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Graduate Center of the City University of New York
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Papers by EL JO
Journal of Symbolic Computation, 2000
International audienc
Nature Genetics, 2006
Atopic disease, including atopic dermatitis (eczema), allergy and asthma, has increased in freque... more Atopic disease, including atopic dermatitis (eczema), allergy and asthma, has increased in frequency in recent decades 1 and now affects B20% of the population in the developed world. Twin and family studies have shown that predisposition to atopic disease is highly heritable 2. Although most genetic studies have focused on immunological mechanisms, a primary epithelial barrier defect has been anticipated 3. Filaggrin is a key protein that facilitates terminal differentiation of the epidermis and formation of the skin barrier. Here we show that two independent loss-of-function genetic variants (R510X and 2282del4) in the gene encoding filaggrin (FLG) are very strong predisposing factors for atopic dermatitis. These variants are carried by B9% of people of European origin. These variants also show highly significant association with asthma occurring in the context of atopic dermatitis. This work establishes a key role for impaired skin barrier function in the development of atopic disease.
Journal of Symbolic Computation, 2000
Recent theoretical advances in elimination theory use straight-line programs as a datastructure t... more Recent theoretical advances in elimination theory use straight-line programs as a datastructure to represent multivariate polynomials. We present here the Projective Noether Package which is a Maple implementation of one of these new algorithms, yielding as a byproduct a computation of the dimension of a projective variety. Comparative results on benchmarks for time and space of several families of multivariate polynomial equation systems are given and we point out both weaknesses and advantages of different approaches.
Journal of Symbolic Computation, 2000
International audienc
Nature Genetics, 2006
Atopic disease, including atopic dermatitis (eczema), allergy and asthma, has increased in freque... more Atopic disease, including atopic dermatitis (eczema), allergy and asthma, has increased in frequency in recent decades 1 and now affects B20% of the population in the developed world. Twin and family studies have shown that predisposition to atopic disease is highly heritable 2. Although most genetic studies have focused on immunological mechanisms, a primary epithelial barrier defect has been anticipated 3. Filaggrin is a key protein that facilitates terminal differentiation of the epidermis and formation of the skin barrier. Here we show that two independent loss-of-function genetic variants (R510X and 2282del4) in the gene encoding filaggrin (FLG) are very strong predisposing factors for atopic dermatitis. These variants are carried by B9% of people of European origin. These variants also show highly significant association with asthma occurring in the context of atopic dermatitis. This work establishes a key role for impaired skin barrier function in the development of atopic disease.
Journal of Symbolic Computation, 2000
Recent theoretical advances in elimination theory use straight-line programs as a datastructure t... more Recent theoretical advances in elimination theory use straight-line programs as a datastructure to represent multivariate polynomials. We present here the Projective Noether Package which is a Maple implementation of one of these new algorithms, yielding as a byproduct a computation of the dimension of a projective variety. Comparative results on benchmarks for time and space of several families of multivariate polynomial equation systems are given and we point out both weaknesses and advantages of different approaches.