.008. CASPubMed Google Scholar
von Rotz RC, Kohli BM, Bosset J, Meier M, Suzuki T, Nitsch RM, Konietzko U: The APP intracellular domain forms nuclear multiprotein complexes and regulates the transcription of its own precursor. J Cell Sci. 2004, 117: 4435-4448. 10.1242/jcs.01323. CASPubMed Google Scholar
Zhang YW, Wang R, Liu Q, Zhang H, Liao FF, Xu H: Presenilin/gamma-secretase-dependent processing of beta-amyloid precursor protein regulates EGF receptor expression. Proc Natl Acad Sci USA. 2007, 104: 10613-10618. 10.1073/pnas.0703903104. PubMed CentralCASPubMed Google Scholar
Liu Q, Zerbinatti CV, Zhang J, Hoe HS, Wang B, Cole SL, Herz J, Muglia L, Bu G: Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1. Neuron. 2007, 56: 66-78. 10.1016/j.neuron.2007.08.008. PubMed CentralCASPubMed Google Scholar
Giliberto L, Zhou D, Weldon R, Tamagno E, De Luca P, Tabaton M, D'Adamio L: Evidence that the Amyloid beta Precursor Protein-intracellular domain lowers the stress threshold of neurons and has a "regulated" transcriptional role. Mol Neurodegener. 2008, 3: 12-10.1186/1750-1326-3-12. PubMed CentralPubMed Google Scholar
Kinoshita A, Whelan CM, Berezovska O, Hyman BT: The gamma secretase-generated carboxyl-terminal domain of the amyloid precursor protein induces apoptosis via Tip60 in H4 cells. J Biol Chem. 2002, 277: 28530-28536. 10.1074/jbc.M203372200. CASPubMed Google Scholar
Tamayev R, Zhou D, D'Adamio L: The interactome of the amyloid beta precursor protein family members is shaped by phosphorylation of their intracellular domains. Mol Neurodegener. 2009, 4: 28-10.1186/1750-1326-4-28. PubMed CentralPubMed Google Scholar
Park SA, Shaked GM, Bredesen DE, Koo EH: Mechanism of cytotoxicity mediated by the C31 fragment of the amyloid precursor protein. Biochem Biophys Res Commun. 2009, 388: 450-455. 10.1016/j.bbrc.2009.08.042. PubMed CentralCASPubMed Google Scholar
Gervais FG, Xu D, Robertson GS, Vaillancourt JP, Zhu Y, Huang J, LeBlanc A, Smith D, Rigby M, Shearman MS, et al: Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation. Cell. 1999, 97: 395-406. 10.1016/S0092-8674(00)80748-5. CASPubMed Google Scholar
Bredesen DE: Neurodegeneration in Alzheimer's disease: caspases and synaptic element interdependence. Mol Neurodegener. 2009, 4: 27-10.1186/1750-1326-4-27. PubMed CentralPubMed Google Scholar
Soriano S, Lu DC, Chandra S, Pietrzik CU, Koo EH: The amyloidogenic pathway of amyloid precursor protein (APP) is independent of its cleavage by caspases. J Biol Chem. 2001, 276: 29045-29050. 10.1074/jbc.M102456200. CASPubMed Google Scholar
Lu DC, Soriano S, Bredesen DE, Koo EH: Caspase cleavage of the amyloid precursor protein modulates amyloid beta-protein toxicity. J Neurochem. 2003, 87: 733-741. 10.1046/j.1471-4159.2003.02059.x. CASPubMed Google Scholar
Galvan V, Gorostiza OF, Banwait S, Ataie M, Logvinova AV, Sitaraman S, Carlson E, Sagi SA, Chevallier N, Jin K, et al: Reversal of Alzheimer's-like pathology and behavior in human APP transgenic mice by mutation of Asp664. Proc Natl Acad Sci USA. 2006, 103: 7130-7135. 10.1073/pnas.0509695103. PubMed CentralCASPubMed Google Scholar
Shankar GM, Walsh DM: Alzheimer's disease: synaptic dysfunction and Abeta. Mol Neurodegener. 2009, 4: 48-10.1186/1750-1326-4-48. PubMed CentralPubMed Google Scholar
