Chiara Giacomini - Academia.edu (original) (raw)

Chiara Giacomini

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Papers by Chiara Giacomini

Research paper thumbnail of Immunoregulation in the Hematopoietic Stem Cell Niche

Abstract The identification of cell populations of immunological origin and function in the hemat... more Abstract The identification of cell populations of immunological origin and function in the hematopoietic stem cell (HSC) niche has unveiled an unconventional role of the niche in regulating HSC activity. These immune cells cooperate with the well-known properties of mesenchymal and vascular cells in orchestrating HSC quiescence, self-renewal, and differentiation by controlling local inflammation. Monocytes/macrophages and other diverse cells of myeloid origin, as well as conventional and regulatory T cells have been characterized as critical players. Interestingly, mesenchymal stromal cells might modulate many aspects of this complex cellular cross-talk, providing fundamental insights on how inflammation ultimately regulates tissue repair and regeneration.

Research paper thumbnail of Safety and Efficacy of Topical Infliximab in a Mouse Model of Ocular Surface Scarring

Investigative Ophthalmology & Visual Science, Mar 1, 2013

Research paper thumbnail of Substance P Expression and Its Inhibition in Corneal Neovascularization

Research paper thumbnail of Tie2-gfp Transgenic Mouse As A New Model To Study Corneal Neovascularization

Investigative Ophthalmology & Visual Science, 2012

Research paper thumbnail of Safety and Efficacy of Topical Infliximab in a Mouse Model of Ocular Surface Scarring

Investigative Opthalmology & Visual Science, 2013

Research paper thumbnail of Immunoregulation in the Hematopoietic Stem Cell Niche

Abstract The identification of cell populations of immunological origin and function in the hemat... more Abstract The identification of cell populations of immunological origin and function in the hematopoietic stem cell (HSC) niche has unveiled an unconventional role of the niche in regulating HSC activity. These immune cells cooperate with the well-known properties of mesenchymal and vascular cells in orchestrating HSC quiescence, self-renewal, and differentiation by controlling local inflammation. Monocytes/macrophages and other diverse cells of myeloid origin, as well as conventional and regulatory T cells have been characterized as critical players. Interestingly, mesenchymal stromal cells might modulate many aspects of this complex cellular cross-talk, providing fundamental insights on how inflammation ultimately regulates tissue repair and regeneration.

Research paper thumbnail of Safety and Efficacy of Topical Infliximab in a Mouse Model of Ocular Surface Scarring

Investigative Ophthalmology & Visual Science, Mar 1, 2013

Research paper thumbnail of Substance P Expression and Its Inhibition in Corneal Neovascularization

Research paper thumbnail of Tie2-gfp Transgenic Mouse As A New Model To Study Corneal Neovascularization

Investigative Ophthalmology & Visual Science, 2012

Research paper thumbnail of Safety and Efficacy of Topical Infliximab in a Mouse Model of Ocular Surface Scarring

Investigative Opthalmology & Visual Science, 2013

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