Feyza Demir - Academia.edu (original) (raw)

Papers by Feyza Demir

Selçuk Sağlık Dergisi, Dec 2, 2021

Necmettin Erbakan Üniversitesi, 2013

Marife Dini Araştırmalar Dergisi, 2016

Orijinal metinde italik olarak geçen kelimeler çeviride de italik olarak gösterilmiştir (çeviren ... more Orijinal metinde italik olarak geçen kelimeler çeviride de italik olarak gösterilmiştir (çeviren notu)

Ankara : İhsan Doğramacı Bilkent Üniversitesi İktisadi, İdari ve Sosyal Bilimler Fakültesi, Tarih... more Ankara : İhsan Doğramacı Bilkent Üniversitesi İktisadi, İdari ve Sosyal Bilimler Fakültesi, Tarih Bölümü, 2015.This work is a student project of the The Department of History, Faculty of Economics, Administrative and Social Sciences, İhsan Doğramacı Bilkent University.by Ünsal, Mehmet Süha

Graduate and PhD students of METU Informatics Institute have calculated cost of quality of real p... more Graduate and PhD students of METU Informatics Institute have calculated cost of quality of real projects in their own organization as an assignment and analyzed their findings. This study examines the results of these analyses and this type of assignments on industry and on Professional viewpoints of the students who are also participants in the industry. Anahtar kelimeler: Kalite maliyeti, yazılım kalitesi, süreç iyileştirme

Flora the Journal of Infectious Diseases and Clinical Microbiology, 2018

* bu çalışmanın bir bölümü 6. ulusal Tanısal ve Moleküler Mikrobiyoloji Kongresi (15-19 Haziran 2... more * bu çalışmanın bir bölümü 6. ulusal Tanısal ve Moleküler Mikrobiyoloji Kongresi (15-19 Haziran 2010, Ankara)'nde poster olarak sunulmuştur. ÖZET Giriş: Aspergillus cinsi küf mantarlarının klinik örneklerde kültürde üretilme başarısı %50'yi geçmemektedir. Nötropenik ateş dönemindeki hastaların bir çoğunda ampirik antifungal tedavi başlanması nedeniyle, kültürde herhangi bir mantarın üretilebilme olasılığı azalmaktadır. Moleküler yöntemlerde hedeflenen mikroorganizmanın DNA'sı gösterildiği için tedavi başlanmış olması tanıyı olumsuz yönde etkilememektedir. Bu çalışmada, Aspergillus cinsi mantarların DNA'sının gösterilmesi için geliştirilen kalitatif gerçek zamanlı polimeraz zincir reaksiyonu yöntemi sunulmuştur. Materyal ve Metod: Örneklerden DNA izolasyonu hazır sistem kullanılmadan yapılmıştır. Aspergillus cinsi mantarların rDNA gen bölgesinden 28S alt ünitesi hedeflenmiş, TaqMan amplifikasyon gerçekleştirilmiştir. Yöntemin aspergillozdaki tanısal değeri farklı örnekler kullanılarak incelenmiştir. Aspergillus kolonisi ile kontamine edilen "simüle" kan örnekleri, aspergilloz oluşturulan deney hayvanı kan ve dokuları ve aspergilloz şüphesiyle takip edilen hasta örnekleri ile toplam 60 örnek çalışılmıştır. Bulgular: En çok yalancı negatiflik deneysel olarak aspergilloz oluşturulmuş hayvanların doku örneklerinde elde edilmiştir. Hayvan doku örneklerinin 4 (%40)'ünde, hayvan kan örneklerinin 3 (%30)'ünde, simüle kan örneklerinin 2 (%20)'sinde, hasta örneklerinin 1 (%10)'inde yalancı negatif sonuç alınmıştır. Koloni süspansiyonlarının tamamı pozitif bulunmuştur. Sonuç: Geliştirdiğimiz yöntemin kan örneklerinde Aspergillus DNA'sının gösterilmesinde başarılı olduğu ancak, doku örnekleri için geliştirilmesi gerektiğine karar verilmiştir. Yöntemin tanısal değerinin geniş gruplarda yapılacak çalışmalar ile desteklenmesi gerekmektedir.

