Ballard KJ, Holt SJ (1968) Cytological and cytochemical studies on cell death and digestion in the foetal rat foot: the role of macrophages and hydrolytic enzymes. J Cell Sci 3:245–262 PubMedCAS Google Scholar
Kerr JF, Wyllie AH, Currie AR (1972) Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 26:239–257 PubMedCAS Google Scholar
Ellis HM, Horvitz HR (1986) Genetic control of programmed cell death in the nematode C. elegans. Cell 44:817–829 ArticlePubMedCAS Google Scholar
Yuan J et al (1993) The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme. Cell 75:641–652 ArticlePubMedCAS Google Scholar
Riedl SJ, Shi Y (2004) Molecular mechanisms of caspase regulation during apoptosis. Nat Rev Mol Cell Biol 5:897–907 ArticlePubMedCAS Google Scholar
Kuida K et al (1996) Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice. Nature 384:368–372 ArticlePubMedCAS Google Scholar
Cecconi F et al (1998) Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development. Cell 94:727–737 ArticlePubMedCAS Google Scholar
Yoshida H et al (1998) Apaf1 is required for mitochondrial pathways of apoptosis and brain development. Cell 94:739–750 ArticlePubMedCAS Google Scholar
Kuida K et al (1998) Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9. Cell 94:325–337 ArticlePubMedCAS Google Scholar
Hakem R et al (1998) Differential requirement for caspase 9 in apoptotic pathways in vivo. Cell. 94:339–352 ArticlePubMedCAS Google Scholar
Varfolomeev EE et al (1998) Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally. Immunity. 9:267–276 ArticlePubMedCAS Google Scholar
Yeh WC et al (1998) FADD: essential for embryo development and signaling from some, but not all, inducers of apoptosis. Science 279:1954–1958 ArticlePubMedCAS Google Scholar
Fan TJ et al (2005) Caspase family proteases and apoptosis. Acta Biochim Biophys Sin (Shanghai) 37:719–727 ArticleCAS Google Scholar
Curtin JF, Cotter TG (2003) Live and let die: regulatory mechanisms in Fas-mediated apoptosis. Cell Signal 15:983–992 ArticlePubMedCAS Google Scholar
Donovan M, Cotter TG (2004) Control of mitochondrial integrity by Bcl-2 family members and caspase-independent cell death. Biochim Biophys Acta 1644:133–147 ArticlePubMedCAS Google Scholar
Walensky LD (2006) BCL-2 in the crosshairs: tipping the balance of life and death. Cell Death Differ 13:1339–1350 ArticlePubMedCAS Google Scholar
Tsujimoto Y, Nakagawa T, Shimizu S (2006) Mitochondrial membrane permeability transition and cell death. Biochim Biophys Acta 1757:1297–1300 ArticlePubMedCAS Google Scholar
Slee EA et al (1999) Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner. J Cell Biol 144:281–292 ArticlePubMedCAS Google Scholar
Slee EA, Adrain C, Martin SJ (2001) Executioner caspase-3, -6, and -7 perform distinct, non-redundant roles during the demolition phase of apoptosis. J Biol Chem 276:7320–7326 ArticlePubMedCAS Google Scholar
Buss RR, Oppenheim RW (2004) Role of programmed cell death in normal neuronal development and function. Anat Sci Int 79:191–197 ArticlePubMed Google Scholar
Jacobson MD, Weil M, Raff MC (1997) Programmed cell death in animal development. Cell 88:347–354 ArticlePubMedCAS Google Scholar
Raff MC et al (1993) Programmed cell death and the control of cell survival: lessons from the nervous system. Science 262:695–700 ArticlePubMedCAS Google Scholar
Leonard JR et al (2002) Strain-dependent neurodevelopmental abnormalities in caspase-3-deficient mice. J Neuropathol Exp Neurol 61:673–677 PubMed Google Scholar
Houde C et al (2004) Caspase-7 expanded function and intrinsic expression level underlies strain-specific brain phenotype of caspase-3-null mice. J Neurosci 24:9977–9984 ArticlePubMedCAS Google Scholar
Zheng TS, Flavell RA (2000) Divinations and surprises: genetic analysis of caspase function in mice. Exp Cell Res 256:67–73 ArticlePubMedCAS Google Scholar
Lakhani SA et al (2006) Caspases 3 and 7: key mediators of mitochondrial events of apoptosis. Science 311:847–851 ArticlePubMedCAS Google Scholar
Hensch TK (2005) Critical period plasticity in local cortical circuits. Nat Rev Neurosci 6:877–888 ArticlePubMedCAS Google Scholar
Ferrer I et al (1990) Naturally occurring cell death in the cerebral cortex of the rat and removal of dead cells by transitory phagocytes. Neuroscience 39:451–458 ArticlePubMedCAS Google Scholar
