Testosterone increases analgesia, anxiolysis, and cognitive performance of male rats (original) (raw)

References

• Astur, R. S., Ortiz, M. L., & Sutherland, R. J. (1998). A characterization of performance by men and women in a virtual Morris water task: A large and reliable sex difference. Behavioural Brain Research, 93, 185–190.
  Article PubMed Google Scholar
• Bardo, M. T., & Valone, M. J. (1994). Morphine-conditioned analgesia using a taste cue dissociation of taste aversion and analgesia. Psychopharmacology, 114, 269–274.
  Article PubMed Google Scholar
• Beatty, W. W. (1984). Hormonal organization of sex differences in play fighting and spatial behavior. Progress in Brain Research, 61, 315–330.
  Article PubMed Google Scholar
• Bitran, D., Kellogg, C. K., & Hilvers, R. J. (1993). Treatment with an anabolic-androgenic steroid affects anxiety-related behavior and alters the sensitivity of cortical GABAA receptors in the rat. Hormones & Behavior, 27, 568–583.
  Article Google Scholar
• Boissy, A., & Bouissou, M. F. (1994). Effects of androgen treatment on behavioral and physiological responses of heifers to fear-eliciting situations. Hormones & Behavior, 28, 66–83.
  Article Google Scholar
• Bradley, D. R., & Wygant, C. R. (1998). Male and female differences in anxiety about statistics are not reflected in performance. Psychological Reports, 82, 245–246.
  Article PubMed Google Scholar
• Brudzynski, S. M., & Krol, S. (1997). Analysis of locomotor activity in the rat: Parallelism index, a new measure of locomotor exploratory pattern. Physiology & Behavior, 62, 635–642.
  Article Google Scholar
• Cheeta, S., Irvine, E. E., Kenny, P. J., & File, S. E. (2001). The dorsal raphe nucleus is a crucial structure mediating nicotine's anxiolytic effects and the development of tolerance and withdrawal responses. Psychopharmacology, 155, 78–85.
  Article PubMed Google Scholar
• Christiansen, K., & Knussmann, R. (1987). Sex hormones and cognitive functioning in men. Neuropsychobiology, 18, 27–36.
  Article PubMed Google Scholar
• Cunningham, G. R., Tindall, D. J., & Means, A. R. (1979). Differences in steroid specif icity for rat androgen binding protein and the cytoplasmic receptor. Steroids, 33, 261–276.
  Article PubMed Google Scholar
• D'Amour, F. E., & Smith, D. L. (1941). A method for determining loss of pain sensation. Journal of Pharmacology & Experimental Therapeutics, 72, 74–79.
  Google Scholar
• Davis, S. (2001). Testosterone deficiency in women. Journal of Reproductive Medicine, 46, 291–296.
  PubMed Google Scholar
• Dawson, J. L. (1972). Effects of sex hormones on cognitive style in rats and men. Behavior Genetics, 2, 21–42.
  Article PubMed Google Scholar
• Dunn, R., Copeland, P., Reed, T., & Frye, C. A. (1998). Anti-anxiety effects of nitric oxide inhibitors. Neuropharmacology, 37, 899–904.
  Article PubMed Google Scholar
• Farr, S. A., Banks, W. A., & Morley, J. E. (2000). Estradiol potentiates acetylcholine and glutamate-mediated post-trial memory processing in the hippocampus. Brain Research, 864, 263–269.
  Article PubMed Google Scholar
• File, S. E, Pellow, S., & Braestrup, C. (1985). Effects of the betacarboline, FG 7142, in the social interaction test of anxiety and the holeboard: Correlations between behaviour and plasma concentrations. Pharmacology, Biochemistry & Behavior, 22, 941–944.
  Article Google Scholar
• Flood, J. F., Farr, S. A., Kaiser, F. E., La Regina, M., & Morley, J. E. (1995). Age-related decrease of plasma testosterone in SAMP8 mice: Replacement improves age-related impairment of learning and memory. Physiology & Behavior, 57, 669–673.