Burdick D, Soreghan B, Kwon M, Kosmoski J, Knauer M, Henschen A, Yates J, Cotman C, Glabe C: Assembly and aggregation properties of synthetic Alzheimer's A4/beta amyloid peptide analogs. J Biol Chem. 1992, 267: 546-554. CASPubMed Google Scholar
Scheuner D, Eckman C, Jensen M, Song X, Citron M, Suzuki N, Bird TD, Hardy J, Hutton M, Kukull W, et al: Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. Nat Med. 1996, 2: 864-870. 10.1038/nm0896-864. CASPubMed Google Scholar
Jarrett JT, Berger EP, Lansbury PT: The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease. Biochemistry. 1993, 32: 4693-4697. 10.1021/bi00069a001. CASPubMed Google Scholar
Iwatsubo T, Odaka A, Suzuki N, Mizusawa H, Nukina N, Ihara Y: Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43). Neuron. 1994, 13: 45-53. 10.1016/0896-6273(94)90458-8. CASPubMed Google Scholar
Gouras GK, Tsai J, Naslund J, Vincent B, Edgar M, Checler F, Greenfield JP, Haroutunian V, Buxbaum JD, Xu H, et al: Intraneuronal Abeta42 accumulation in human brain. Am J Pathol. 2000, 156: 15-20. PubMed CentralCASPubMed Google Scholar
Gyure KA, Durham R, Stewart WF, Smialek JE, Troncoso JC: Intraneuronal abeta-amyloid precedes development of amyloid plaques in Down syndrome. Arch Pathol Lab Med. 2001, 125: 489-492. CASPubMed Google Scholar
Mori C, Spooner ET, Wisniewsk KE, Wisniewski TM, Yamaguch H, Saido TC, Tolan DR, Selkoe DJ, Lemere CA: Intraneuronal Abeta42 accumulation in Down syndrome brain. Amyloid. 2002, 9: 88-102. CASPubMed Google Scholar
Oddo S, Caccamo A, Shepherd JD, Murphy MP, Golde TE, Kayed R, Metherate R, Mattson MP, Akbari Y, LaFerla FM: Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction. Neuron. 2003, 39: 409-421. 10.1016/S0896-6273(03)00434-3. CASPubMed Google Scholar
Oddo S, Caccamo A, Smith IF, Green KN, LaFerla FM: A dynamic relationship between intracellular and extracellular pools of Abeta. Am J Pathol. 2006, 168: 184-194. 10.2353/ajpath.2006.050593. PubMed CentralCASPubMed Google Scholar
Oakley H, Cole SL, Logan S, Maus E, Shao P, Craft J, Guillozet-Bongaarts A, Ohno M, Disterhoft J, Van Eldik L, et al: Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation. J Neurosci. 2006, 26: 10129-10140. 10.1523/JNEUROSCI.1202-06.2006. CASPubMed Google Scholar
Espana J, Gimenez-Llort L, Valero J, Minano A, Rabano A, Rodriguez-Alvarez J, LaFerla FM, Saura CA: Intraneuronal beta-amyloid accumulation in the amygdala enhances fear and anxiety in Alzheimer's disease transgenic mice. Biol Psychiatry. 2010, 67: 513-521. 10.1016/j.biopsych.2009.06.015. CASPubMed Google Scholar
Friedrich RP, Tepper K, Ronicke R, Soom M, Westermann M, Reymann K, Kaether C, Fandrich M: Mechanism of amyloid plaque formation suggests an intracellular basis of Abeta pathogenicity. Proc Natl Acad Sci USA. 2010, 107: 1942-1947. 10.1073/pnas.0904532106. PubMed CentralCASPubMed Google Scholar
Seubert P, Vigo-Pelfrey C, Esch F, Lee M, Dovey H, Davis D, Sinha S, Schlossmacher M, Whaley J, Swindlehurst C, et al: Isolation and quantification of soluble Alzheimer's beta-peptide from biological fluids. Nature. 1992, 359: 325-327. 10.1038/359325a0. CASPubMed Google Scholar
Haass C, Schlossmacher MG, Hung AY, Vigo-Pelfrey C, Mellon A, Ostaszewski BL, Lieberburg I, Koo EH, Schenk D, Teplow DB, et al: Amyloid beta-peptide is produced by cultured cells during normal metabolism. Nature. 1992, 359: 322-325. 10.1038/359322a0. CASPubMed Google Scholar