Mikrobiyoloji Bulteni, 2014

Clinical and Experimental Obstetrics & Gynecology, 2017

Though the number is on the increase throughout the world each day, an estimated 100 million fema... more Though the number is on the increase throughout the world each day, an estimated 100 million females worldwide so far are known to have been subjected to genital mutilation. Female genital mutilation (FGM), which is also known as female circumcision (FC), is a lifethreatening practice that results in many long-lasting health complications in both women and children's lives, especially in underdeveloped regions where its practice is carried out under unhygienic conditions by people who lack medical knowledge even without using any anesthesia and equipment. Furthermore, this non-medical practice brings about a number of both immediate and later complications. In addition to causing sexually dysfunctional, the other immediate effects following the circumcision can be bleeding, infections. psychological shock, and not being able to pass urine. Other complications include repetitive infections of urinary tract, urinary genital tract fistula, pelvic pain, sexually dysfunctional, complications during delivery such as bleeding because of tears and cuts, and maternal and fatal morbidity in case of prolonged stages of labour, thus leading to an increase in mortalities. Despite the opposition of World Health Organization (WHO), UNICEF and the efforts of many Civil Works Organisations, along with the legislations of the Governments for its eradication, circumcision is still continuing to be practised in Africa. In this article the authors aimed to present a case of a ten-year-old child who has a two-year history of type 3 circumcision and discuss the complications of female circumcision performed at early ages.

European Journal of Gynaecological Oncology, 2021

Background: Selective tropomyosin receptor kinase (Trk) inhibitors are known to provide promising... more Background: Selective tropomyosin receptor kinase (Trk) inhibitors are known to provide promising outcomes in selected tumor patients with neurotrophic tyrosine receptor kinase (NTRK) gene fusions. In the present study, we aimed to determine whether there was a NTRK1 and NTRK2 expression in cervical squamous cell carcinoma (SCC) and precursor lesions. Materials and methods: A total of 92 formalin-fixed paraffin-embedded tissue samples of cervical SCC, squamous intraepithelial lesion (SIL) and non-neoplastic cervical tissue (NCT) were subjected to immunohistochemical (IHC) staining with NTRK1 and NTRK2 antibodies. These stainings were compared with p16/Ki-67 (IHC) and the low-risk/high-risk Human papillomavirus (HPV) in situ hybridization stainings that were previously administered. Results: In IHC analysis, NTRK1 expression was detected in 3.2% and 12.5% of SCC and cervical intraepithelial neoplasia (CIN)-2 samples, respectively. In addition, NTRK2 expression was detected in 6.5% and 6.3% of SCC and CIN-2 samples, respectively. However, NTRK1/NTRK2 expression was not detected in samples of NCT, CIN-1, and CIN-3. The p16 and Ki-67 expression and high-risk HPV positivity increased as the grade of the lesion increased. Conclusions: The results indicated that both NTRK1 and NTRK2 had no contributory effect on the grading and differentiation of cervical SCC and SIL. We consider that the IHC method is likely to be used for the screening of NTRK gene fusions in patients with cervical SCC. Trk inhibitors are likely to be a favorable therapeutic alternative for this low number of SCC cases with positive NTRK1/NTRK2 staining. Further studies are needed to confirm these ideas.

which permits unrestricted use, distribution, and reproduction in any medium, provided the origin... more which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. About 100millionwomen are estimated to be circumcised globally. Various rates of complications have been encountered, especially after circumcision, such as bleeding, infection, shock, menstrual irregularity, difficulty in urination or common urinary tract infections, inguinal pain, difficulty in sexual intercourse, and genital circumcision scar especially at the vulvar region, and cystic or solid character mass in short and long term. Furthermore, the maternal-fetal morbidity and mortality increase due to bleeding and fistula, which develop after prolonged labor, travail, and difficult labors. Our aim in this paper was to discuss a 42-year-old multiparous female case who had undergone type 2 radical genital mutilation (circumcision) when she was 7 years of age, along with the literature, which has been evaluated for the gradually growing mass at the left ingui...

Journal of Current Pathology, 2017

Amaç: serviks kanseri, önleme programlarına rağmen dünya genelinde kadın ölümlerinin önde gelen n... more Amaç: serviks kanseri, önleme programlarına rağmen dünya genelinde kadın ölümlerinin önde gelen nedenlerindendir. bu çalışmanın amacı, servikal intraepitelyal neoplazi ve skuamöz hücreli karsinom olgularında, HPV-HR ve p16 değerlendirilmesi ile sitolojik ve histopatolojik sonuçların karşılaştırılmasıdır. Gereç ve Yöntem: Hastanemiz Patoloji Kliniğinde histopatolojik olarak servikal intraepitelyal neoplazi ve skuamöz hücreli karsinom tanısı almış 51 olgu daha önceki servikal smear sonuçları ile uyumluluk açısından değerlendirildi. silver in situ hibridizasyon yöntemi ile servikal intraepitelyal neoplazi ve skuamöz hücreli karsinom olgularında HPV-HR varlığı ve aynı doku biyopsilerinde immünohistokimyasal olarak p16 ekspresyonu değerlendirildi. Bulgular: smear sonuçlarına göre servikal intraepitelyal neoplazi düzeyinin farklılık gösterdiği saptandı. Mevcut bulgulardan smearlerinde yüksek dereceli skuamöz intraepitelyal lezyon ile ayrılamayan atipik skuamöz hücreler ve yüksek dereceli skuamöz intraepitelyal lezyon saptanmış olan olguların, doku biyopsilerinde CIn I'e nazaran daha çok CIn II ve CIn III tanısı aldıkları saptanmıştır. Aynı test ile değerlendirildiğinde HPV-HR düzeyine göre histolojik tanı tiplerinin farklılık gösterdiği saptandı. Histopatolojik incelemede CIn I olarak değerlendirilen olguların %35'inde, CIn II olarak değerlendirilen olguların %93.3'ünde, CIn III olarak değerlendirilen olguların %92.3'ünde ve skuamöz hücreli karsinom olarak değerlendirilen olguların %100'ünde p16 ile pozitif boyanma görülmüştür. Sonuç: servikal smear testi, in situ hibridizasyon yöntemi ile HPV-HR değerlendirilmesi ve immünohistokimyasal olarak p16 uygulanması, servikal intraepitelyal neoplazilerin erken tanı ve tedavisinde oldukça önemli ve gereklidir.

