Andrina Rambe - Academia.edu (original) (raw)

Papers by Andrina Rambe

Zenodo (CERN European Organization for Nuclear Research), Jun 14, 2022

Pleomorphic adenoma is one kind of tumor which is the most common benign tumor of major salivary ... more Pleomorphic adenoma is one kind of tumor which is the most common benign tumor of major salivary gland tumors. And can occur in the minor salivary gland tissue that can be found in the nasal cavity. Intranasal pleomorphic adenomas are usually formed by the mucous glands of the nasal septum. We found the pathology result of endoscopic surgery. The purpose of this study was to demonstrate an endoscopic approach to surgery for pleomorphic adenoma of the nasal septum. A 34-year-old woman presented with complaints of nasal congestion and occasional bleeding for at least 3 years. We provide treatment with endoscopic surgery to remove the tumor. In this case we ressected the tumor and also the submucous part of the nasal septal to reach tumor-free margins. Microscopic examination shows epithelial tissue, mesenchymal composed of myxoid stroma and also myoepithelial component with H&E staining. The postoperative follow-up of the patient was good, and there were no complications found in the patient. Benign nasal tumors of the minor salivary glands or benign pleomorphic adenomas of the nose are rare tumors and should be considered in their management. A correct histological diagnosis can be confirmed. Treatment for this disease can be done endoscopically endonasal surgery.

International Journal of Health and Medical Sciences, 2018

Sinonasal disease, especially rhinosinusitis, is the most prevalent disease in the Otorhinolaryng... more Sinonasal disease, especially rhinosinusitis, is the most prevalent disease in the Otorhinolaryngology-Head and Neck Surgery Department. Different anatomical variations of the lateral walls of the nose play an important role in contributing to osteomeatal complex obstruction and drainage and ventilation distruption, which eventually causes inflammation of the sinus mucosa. To discover the characteristics of sinonasal anatomical variations in patients with chronic rhinosinusitis based on their CT scan findings. This is an observative descriptive study using a cross-sectional design. All chronic rhinosinusitis patients who came to Otorhinolaryngology in

Sumatera Medical Journal

Background: Allergic rhinitis is an inflammation mediated by Immunoglobulin E (IgE) with symptoms... more Background: Allergic rhinitis is an inflammation mediated by Immunoglobulin E (IgE) with symptoms such as runny nose, sneezing, nasal congestion, with or without itchy nose. Although allergic rhinitis is not a dangerous disease, this disease has an impact on decreasing the quality of life of the sufferer which can interfere with daily activities. Objective: This study use to determine the relationship between allergic rhinitis and quality of life among students of the Faculty of Medicine, Universitas Sumatera Utara, batch 2018. Methods: This study used an observational analytical method with a cross-sectional study approach. The research sample was determined by simple random sampling technique and used two questionnaires, namely SFAR to assess allergic rhinitis and SF 36 to assess quality of life. Results: Based on the study, the number of allergic rhinitis sufferers from 72 students of the Faculty of Medicine, Universitas Sumatera Utara, batch 2018, 38 students suffering from alle...

Syntax Literate ; Jurnal Ilmiah Indonesia

Pandemi Coronavirus Disease 2019 (COVID-19) masih terus berlangsung hingga saat ini. Pandemi ini ... more Pandemi Coronavirus Disease 2019 (COVID-19) masih terus berlangsung hingga saat ini. Pandemi ini disebabkan oleh infeksi Severe Acute Respiratory Syndrome – Coronavirus -2 (SARS-CoV-2). Infeksi SARS-CoV-2 dapat menimbulkan gangguan penciuman dan pengecapan. Kejadian gangguan penciuman ini diketahui lebih banyak dialami oleh pasien rawat jalan dibandingkan rawat inap. Durasi pemulihan dari gangguan pengecapan dan penciuman bervariasi antar penelitian.Untuk mengetahui hubungan usia, jenis kelamin dan komorbid terhadap durasi dari gangguan penciuman pengecapan pada penderita COVID-19 yang berobat jalan di Poli COVID-19 RSUP Haji Adam Malik Medan.penelitian ini menggunakan desain potong lintang (cross-sectional). Penelitian ini menggunakan data dari bulan Agustus-Desember 2021. Besar sampel pada penelitian sebanyak 40 subjek yang diambil dengan pendekatan consecutive sampling. Untuk data karakteristik demografi, gangguan penciuman dan pengecapan menggunakan rekam medis sedangkan untuk d...

Open Access Macedonian Journal of Medical Sciences

BACKGROUND: Nasal polyps are benign masses in the nasal cavity and the abnormal growth of sinonas... more BACKGROUND: Nasal polyps are benign masses in the nasal cavity and the abnormal growth of sinonasal tissue due to a chronic inflammatory process. Many fibroblasts populate the nasal polyp stroma release cytokines such as Transforming Growth Factor (TGF) and producing a variety of cytokines resulting in inflammatory cell infiltration. Thymoquinone (TQ) is the main active component in Nigella sativa oil and has the ability to reduces cell viability in many cancer cell line. AIM: The purpose of this study was to determine the effect of TQ and TGF-β1 on cell viability of Nasal Polyp-Derived Fibroblast. MATERIALS AND METHODS: Nasal polyp-derived fibroblasts were isolated from nasal polyp specimen and treated with various concentrations of TQ at 1–1000 μM and TGF-β1 at 5 ng/ml to determine the cell viability using the Cell Counting Kit-8 assay after 48 h incubation. RESULTS: TQ significantly reduced the viability of nasal polyp fibroblast cells to 72.49% at 20 μM and reduced to 5% at 50 μ...