Puzzo D, Privitera L, Leznik E, Fa M, Staniszewski A, Palmeri A, Arancio O: Picomolar amyloid-beta positively modulates synaptic plasticity and memory in hippocampus. J Neurosci. 2008, 28: 14537-14545. 10.1523/JNEUROSCI.2692-08.2008. PubMed CentralCASPubMed Google Scholar
Morley JE, Farr SA, Banks WA, Johnson SN, Yamada KA, Xu L: A physiological role for amyloid-beta protein:enhancement of learning and memory. J Alzheimers Dis. 2010, 19: 441-449. CASPubMed Google Scholar
Plant LD, Boyle JP, Smith IF, Peers C, Pearson HA: The production of amyloid beta peptide is a critical requirement for the viability of central neurons. J Neurosci. 2003, 23: 5531-5535. CASPubMed Google Scholar
Plant LD, Webster NJ, Boyle JP, Ramsden M, Freir DB, Peers C, Pearson HA: Amyloid beta peptide as a physiological modulator of neuronal 'A'-type K+ current. Neurobiol Aging. 2006, 27: 1673-1683. 10.1016/j.neurobiolaging.2005.09.038. CASPubMed Google Scholar
Minniti AN, Rebolledo DL, Grez PM, Fadic R, Aldunate R, Volitakis I, Cherny RA, Opazo C, Masters C, Bush AI, et al: Intracellular amyloid formation in muscle cells of Abeta-transgenic Caenorhabditis elegans: determinants and physiological role in copper detoxification. Mol Neurodegener. 2009, 4: 2-10.1186/1750-1326-4-2. PubMed CentralPubMed Google Scholar
King GD, Scott Turner R: Adaptor protein interactions: modulators of amyloid precursor protein metabolism and Alzheimer's disease risk?. Exp Neurol. 2004, 185: 208-219. 10.1016/j.expneurol.2003.10.011. CASPubMed Google Scholar
Rogelj B, Mitchell JC, Miller CC, McLoughlin DM: The X11/Mint family of adaptor proteins. Brain Res Rev. 2006, 52: 305-315. 10.1016/j.brainresrev.2006.04.005. CASPubMed Google Scholar
Borg JP, Ooi J, Levy E, Margolis B: The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein. Mol Cell Biol. 1996, 16: 6229-6241. PubMed CentralCASPubMed Google Scholar
Borg JP, Yang Y, De Taddeo-Borg M, Margolis B, Turner RS: The X11alpha protein slows cellular amyloid precursor protein processing and reduces Abeta40 and Abeta42 secretion. J Biol Chem. 1998, 273: 14761-14766. 10.1074/jbc.273.24.14761. CASPubMed Google Scholar
Salcini AE, Chen H, Iannolo G, De Camilli P, Di Fiore PP: Epidermal growth factor pathway substrate 15, Eps15. Int J Biochem Cell Biol. 1999, 31: 805-809. 10.1016/S1357-2725(99)00042-4. CASPubMed Google Scholar
Sorkin A: Cargo recognition during clathrin-mediated endocytosis: a team effort. Curr Opin Cell Biol. 2004, 16: 392-399. 10.1016/j.ceb.2004.06.001. CASPubMed Google Scholar
Maldonado-Baez L, Wendland B: Endocytic adaptors: recruiters, coordinators and regulators. Trends Cell Biol. 2006, 16: 505-513. 10.1016/j.tcb.2006.08.001. CASPubMed Google Scholar
Chyung JH, Selkoe DJ: Inhibition of receptor-mediated endocytosis demonstrates generation of amyloid beta-protein at the cell surface. J Biol Chem. 2003, 278: 51035-51043. 10.1074/jbc.M304989200. CASPubMed Google Scholar
Carey RM, Balcz BA, Lopez-Coviella I, Slack BE: Inhibition of dynamin-dependent endocytosis increases shedding of the amyloid precursor protein ectodomain and reduces generation of amyloid beta protein. BMC Cell Biol. 2005, 6: 30-10.1186/1471-2121-6-30. PubMed CentralPubMed Google Scholar
Cai D, Leem JY, Greenfield JP, Wang P, Kim BS, Wang R, Lopes KO, Kim SH, Zheng H, Greengard P, et al: Presenilin-1 regulates intracellular trafficking and cell surface delivery of beta-amyloid precursor protein. J Biol Chem. 2003, 278: 3446-3454. 10.1074/jbc.M209065200. CASPubMed Google Scholar