Van Medical Journal, 2021

Objective: Epstein Barr virus (EBV) is a type of virus associated with many types of cancer in hu... more Objective: Epstein Barr virus (EBV) is a type of virus associated with many types of cancer in humans. The relation between EBV and breast cancer varies in different studies. We also studied the presence of EBV in breast neoplasms, in our region. Materials and Methods: In this study, breast biopsy samples from 57 patients embedded in paraffin blocks were used. Twenty of these patients were diagnosed with fibroadenoma. Thirty-seven of the patients were diagnosed with invasive ductal carcinoma. Out of the 37 invasive ductal carcinoma patients, 13 were graded as grade 1, 12 as grade 2 and 12 as grade 3 based on the Nottingham modification of the Bloom Richardson system. Epstein-Barr Virus Early RNA (EBER) in situ hybridization method was applied to all biopsies to research the presence of EBV. Results: The EBER in situ hybridization method shows, positive staining in 5 of 20 fibroadenomas, 4 of 13 Grade 1 invasive ductal carcinomas and 2 of 12 Grade 2 invasive ductal carcinomas. All cases with grade 3 invasive ductal carcinoma were negative. Conclusion: Although there was no statistically significant difference in our study, it was thought that further studies which are more sensitive on demonstrating the presence of EBV are needed, since staining was observed in some tumor cells.

Turkish Bulletin of Hygiene and Experimental Biology, 2021

Brucella Coombs gel test: Can it replace other serological methods as a rapid test in serological... more Brucella Coombs gel test: Can it replace other serological methods as a rapid test in serological diagnosis of brucellosis? Brucella Coombs jel testi: Brusellozun serolojik tanısında hızlı bir test olarak diğer serolojik yöntemlerin yerini alabilir mi? Begüm Nalça ERDIN 1 (ID), Mehmet PARLAK 2 (ID), Ayşe GÜVEN AYDINLI 3 (ID), Feyza DEMIR 2 (ID) ÖZET Amaç: Çalışmada brusellozun serolojik tanısında kullanılan Standart tüp aglütinasyon testi (STA), Coombs anti-Brucella testi (CAB) ve Brucellacapt testi (CAPT) ile Brucella Coombs jel testinin (BCGT) sonuçlarının karşılaştırılması amaçlanmıştır. Yöntem: 180 kan örneği çalışmaya dâhil edilmiş ve eş zamanlı olarak STA, CAB, CAPT ve BCGT çalışılmıştır. Testlerin sonuçları tanısal performans ve kappa uyumu açısından değerlendirilmiştir. Bulgular: Testler tanısal performans açısından brusellozun serolojik tanısında referans bir yöntem olan CAB testiyle karşılaştırıldığında, en yüksek duyarlılık (%98,1) ve doğruluk (%98,9) BCGT testinde bulunmuştur. Testler Kappa analizi ile değerlendirilip yöntemler arası uyuma bakıldığında, yine BCGT'nin en yüksek değere (0.796) ve CAB ile önemli derecede uyuma sahip olduğu görülmüştür. Sonuç: Sonuç olarak, CAB ile karşılaştırıldığında, testler arasında BCGT'nin en yüksek duyarlılık ve doğruluğu gösterdiği ve CAB ile istatistiksel olarak anlamlı ve önemli düzeyde bir uyuma sahip olduğu görülmüştür. Ayrıca, test sonuçları için sürenin kısalması ve deneyimli personele duyulan ihtiyacı ortadan kaldırılması, bu testi diğer yöntemlerden üstün kılmaktadır. Her ne kadar BCGT, brusellozun serolojik tanısında diğer testlerin yerini alabilecek gibi görünse de kültür ile doğrulanmış vaka ABSTRACT Objective: The aim of the study was to compare the results of Brucella Coombs gel test (BCGT) with Standart tube agglutination test (STA), Coombs anti-Brucella test (CAB), Brucellacapt test (CAPT) for the serological diagnosis of brucellosis. Methods: A total of 180 blood samples, were included in the study and were simultaneously tested with STA, CAB, CAPT and BCGT. Results of the tests were evaluated in terms of diagnostic performance and Kappa coefficient. Results: When the tests were compared to CAB test, which is a reference method in the serological diagnosis of the brucellosis, in terms of diagnostic performance; the highest sensitivity (98.1%) and accuracy (98.9%) was found with BCGT. When tests were evaluated in terms of Kappa coefficient, BCGT had the highest value (0.796) and substantial agreement with CAB. Conclusion: In conclusion, when compared with CAB, BCGT showed substantial agreement and highest sensitivity and accuracy. In addition, reduction of the period for test results and elimination of the need for experienced staff makes this test superior to other methods. Although BCGT seems to replace other tests in the serological diagnosis of brucellosis, its sensitivity and specificity should be put forward in culture-confirmed