  Article Google Scholar
• Flood, J. F., Morley, J. E., & Roberts, E. (1992). Memory-enhancing effects in male mice of pregnenolone and steroids metabolically derived from it. Proceedings of the National Academy of Sciences, 89, 1567–1571.
  Article Google Scholar
• Forman, L. J., Tingle, V., Estilow, S., & Cater, J. (1989). The response to analgesia testing is affected by gonadal steroids in the rat. Life Sciences, 45, 447–454.
  Article PubMed Google Scholar
• Frick, K. M., Burlingame, L. A., Arters, J. A., & Berger-Sweeney, J. (2000). Reference memory, anxiety and estrous cyclicity in C57BL/ 6NIA mice are affected by age and sex. Neuroscience, 95, 293–307.
  Article PubMed Google Scholar
• Frye, C. A. (1995). Estrus-associated decrements in a water maze task are limited to acquisition. Physiology & Behavior, 57, 5–14.
  Article Google Scholar
• Frye, C. A. (2001). Estradiol tends to improve inhibitory avoidance performance in adrenalectomized male rats and reduces pyknotic cells in the dentate gyrus of adrenalectomized male and female rats. Brain Research, 889, 358–363.
  Article PubMed Google Scholar
• Frye, C. A., & Duncan, J. E. (1994). Progesterone metabolites, effective at the GABAA receptor complex, attenuate pain sensitivity in rats. Brain Research, 643, 194–203.
  Article PubMed Google Scholar
• Frye, C. A., & Duncan, J. E. (1995). Estradiol benzoate potentiates neuroactive steroids' effects on pain sensitivity. Pharmacology, Biochemistry & Behavior, 53, 27–32.
  Article Google Scholar
• Frye, C. A., Duncan, J. E., Basham, M., & Erskine, M. S. (1996). Behavioral effects of 3a-androstanediol. II: Hypothalamic and preoptic area actions via a GABAergic mechanism. Behavioral Brain Research, 79, 119–130.
  Article Google Scholar
• Frye, C. A., & Lacey, E. H. (2001). Posttraining androgens' enhancement of cognitive performance is temporally distinct from androgens' increases in affective behavior. Cognitive, Affective, & Behavioral Neuroscience, 2, 172–182
  Article Google Scholar
• Frye, C. A., & McCormick, C. M. (2000). The neurosteroid, 3_α_-androstanediol, prevents inhibitory avoidance deficits and pyknotic cells in the granule layer of the dentate gyrus induced by adrenalectomy in rats. Brain Research, 7, 166–170.
  Article Google Scholar
• Frye, C. A., McCormick, C. M., Coopersmith, C., & Erskine, M. S. (1996). Effects of paced and non-paced mating stimulation on plasma progesterone, 3_α_-diol and corticosterone. Psychoneuroendocrinology, 21, 431–439.
  Article PubMed Google Scholar
• Frye, C. A., Park, D., Tanaka, M., Rosellini, R, & Svare, B. (2001). The testosterone metabolite and neurosteroid 3_α_-androstanediol may mediate the effects of testosterone on conditioned place preference. Psychoneuroendocrinology, 26, 731–750.
  Article PubMed Google Scholar
• Frye, C. A., Petralia, S. M., & Rhodes, M. E. (2000). Estrous cycle and sex differences in performance on anxiety tasks coincide with increases in hippocampal progesterone and 3_α_,5_α_-THP. Pharmacology, Biochemistry & Behavior, 67, 1–10.
  Article Google Scholar
• Frye, C. A., & Reed, T. A. (1998). Androgenic neurosteroids: Anti-seizure effects in an animal model of epilepsy. Psychoneuroendocrinology, 23, 385–399.
  Article PubMed Google Scholar
• Frye, C. A., Van Keuren, K. R., & Erskine, M. S. (1996). Behavioral effects of 3_α_-androstanediol. I: Modulation of sexual receptivity and promotion of GABA-stimulated chloride flux. Behavioural Brain Research, 79, 109–118.
  Article PubMed Google Scholar
• Frye, C. A., Van Keuren, K. R., Rao, P. N., & Erskine, M. S. (1996a). Analgesic effects of the neurosteroid 3_α_-androstanediol. Brain Research, 709, 1–9.