Open Access Macedonian Journal of Medical Sciences, Mar 17, 2022

BACKGROUND: Abnormal uterine bleeding (AUB) is one of the clinical symptoms found in malignant co... more BACKGROUND: Abnormal uterine bleeding (AUB) is one of the clinical symptoms found in malignant conditions where the incidence of newly diagnosed cancers reached 100,000 cases in Europe in 2012 with an incidence of around 14.7/100,000 women. The International Endometrial Tumor Analysis (IETA) group, formed in Chicago in 2008, published a consensus stating how to examine and measure the endometrium. CASE REPORT: Mrs. M, 49 years old, came to Gynecology Clinic of USU Hospital on February 22, 2021, at 13.00 WIB with the complaints of prolonged menstruation for 2 months with a volume of >10 times changing pads. Menstrual pain was found. Low back pain was found. A history of bleeding between menstrual cycles was found. On ultrasound examination, anteflexed uterus was found with size of 6.95 × 4.2 × 3.85 cm, thickness of the endometrium: 1.64 cm and concluded as AUB-M (thickening of the endometrium). Then, the patient is diagnosed with AUB-M (thickening of the endometrium) and is planned to undergo a diagnostic curettage. Anatomical pathology results showed a complex hyperplasia endometrium without atypia cells. Acute AUB is defined as bleeding profusely so that prompt treatment is needed to prevent blood loss. Ultrasound examination is performed to assess the size, shape of the uterus, the presence of fibroids, polyps, adenomyosis, and uterine anomalies such as uterine didelphys, sometimes polycystic ovaries are also found. Endometrial biopsy can detect more than 90% of cancers. The pathology of the endometrium can diagnose endometrial cancer or determine the likelihood of cancer. These investigative modalities can assist in the diagnosis of endometrial polyps, adenomyosis, leiomyomas, uterine anomalies, and endometrial thickening associated with hyperplasia and malignancy. Curettage is considered to relieve ongoing menorrhagia. According to the SOGC, administration of nonsteroidal anti-inflammatory drugs can inhibit cyclo-oxygenase and reduce levels of endometrial prostaglandins. DISCUSSION: Acute AUB is defined as bleeding profusely so that prompt treatment is needed to prevent blood loss. Ultrasound examination is performed to assess the size, shape of the uterus, the presence of fibroids, polyps, adenomyosis, and uterine anomalies such as uterine didelphys, sometimes polycystic ovaries are also found. Endometrial biopsy can detect more than 90% of cancers. The pathology of the endometrium can diagnose endometrial cancer or determine the likelihood of cancer. These investigative modalities can assist in the diagnosis of endometrial polyps, adenomyosis, leiomyomas, uterine anomalies, and endometrial thickening associated with hyperplasia and malignancy. Curettage is considered to relieve ongoing menorrhagia. According to the SOGC, administration of nonsteroidal anti-inflammatory drugs can inhibit cyclo-oxygenase and reduce levels of endometrial prostaglandins. CONCLUSION: According to IETA, the vascular pattern in the endometrium is reported to be associated with the presence or absence of a "dominant vessel" or other specific pattern. Endometrial thickness is the maximum measurement in the sagittal plane. The accompanying ultrasound provides the measurement of endometrial thickness in the absence of intracavity fluid; the endometrium should be measured where it appears thickest. If intracavity pathology is present, total thickness of endometrium including the lesion should be recorded. Anatomic pathology by curettage is required in women with abnormal bleeding; histological evaluation of the endometrium may identify infectious or neoplastic lesions such as endometrial hyperplasia or cancer.

Open Access Macedonian Journal of Medical Sciences

Pediatric gynecological examination is one of the gynecological examinations that are quite simpl... more Pediatric gynecological examination is one of the gynecological examinations that are quite simple, but many doctors are unable to do it properly because of the infrequentness of doing this examination. Consulting a child with gynecological complaints, endocrine problems, or sexual abuse often takes a long time and is thorough. However, evidence-based data on the problem of gynecological examinations in children and adolescents are inadequate because of the high bias in many studies. The purpose of this review is to seek from the literature regarding the correct procedures for gynecological examinations in children and adolescents, the order of examinations, and how to carry out a good examination so as not to leave a traumatic experience for children.

