Adamu Abdullahi - Academia.edu (original) (raw)

Papers by Adamu Abdullahi

BackgroundOwing to high levels of resistance to previous first-line non-nucleoside reverse transc... more BackgroundOwing to high levels of resistance to previous first-line non-nucleoside reverse transcriptase inhibitors (NNRTI)-based antiretroviral therapy (ART), consolidated recommendations since 2019, from the WHO and others, have indicated that dolutegravir (DTG) is the preferred drug of choice for HIV treatment, globally. There is a paucity of resistance outcome data from non-B HIV subtypes circulating across West Africa.AimWe aimed to characterise the mutational profiles of HIV-positive patients from a small North-East Nigeria cohort, failing a DTG-based ART regimen.MethodsPlasma samples were collected and stored from 61 HIV-1 infected participants. Following failure of DTG-based ART, all samples were sequenced by Illumina whole-genome, ultra-deep sequencing. Sequencing was successful in (n=33) participants with median age of 40 years and median time on ART of 9 years. HIV-1 subtyping was performed using SNAPPy. Haplotype reconstruction and transmission were inferred using standa...

Best Practice & Research Clinical Anaesthesiology

Cancer Epidemiology, Biomarkers & Prevention

Colorectal cancer incidence rates are rising among individuals age younger than 50 years (early-o... more Colorectal cancer incidence rates are rising among individuals age younger than 50 years (early-onset CRC) globally with causes unknown. Racial and ethnic disparities in early-onset CRC have also grown more pronounced, as blacks have higher early- onset CRC incidence and poorer survival compared with whites. We described the prevalence and burden of early-onset CRC among Africans in Nigeria and African Americans in the United States. We identified black individuals diagnosed with a first primary colorectal cancer ages 18 to 49 years between 1989 and 2017 at Ahmadu Bello University Teaching Hospital in Zaria, Nigeria using the Zaria Cancer Registry (Nigerians), and from population-based cancer registries across the US (African Americans) using the NIH/NCI’s Surveillance, Epidemiology, and End Results (SEER) program. Multivariable logistic regression models were used to investigate clinicopathologic and demographic differences between Nigerians and African Americans with early-onset C...

Cancer Epidemiology, Biomarkers & Prevention

The African continent is facing enormous challenges from cancer crisis, and the lack of reliable ... more The African continent is facing enormous challenges from cancer crisis, and the lack of reliable population database on cancer incidence and mortality hinders high quality decision on prevention and management modalities. The objective of this study is to analyze the trend of malignant tumors in a population of rural Africans attending Ahmadu Bello University Teaching (ABUTH) Hospital Zaria, Nigeria with particular emphasis on the first eighteen (18) frequently diagnosed cancers over a period of 46 consecutive years (1972 - 2019) excluding the year 1988. Histologically diagnosed cancers from the population-based cancer registry of the ABUTH Zaria were included in this study. There were 19, 884 histologically diagnosed cancers over 46 years in ABUTH Zaria with the following in descending order: Cervical cancer 2,335 (12%, [squamous cell carcinoma = 1, 809; others = 529]), Breast cancer 1,982 (10% [invasive ductal carcinoma = 1,589; others = 393]), Lymphoma 1,927 (10% [non–Hodgkin’s l...

2020 24th International Conference on System Theory, Control and Computing (ICSTCC)

This paper presents a Model Reference Adaptive Control (MRAC) based framework for vehicle adaptiv... more This paper presents a Model Reference Adaptive Control (MRAC) based framework for vehicle adaptive cruise control systems. The linear longitudinal dynamic model is created with uncertainties in the state and input matrix. The controller structure aims to handle these uncertainties and also maintains the desired distance with the lead vehicle. To evaluate the performance of the proposed controller, several simulation studies are conducted by comparing the results with a linear state feedback controller via MATLAB/Simulink. Whereas the linear controller underperforms under uncertain conditions, it is seen that MRAC achieves the desired performance despite model uncertainties.

Kanem Journal Medical Sciences, 2022

Background: Phyllodes tumours are rare breast neoplasm. Its clinical spectrum ranges from a benig... more Background: Phyllodes tumours are rare breast neoplasm. Its clinical spectrum ranges from a benign and locally recurrent form of behaviour to malignant and metastatic forms. The age at risk is between 35 and 45 years. Giant phyllodes tumours are larger than 10cm in diameter. Case Report: Herewith, we present a rare case of giant malignant phyllodes tumour (40x30x20cm) in a young lady who survived 10 years post-treatment in which most literature reported 10-year survival of 23% to 42%. The patient had mastectomy and radiotherapy to the anterior chest wall. Conclusion: A young lady with a giant malignant phyllodes tumour survived 10 years following treatment.

Solanum tuberosum - A Promising Crop for Starvation Problem, 2021

Among food crops in terms of consumption, potato ranks fourth, most important and valuable crop w... more Among food crops in terms of consumption, potato ranks fourth, most important and valuable crop worldwide in terms of production and area harvested after maize, wheat and rice. In the coming years, potato production must keep pace with global population expansion nutritiously and sustainably which can partially be achieved by reducing the yield losses caused by the destructive pest and disease activities to the crop. The challenge of 70–80% total microbial crop yield loss posed by pathogens must be addressed for sustainable potato production in order to properly alleviate the global starvation problem. Potato as a food security crop can help to achieve the four food security requirements: food availability, quality, accessibility and stability. Health benefits of potato have shown the presence of phytochemicals as well as resistant starch which serve as anticancer and antidiabetic. The role of potato in the global food security should not be over emphasized, hence in this chapter we...

