Francisco Parra - Academia.edu (original) (raw)

Francisco Parra

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UERJ - Universidade do Estado do Rio de Janeiro / Rio de Janeiro State University

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Papers by Francisco Parra

Research paper thumbnail of Biochemical and structural characterization of the putative dihydropteroate synthase ortholog Rv1207 of Mycobacterium tuberculosis

Research paper thumbnail of 2-Alkoxydihydrocinnamates as PPAR agonists. Activity modulation by the incorporation of phenoxy …

Bioorganic & Medicinal Chemistry Letters

In our investigations, we sought PPARγ agonists outside the glitazone class that would produce im... more In our investigations, we sought PPARγ agonists outside the glitazone class that would produce improved glycemic and lipid control in animal models of diabetes that could be translated to man. During our search, we found that ...

Research paper thumbnail of 2-Alkoxydihydrocinnamates as PPAR agonists. Activity modulation by the incorporation of phenoxy …

Bioorganic & Medicinal Chemistry Letters

In our investigations, we sought PPARγ agonists outside the glitazone class that would produce im... more In our investigations, we sought PPARγ agonists outside the glitazone class that would produce improved glycemic and lipid control in animal models of diabetes that could be translated to man. During our search, we found that ...

Research paper thumbnail of Effects of 2-deoxy-d-glucose on the synthesis of RNA and protein in Saccharomyces carlsbergensis G-517

Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1980

When Saccharomyces carlsbergensis G-517 was grown with 10 mM galactose as the carbon source, the ... more When Saccharomyces carlsbergensis G-517 was grown with 10 mM galactose as the carbon source, the addition of 2-deoxy-D-glucose restricted the uptake of galactose, [3H]uridine and [3H]leucine, and restricted invertase synthesis (~-Dfructofuranoside fructohydrolase; EC 3.2.1.26) for a period of 60-90 min. During this time, the radioactive antimetabolite was taken up by the cells; afterwards, invertase synthesis was enhanced, and the utilization rate of galactose, [3H]uridine and [3H]leucine increased until it reached that of the control culture. When glucose was used as a carbon source, sugar utilization and uptake of radioactive precursors were unaffected by addition of the deoxysugar.

Research paper thumbnail of Biochemical and structural characterization of the putative dihydropteroate synthase ortholog Rv1207 of Mycobacterium tuberculosis

Research paper thumbnail of 2-Alkoxydihydrocinnamates as PPAR agonists. Activity modulation by the incorporation of phenoxy …

Bioorganic & Medicinal Chemistry Letters

In our investigations, we sought PPARγ agonists outside the glitazone class that would produce im... more In our investigations, we sought PPARγ agonists outside the glitazone class that would produce improved glycemic and lipid control in animal models of diabetes that could be translated to man. During our search, we found that ...

Research paper thumbnail of 2-Alkoxydihydrocinnamates as PPAR agonists. Activity modulation by the incorporation of phenoxy …

Bioorganic & Medicinal Chemistry Letters

In our investigations, we sought PPARγ agonists outside the glitazone class that would produce im... more In our investigations, we sought PPARγ agonists outside the glitazone class that would produce improved glycemic and lipid control in animal models of diabetes that could be translated to man. During our search, we found that ...

Research paper thumbnail of Effects of 2-deoxy-d-glucose on the synthesis of RNA and protein in Saccharomyces carlsbergensis G-517

Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1980

When Saccharomyces carlsbergensis G-517 was grown with 10 mM galactose as the carbon source, the ... more When Saccharomyces carlsbergensis G-517 was grown with 10 mM galactose as the carbon source, the addition of 2-deoxy-D-glucose restricted the uptake of galactose, [3H]uridine and [3H]leucine, and restricted invertase synthesis (~-Dfructofuranoside fructohydrolase; EC 3.2.1.26) for a period of 60-90 min. During this time, the radioactive antimetabolite was taken up by the cells; afterwards, invertase synthesis was enhanced, and the utilization rate of galactose, [3H]uridine and [3H]leucine increased until it reached that of the control culture. When glucose was used as a carbon source, sugar utilization and uptake of radioactive precursors were unaffected by addition of the deoxysugar.

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