Open Access Macedonian Journal of Medical Sciences, 2019

BACKGROUND: Uterodidelphys with obstructed hemivagina and ipsilateral renal agenesis is referred ... more BACKGROUND: Uterodidelphys with obstructed hemivagina and ipsilateral renal agenesis is referred to as the Herlyn Werner Wunderlich (HWW) syndrome. Herlyn-Werner-Wunderlich (HWW) syndrome is a very rare congenital anomaly of the urogenital tract involving Müllerian ducts and Wolffian structures, and it is Werner by the triad of uterus didelphys, obstructed hemivagina and ipsilateral renal agenesis. CASE REPORT: Here, we describe a 17-year-old female patient presented with severe and increasing cyclical abdominal pain. She attained menarche 3 years back. The patient had irregular and scanty menstruation associated with dysmenorrhoea. On physical examination, secondary sexual characters were well developed, and on palpation, lower abdomen tenderness was not present. Diagnosed with HWW syndrome, who was taken up for diagnostic sonography and MRI, followed by vaginal septal resection, CONCLUSION: In addition to a definitive diagnosis, this approach helped in symptomatic relief to the pa...

Oto Rhino Laryngologica Indonesiana, 2013

Latar belakang: Rinitis alergi merupakan masalah kesehatan global dengan prevalensi yang terusmen... more Latar belakang: Rinitis alergi merupakan masalah kesehatan global dengan prevalensi yang terusmeningkat serta dapat berdampak pada penurunan kualitas hidup penderitanya. Ko-morbiditas rinitis alergi salahsatunya adalah otitis media yang sangat erat hubungannya dengan gangguan fungsi tuba Eustachius yangberkaitan dengan tekanan telinga tengah. Tujuan: Mengetahui hubungan rinitis alergi dengan disfungsi tubaEustachius dengan menggunakan timpanometri. Metode: Satu studi kasus-kontrol. Disfungsi tuba ditentukandengan pemeriksaan timpanometri (MEP negatif/

Oto Rhino Laryngologica Indonesiana

Background: Chronic rhinosinusitis (CRS) is an inflammation of the nasal and paranasal sinus muc... more Background: Chronic rhinosinusitis (CRS) is an inflammation of the nasal and paranasal sinus mucosa, which are closely related to the involvement of ostiomeatal complex as the drainage pathway of of maxillary and frontal sinuses. Inflammation or edema at the ostiomeatal complex could cause drainage problems leading to rhinosinusitis. Increased expression of COX-2 regulation was considered to play an important role in the development of CRS and increased airway inflammation in the nasal mucosa and paranasal sinuses. Purpose: To find out the expression of Cyclooxygenase-2 in our CRS patients. Methods: This descriptive research was conducted on July 2011 - December 2011 at ENT Department and Pathology Anatomy Department of Medical Faculty of Sumatera Utara University/H. Adam Malik General Hospital, Medan, to all patients diagnosed with CRS and underwent sinus surgery on July 2011 - December 2011. Results: The highest proportion of pain in patients with CRS is facial pain/pressure an...

Sumatera Medical Journal

Background: Chronic exposure of volatile substances can cause the impaired olfactory function. Ob... more Background: Chronic exposure of volatile substances can cause the impaired olfactory function. Objective: To identify the difference of olfactory function at Gas Station workers in Medan city. Method: Cross-sectional analitic study. A total of 80 persons consisting of 40 gas station operators and 40 non-operators who fulfilled the inclusion criteria. The applied statistical analysis was Mann Whitney, Fisher's Exact, Chi Square, T independent, Spearman with 95% confidence level. Result: Proportion of the impaired olfactory function in the gas station operator group by 77.5% and non-operator group by 0%. Significant correlation was obtained between age, duration of work with the impaired olfactory function (p = 0,047, p = 0,001). The gas station operators will suffer the impaired olfactory function if they works for ≥ 3.89 years. Conclusion: There were differences of olfactory functions on the gas station workers by using Sniffin 'Sticks Test.

Sumatera Medical Journal

Sinonasal tumor is a neoplasm that arises from nasal and paranasal sinus tissue. It is rarely fou... more Sinonasal tumor is a neoplasm that arises from nasal and paranasal sinus tissue. It is rarely found, only <3% of all malignancy in head and neck, and 1% of all malignancy in the body. Although it is rarely found, it can cause serious complication in adult. Unspecific sign and symptoms of sinonasal tumor often make the patients ignore the disease. It leads to the diagnosis of this disease becomes late and the patients come to the doctor in advanced stage. This research was conducted to know about the profile of sinonasal tumor patients in H. Adam Malik Medan Hospital on 2016-2018. The study was a descriptive study with retrospective approach. The data used are secondary data taken from medical records. The data were analyzed using a statistical application programs. Sinonasal tumor patients in RSUP HAM Medan are 158 patients, where 95 patients met the inclusion criteria, consisting of 24 benign tumors (25,3%) and 71 malignant tumors (74,7%). The majority of patients are male (71,6%), and the highest age group in in 51-60 years old (31,6%). The main complaints felt by the patients were nasal symptoms (64,2%), the location of tumors mostly found in nasal cavity (50,5%), the most histopathological type is NKSCC (43,2%), the most occupation is self-employment (26%), and the treatment of the patients are surgery (29,5%).