  Article PubMed Google Scholar
• Frye, C. A., Van Keuren, K. R., Rao, P. N., & Erskine, M. S. (1996b). Progesterone and 3_α_-androstanediol conjugated to bovine serum albumin affects estrous behavior when applied to the MBH and POA. Behavioral Neuroscience, 110, 603–612.
  Article PubMed Google Scholar
• Gallagher, A. M., De Lisi, R., Holst, P. C., McGillicuddy-De Lisi, A. V., Morely, M., & Cahalan, C. (2000). Gender differences in advanced mathematical problem solving. Journal of Experimental Child Psychology, 75, 165–190.
  Article PubMed Google Scholar
• Gallo, M. A., & Smith, S. S. (1993). Progesterone withdrawal decreases latency to and increases duration of electrified prod burial: A possible rat model of PMS anxiety. Pharmacology, Biochemistry & Behavior, 46, 897–904.
  Article Google Scholar
• Gaulin, S. J. C., & Fitzgerald, R. W. (1989). Sexual selection for spatial-learning ability. Animal Behaviour, 37, 322–331.
  Article Google Scholar
• Ge, J., Barnes, N. M., Costall, B., & Naylor, R. J. (1997). Effect of aversive stimulation on 5-hydroxytryptamine and dopamine metabolism in the rat brain. Pharmacology, Biochemistry & Behavior, 58, 775–783.
  Article Google Scholar
• Gee, K. W. (1988). Steroid modulation of the GABA/benzodiazepine receptor-linked chloride ionophore. Molecular Neurobiology, 2, 291–317.
  Article PubMed Google Scholar
• Gonzalez, M. I., Farabollini, F., Albonetti, E., & Wilson, C. A. (1994). Interactions between 5-hydroxytryptamine (5-HT) and testosterone in the control of sexual and nonsexual behavior in male and female rats. Pharmacology, Biochemistry & Behavior, 47, 591–601.
  Article Google Scholar
• Gupta, D., Rager, K., Zarzycki, & Eichner, M. (1975). Levels of luteinizing hormone, follicle-stimulating hormone, testosterone, and dihydrotestosterone in the circulation of sexually maturing intact male rats and after orchidectomy and experimental bilateral cryptorchidism. Journal of Endocrinology, 66, 183–193.
  Article PubMed Google Scholar
• Holson, R. R., Ali, S. F., Scallet, A. C., Slikker, W., & Paule, M.G. (1989). Benzodiazepine-like behavioral effects following withdrawal from chronic delta-9-tetrahydrocaanabinol administration in rats. Neurotoxicology, 10, 605–619.
  PubMed Google Scholar
• Isgor, C., & Sengelaub, D. R. (1998). Prenatal gonadal steroids affect spatial behavior, CA1 and CA3 pyramidal cell morphology in rats. Hormones & Behavior, 34, 183–198.
  Article Google Scholar
• Janowsky, J. S., Chavez, B., & Orwoll, E. (2000). Sex steroids modify working memory. Journal of Cognitive Neuroscience, 12, 407–414.
  Article PubMed Google Scholar
• Janowsky, J. S., Oviatt, S. K., & Orwoll, E. S. (1994). Testosterone influences spatial cognition in older men. Behavioral Neuroscience, 108, 325–332.
  Article PubMed Google Scholar
• Johnson, U. (1997). Coping strategies among long-term injured competitive athletes. A study of 81 men and women in team and individual sports. Scandinavian Journal of Medicine & Science in Sports, 7, 367–372.
  Google Scholar
• Johnston, A. L., & File, S. E. (1991). Sex differences in animal tests of anxiety. Physiology & Behavior, 49, 245–250.
  Article Google Scholar
• Kritzer, M. F., McLaughlin, P. J., Smirlis, T., & Robinson, J. K. (2001). Gonadectomy impairs T-maze acquisition in adult male rats. Hormones & Behavior, 39, 167–174.
  Article Google Scholar
• Lambadjieva, N. D. (1998). Influence of testosterone on some behavioral reactions of male immature rats. Methods & Findings in Experimental & Clinical Pharmacology, 20, 673–677.