Dumanchin C, Czech C, Campion D, Cuif MH, Poyot T, Martin C, Charbonnier F, Goud B, Pradier L, Frebourg T: Presenilins interact with Rab11, a small GTPase involved in the regulation of vesicular transport. Hum Mol Genet. 1999, 8: 1263-1269. 10.1093/hmg/8.7.1263. CASPubMed Google Scholar
Scheper W, Zwart R, Sluijs P, Annaert W, Gool WA, Baas F: Alzheimer's presenilin 1 is a putative membrane receptor for rab GDP dissociation inhibitor. Hum Mol Genet. 2000, 9: 303-310. 10.1093/hmg/9.2.303. CASPubMed Google Scholar
Scheper W, Zwart R, Baas F: Rab6 membrane association is dependent of Presenilin 1 and cellular phosphorylation events. Brain Res Mol Brain Res. 2004, 122: 17-23. 10.1016/j.molbrainres.2003.11.013. CASPubMed Google Scholar
Cai D, Netzer WJ, Zhong M, Lin Y, Du G, Frohman M, Foster DA, Sisodia SS, Xu H, Gorelick FS, et al: Presenilin-1 uses phospholipase D1 as a negative regulator of beta-amyloid formation. Proc Natl Acad Sci USA. 2006, 103: 1941-1946. 10.1073/pnas.0510708103. PubMed CentralCASPubMed Google Scholar
Cai D, Zhong M, Wang R, Netzer WJ, Shields D, Zheng H, Sisodia SS, Foster DA, Gorelick FS, Xu H, et al: Phospholipase D1 corrects impaired betaAPP trafficking and neurite outgrowth in familial Alzheimer's disease-linked presenilin-1 mutant neurons. Proc Natl Acad Sci USA. 2006, 103: 1936-1940. 10.1073/pnas.0510710103. PubMed CentralCASPubMed Google Scholar
Scherzer CR, Offe K, Gearing M, Rees HD, Fang G, Heilman CJ, Schaller C, Bujo H, Levey AI, Lah JJ: Loss of apolipoprotein E receptor LR11 in Alzheimer disease. Arch Neurol. 2004, 61: 1200-1205. 10.1001/archneur.61.8.1200. PubMed Google Scholar
Grear KE, Ling IF, Simpson JF, Furman JL, Simmons CR, Peterson SL, Schmitt FA, Markesbery WR, Liu Q, Crook JE, et al: Expression of SORL1 and a novel SORL1 splice variant in normal and Alzheimers disease brain. Mol Neurodegener. 2009, 4: 46-10.1186/1750-1326-4-46. PubMed CentralPubMed Google Scholar
Yamazaki H, Bujo H, Kusunoki J, Seimiya K, Kanaki T, Morisaki N, Schneider WJ, Saito Y: Elements of neural adhesion molecules and a yeast vacuolar protein sorting receptor are present in a novel mammalian low density lipoprotein receptor family member. J Biol Chem. 1996, 271: 24761-24768. 10.1074/jbc.271.11.6483. CASPubMed Google Scholar
Jacobsen L, Madsen P, Moestrup SK, Lund AH, Tommerup N, Nykjaer A, Sottrup-Jensen L, Gliemann J, Petersen CM: Molecular characterization of a novel human hybrid-type receptor that binds the alpha2-macroglobulin receptor-associated protein. J Biol Chem. 1996, 271: 31379-31383. 10.1074/jbc.271.49.31379. CASPubMed Google Scholar
Andersen OM, Reiche J, Schmidt V, Gotthardt M, Spoelgen R, Behlke J, von Arnim CA, Breiderhoff T, Jansen P, Wu X, et al: Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein. Proc Natl Acad Sci USA. 2005, 102: 13461-13466. 10.1073/pnas.0503689102. PubMed CentralCASPubMed Google Scholar
Rogaeva E, Meng Y, Lee JH, Gu Y, Kawarai T, Zou F, Katayama T, Baldwin CT, Cheng R, Hasegawa H, et al: The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease. Nat Genet. 2007, 39: 168-177. 10.1038/ng1943. PubMed CentralCASPubMed Google Scholar
Trommsdorff M, Borg JP, Margolis B, Herz J: Interaction of cytosolic adaptor proteins with neuronal apolipoprotein E receptors and the amyloid precursor protein. J Biol Chem. 1998, 273: 33556-33560. 10.1074/jbc.273.50.33556. CASPubMed Google Scholar