Open Access Macedonian Journal of Medical Sciences, 2021

AIM: The objective of the study was to report the endometriosis case and surgical technique to re... more AIM: The objective of the study was to report the endometriosis case and surgical technique to reduce the diminished ovarian reserve risk. CASE PRESENTATION: A 32-year-old woman was presented with the lower abdominal pain since 1 year ago, intermittent, and got worse during menstruation. The mobile cystic mass was palpable on the abdomen without pain during palpation. Vaginal examination showed mobile and smooth surface cystic mass was palpable, the upper pole was three fingers below the umbilicus, and lower pole was in line with pubic symphysis. Transvaginal ultrasonography (TVUS) showed uterus and right ovary enlargement; and unilocular cyst with homogenous echo pattern. There was a marked increase in CA-125. Based on International Tumor Analysis, the tumor was classified as B1 unilocular cyst and the malignancy risk index was 600. The patient was diagnosed with endometriosis and laparotomy cystectomy was performed. CONCLUSION: Patient was diagnosed with endometrial cyst and lapar...

Open Access Macedonian Journal of Medical Sciences, 2021

BACKGROUND: Mayer-Rokitansky-Kuster-Hauser (MRKH) syndrome is a rare disorder described as aplasi... more BACKGROUND: Mayer-Rokitansky-Kuster-Hauser (MRKH) syndrome is a rare disorder described as aplasia or hypoplasia of uterus and vagina due to an early arrest in the development of Mullerian ducts. The etiology of MRKH syndrome remains uncertain: Although at the beginning, it was mentioned that this syndrome was the result of sporadic abnormalities. It has recently been assumed the genetic background is the cause of the increasing number of familial cases. CASE REPORT: A 29-year-old female patient presented with amenorrhea. She also has normal pubic and axillary hair and breast development. Routine investigations were normal. Genitalia inspection shows that pubic hair was well developed, labia majora and vagina were seen. Inspeculo show that vaginal wall was smooth, but portio was not seen. Vaginal examination result: The uterus was unpalpable, both adnexa were normal, parametrium was laxed, and Douglas pouch was not protruded. Rectal examination shows that uterus and both adnexa were...

Gangguan pendengaran akibat bising (noise induced hearing loss / NIHL) adalah tuli akibat terpapa... more Gangguan pendengaran akibat bising (noise induced hearing loss / NIHL) adalah tuli akibat terpapar oleh bising yang cukup keras dalam jangka waktu yang cukup lama dan biasanya diakibatkan oleh bising lingkungan kerja. 1,2 Tuli akibat bising merupakan jenis ketulian sensorineural yang paling sering dijumpai setelah presbikusis. 3,4 Secara umum bising adalah bunyi yang tidak diinginkan. Bising yang intensitasnya 85 desibel (dB) atau lebih dapat menyebabkan kerusakan reseptor pendengaran Corti pada telinga dalam. Sifat ketuliannya adalah tuli saraf koklea dan biasanya terjadi pada kedua telinga. 1,5 Banyak hal yang mempermudah seseorang menjadi tuli akibat terpapar bising antara lain intensitas bising yang lebih tinggi, berfrekwensi tinggi, lebih lama terpapar bising, kepekaan individu dan faktor lain yang dapat menimbulkan ketulian.

Background: Children with preterm labor and low birth weight history tend to suffer various healt... more Background: Children with preterm labor and low birth weight history tend to suffer various health complications, from growth and development problems, inadequate organ functions, and central nervous system disturbances. Hearing impairment is the most common health problem that occurs in children with preterm labor and low birth weight history. Hearing impairment affects speech and language learning in children, since children need to comprehend various types of voices to learn speech and language thoroughly. Hearing examination is important to be done as early as possible. Hearing function can be examined as newborns reached 2 days after labor (48 hours). Hearing examination that is recommended for babies and children is Otoacoustic Emission (OAE) examination, since it is easy to conduct, no requirement for trained operator, is safe, and objectively accurate. Objectives: The purpose of this research is to determine the relationship between preterm labor and low birth weight history...

BACKGROUND: Candida albicans was the common causes of vulvovaginalis candidiasis (VVC) in human. ... more BACKGROUND: Candida albicans was the common causes of vulvovaginalis candidiasis (VVC) in human. To avoid complications, prompt and proper treatment of VVC must be performed. The pharmacological effects of Nigella sativa include antimicrobial, anti-inflammatory, immune stimulation, and anti-cancer properties. AIM: N. sativa has been shown to have an in vivo antifungal effect and the purpose of this study was to determine the antifungal and potential in vivo therapeutic effects. METHODS: This research was an empirical study which evaluated the therapeutic effect of the vaginal candidiasis model of N. sativa in rats. The subjects were 28 rats inoculated with C. albicans and were divided into four groups: Control group (G1), fluconazole group (G2), N. sativa group (G3), and N. sativa and fluconazole group combinations (G4). The colony of C. albicans was assessed to determine the treatment’s therapeutic effect. RESULTS: There was no difference in the number of colonies of C. albicans be...