  Article Google Scholar
• Linn, M. C., & Petersen, A. C. (1985). Emergence and characterization of sex differences in spatial ability: a meta-analysis. Child Development, 56, 1479–1498.
  Article PubMed Google Scholar
• Lund, B. C., Bever-Stille, K. A., & Perry, P. J. (1999). Testosterone and andropause: The feasibility of testosterone replacement therapy in elderly men. Pharmacotherapy, 19, 951–956.
  Article PubMed Google Scholar
• McCarthy, M. M., Felzenberg, E., Robbins, A., Pfaff, D. W., & Schwartz-Giblin, S. (1995). Infusions of diazepam and allopregnanolone into the midbrain central gray facilitate open-field behavior and sexual receptivity in female rats. Hormones & Behavior, 29, 279–295.
  Article Google Scholar
• McCleary, R., & Zucker, E. L. (1991). Higher trait- and state-anxiety in female law students than male law students. Psychological Reports, 68, 1075–1078.
  Article PubMed Google Scholar
• McGee, M. G. (1979). Human spatial abilities: Psychometric studies and environmental, genetic, hormonal, and neurological influences. Psychological Bulletin, 86, 889–918.
  Article PubMed Google Scholar
• Moger, W. H. (1977). Serum 5_α_-androstane-3_α_,17_β_-diol, androsterone, and testosterone concentrations in the male rat. Influence of age and gonadotropin secretion. Endocrinology, 100, 1027–1032.
  Article PubMed Google Scholar
• Molina, N., Bedran-de-Castro, M. T., & Bedran-de-Castro, J. C. (1994). Sex-related differences in the analgesic response to the rat tail immersion test. Brazilian Journal of Medical & Biological Research, 27, 1669–1672.
  Google Scholar
• Morley, J. E. (2000). Andropause, testosterone therapy, and quality of life in aging men. Cleveland Clinic Journal of Medicine, 67, 880–882.
  PubMed Google Scholar
• Morley, J. E., Kaiser F. E., Sih, R., Hajjar, R., & Perry, H. M., III. (1997). Testosterone and frailty. Clinics in Geriatric Medicine, 13, 685–695.
  PubMed Google Scholar
• Morley, K. C., & McGregor, I. S. (2000). (+/-)-3,4-methylenedioxymethamphetamine (MDMA, “Ecstasy”) increases social interaction in rats. European Journal of Pharmacology, 408, 41–49.
  Article PubMed Google Scholar
• O'Connell, A., Earley, B., & Leonard, B. E. (1994). Phencyclidine prevents spatial navigation and passive avoidance deficits in ibotenate lesioned rats. Neuropharmacology, 33, 1095–1101.
  Article PubMed Google Scholar
• Pellow, S., Chopin, P., File, S. E., & Briley, M. (1985). Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety in the rat. Journal of Neuroscience Methods, 14, 149–167.
  Article PubMed Google Scholar
• Pellow, S., & File, S. E. (1986). Anxiolytic and anxiogenic drug effects on exploratory activity in an elevated plus-maze: A novel test of anxiety in the rat. Pharmacology, Biochemistry & Behavior, 24, 525–529.
  Article Google Scholar
• Postma, A., Meyer, G., Tuiten, A., van Honk, J., Kessels, R. P., & Thijssen, J. (2000). Effects of testosterone administration on selective aspects of object-location memory in healthy young women. Psychoneuroendocrinology, 25, 563–575.
  Article PubMed Google Scholar
• Rodriguez, M., Sosa, J., Hernandez, G., & Mas, M. (1984). Pineal indols and testosterone affect exploratory activity of male rats. Experientia, 40, 397–398.
  Article PubMed Google Scholar
• Romero, M. T., Cooper, M. L., Komisaruk, B. R., & Bodnar, R. J. (1988). Gender-specific and gonadectomy-specific effects upon swim analgesia: Role of steroid replacement therapy. Physiology & Behavior, 44, 257–265.
  Article Google Scholar
• Roselli, C. E. (1991). Sex differences in androgen receptors and aromatase activity in microdissected regions of the rat brain. Endocrinology, 128, 1310–1315.
