Abdelmoneim A. Makhlouf - Academia.edu (original) (raw)
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Papers by Abdelmoneim A. Makhlouf
International Journal of Impotence Research, 2006
![Research paper thumbnail of ChemInform Abstract: Utility of Cyanoacetamides as Precursors to Pyrazolo[3,4-d]pyrimidin-4-ones, 2-Aryl-6-substituted 1,2,3-Triazolo[4,5-d]pyrimidines and Pyrazolo[1,5-a]pyrimidine-3-carboxamides](https://attachments.academia-assets.com/110386492/thumbnails/1.jpg)
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Drug Research, Dec 25, 2011
A new series of arylidene 5-phenyl-4-R-pyrrole-3-carbohydrazides 1a-j were prepared and evaluated... more A new series of arylidene 5-phenyl-4-R-pyrrole-3-carbohydrazides 1a-j were prepared and evaluated for their analgesic-antiinflammatory activities. All synthesized compounds showed a significant analgesic action in mice after intraperitoneal administration at a dose of 100 µM/kg. Two of these, 1b, (4′-methylbenzylidene)-5-phenyl-1H-pyrrole-3-carbohydrazide, and 1d, (4′-chlorobenzylidene)-5-phenyl-1H-pyrrole-3-carbohydrazide, were found to be more potent as antinociceptive agents respect to dipyrone and indometacin, used as reference drugs. Among compounds 1, only 1b showed a moderate antiinflammatory effect in rats while 1d proved to be a potent non antiinflammatory analgesic.
Chemischer Informationsdienst, 1977
ChemInform Abstract Die Titelverbindungen (I) werden aus den entsprechenden Säurechloriden und Am... more ChemInform Abstract Die Titelverbindungen (I) werden aus den entsprechenden Säurechloriden und Aminosäureester-hydrochloriden dargestellt. Durch Hydrolyse der entsprechenden Ester (I) werden die freien Säuren (II) und durch Reaktion der entsprechenden Methylester (Ic) mit Hydrazinhydrat die Hydrazide (III) gewonnen. Die Produkte (I)
Archiv der Pharmazie, 2001
A variety of novel 3-(3-methoxyphenyl)-2substituted amino-quinazolin-4(3H)-ones were synthesized ... more A variety of novel 3-(3-methoxyphenyl)-2substituted amino-quinazolin-4(3H)-ones were synthesized by reacting the amino group of 2-hydrazino-3-(3-methoxyphenyl)-quinazolin-4(3H)-one with a variety of aldehydes and ketones. The starting material 2-hydrazino-3-(3methoxyphenyl)-quinazolin-4(3H)-one was synthesized from 3-methoxy aniline. The title compounds were investigated for analgesic, anti-inflammatory, and ulcerogenic behavior. Among these the compound 2-(1-methyl butylidene-hydrazino)-3-(3-methoxyphenyl)-3H-quinazolin-4-one (AS3) emerged as the most active compound for the analgesic activity, while the compound 2-(1-ethyl propylidene-hydrazino)-3-(3-methyoxyphenyl)-3H-quinazolin-4one (AS2) showed most potent anti-inflammatory activity of the series and these compounds are moderately more potent when compared to the reference standard diclofenac sodium. Interestingly the test compounds showed only mild ulcerogenic potential when compared to acetylsalicylic acid.
Chemischer Informationsdienst, 1978
Journal of Biological …, 2007
... EPA, DHA, and ·-linolenic acid (ALA) are Cod liver oil in chemically-induced diabetes mellitu... more ... EPA, DHA, and ·-linolenic acid (ALA) are Cod liver oil in chemically-induced diabetes mellitus in rats ... Suresh & Das (2003) reported that, simulta-neous and pre-treatment withALA of rats resulted in 70% and 10% incidence of DM, respectively. ...