Zenodo (CERN European Organization for Nuclear Research), Jun 14, 2022

Pleomorphic adenoma is one kind of tumor which is the most common benign tumor of major salivary ... more Pleomorphic adenoma is one kind of tumor which is the most common benign tumor of major salivary gland tumors. And can occur in the minor salivary gland tissue that can be found in the nasal cavity. Intranasal pleomorphic adenomas are usually formed by the mucous glands of the nasal septum. We found the pathology result of endoscopic surgery. The purpose of this study was to demonstrate an endoscopic approach to surgery for pleomorphic adenoma of the nasal septum. A 34-year-old woman presented with complaints of nasal congestion and occasional bleeding for at least 3 years. We provide treatment with endoscopic surgery to remove the tumor. In this case we ressected the tumor and also the submucous part of the nasal septal to reach tumor-free margins. Microscopic examination shows epithelial tissue, mesenchymal composed of myxoid stroma and also myoepithelial component with H&E staining. The postoperative follow-up of the patient was good, and there were no complications found in the patient. Benign nasal tumors of the minor salivary glands or benign pleomorphic adenomas of the nose are rare tumors and should be considered in their management. A correct histological diagnosis can be confirmed. Treatment for this disease can be done endoscopically endonasal surgery.

International Journal of Health and Medical Sciences, 2018

Sinonasal disease, especially rhinosinusitis, is the most prevalent disease in the Otorhinolaryng... more Sinonasal disease, especially rhinosinusitis, is the most prevalent disease in the Otorhinolaryngology-Head and Neck Surgery Department. Different anatomical variations of the lateral walls of the nose play an important role in contributing to osteomeatal complex obstruction and drainage and ventilation distruption, which eventually causes inflammation of the sinus mucosa. To discover the characteristics of sinonasal anatomical variations in patients with chronic rhinosinusitis based on their CT scan findings. This is an observative descriptive study using a cross-sectional design. All chronic rhinosinusitis patients who came to Otorhinolaryngology in

Sumatera Medical Journal

Background: Allergic rhinitis is an inflammation mediated by Immunoglobulin E (IgE) with symptoms... more Background: Allergic rhinitis is an inflammation mediated by Immunoglobulin E (IgE) with symptoms such as runny nose, sneezing, nasal congestion, with or without itchy nose. Although allergic rhinitis is not a dangerous disease, this disease has an impact on decreasing the quality of life of the sufferer which can interfere with daily activities. Objective: This study use to determine the relationship between allergic rhinitis and quality of life among students of the Faculty of Medicine, Universitas Sumatera Utara, batch 2018. Methods: This study used an observational analytical method with a cross-sectional study approach. The research sample was determined by simple random sampling technique and used two questionnaires, namely SFAR to assess allergic rhinitis and SF 36 to assess quality of life. Results: Based on the study, the number of allergic rhinitis sufferers from 72 students of the Faculty of Medicine, Universitas Sumatera Utara, batch 2018, 38 students suffering from alle...

Syntax Literate ; Jurnal Ilmiah Indonesia

Pandemi Coronavirus Disease 2019 (COVID-19) masih terus berlangsung hingga saat ini. Pandemi ini ... more Pandemi Coronavirus Disease 2019 (COVID-19) masih terus berlangsung hingga saat ini. Pandemi ini disebabkan oleh infeksi Severe Acute Respiratory Syndrome – Coronavirus -2 (SARS-CoV-2). Infeksi SARS-CoV-2 dapat menimbulkan gangguan penciuman dan pengecapan. Kejadian gangguan penciuman ini diketahui lebih banyak dialami oleh pasien rawat jalan dibandingkan rawat inap. Durasi pemulihan dari gangguan pengecapan dan penciuman bervariasi antar penelitian.Untuk mengetahui hubungan usia, jenis kelamin dan komorbid terhadap durasi dari gangguan penciuman pengecapan pada penderita COVID-19 yang berobat jalan di Poli COVID-19 RSUP Haji Adam Malik Medan.penelitian ini menggunakan desain potong lintang (cross-sectional). Penelitian ini menggunakan data dari bulan Agustus-Desember 2021. Besar sampel pada penelitian sebanyak 40 subjek yang diambil dengan pendekatan consecutive sampling. Untuk data karakteristik demografi, gangguan penciuman dan pengecapan menggunakan rekam medis sedangkan untuk d...

Open Access Macedonian Journal of Medical Sciences

BACKGROUND: Nasal polyps are benign masses in the nasal cavity and the abnormal growth of sinonas... more BACKGROUND: Nasal polyps are benign masses in the nasal cavity and the abnormal growth of sinonasal tissue due to a chronic inflammatory process. Many fibroblasts populate the nasal polyp stroma release cytokines such as Transforming Growth Factor (TGF) and producing a variety of cytokines resulting in inflammatory cell infiltration. Thymoquinone (TQ) is the main active component in Nigella sativa oil and has the ability to reduces cell viability in many cancer cell line. AIM: The purpose of this study was to determine the effect of TQ and TGF-β1 on cell viability of Nasal Polyp-Derived Fibroblast. MATERIALS AND METHODS: Nasal polyp-derived fibroblasts were isolated from nasal polyp specimen and treated with various concentrations of TQ at 1–1000 μM and TGF-β1 at 5 ng/ml to determine the cell viability using the Cell Counting Kit-8 assay after 48 h incubation. RESULTS: TQ significantly reduced the viability of nasal polyp fibroblast cells to 72.49% at 20 μM and reduced to 5% at 50 μ...