Cancer Epidemiology, Biomarkers & Prevention, 2020

This study was conducted to determine if prostate cancer status, demographic and health factors a... more This study was conducted to determine if prostate cancer status, demographic and health factors as well as social support, illness perception, financial toxicity and resilience predict the quality of life (QoL) in men and to ascertain the differences between men with and without cancer of the prostate (CaP) in the QoL subscales and significant predictors of QoL. Quality of life, social support, illness perception, financial toxicity and resilience were assessed using the Functional Assessment of Cancer Therapy-Prostate (FACT-P), the Multidimensional Scale of Perceived Social Support (MSPSS), Brief Illness Perception Questionnaire (BriefIPQ), The COmprehensive Score for financial Toxicity (Cost Facit) and the Brief Resilience Scale (BRS) respectively. Each scale was assessed and found to possess acceptable levels of reliability (Alpha =.551 to .899). Demographic and clinical information were also collected include age, marital status, religion, education, income, ethnic group, health...

Lecture Notes in Electrical Engineering, 2021

There has been a constant rise in interest on the subjects of robotics and additive manufacturing... more There has been a constant rise in interest on the subjects of robotics and additive manufacturing. Although robotics being older than additive manufacturing, both subjects have gained increased publicity in terms of research over the years. The objective of this paper is to review 3D printing, robotics education, and finally how 3D printing has contributed to robotics education over a period of ten years between 2011 and 2020. the last ten (10) years. By restricting the search to academic articles only, papers comprising of journal papers and conference proceedings were reviewed. For each paper, three information were sought which includes; robotics education, 3D printing, and finally how these two have been used together. We expect that the result of this review will serve as a pivot for schools at all levels to combine both subject areas and include the union into their STEM curricula which is believed to improve robotics education. The review shows that both tertiary and lower educational levels of robotics education benefit immensely from 3D printing. We also find out that most of the contributions of 3D printing to robotics education comes more in the form of using already printed parts rather than using the 3D printer itself. The challenges and trends are highlighted and future research directions have been suggested in this paper.

Asian Journal of Advanced Research and Reports, 2018

Synthetic molluscicides widely used for the control of urinary schistosomiasis are expensive, tox... more Synthetic molluscicides widely used for the control of urinary schistosomiasis are expensive, toxic to non-target organisms, not available and may have deleterious long-term effects in the environment. The aim of this research is to compare the efficacy of column purified fractions of Allium cepa and Allium sativum against Bulinus globosus specimens (intermediate host of urinary schistosomiasis) under laboratory conditions as an increment for the cheaper, non-toxic, available way of controlling urinary schistosomiasis. Extracts were obtained using cold maceration method with methanol as a polar solvent; column purification was achieved using silica gel (stationary phase) while ethyl acetate and n-hexane (mobile phase); thirteen fractions were collected from each plant and each fraction contained 10ml of the eluent; the fractions were left open for 48 hours for evaporation of the solvents. Experiments were performed according to the methodology described by the World Health Organizat...

International Journal of Research and Review, 2021

Rodents are one of the most important groups of mammalian animal with more than 42%of the known m... more Rodents are one of the most important groups of mammalian animal with more than 42%of the known mammalian species, with 1700 species which belongs to three different families include Muridae, microtidaie and sigmodontidae. The aim of this study is to examine endo and ecto parasitic infection of African Giant rat (Cricetomys Gambianus). Intestinal parasite were detected and identified from the stool samples using formalin ethyl-acetate concentration technique. A total of 18 African giant rats were captured, all of the captured rats were found infected with at least one or more endoparasites (100%). Whereas there’s no any ectoparasites identified from the rat. 16(89%) of the rats captured were found positive for haemoparasite. Therefore, the results of this study have shown that the rats are infected with parasite species that may play an important role in transmission of certain zoonotic diseases to humans. Keywords: African Giant rat, Cricetomys Gambianus, endo and ecto parasitic in...

PLOS ONE, 2021

Evasion of apoptosis is associated with treatment resistance and metastasis in colorectal cancer ... more Evasion of apoptosis is associated with treatment resistance and metastasis in colorectal cancer (CRC). Various cellular processes are associated with evasion of apoptosis. These include overexpression of pro-apoptotic proteins (including p53 and PD-L1), anti-apoptotic proteins (BIRC7/Livin and Bcl-2), chemokine receptors (including DARC), and dysregulation of DNA mismatch repair proteins (including MSH2 and PMS2). The aim of this study was to determine the effect of folinic acid, 5-FU and oxaliplatin (FOLFOX) as a single agent and aspirin plus FOLFOX in various combinations on the aforementioned proteins in human CRC, SW480 cell line and rat models of N-Methyl-N-Nitrosourea (NMU)-induced CRC. In addition, effects of the NMU-induced CRC and chemotherapeutic regimens on haematological and biochemical parameters in the rat models were studied. Immunohistochemistry, immunofluorescence and immunoblot techniques were used to study the expression pattern of the related proteins in the hum...