Narita M, Holtzman DM, Schwartz AL, Bu G: Alpha2-macroglobulin complexes with and mediates the endocytosis of beta-amyloid peptide via cell surface low-density lipoprotein receptor-related protein. J Neurochem. 1997, 69: 1904-1911. 10.1046/j.1471-4159.1997.69051904.x. CASPubMed Google Scholar
Deane R, Wu Z, Sagare A, Davis J, Du Yan S, Hamm K, Xu F, Parisi M, LaRue B, Hu HW, et al: LRP/amyloid beta-peptide interaction mediates differential brain efflux of Abeta isoforms. Neuron. 2004, 43: 333-344. 10.1016/j.neuron.2004.07.017. CASPubMed Google Scholar
Ulery PG, Beers J, Mikhailenko I, Tanzi RE, Rebeck GW, Hyman BT, Strickland DK: Modulation of beta-amyloid precursor protein processing by the low density lipoprotein receptor-related protein (LRP). Evidence that LRP contributes to the pathogenesis of Alzheimer's disease. J Biol Chem. 2000, 275: 7410-7415. 10.1074/jbc.275.10.7410. CASPubMed Google Scholar
Zerbinatti CV, Wozniak DF, Cirrito J, Cam JA, Osaka H, Bales KR, Zhuo M, Paul SM, Holtzman DM, Bu G: Increased soluble amyloid-beta peptide and memory deficits in amyloid model mice overexpressing the low-density lipoprotein receptor-related protein. Proc Natl Acad Sci USA. 2004, 101: 1075-1080. 10.1073/pnas.0305803101. PubMed CentralCASPubMed Google Scholar
Cam JA, Zerbinatti CV, Knisely JM, Hecimovic S, Li Y, Bu G: The low density lipoprotein receptor-related protein 1B retains beta-amyloid precursor protein at the cell surface and reduces amyloid-beta peptide production. J Biol Chem. 2004, 279: 29639-29646. 10.1074/jbc.M313893200. CASPubMed Google Scholar
Tang MX, Jacobs D, Stern Y, Marder K, Schofield P, Gurland B, Andrews H, Mayeux R: Effect of oestrogen during menopause on risk and age at onset of Alzheimer's disease. Lancet. 1996, 348: 429-432. 10.1016/S0140-6736(96)03356-9. CASPubMed Google Scholar
Waring SC, Rocca WA, Petersen RC, O'Brien PC, Tangalos EG, Kokmen E: Postmenopausal estrogen replacement therapy and risk of AD: a population-based study. Neurology. 1999, 52: 965-970. CASPubMed Google Scholar
Baldereschi M, Di Carlo A, Lepore V, Bracco L, Maggi S, Grigoletto F, Scarlato G, Amaducci L: Estrogen-replacement therapy and Alzheimer's disease in the Italian Longitudinal Study on Aging. Neurology. 1998, 50: 996-1002. CASPubMed Google Scholar
Paganini-Hill A: Estrogen replacement therapy--something to smile about. Compend Contin Educ Dent Suppl. 1998, S4-8. Google Scholar
Wise PM, Dubal DB, Wilson ME, Rau SW, Bottner M, Rosewell KL: Estradiol is a protective factor in the adult and aging brain: understanding of mechanisms derived from in vivo and in vitro studies. Brain Res Brain Res Rev. 2001, 37: 313-319. 10.1016/S0165-0173(01)00136-9. CASPubMed Google Scholar
Colton CA, Brown CM, Vitek MP: Sex steroids, APOE genotype and the innate immune system. Neurobiol Aging. 2005, 26: 363-372. 10.1016/j.neurobiolaging.2004.08.001. CASPubMed Google Scholar
Ghosh S, Thakur MK: PS1 expression is downregulated by gonadal steroids in adult mouse brain. Neurochem Res. 2008, 33: 365-369. 10.1007/s11064-007-9424-8. CASPubMed Google Scholar
Greenfield JP, Leung LW, Cai D, Kaasik K, Gross RS, Rodriguez-Boulan E, Greengard P, Xu H: Estrogen lowers Alzheimer beta-amyloid generation by stimulating trans-Golgi network vesicle biogenesis. J Biol Chem. 2002, 277: 12128-12136. 10.1074/jbc.M110009200. CASPubMed Google Scholar