Open Access Macedonian Journal of Medical Sciences, Mar 17, 2022

BACKGROUND: Abnormal uterine bleeding (AUB) is one of the clinical symptoms found in malignant co... more BACKGROUND: Abnormal uterine bleeding (AUB) is one of the clinical symptoms found in malignant conditions where the incidence of newly diagnosed cancers reached 100,000 cases in Europe in 2012 with an incidence of around 14.7/100,000 women. The International Endometrial Tumor Analysis (IETA) group, formed in Chicago in 2008, published a consensus stating how to examine and measure the endometrium. CASE REPORT: Mrs. M, 49 years old, came to Gynecology Clinic of USU Hospital on February 22, 2021, at 13.00 WIB with the complaints of prolonged menstruation for 2 months with a volume of >10 times changing pads. Menstrual pain was found. Low back pain was found. A history of bleeding between menstrual cycles was found. On ultrasound examination, anteflexed uterus was found with size of 6.95 × 4.2 × 3.85 cm, thickness of the endometrium: 1.64 cm and concluded as AUB-M (thickening of the endometrium). Then, the patient is diagnosed with AUB-M (thickening of the endometrium) and is planned to undergo a diagnostic curettage. Anatomical pathology results showed a complex hyperplasia endometrium without atypia cells. Acute AUB is defined as bleeding profusely so that prompt treatment is needed to prevent blood loss. Ultrasound examination is performed to assess the size, shape of the uterus, the presence of fibroids, polyps, adenomyosis, and uterine anomalies such as uterine didelphys, sometimes polycystic ovaries are also found. Endometrial biopsy can detect more than 90% of cancers. The pathology of the endometrium can diagnose endometrial cancer or determine the likelihood of cancer. These investigative modalities can assist in the diagnosis of endometrial polyps, adenomyosis, leiomyomas, uterine anomalies, and endometrial thickening associated with hyperplasia and malignancy. Curettage is considered to relieve ongoing menorrhagia. According to the SOGC, administration of nonsteroidal anti-inflammatory drugs can inhibit cyclo-oxygenase and reduce levels of endometrial prostaglandins. DISCUSSION: Acute AUB is defined as bleeding profusely so that prompt treatment is needed to prevent blood loss. Ultrasound examination is performed to assess the size, shape of the uterus, the presence of fibroids, polyps, adenomyosis, and uterine anomalies such as uterine didelphys, sometimes polycystic ovaries are also found. Endometrial biopsy can detect more than 90% of cancers. The pathology of the endometrium can diagnose endometrial cancer or determine the likelihood of cancer. These investigative modalities can assist in the diagnosis of endometrial polyps, adenomyosis, leiomyomas, uterine anomalies, and endometrial thickening associated with hyperplasia and malignancy. Curettage is considered to relieve ongoing menorrhagia. According to the SOGC, administration of nonsteroidal anti-inflammatory drugs can inhibit cyclo-oxygenase and reduce levels of endometrial prostaglandins. CONCLUSION: According to IETA, the vascular pattern in the endometrium is reported to be associated with the presence or absence of a "dominant vessel" or other specific pattern. Endometrial thickness is the maximum measurement in the sagittal plane. The accompanying ultrasound provides the measurement of endometrial thickness in the absence of intracavity fluid; the endometrium should be measured where it appears thickest. If intracavity pathology is present, total thickness of endometrium including the lesion should be recorded. Anatomic pathology by curettage is required in women with abnormal bleeding; histological evaluation of the endometrium may identify infectious or neoplastic lesions such as endometrial hyperplasia or cancer.

Open Access Macedonian Journal of Medical Sciences

Pediatric gynecological examination is one of the gynecological examinations that are quite simpl... more Pediatric gynecological examination is one of the gynecological examinations that are quite simple, but many doctors are unable to do it properly because of the infrequentness of doing this examination. Consulting a child with gynecological complaints, endocrine problems, or sexual abuse often takes a long time and is thorough. However, evidence-based data on the problem of gynecological examinations in children and adolescents are inadequate because of the high bias in many studies. The purpose of this review is to seek from the literature regarding the correct procedures for gynecological examinations in children and adolescents, the order of examinations, and how to carry out a good examination so as not to leave a traumatic experience for children.