Archiv der Pharmazie, 2004
ABSTRACT
Journal of Coordination Chemistry
An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
Egyptian journal of pharmaceutical sciences, 1996
Archives of Applied Science Research, 2014
Alkylation of 6-aryl-4-oxo-2-thioxopyrimidine-5-carbonitriles (1a-c) afforded the key intermediat... more Alkylation of 6-aryl-4-oxo-2-thioxopyrimidine-5-carbonitriles (1a-c) afforded the key intermediates 2a-e, which underwent further alkylation at N-3 nitrogen atom, upon treatment with α-halofunctionalized compounds, namely: ethyl bromoacetate, chloroacetone, chloroacetylacetone, chloroacetonirile, or monobromomalononitrile to perform 2-alkylthio-6-aryl-5-cyano-4-oxo-3-substituted-3,4-dihydropyrimidines 7-9. Heating 7-9 with hydrazine hydrate produced imidazo[1,2-a]pyrimidine derivatives 10-15. Treatment of 10a with each of ethyl cyanoacetate, ethyl acetoacetate, or acetylacetone gave pyrazoloimidazopyrimidine derivatives 18a,b, 19, respectively. Compound 10a reacted with carbon disulphide to give oxazoloimidazopyrimidine20. Reaction of the imidazopyrimidine derivative 15a with glacial acetic acid or thiourea afforded triazoloimidazopyrimidines21,22. Also, compound 15aunderwent cycloaddition reaction upon treatment with either of phthalic anhydride or acrylonitrile to give 2-phenyl-4,...
Applied Organometallic Chemistry, 2021
Journal of Scientific Research in Science, 2018
Thermal reaction of Co(II), Ni(II), Cu(II), Zn(II), Cd(II) and Ru(III) metal ions with a tridenta... more Thermal reaction of Co(II), Ni(II), Cu(II), Zn(II), Cd(II) and Ru(III) metal ions with a tridentate Schiff-base ligand(HL) derived from the condensation of 2-aminothiazole and 2hydroxy-1-naphthaldehyde resulted in the formation of a series of six new metal complexes: [Co(HL) 2 Cl 2 ]; 1,[Ni(L)(CH 3 COO)(H 2 O)]; 2,[Cu(L) 2 ]; 3, [Zn(L) 2 ]; 4, [Cd(L)(CH 3 COO) (H 2 O)]H 2 O; 5, [Ru(L) 2 (H 2 O) 2 ]Cl; 6. The ligand and its complexes were characterized by means of elemental and thermal analyses along with molar conductance and magnetic moment measurements as well as different spectroscopic techniques. The ESR spectrum of Cu(II) complex indicated elongated and covalent character of octahedral environment.
Journal of Molecular Structure, 2020
This is a self-archived version of an original article. This version may differ from the original... more This is a self-archived version of an original article. This version may differ from the original in pagination and typographic details.
International Journal of Impotence Research, 2006
Drug Research, Dec 25, 2011
A new series of arylidene 5-phenyl-4-R-pyrrole-3-carbohydrazides 1a-j were prepared and evaluated... more A new series of arylidene 5-phenyl-4-R-pyrrole-3-carbohydrazides 1a-j were prepared and evaluated for their analgesic-antiinflammatory activities. All synthesized compounds showed a significant analgesic action in mice after intraperitoneal administration at a dose of 100 µM/kg. Two of these, 1b, (4′-methylbenzylidene)-5-phenyl-1H-pyrrole-3-carbohydrazide, and 1d, (4′-chlorobenzylidene)-5-phenyl-1H-pyrrole-3-carbohydrazide, were found to be more potent as antinociceptive agents respect to dipyrone and indometacin, used as reference drugs. Among compounds 1, only 1b showed a moderate antiinflammatory effect in rats while 1d proved to be a potent non antiinflammatory analgesic.