Xu H, Gouras GK, Greenfield JP, Vincent B, Naslund J, Mazzarelli L, Fried G, Jovanovic JN, Seeger M, Relkin NR, et al: Estrogen reduces neuronal generation of Alzheimer beta-amyloid peptides. Nat Med. 1998, 4: 447-451. 10.1038/nm0498-447. CASPubMed Google Scholar
Xu H, Wang R, Zhang YW, Zhang X: Estrogen, beta-amyloid metabolism/trafficking, and Alzheimer's disease. Ann N Y Acad Sci. 2006, 1089: 324-342. 10.1196/annals.1386.036. CASPubMed Google Scholar
Zhang S, Huang Y, Zhu YC, Yao T: Estrogen stimulates release of secreted amyloid precursor protein from primary rat cortical neurons via protein kinase C pathway. Acta Pharmacol Sin. 2005, 26: 171-176. 10.1111/j.1745-7254.2005.00538.x. PubMed Google Scholar
Buxbaum JD, Gandy SE, Cicchetti P, Ehrlich ME, Czernik AJ, Fracasso RP, Ramabhadran TV, Unterbeck AJ, Greengard P: Processing of Alzheimer beta/A4 amyloid precursor protein: modulation by agents that regulate protein phosphorylation. Proc Natl Acad Sci USA. 1990, 87: 6003-6006. 10.1073/pnas.87.15.6003. PubMed CentralCASPubMed Google Scholar
Caporaso GL, Gandy SE, Buxbaum JD, Ramabhadran TV, Greengard P: Protein phosphorylation regulates secretion of Alzheimer beta/A4 amyloid precursor protein. Proc Natl Acad Sci USA. 1992, 89: 3055-3059. 10.1073/pnas.89.7.3055. PubMed CentralCASPubMed Google Scholar
Gillespie SL, Golde TE, Younkin SG: Secretory processing of the Alzheimer amyloid beta/A4 protein precursor is increased by protein phosphorylation. Biochem Biophys Res Commun. 1992, 187: 1285-1290. 10.1016/0006-291X(92)90442-N. CASPubMed Google Scholar
Hung AY, Haass C, Nitsch RM, Qiu WQ, Citron M, Wurtman RJ, Growdon JH, Selkoe DJ: Activation of protein kinase C inhibits cellular production of the amyloid beta-protein. J Biol Chem. 1993, 268: 22959-22962. CASPubMed Google Scholar
Gandy S, Czernik AJ, Greengard P: Phosphorylation of Alzheimer disease amyloid precursor peptide by protein kinase C and Ca2+/calmodulin-dependent protein kinase II. Proc Natl Acad Sci USA. 1988, 85: 6218-6221. 10.1073/pnas.85.16.6218. PubMed CentralCASPubMed Google Scholar
Xu H, Sweeney D, Greengard P, Gandy S: Metabolism of Alzheimer beta-amyloid precursor protein: regulation by protein kinase A in intact cells and in a cell-free system. Proc Natl Acad Sci USA. 1996, 93: 4081-4084. 10.1073/pnas.93.9.4081. PubMed CentralCASPubMed Google Scholar
Driscoll I, Resnick SM: Testosterone and cognition in normal aging and Alzheimer's disease: an update. Curr Alzheimer Res. 2007, 4: 33-45. 10.2174/156720507779939878. CASPubMed Google Scholar
Goodenough S, Engert S, Behl C: Testosterone stimulates rapid secretory amyloid precursor protein release from rat hypothalamic cells via the activation of the mitogen-activated protein kinase pathway. Neurosci Lett. 2000, 296: 49-52. 10.1016/S0304-3940(00)01622-0. CASPubMed Google Scholar
Gouras GK, Xu H, Gross RS, Greenfield JP, Hai B, Wang R, Greengard P: Testosterone reduces neuronal secretion of Alzheimer's beta-amyloid peptides. Proc Natl Acad Sci USA. 2000, 97: 1202-1205. 10.1073/pnas.97.3.1202. PubMed CentralCASPubMed Google Scholar
McAllister C, Long J, Bowers A, Walker A, Cao P, Honda S, Harada N, Staufenbiel M, Shen Y, Li R: Genetic targeting aromatase in male amyloid precursor protein transgenic mice down-regulates beta-secretase (BACE1) and prevents Alzheimer-like pathology and cognitive impairment. J Neurosci. 2010, 30: 7326-7334. 10.1523/JNEUROSCI.1180-10.2010. PubMed CentralCASPubMed Google Scholar