Open Access Macedonian Journal of Medical Sciences, 2019

BACKGROUND: Uterodidelphys with obstructed hemivagina and ipsilateral renal agenesis is referred ... more BACKGROUND: Uterodidelphys with obstructed hemivagina and ipsilateral renal agenesis is referred to as the Herlyn Werner Wunderlich (HWW) syndrome. Herlyn-Werner-Wunderlich (HWW) syndrome is a very rare congenital anomaly of the urogenital tract involving Müllerian ducts and Wolffian structures, and it is Werner by the triad of uterus didelphys, obstructed hemivagina and ipsilateral renal agenesis. CASE REPORT: Here, we describe a 17-year-old female patient presented with severe and increasing cyclical abdominal pain. She attained menarche 3 years back. The patient had irregular and scanty menstruation associated with dysmenorrhoea. On physical examination, secondary sexual characters were well developed, and on palpation, lower abdomen tenderness was not present. Diagnosed with HWW syndrome, who was taken up for diagnostic sonography and MRI, followed by vaginal septal resection, CONCLUSION: In addition to a definitive diagnosis, this approach helped in symptomatic relief to the pa...

Oto Rhino Laryngologica Indonesiana, 2013

Latar belakang: Rinitis alergi merupakan masalah kesehatan global dengan prevalensi yang terusmen... more Latar belakang: Rinitis alergi merupakan masalah kesehatan global dengan prevalensi yang terusmeningkat serta dapat berdampak pada penurunan kualitas hidup penderitanya. Ko-morbiditas rinitis alergi salahsatunya adalah otitis media yang sangat erat hubungannya dengan gangguan fungsi tuba Eustachius yangberkaitan dengan tekanan telinga tengah. Tujuan: Mengetahui hubungan rinitis alergi dengan disfungsi tubaEustachius dengan menggunakan timpanometri. Metode: Satu studi kasus-kontrol. Disfungsi tuba ditentukandengan pemeriksaan timpanometri (MEP negatif/

Oto Rhino Laryngologica Indonesiana

Background: Chronic rhinosinusitis (CRS) is an inflammation of the nasal and paranasal sinus muc... more Background: Chronic rhinosinusitis (CRS) is an inflammation of the nasal and paranasal sinus mucosa, which are closely related to the involvement of ostiomeatal complex as the drainage pathway of of maxillary and frontal sinuses. Inflammation or edema at the ostiomeatal complex could cause drainage problems leading to rhinosinusitis. Increased expression of COX-2 regulation was considered to play an important role in the development of CRS and increased airway inflammation in the nasal mucosa and paranasal sinuses. Purpose: To find out the expression of Cyclooxygenase-2 in our CRS patients. Methods: This descriptive research was conducted on July 2011 - December 2011 at ENT Department and Pathology Anatomy Department of Medical Faculty of Sumatera Utara University/H. Adam Malik General Hospital, Medan, to all patients diagnosed with CRS and underwent sinus surgery on July 2011 - December 2011. Results: The highest proportion of pain in patients with CRS is facial pain/pressure an...

Sumatera Medical Journal

Background: Chronic exposure of volatile substances can cause the impaired olfactory function. Ob... more Background: Chronic exposure of volatile substances can cause the impaired olfactory function. Objective: To identify the difference of olfactory function at Gas Station workers in Medan city. Method: Cross-sectional analitic study. A total of 80 persons consisting of 40 gas station operators and 40 non-operators who fulfilled the inclusion criteria. The applied statistical analysis was Mann Whitney, Fisher's Exact, Chi Square, T independent, Spearman with 95% confidence level. Result: Proportion of the impaired olfactory function in the gas station operator group by 77.5% and non-operator group by 0%. Significant correlation was obtained between age, duration of work with the impaired olfactory function (p = 0,047, p = 0,001). The gas station operators will suffer the impaired olfactory function if they works for ≥ 3.89 years. Conclusion: There were differences of olfactory functions on the gas station workers by using Sniffin 'Sticks Test.

Sumatera Medical Journal

Sinonasal tumor is a neoplasm that arises from nasal and paranasal sinus tissue. It is rarely fou... more Sinonasal tumor is a neoplasm that arises from nasal and paranasal sinus tissue. It is rarely found, only <3% of all malignancy in head and neck, and 1% of all malignancy in the body. Although it is rarely found, it can cause serious complication in adult. Unspecific sign and symptoms of sinonasal tumor often make the patients ignore the disease. It leads to the diagnosis of this disease becomes late and the patients come to the doctor in advanced stage. This research was conducted to know about the profile of sinonasal tumor patients in H. Adam Malik Medan Hospital on 2016-2018. The study was a descriptive study with retrospective approach. The data used are secondary data taken from medical records. The data were analyzed using a statistical application programs. Sinonasal tumor patients in RSUP HAM Medan are 158 patients, where 95 patients met the inclusion criteria, consisting of 24 benign tumors (25,3%) and 71 malignant tumors (74,7%). The majority of patients are male (71,6%), and the highest age group in in 51-60 years old (31,6%). The main complaints felt by the patients were nasal symptoms (64,2%), the location of tumors mostly found in nasal cavity (50,5%), the most histopathological type is NKSCC (43,2%), the most occupation is self-employment (26%), and the treatment of the patients are surgery (29,5%).