Molecules, 2021

The bacterial leaf blight (BLB) caused by Xanthomonas oryzae pv. oryzae (Xoo) is one of the most ... more The bacterial leaf blight (BLB) caused by Xanthomonas oryzae pv. oryzae (Xoo) is one of the most serious rice diseases, causing huge yield losses worldwide. Several technologies and approaches have been opted to reduce the damage; however, these have had limited success. Recently, scientists have been focusing their efforts on developing efficient and environmentally friendly nanobactericides for controlling bacterial diseases in rice fields. In the present study, a scanning electron microscope (SEM), transmission electron microscope (TEM), and a confocal laser scanning microscope (CLSM) were utilized to investigate the mode of actions of ginger EOs on the cell structure of Xoo. The ginger EOs caused the cells to grow abnormally, resulting in an irregular form with hollow layers, whereas the dimethylsulfoxide (DMSO) treatment showed a typical rod shape for the Xoo cell. Ginger EOs restricted the growth and production of biofilms by reducing the number of biofilms generated as indica...

European Journal of Biology and Biotechnology, 2020

Introduction: Although, used of molluscicides to control the intermediate host of schistosomes is... more Introduction: Although, used of molluscicides to control the intermediate host of schistosomes is the best method of choice to control the spread of the snail fever among the people, synthetic molluscicides widely used are cost effective, not available and toxic to the aquatic lives and people that are completely or partially dependents on rivers or lakes water for their everyday supplement. Aim: this research was aimed at investigation and comparison for the molluscicidal efficacy for S. occidentalis and M. oleifera leaves extracts against B. globosus (intermediate host of Schistosoma haematobium). Methodology: Each of the plant was grinded into powder and purified through column using different solvents, B. globosus snails were collected from Shagari and Goronyo dams; we identified the animal using chart initially, later on the animals were confirmed as B. globosus by malacologist from Ahmadu Bello University Zaria, Nigeria; the Molluscicidal efficacy of the plants was tested agai...

JCO Global Oncology, 2020

PURPOSE Colorectal cancer (CRC) incidence rates are increasing among individuals < 50 years of... more PURPOSE Colorectal cancer (CRC) incidence rates are increasing among individuals < 50 years of age (early-onset CRC) globally with causes unknown. Racial/ethnic disparities in early-onset CRC have also grown more pronounced, because Black individuals have higher early-onset CRC incidence and poorer survival compared with White individuals. We describe the prevalence and burden of early-onset CRC among Africans in Nigeria and African Americans (AAs) in the United States. PATIENTS AND METHODS We identified Black individuals diagnosed with a first primary CRC ages 18 to 49 years between 1989 and 2017 at Ahmadu Bello University Teaching Hospital in Zaria, Nigeria (Nigerians), and in the United States (AAs) using the National Institutes of Health/National Cancer Institute’s SEER program of cancer registries. Multivariable logistic regression models were used to investigate clinical and demographic differences between Nigerians and AAs with early-onset CRC, adjusted for age, sex, tumor...

IOSR Journal of Environmental Science, Toxicology and Food Technology, 2014

Ecotourism is an approach that should be environmentally, socially and economically sustainable. ... more Ecotourism is an approach that should be environmentally, socially and economically sustainable. For this reason, monitoring and evaluating the ecotourism destination is very important. A good practice is using an indicator system for planning and applying ecotourism models that emphasis on the sustainability approach. Ranking and prioritising of sustainabilitycriteria and indicators facilitates evaluating the situation of the destination by managers. The purpose of this study was to prioritizing and ranking the sustainability criteria and indicators for monitoring and assessment of ecotourism management in Penang National Park, Malaysia. A Fuzzy Analytic hierarchical process (FAHP) was used for prioritizing 9 criteria and 21 indicators from four dimensions of 'ecological', 'social', 'economic' and 'institutional' which obtained from a modified Delphi survey. Five experts from academic and non-academics had provided their judgment for the prioritizing process.Ecological dimension had the highest priority and institutional dimension had the least priority. Conservation of biodiversity, community economic improvement and visitor safety had the highest priorityin the ecological, economic and social dimensions respectively. Prioritised criteria and indicator in this study can help managers and stakeholders in monitoring decision making of different sustainability issues in the national park.