  Article PubMed Google Scholar
• Rosellini, R. A., Svare, B. B., Rhodes, M. E., & Frye, C. A. (2001). The testosterone metabolite and neurosteroid 3_α_-androstanediol may mediate the effects of testosterone on conditioned place preference. Brain Research Reviews, 37, 162–171.
  Article PubMed Google Scholar
• Silverman, I., Kastuk, D., Choi, J., & Phillips, K. (1999). Testosterone levels and spatial ability in men. Psychoneuroendocrinology, 24, 813–822.
  Article PubMed Google Scholar
• Smythe, J. W., McCormick, C. M., Rochford, J., & Meaney, M. J. (1994). The interaction between prenatal stress and neonatal handling on nociceptive response latencies in male and female rats. Physiology & Behavior, 55, 971–974.
  Article Google Scholar
• Sternbach, H. (1998). Age-associated testosterone decline in men: Clinical issues for psychiatry. American Journal of Psychiatry, 155, 1310–1318.
  PubMed Google Scholar
• Stewart, J., Skvarenina, A., & Pottier, J. (1975). Effects of neonatal androgens on open-field behavior and maze learning in the prepubescent and adult rat. Physiology & Behavior, 14, 291–295.
  Article Google Scholar
• Stumpf, W., & Sar, M. (1976). Steroid hormone target sites in the brain: The differential distribution of estrogen, progestin, androgen and glucocorticosteroid. Journal of Steroid Biochemistry, 7, 1163–1170.
  Article PubMed Google Scholar
• Svensson, A. I., Soderpalm, B., & Engel, J. A. (2000). Gonadectomy enhances shock-induced behavioral inhibition in adult male rats: Implications for impulsive behavior. Pharmacology, Biochemistry & Behavior, 65, 731–736.
  Article Google Scholar
• Treit, D. (1985). The inhibitory effect of diazepam on defensive burying: Anxiolytic vs. analgesic effects. Pharmacology, Biochemistry & Behavior, 22, 47–52.
  Article Google Scholar
• Treit, D., Pinel, J. P., & Fibiger, H. C. (1981). Conditioned defensive burying: A new paradigm for the study of anxiolytic agents. Pharmacology, Biochemistry & Behavior, 15, 619–626.
  Article Google Scholar
• Vandenheede, M., & Bouissou, M. F. (1993). Effect of androgen treatment on fear reactions in ewes. Hormones & Behavior, 27, 435–448.
  Article Google Scholar
• Vazquez-Pereyra, F., Rivas-Arancibia, S., Loaeza-Del Castillo, A., & Schneider-Rivas, S. (1995). Modulation of short term and long term memory by steroid sexual hormones. Life Sciences, 56, PL255-PL260.
  Article PubMed Google Scholar
• Venault, P., Chapouthier, G., de Carvalho, L. P., Simian, J., Morre, M., Dodd, R. H., & Rossier, J. (1986). Benzodiazpine impairs and beta-carboline enhances performance in learning and memory tasks. Nature, 321, 864–866.
  Article PubMed Google Scholar
• Verhoeven, G., Heyns, W., & De Moor, P. (1975). Testosterone receptors in the prostate and other tissues. Vitamins & Hormones, 33, 265–281.
  Article Google Scholar
• Warren, S. G., & Juraska, J. M. (1997). Spatial and nonspatial learning across the rat estrous cycle. Behavioral Neuroscience, 111, 259–266.
  Article PubMed Google Scholar
• Williams, C. L., Barnett, A., & Meck, W. H. (1991). Organizational effects of early gonadal secretions on sexual differentiation in spatial memory. Behavioral Neuroscience, 104, 84–97.
  Article Google Scholar
• Williams, C. L., & Meck, W. H. (1991). The organizational effects of gonadal steroids on sexually dimorphic spatial ability. Psychoneuroendocrinology, 16, 155–176.
  Article PubMed Google Scholar
• Zangrossi, H., & File, S. E. (1992). Behavioral consequences in animal tests of anxiety and exploration of exposure to cat odor. Brain Research Bulletin, 29, 381–388.
  Article PubMed Google Scholar

Download references