Open Access Macedonian Journal of Medical Sciences, 2021

AIM: The objective of the study was to report the endometriosis case and surgical technique to re... more AIM: The objective of the study was to report the endometriosis case and surgical technique to reduce the diminished ovarian reserve risk. CASE PRESENTATION: A 32-year-old woman was presented with the lower abdominal pain since 1 year ago, intermittent, and got worse during menstruation. The mobile cystic mass was palpable on the abdomen without pain during palpation. Vaginal examination showed mobile and smooth surface cystic mass was palpable, the upper pole was three fingers below the umbilicus, and lower pole was in line with pubic symphysis. Transvaginal ultrasonography (TVUS) showed uterus and right ovary enlargement; and unilocular cyst with homogenous echo pattern. There was a marked increase in CA-125. Based on International Tumor Analysis, the tumor was classified as B1 unilocular cyst and the malignancy risk index was 600. The patient was diagnosed with endometriosis and laparotomy cystectomy was performed. CONCLUSION: Patient was diagnosed with endometrial cyst and lapar...

Open Access Macedonian Journal of Medical Sciences, 2021

BACKGROUND: Mayer-Rokitansky-Kuster-Hauser (MRKH) syndrome is a rare disorder described as aplasi... more BACKGROUND: Mayer-Rokitansky-Kuster-Hauser (MRKH) syndrome is a rare disorder described as aplasia or hypoplasia of uterus and vagina due to an early arrest in the development of Mullerian ducts. The etiology of MRKH syndrome remains uncertain: Although at the beginning, it was mentioned that this syndrome was the result of sporadic abnormalities. It has recently been assumed the genetic background is the cause of the increasing number of familial cases. CASE REPORT: A 29-year-old female patient presented with amenorrhea. She also has normal pubic and axillary hair and breast development. Routine investigations were normal. Genitalia inspection shows that pubic hair was well developed, labia majora and vagina were seen. Inspeculo show that vaginal wall was smooth, but portio was not seen. Vaginal examination result: The uterus was unpalpable, both adnexa were normal, parametrium was laxed, and Douglas pouch was not protruded. Rectal examination shows that uterus and both adnexa were...

Gangguan pendengaran akibat bising (noise induced hearing loss / NIHL) adalah tuli akibat terpapa... more Gangguan pendengaran akibat bising (noise induced hearing loss / NIHL) adalah tuli akibat terpapar oleh bising yang cukup keras dalam jangka waktu yang cukup lama dan biasanya diakibatkan oleh bising lingkungan kerja. 1,2 Tuli akibat bising merupakan jenis ketulian sensorineural yang paling sering dijumpai setelah presbikusis. 3,4 Secara umum bising adalah bunyi yang tidak diinginkan. Bising yang intensitasnya 85 desibel (dB) atau lebih dapat menyebabkan kerusakan reseptor pendengaran Corti pada telinga dalam. Sifat ketuliannya adalah tuli saraf koklea dan biasanya terjadi pada kedua telinga. 1,5 Banyak hal yang mempermudah seseorang menjadi tuli akibat terpapar bising antara lain intensitas bising yang lebih tinggi, berfrekwensi tinggi, lebih lama terpapar bising, kepekaan individu dan faktor lain yang dapat menimbulkan ketulian.

Background: Children with preterm labor and low birth weight history tend to suffer various healt... more Background: Children with preterm labor and low birth weight history tend to suffer various health complications, from growth and development problems, inadequate organ functions, and central nervous system disturbances. Hearing impairment is the most common health problem that occurs in children with preterm labor and low birth weight history. Hearing impairment affects speech and language learning in children, since children need to comprehend various types of voices to learn speech and language thoroughly. Hearing examination is important to be done as early as possible. Hearing function can be examined as newborns reached 2 days after labor (48 hours). Hearing examination that is recommended for babies and children is Otoacoustic Emission (OAE) examination, since it is easy to conduct, no requirement for trained operator, is safe, and objectively accurate. Objectives: The purpose of this research is to determine the relationship between preterm labor and low birth weight history...

BACKGROUND: Candida albicans was the common causes of vulvovaginalis candidiasis (VVC) in human. ... more BACKGROUND: Candida albicans was the common causes of vulvovaginalis candidiasis (VVC) in human. To avoid complications, prompt and proper treatment of VVC must be performed. The pharmacological effects of Nigella sativa include antimicrobial, anti-inflammatory, immune stimulation, and anti-cancer properties. AIM: N. sativa has been shown to have an in vivo antifungal effect and the purpose of this study was to determine the antifungal and potential in vivo therapeutic effects. METHODS: This research was an empirical study which evaluated the therapeutic effect of the vaginal candidiasis model of N. sativa in rats. The subjects were 28 rats inoculated with C. albicans and were divided into four groups: Control group (G1), fluconazole group (G2), N. sativa group (G3), and N. sativa and fluconazole group combinations (G4). The colony of C. albicans was assessed to determine the treatment’s therapeutic effect. RESULTS: There was no difference in the number of colonies of C. albicans be...