Sub-Saharan African Journal of Medicine, 2017

Context: Endometrial malignancies are uncommon tumors in sub-Saharan Africa. However, it has been... more Context: Endometrial malignancies are uncommon tumors in sub-Saharan Africa. However, it has been observed that the incidence of endometrial cancer may be increasing. Objectives: To document the prevalence, clinical profile, and histological types of endometrial malignancies in Ahmadu Bello University Teaching Hospital Zaria, Northern Nigeria. Study Design: Descriptive study. Setting: Departments of Obstetrics & Gynecology and Histo-Pathology Ahmadu Bello University Teaching Hospital Zaria. Materials and Methods: Data of histologically proven cases of endometrial malignant tumors from January 1992–December 2011 were extracted from case notes, cancer registry and histology forms/reports and analyzed using the Statistical Package for the Social Sciences version 17.0 software (SPSS Inc., Chicago, IL, USA). Results: Seventy-seven cases were recorded during the period under review, and this constituted 5% of all genital tract malignancies. The number of cases seen in the first 10 years under review (1992–2001) were 24 (2.4 cases/year), while that of the second decade (2002–2011) were 55 (5.5 cases/year), reflecting more than two-fold increase. The mean age and parity of the patients were 52 ± 14.9 years and 7.4 ± 2.5, respectively. Over 67% of the cases were postmenopausal. Vaginal bleeding was the principal presenting symptom occurring in 100% of cases, and the uterus was enlarged in 82% of patients. Endometrial biopsy was the main method of diagnosis (60% of cases), and 89% of cases were diagnosed in clinical stages 1 and 11. Adenocarcinoma was seen in 78% of cases, while stromal sarcoma constituted 13% and mixed Mullerian tumor accounted for 9%. Total abdominal hysterectomy and bilateral salpingo-oophorectomy was the main treatment offered. Conclusion: The incidence of endometrial carcinoma may be on the increase in our setting. High index of suspicion and endometrial biopsy will diagnose majority of cases.

Molecular and Cellular Biology / Genetics, 2019

Colorectal cancer (CRC) has disproportionately overburden Africans with advanced stage at diagnos... more Colorectal cancer (CRC) has disproportionately overburden Africans with advanced stage at diagnosis and higher mortality rate due in part to issues that include grossly inadequate resources for management and poor understanding of the pathobiology of the disease. Accumulating evidences support the effectiveness of Aspirin in prevention and inhibition of CRC occurrence and cellular growth respectively. The utilisation of 5-fluorouracil (5-FU)-based regimens which include folinic acid, 5-FU and oxaliplatin (FOLFOX) combination in CRC management have not completely halt the distant recurrences and poor prognosis of CRC. In this study, we highlighted evidences that prove Aspirin plus FOLFOX to be promising alternative for clinical trial in Black men with CRC. Our study aims in this research were: to identify the expression pattern of BIRC7 in human CRC cells, SW480 cell line and N-methyl-N-nitrosourea (NMU)-induced CRC in rat; to determine the relationship between BIRC7 and BCL2, p53, PDL-1, MSH1, PMS2, DARC and Annexin V expression in CRC. to examine the efficacy of Aspirin plus neoadjuvant FOLFOX on the BIRC7 in CRC cells in-vivo in rat. Results show significant (P = 0.0001) expression of the BIRC7 in the CRC tissues compared to normal sections. When comparing this expression with Data from TCGA data bank, we observed a significant increase in BIRC7 expression in Caucasian than the Black and Indian and The expression pattern of the BIRC7 was significantly higher (P = 0.0001) in CRC not otherwise specified compared to mucinous CRC histology. The SW480 cell line show increased expression of the BIRC7 protein in-vitro. There was significant expression of the BIRC7 in the NMU-induced CRC cells compared the normal colonic lesion. There was increased expression of the BCL-2 and reduced expression of p53 in the human CRC cases and in the NMU-induced CRC cells model. There was increased expression of the Annexin V, absence of the MSH1, PMS2, PDL1 and DARC protiens in the CRC sections. Aspirin plus FOLFOX may serve as an important adjuvant treatment component for colorectal cancer metastasis and local recurrence in Blacks, Caucasian and Asians. There is need to explore the potential of Aspirin plus FOLFOX for clinical trial in colorectal cancer management in Blacks and other population using approach from our findings. Note: This abstract was not presented at the meeting. Citation Format: Faruk Mohammed, Sani Ibrahim, Sirajo Mohammed Aminu, Ahmed Adamu, Adamu Abdullahi, Abdulmumini Hassan Rafindadi, Yawale Iliyasu, John Idoko, Abdullahi Jubril Randawa, Mohammed Sani Shehu, Atara Ntekim, Abdullahi Mohammed, Aishatu Maude Suleiman, Yahaya Ukwenya, Khalid Zahir Shah, Ahmad Bello, Sani Abubakar, Kasimu Umar Adoke, Cheh Augustin Awasum, Ahmad Mai, Hussaini Yusuf Maitama, Dauda Maigatari. Aspirin plus FOLFOX for colorectal cancer management: A promising alternative for clinical trial in Africans with the disease [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 720.

Cancer Research, 2017

The mechanism of cancer resistance to chemotherapy regimen remains uncertain. Colorectal mucinous... more The mechanism of cancer resistance to chemotherapy regimen remains uncertain. Colorectal mucinous adenocarcinoma is one of the distinct histological subtypes of the disease implicated in chemotherapeutic resistance associated with nodal and peritoneal metastases and worse disease-free survival as an index of poor prognosis. One of the important acquired capabilities used by the cancer cells to resist anticancer therapies is evasion of apoptosis possibly via inhibitor of apoptosis proteins for which Livin is one. This protein contains baculoviral IAP repeat domains in addition to a RING finger, a protein-protein motif important for binding and inhibition of active caspases that interfere with intrinsic and/or extrinsic pathway and the ensuing blockade of apoptosis. Thus, understanding the molecular events on how cancer cells of mucinous histology evade apoptotic death may provide a novel paradigm for a molecular targeted therapy in the management of colorectal mucinous adenocarcinoma...