Chemischer Informationsdienst, 1977
ChemInform Abstract Die Titelverbindungen (I) werden aus den entsprechenden Säurechloriden und Am... more ChemInform Abstract Die Titelverbindungen (I) werden aus den entsprechenden Säurechloriden und Aminosäureester-hydrochloriden dargestellt. Durch Hydrolyse der entsprechenden Ester (I) werden die freien Säuren (II) und durch Reaktion der entsprechenden Methylester (Ic) mit Hydrazinhydrat die Hydrazide (III) gewonnen. Die Produkte (I)
Archiv der Pharmazie, 2001
A variety of novel 3-(3-methoxyphenyl)-2substituted amino-quinazolin-4(3H)-ones were synthesized ... more A variety of novel 3-(3-methoxyphenyl)-2substituted amino-quinazolin-4(3H)-ones were synthesized by reacting the amino group of 2-hydrazino-3-(3-methoxyphenyl)-quinazolin-4(3H)-one with a variety of aldehydes and ketones. The starting material 2-hydrazino-3-(3methoxyphenyl)-quinazolin-4(3H)-one was synthesized from 3-methoxy aniline. The title compounds were investigated for analgesic, anti-inflammatory, and ulcerogenic behavior. Among these the compound 2-(1-methyl butylidene-hydrazino)-3-(3-methoxyphenyl)-3H-quinazolin-4-one (AS3) emerged as the most active compound for the analgesic activity, while the compound 2-(1-ethyl propylidene-hydrazino)-3-(3-methyoxyphenyl)-3H-quinazolin-4one (AS2) showed most potent anti-inflammatory activity of the series and these compounds are moderately more potent when compared to the reference standard diclofenac sodium. Interestingly the test compounds showed only mild ulcerogenic potential when compared to acetylsalicylic acid.
Chemischer Informationsdienst, 1978
Journal of Biological …, 2007
... EPA, DHA, and ·-linolenic acid (ALA) are Cod liver oil in chemically-induced diabetes mellitu... more ... EPA, DHA, and ·-linolenic acid (ALA) are Cod liver oil in chemically-induced diabetes mellitus in rats ... Suresh & Das (2003) reported that, simulta-neous and pre-treatment withALA of rats resulted in 70% and 10% incidence of DM, respectively. ...
Archiv der Pharmazie, 2004
ABSTRACT
Journal of Coordination Chemistry
An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
Egyptian journal of pharmaceutical sciences, 1996
Archives of Applied Science Research, 2014
Alkylation of 6-aryl-4-oxo-2-thioxopyrimidine-5-carbonitriles (1a-c) afforded the key intermediat... more Alkylation of 6-aryl-4-oxo-2-thioxopyrimidine-5-carbonitriles (1a-c) afforded the key intermediates 2a-e, which underwent further alkylation at N-3 nitrogen atom, upon treatment with α-halofunctionalized compounds, namely: ethyl bromoacetate, chloroacetone, chloroacetylacetone, chloroacetonirile, or monobromomalononitrile to perform 2-alkylthio-6-aryl-5-cyano-4-oxo-3-substituted-3,4-dihydropyrimidines 7-9. Heating 7-9 with hydrazine hydrate produced imidazo[1,2-a]pyrimidine derivatives 10-15. Treatment of 10a with each of ethyl cyanoacetate, ethyl acetoacetate, or acetylacetone gave pyrazoloimidazopyrimidine derivatives 18a,b, 19, respectively. Compound 10a reacted with carbon disulphide to give oxazoloimidazopyrimidine20. Reaction of the imidazopyrimidine derivative 15a with glacial acetic acid or thiourea afforded triazoloimidazopyrimidines21,22. Also, compound 15aunderwent cycloaddition reaction upon treatment with either of phthalic anhydride or acrylonitrile to give 2-phenyl-4,...
Applied Organometallic Chemistry, 2021
Journal of Scientific Research in Science, 2018
Thermal reaction of Co(II), Ni(II), Cu(II), Zn(II), Cd(II) and Ru(III) metal ions with a tridenta... more Thermal reaction of Co(II), Ni(II), Cu(II), Zn(II), Cd(II) and Ru(III) metal ions with a tridentate Schiff-base ligand(HL) derived from the condensation of 2-aminothiazole and 2hydroxy-1-naphthaldehyde resulted in the formation of a series of six new metal complexes: [Co(HL) 2 Cl 2 ]; 1,[Ni(L)(CH 3 COO)(H 2 O)]; 2,[Cu(L) 2 ]; 3, [Zn(L) 2 ]; 4, [Cd(L)(CH 3 COO) (H 2 O)]H 2 O; 5, [Ru(L) 2 (H 2 O) 2 ]Cl; 6. The ligand and its complexes were characterized by means of elemental and thermal analyses along with molar conductance and magnetic moment measurements as well as different spectroscopic techniques. The ESR spectrum of Cu(II) complex indicated elongated and covalent character of octahedral environment.
Journal of Molecular Structure, 2020
This is a self-archived version of an original article. This version may differ from the original... more This is a self-archived version of an original article. This version may differ from the original in pagination and typographic details.