Ferrer I, Serrano T, Soriano E (1990) Naturally occurring cell death in the subicular complex and hippocampus in the rat during development. Neurosci Res 8:60–66 ArticlePubMedCAS Google Scholar
Tanaka M, Marunouchi T (1998) Immunohistochemical analysis of developmental stage of external granular layer neurons which undergo apoptosis in postnatal rat cerebellum. Neurosci Lett 242:85–88 ArticlePubMedCAS Google Scholar
Krueger BK, Burne JF, Raff MC (1995) Evidence for large-scale astrocyte death in the developing cerebellum. J Neurosci 15:3366–3374 PubMedCAS Google Scholar
Barres BA et al (1992) Cell death and control of cell survival in the oligodendrocyte lineage. Cell 70:31–46 ArticlePubMedCAS Google Scholar
Madden SD, Donovan M, Cotter TG (2007) Key apoptosis regulating proteins are down-regulated during postnatal tissue development. Int J Dev Biol 51:415–424 ArticlePubMedCAS Google Scholar
Donovan M, Cotter TG (2002) Caspase-independent photoreceptor apoptosis in vivo and differential expression of apoptotic protease activating factor-1 and caspase-3 during retinal development. Cell Death Differ 9:1220–1231 ArticlePubMedCAS Google Scholar
Donovan M, Doonan F, Cotter TG (2006) Decreased expression of pro-apoptotic Bcl-2 family members during retinal development and differential sensitivity to cell death. Dev Biol 291:154–169 ArticlePubMedCAS Google Scholar
Young RW (1984) Cell death during differentiation of the retina in the mouse. J Comp Neurol 229:362–373 ArticlePubMedCAS Google Scholar
Lu DC et al (2000) A second cytotoxic proteolytic peptide derived from amyloid beta-protein precursor. Nat Med 6:397–404 ArticlePubMedCAS Google Scholar
Rohn TT et al (2002) Caspase-9 activation and caspase cleavage of tau in the Alzheimer’s disease brain. Neurobiol Dis 11:341–354 ArticlePubMedCAS Google Scholar
Inoue H et al (2003) The crucial role of caspase-9 in the disease progression of a transgenic ALS mouse model. Embo J 22:6665–6674 ArticlePubMedCAS Google Scholar
Morishima N et al (2002) An endoplasmic reticulum stress-specific caspase cascade in apoptosis. Cytochrome c-independent activation of caspase-9 by caspase-12. J Biol Chem 277:34287–34294 ArticlePubMedCAS Google Scholar
Rao RV et al (2002) Coupling endoplasmic reticulum stress to the cell death program. An Apaf-1-independent intrinsic pathway. J Biol Chem 277:21836–21842 ArticlePubMedCAS Google Scholar
Gyrd-Hansen M et al (2006) Apoptosome-independent activation of the lysosomal cell death pathway by caspase-9. Mol Cell Biol 26:7880–7891 ArticlePubMedCAS Google Scholar
Bahr BA, Bendiske J (2002) The neuropathogenic contributions of lysosomal dysfunction. J Neurochem 83:481–489 ArticlePubMedCAS Google Scholar
Mochizuki H et al (2001) An AAV-derived Apaf-1 dominant negative inhibitor prevents MPTP toxicity as antiapoptotic gene therapy for Parkinson’s disease. Proc Natl Acad Sci U S A 98:10918–10923 ArticlePubMedCAS Google Scholar
Stadelmann C et al (1999) Activation of caspase-3 in single neurons and autophagic granules of granulovacuolar degeneration in Alzheimer’s disease. Evidence for apoptotic cell death. Am J Pathol 155:1459–1466 PubMedCAS Google Scholar
Rohn TT et al (2001) Activation of caspase-8 in the Alzheimer’s disease brain. Neurobiol Dis 8:1006–1016 ArticlePubMedCAS Google Scholar
Yakovlev AG et al (2001) Differential expression of apoptotic protease-activating factor-1 and caspase-3 genes and susceptibility to apoptosis during brain development and after traumatic brain injury. J Neurosci 21:7439–7446 PubMedCAS Google Scholar
Fortin A et al (2001) APAF1 is a key transcriptional target for p53 in the regulation of neuronal cell death. J Cell Biol 155:207–216 ArticlePubMedCAS Google Scholar
Moroni MC et al (2001) Apaf-1 is a transcriptional target for E2F and p53. Nat Cell Biol 3:552–558 ArticlePubMedCAS Google Scholar
Furukawa Y et al (2002) Apaf-1 is a mediator of E2F-1-induced apoptosis. J Biol Chem 277:39760–39768 ArticlePubMedCAS Google Scholar
Nahle Z et al (2002) Direct coupling of the cell cycle and cell death machinery by E2F. Nat Cell Biol 4:859–864 ArticlePubMedCAS Google Scholar
Brehm A et al (1998) Retinoblastoma protein recruits histone deacetylase to repress transcription. Nature 391:597–601 ArticlePubMedCAS Google Scholar
Wallace DM, Donovan M, Cotter TG (2006) Histone deacetylase activity regulates apaf-1 and caspase 3 expression in the developing mouse retina. Invest Ophthalmol Vis Sci 47:2765–2772 ArticlePubMed Google Scholar