BackgroundOwing to high levels of resistance to previous first-line non-nucleoside reverse transc... more BackgroundOwing to high levels of resistance to previous first-line non-nucleoside reverse transcriptase inhibitors (NNRTI)-based antiretroviral therapy (ART), consolidated recommendations since 2019, from the WHO and others, have indicated that dolutegravir (DTG) is the preferred drug of choice for HIV treatment, globally. There is a paucity of resistance outcome data from non-B HIV subtypes circulating across West Africa.AimWe aimed to characterise the mutational profiles of HIV-positive patients from a small North-East Nigeria cohort, failing a DTG-based ART regimen.MethodsPlasma samples were collected and stored from 61 HIV-1 infected participants. Following failure of DTG-based ART, all samples were sequenced by Illumina whole-genome, ultra-deep sequencing. Sequencing was successful in (n=33) participants with median age of 40 years and median time on ART of 9 years. HIV-1 subtyping was performed using SNAPPy. Haplotype reconstruction and transmission were inferred using standa...

Best Practice & Research Clinical Anaesthesiology

Cancer Epidemiology, Biomarkers & Prevention

Colorectal cancer incidence rates are rising among individuals age younger than 50 years (early-o... more Colorectal cancer incidence rates are rising among individuals age younger than 50 years (early-onset CRC) globally with causes unknown. Racial and ethnic disparities in early-onset CRC have also grown more pronounced, as blacks have higher early- onset CRC incidence and poorer survival compared with whites. We described the prevalence and burden of early-onset CRC among Africans in Nigeria and African Americans in the United States. We identified black individuals diagnosed with a first primary colorectal cancer ages 18 to 49 years between 1989 and 2017 at Ahmadu Bello University Teaching Hospital in Zaria, Nigeria using the Zaria Cancer Registry (Nigerians), and from population-based cancer registries across the US (African Americans) using the NIH/NCI’s Surveillance, Epidemiology, and End Results (SEER) program. Multivariable logistic regression models were used to investigate clinicopathologic and demographic differences between Nigerians and African Americans with early-onset C...

Cancer Epidemiology, Biomarkers & Prevention

The African continent is facing enormous challenges from cancer crisis, and the lack of reliable ... more The African continent is facing enormous challenges from cancer crisis, and the lack of reliable population database on cancer incidence and mortality hinders high quality decision on prevention and management modalities. The objective of this study is to analyze the trend of malignant tumors in a population of rural Africans attending Ahmadu Bello University Teaching (ABUTH) Hospital Zaria, Nigeria with particular emphasis on the first eighteen (18) frequently diagnosed cancers over a period of 46 consecutive years (1972 - 2019) excluding the year 1988. Histologically diagnosed cancers from the population-based cancer registry of the ABUTH Zaria were included in this study. There were 19, 884 histologically diagnosed cancers over 46 years in ABUTH Zaria with the following in descending order: Cervical cancer 2,335 (12%, [squamous cell carcinoma = 1, 809; others = 529]), Breast cancer 1,982 (10% [invasive ductal carcinoma = 1,589; others = 393]), Lymphoma 1,927 (10% [non–Hodgkin’s l...

2020 24th International Conference on System Theory, Control and Computing (ICSTCC)

This paper presents a Model Reference Adaptive Control (MRAC) based framework for vehicle adaptiv... more This paper presents a Model Reference Adaptive Control (MRAC) based framework for vehicle adaptive cruise control systems. The linear longitudinal dynamic model is created with uncertainties in the state and input matrix. The controller structure aims to handle these uncertainties and also maintains the desired distance with the lead vehicle. To evaluate the performance of the proposed controller, several simulation studies are conducted by comparing the results with a linear state feedback controller via MATLAB/Simulink. Whereas the linear controller underperforms under uncertain conditions, it is seen that MRAC achieves the desired performance despite model uncertainties.

Kanem Journal Medical Sciences, 2022

Background: Phyllodes tumours are rare breast neoplasm. Its clinical spectrum ranges from a benig... more Background: Phyllodes tumours are rare breast neoplasm. Its clinical spectrum ranges from a benign and locally recurrent form of behaviour to malignant and metastatic forms. The age at risk is between 35 and 45 years. Giant phyllodes tumours are larger than 10cm in diameter. Case Report: Herewith, we present a rare case of giant malignant phyllodes tumour (40x30x20cm) in a young lady who survived 10 years post-treatment in which most literature reported 10-year survival of 23% to 42%. The patient had mastectomy and radiotherapy to the anterior chest wall. Conclusion: A young lady with a giant malignant phyllodes tumour survived 10 years following treatment.

Solanum tuberosum - A Promising Crop for Starvation Problem, 2021

Among food crops in terms of consumption, potato ranks fourth, most important and valuable crop w... more Among food crops in terms of consumption, potato ranks fourth, most important and valuable crop worldwide in terms of production and area harvested after maize, wheat and rice. In the coming years, potato production must keep pace with global population expansion nutritiously and sustainably which can partially be achieved by reducing the yield losses caused by the destructive pest and disease activities to the crop. The challenge of 70–80% total microbial crop yield loss posed by pathogens must be addressed for sustainable potato production in order to properly alleviate the global starvation problem. Potato as a food security crop can help to achieve the four food security requirements: food availability, quality, accessibility and stability. Health benefits of potato have shown the presence of phytochemicals as well as resistant starch which serve as anticancer and antidiabetic. The role of potato in the global food security should not be over emphasized, hence in this chapter we...