Turkish Journal of Nephrology, 2020

Eastern Journal Of Medicine, 2020

Papanicolaou cytology (Pap smear) is a screening technique recommended by World Health Organizati... more Papanicolaou cytology (Pap smear) is a screening technique recommended by World Health Organization (WHO), commonly used in the detection of precancerous lesions. This study aimed to compare the Pap smear results and the subsequent biopsy results in 258 patients diagnosed in our clinic to analyse their false-positive and false-negative rates and to discuss the outcomes in light of literature. The study included Pap smear specimens archived for four years that had undergone histopatholojical diagnoses of cervical biopsy, conization, curettage, and/or histerectomy within the three months. In the retrospective analysis, cytological diagnosis and the histological diagnosis which had been established within the subsequent three months were compared and then the false-negative and false-positive rates were calculated. In the cyto-histological comparison, the false-negative and false-positive rates independent of class ratio were 4,3% and 19%, respectively. The sensitivity, selectivity, positive and negative predictive values were 69%, 98%, 89% and 93%, respectively, excluding atypical classes of the cytologic diagnoses. As can be seen in our results, the correlation between Pap smear and biopsy results in our patients displayed an unignorable inconsistency although it was not remarkably different from those reported in the literature. Such discrepancies, which are likely to be detected in the cy to-histopathological studies around the world and do not attenuate the value of cervical cytology despite being unignorable, indicate the necessity of screening schemes involving the combined and effective use of different techniques such as Human papillomavirus (HPV) tests, repeated smear examinations, colposcopic examination, and biopsy in patients diagnosed by cervical cytology.

Eastern Journal Of Medicine, 2018

Castleman's disease (CD) is described as a nodal lympho-follicular hyperplasia and mostly seen in... more Castleman's disease (CD) is described as a nodal lympho-follicular hyperplasia and mostly seen in thoracic cavity. The occurrence in pelvic cavity is very rare. It is usually mimicking the pelvic adnexal solid-heterogenous tumoral mass. So the preoperative diagnosis is mostly difficult. We now present a case of pe lvic CD in a woman who complaint from pelvic pain. The patient underwent laparotomy with suspicious of adnexal tumor. However, the diagnosis was made at histopathologic examination postoperatively. The surgery was curative in this case and no recu rrence was observed in the patient.

Van Medical Journal, 2020

Indian Journal of Surgery, 2020

Alveolar echinococcosis is a rare parasitic disease that is endemic to the northern hemisphere in... more Alveolar echinococcosis is a rare parasitic disease that is endemic to the northern hemisphere in many parts of the world. Humans are coincidental intermediate hosts infected after eating contaminated food, including fruits and vegetables or being in contact with foxes or dogs. Although most alveolar echinococcal infections are localized to the liver, the larvae may spread to other organs by regional extension or distant metastasis along hematogenous or lymphatic pathways. The liver and lungs are the most commonly affected organs. Alveolar echinococcosis involving the kidneys is very rare. Parasitic infection causes granulomatous response on the host immune system. These lesions may be misdiagnosed as malignant neoplasms. Imaging modalities such as MRI provide useful diagnostic information for the accurate diagnosis of alveolar echinococcosis. In this case, we aimed to present radiological imaging and pathological findings of alveolar echinococcosis mimicking renal cell carcinoma of the right kidney with brain metastasis in a 40-year-old male patient with right lumbar pain.

Turkiye Klinikleri Journal of Case Reports, 2018

Van Medical Journal, 2019