Cancer Epidemiology, Biomarkers & Prevention, 2020

This study was conducted to determine if prostate cancer status, demographic and health factors a... more This study was conducted to determine if prostate cancer status, demographic and health factors as well as social support, illness perception, financial toxicity and resilience predict the quality of life (QoL) in men and to ascertain the differences between men with and without cancer of the prostate (CaP) in the QoL subscales and significant predictors of QoL. Quality of life, social support, illness perception, financial toxicity and resilience were assessed using the Functional Assessment of Cancer Therapy-Prostate (FACT-P), the Multidimensional Scale of Perceived Social Support (MSPSS), Brief Illness Perception Questionnaire (BriefIPQ), The COmprehensive Score for financial Toxicity (Cost Facit) and the Brief Resilience Scale (BRS) respectively. Each scale was assessed and found to possess acceptable levels of reliability (Alpha =.551 to .899). Demographic and clinical information were also collected include age, marital status, religion, education, income, ethnic group, health...

Lecture Notes in Electrical Engineering, 2021

There has been a constant rise in interest on the subjects of robotics and additive manufacturing... more There has been a constant rise in interest on the subjects of robotics and additive manufacturing. Although robotics being older than additive manufacturing, both subjects have gained increased publicity in terms of research over the years. The objective of this paper is to review 3D printing, robotics education, and finally how 3D printing has contributed to robotics education over a period of ten years between 2011 and 2020. the last ten (10) years. By restricting the search to academic articles only, papers comprising of journal papers and conference proceedings were reviewed. For each paper, three information were sought which includes; robotics education, 3D printing, and finally how these two have been used together. We expect that the result of this review will serve as a pivot for schools at all levels to combine both subject areas and include the union into their STEM curricula which is believed to improve robotics education. The review shows that both tertiary and lower educational levels of robotics education benefit immensely from 3D printing. We also find out that most of the contributions of 3D printing to robotics education comes more in the form of using already printed parts rather than using the 3D printer itself. The challenges and trends are highlighted and future research directions have been suggested in this paper.

Asian Journal of Advanced Research and Reports, 2018

Synthetic molluscicides widely used for the control of urinary schistosomiasis are expensive, tox... more Synthetic molluscicides widely used for the control of urinary schistosomiasis are expensive, toxic to non-target organisms, not available and may have deleterious long-term effects in the environment. The aim of this research is to compare the efficacy of column purified fractions of Allium cepa and Allium sativum against Bulinus globosus specimens (intermediate host of urinary schistosomiasis) under laboratory conditions as an increment for the cheaper, non-toxic, available way of controlling urinary schistosomiasis. Extracts were obtained using cold maceration method with methanol as a polar solvent; column purification was achieved using silica gel (stationary phase) while ethyl acetate and n-hexane (mobile phase); thirteen fractions were collected from each plant and each fraction contained 10ml of the eluent; the fractions were left open for 48 hours for evaporation of the solvents. Experiments were performed according to the methodology described by the World Health Organizat...

International Journal of Research and Review, 2021

Rodents are one of the most important groups of mammalian animal with more than 42%of the known m... more Rodents are one of the most important groups of mammalian animal with more than 42%of the known mammalian species, with 1700 species which belongs to three different families include Muridae, microtidaie and sigmodontidae. The aim of this study is to examine endo and ecto parasitic infection of African Giant rat (Cricetomys Gambianus). Intestinal parasite were detected and identified from the stool samples using formalin ethyl-acetate concentration technique. A total of 18 African giant rats were captured, all of the captured rats were found infected with at least one or more endoparasites (100%). Whereas there’s no any ectoparasites identified from the rat. 16(89%) of the rats captured were found positive for haemoparasite. Therefore, the results of this study have shown that the rats are infected with parasite species that may play an important role in transmission of certain zoonotic diseases to humans. Keywords: African Giant rat, Cricetomys Gambianus, endo and ecto parasitic in...

PLOS ONE, 2021

Evasion of apoptosis is associated with treatment resistance and metastasis in colorectal cancer ... more Evasion of apoptosis is associated with treatment resistance and metastasis in colorectal cancer (CRC). Various cellular processes are associated with evasion of apoptosis. These include overexpression of pro-apoptotic proteins (including p53 and PD-L1), anti-apoptotic proteins (BIRC7/Livin and Bcl-2), chemokine receptors (including DARC), and dysregulation of DNA mismatch repair proteins (including MSH2 and PMS2). The aim of this study was to determine the effect of folinic acid, 5-FU and oxaliplatin (FOLFOX) as a single agent and aspirin plus FOLFOX in various combinations on the aforementioned proteins in human CRC, SW480 cell line and rat models of N-Methyl-N-Nitrosourea (NMU)-induced CRC. In addition, effects of the NMU-induced CRC and chemotherapeutic regimens on haematological and biochemical parameters in the rat models were studied. Immunohistochemistry, immunofluorescence and immunoblot techniques were used to study the expression pattern of the related proteins in the hum...

Molecules, 2021

The bacterial leaf blight (BLB) caused by Xanthomonas oryzae pv. oryzae (Xoo) is one of the most ... more The bacterial leaf blight (BLB) caused by Xanthomonas oryzae pv. oryzae (Xoo) is one of the most serious rice diseases, causing huge yield losses worldwide. Several technologies and approaches have been opted to reduce the damage; however, these have had limited success. Recently, scientists have been focusing their efforts on developing efficient and environmentally friendly nanobactericides for controlling bacterial diseases in rice fields. In the present study, a scanning electron microscope (SEM), transmission electron microscope (TEM), and a confocal laser scanning microscope (CLSM) were utilized to investigate the mode of actions of ginger EOs on the cell structure of Xoo. The ginger EOs caused the cells to grow abnormally, resulting in an irregular form with hollow layers, whereas the dimethylsulfoxide (DMSO) treatment showed a typical rod shape for the Xoo cell. Ginger EOs restricted the growth and production of biofilms by reducing the number of biofilms generated as indica...

European Journal of Biology and Biotechnology, 2020

Introduction: Although, used of molluscicides to control the intermediate host of schistosomes is... more Introduction: Although, used of molluscicides to control the intermediate host of schistosomes is the best method of choice to control the spread of the snail fever among the people, synthetic molluscicides widely used are cost effective, not available and toxic to the aquatic lives and people that are completely or partially dependents on rivers or lakes water for their everyday supplement. Aim: this research was aimed at investigation and comparison for the molluscicidal efficacy for S. occidentalis and M. oleifera leaves extracts against B. globosus (intermediate host of Schistosoma haematobium). Methodology: Each of the plant was grinded into powder and purified through column using different solvents, B. globosus snails were collected from Shagari and Goronyo dams; we identified the animal using chart initially, later on the animals were confirmed as B. globosus by malacologist from Ahmadu Bello University Zaria, Nigeria; the Molluscicidal efficacy of the plants was tested agai...

JCO Global Oncology, 2020

PURPOSE Colorectal cancer (CRC) incidence rates are increasing among individuals < 50 years of... more PURPOSE Colorectal cancer (CRC) incidence rates are increasing among individuals < 50 years of age (early-onset CRC) globally with causes unknown. Racial/ethnic disparities in early-onset CRC have also grown more pronounced, because Black individuals have higher early-onset CRC incidence and poorer survival compared with White individuals. We describe the prevalence and burden of early-onset CRC among Africans in Nigeria and African Americans (AAs) in the United States. PATIENTS AND METHODS We identified Black individuals diagnosed with a first primary CRC ages 18 to 49 years between 1989 and 2017 at Ahmadu Bello University Teaching Hospital in Zaria, Nigeria (Nigerians), and in the United States (AAs) using the National Institutes of Health/National Cancer Institute’s SEER program of cancer registries. Multivariable logistic regression models were used to investigate clinical and demographic differences between Nigerians and AAs with early-onset CRC, adjusted for age, sex, tumor...

IOSR Journal of Environmental Science, Toxicology and Food Technology, 2014

Ecotourism is an approach that should be environmentally, socially and economically sustainable. ... more Ecotourism is an approach that should be environmentally, socially and economically sustainable. For this reason, monitoring and evaluating the ecotourism destination is very important. A good practice is using an indicator system for planning and applying ecotourism models that emphasis on the sustainability approach. Ranking and prioritising of sustainabilitycriteria and indicators facilitates evaluating the situation of the destination by managers. The purpose of this study was to prioritizing and ranking the sustainability criteria and indicators for monitoring and assessment of ecotourism management in Penang National Park, Malaysia. A Fuzzy Analytic hierarchical process (FAHP) was used for prioritizing 9 criteria and 21 indicators from four dimensions of 'ecological', 'social', 'economic' and 'institutional' which obtained from a modified Delphi survey. Five experts from academic and non-academics had provided their judgment for the prioritizing process.Ecological dimension had the highest priority and institutional dimension had the least priority. Conservation of biodiversity, community economic improvement and visitor safety had the highest priorityin the ecological, economic and social dimensions respectively. Prioritised criteria and indicator in this study can help managers and stakeholders in monitoring decision making of different sustainability issues in the national park.

Sub-Saharan African Journal of Medicine, 2017

Context: Endometrial malignancies are uncommon tumors in sub-Saharan Africa. However, it has been... more Context: Endometrial malignancies are uncommon tumors in sub-Saharan Africa. However, it has been observed that the incidence of endometrial cancer may be increasing. Objectives: To document the prevalence, clinical profile, and histological types of endometrial malignancies in Ahmadu Bello University Teaching Hospital Zaria, Northern Nigeria. Study Design: Descriptive study. Setting: Departments of Obstetrics & Gynecology and Histo-Pathology Ahmadu Bello University Teaching Hospital Zaria. Materials and Methods: Data of histologically proven cases of endometrial malignant tumors from January 1992–December 2011 were extracted from case notes, cancer registry and histology forms/reports and analyzed using the Statistical Package for the Social Sciences version 17.0 software (SPSS Inc., Chicago, IL, USA). Results: Seventy-seven cases were recorded during the period under review, and this constituted 5% of all genital tract malignancies. The number of cases seen in the first 10 years under review (1992–2001) were 24 (2.4 cases/year), while that of the second decade (2002–2011) were 55 (5.5 cases/year), reflecting more than two-fold increase. The mean age and parity of the patients were 52 ± 14.9 years and 7.4 ± 2.5, respectively. Over 67% of the cases were postmenopausal. Vaginal bleeding was the principal presenting symptom occurring in 100% of cases, and the uterus was enlarged in 82% of patients. Endometrial biopsy was the main method of diagnosis (60% of cases), and 89% of cases were diagnosed in clinical stages 1 and 11. Adenocarcinoma was seen in 78% of cases, while stromal sarcoma constituted 13% and mixed Mullerian tumor accounted for 9%. Total abdominal hysterectomy and bilateral salpingo-oophorectomy was the main treatment offered. Conclusion: The incidence of endometrial carcinoma may be on the increase in our setting. High index of suspicion and endometrial biopsy will diagnose majority of cases.

Molecular and Cellular Biology / Genetics, 2019

Colorectal cancer (CRC) has disproportionately overburden Africans with advanced stage at diagnos... more Colorectal cancer (CRC) has disproportionately overburden Africans with advanced stage at diagnosis and higher mortality rate due in part to issues that include grossly inadequate resources for management and poor understanding of the pathobiology of the disease. Accumulating evidences support the effectiveness of Aspirin in prevention and inhibition of CRC occurrence and cellular growth respectively. The utilisation of 5-fluorouracil (5-FU)-based regimens which include folinic acid, 5-FU and oxaliplatin (FOLFOX) combination in CRC management have not completely halt the distant recurrences and poor prognosis of CRC. In this study, we highlighted evidences that prove Aspirin plus FOLFOX to be promising alternative for clinical trial in Black men with CRC. Our study aims in this research were: to identify the expression pattern of BIRC7 in human CRC cells, SW480 cell line and N-methyl-N-nitrosourea (NMU)-induced CRC in rat; to determine the relationship between BIRC7 and BCL2, p53, PDL-1, MSH1, PMS2, DARC and Annexin V expression in CRC. to examine the efficacy of Aspirin plus neoadjuvant FOLFOX on the BIRC7 in CRC cells in-vivo in rat. Results show significant (P = 0.0001) expression of the BIRC7 in the CRC tissues compared to normal sections. When comparing this expression with Data from TCGA data bank, we observed a significant increase in BIRC7 expression in Caucasian than the Black and Indian and The expression pattern of the BIRC7 was significantly higher (P = 0.0001) in CRC not otherwise specified compared to mucinous CRC histology. The SW480 cell line show increased expression of the BIRC7 protein in-vitro. There was significant expression of the BIRC7 in the NMU-induced CRC cells compared the normal colonic lesion. There was increased expression of the BCL-2 and reduced expression of p53 in the human CRC cases and in the NMU-induced CRC cells model. There was increased expression of the Annexin V, absence of the MSH1, PMS2, PDL1 and DARC protiens in the CRC sections. Aspirin plus FOLFOX may serve as an important adjuvant treatment component for colorectal cancer metastasis and local recurrence in Blacks, Caucasian and Asians. There is need to explore the potential of Aspirin plus FOLFOX for clinical trial in colorectal cancer management in Blacks and other population using approach from our findings. Note: This abstract was not presented at the meeting. Citation Format: Faruk Mohammed, Sani Ibrahim, Sirajo Mohammed Aminu, Ahmed Adamu, Adamu Abdullahi, Abdulmumini Hassan Rafindadi, Yawale Iliyasu, John Idoko, Abdullahi Jubril Randawa, Mohammed Sani Shehu, Atara Ntekim, Abdullahi Mohammed, Aishatu Maude Suleiman, Yahaya Ukwenya, Khalid Zahir Shah, Ahmad Bello, Sani Abubakar, Kasimu Umar Adoke, Cheh Augustin Awasum, Ahmad Mai, Hussaini Yusuf Maitama, Dauda Maigatari. Aspirin plus FOLFOX for colorectal cancer management: A promising alternative for clinical trial in Africans with the disease [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 720.

Cancer Research, 2017

The mechanism of cancer resistance to chemotherapy regimen remains uncertain. Colorectal mucinous... more The mechanism of cancer resistance to chemotherapy regimen remains uncertain. Colorectal mucinous adenocarcinoma is one of the distinct histological subtypes of the disease implicated in chemotherapeutic resistance associated with nodal and peritoneal metastases and worse disease-free survival as an index of poor prognosis. One of the important acquired capabilities used by the cancer cells to resist anticancer therapies is evasion of apoptosis possibly via inhibitor of apoptosis proteins for which Livin is one. This protein contains baculoviral IAP repeat domains in addition to a RING finger, a protein-protein motif important for binding and inhibition of active caspases that interfere with intrinsic and/or extrinsic pathway and the ensuing blockade of apoptosis. Thus, understanding the molecular events on how cancer cells of mucinous histology evade apoptotic death may provide a novel paradigm for a molecular targeted therapy in the management of colorectal mucinous adenocarcinoma...