Gyula Oros - Profile on Academia.edu (original) (raw)
Papers by Gyula Oros
Springer eBooks, 2019
Present control technologies of plant pathogenic fungi decouple the pathogen’s life cycle mainly ... more Present control technologies of plant pathogenic fungi decouple the pathogen’s life cycle mainly in two points of ontogeny, either by destroying spores prevent the infection or inhibit the biotrophic thallus, thus anticipating the formation of new infective propagules. Although, nowadays, the only tool for credible control of cultivated plants is the use of synthetic chemicals, the calculability of yield sureness has been worldwide threatened by the emergence of acquired tolerance to this group of pesticides as well as anxious feelings for their undesirable side effects. This situation urges the development of efficient alternative control agents, as threatening the net return even 10% disease incidence can cause economic loss. One approach to discover newer antimicrobial compounds is to search for their presence in natural sources exploiting the defense strategies of plants against their pathogens. Contrary to phytoalexins that are synthesized de novo after the plant is exposed to microbial attack, i.e., being produced in response of elicitors or stressors, the phytoanticipins are not formed in the tissue or released from preexisting plant constituents. These substances are plant antibiotics presented in tissue prior to infection, serving as the basis of pest tolerance. Several thousands of such molecules of different structure have been identified; however, few of them met practical application. In this chapter, we focus on constitutive mechanisms that might be used for controlling phytopathogenic fungi with special regard to organic substances, which might serve either as botanical fungicides or as lead compounds for molecular design. Consequently, the introduction of alien phytoanticipins and precursors of phytoalexins into the proper host/parasite system can represent a prospective tool for disease management. We summarized the results and experiences of past three decades searching for candidates for biofungicides useful in pest management practices. The efficacy of over 100 plant species used as either spices or preparations in traditional medicine or culinary was demonstrated in vitro against 25 phytopathogenic fungi, and possible use of promising candidates was discussed.
Calixin treatment of Corynebacterium michiganense [tomato seeds]
Novenyvedelem (Hungary), 1984
... ISSN, 0133-0829. Vol. No. v. 20(6) p. 262. Submitted by: National Agricultural Library and Do... more ... ISSN, 0133-0829. Vol. No. v. 20(6) p. 262. Submitted by: National Agricultural Library and Documentation Centre (Hungary). Attila Ut 93. 1012 Budapest 1. Tel: 36-1-489-4900. Fax: +36 1 1569928. Email: omgkref@omgk.hu; URL: http://www.omgk.hu/ujEnglish/Eindex.htm. ...
Removal of Synthetic Dyes from Wastewaters Hydroxide Sludge as Adsorbent: A Review
Determination of Hydrophobicity Parameters of Antibiotics by Reversed-Phase Chromatography. The Effect of Support
Biomedical Chromatography, May 1, 1996
The hydrophobicity and specific hydrophilic surface area of 29 antibiotics were determined by rev... more The hydrophobicity and specific hydrophilic surface area of 29 antibiotics were determined by reversed-phase thin-layer chromatography using impregnated silica and alumina supports and methanol:water mixtures as eluents. It was found that the supports retain their original retention characteristics even after impregnation influencing the reversed-phase retention of antibiotics. It was established that the hydrophobicity parameters are intercorrelated both on impregnated silica and alumina layers, indicating that antibiotics behave as a homologous series of solutes. However, the correlations were not strong enough to substitute the parameters with each other in quantitative structure-activity relationship studies. The specific hydrophobic surface areas determined on impregnated silica and alumina showed no significant correlation, proving the decisive role of support characteristics in the determination of this parameter.
De Gruyter eBooks, Dec 31, 1982
Calixin exhibited high activity against some phytopathogenic bacteria (Corynebacterium michiganen... more Calixin exhibited high activity against some phytopathogenic bacteria (Corynebacterium michiganense, C. fascians). In this report we try to show its possible antibacterial mode of action.
Effect of some new crown ethers on plant-related bacteria and their possible mode of action
PubMed, 1986
Binding Characteristics of a Water-Soluble Β-Cyclodextrin Polymer
Journal of Liquid Chromatography & Related Technologies, Jan 18, 2000
The interaction of 18 commercial pesticides with a water-soluble β-cyclodextrin polymer (BCDP) wa... more The interaction of 18 commercial pesticides with a water-soluble β-cyclodextrin polymer (BCDP) was determined by charge-transfer reversed phase thin layer chromatography and the relative strength of interaction was calculated. The relationship between the calculated surface parameters of pesticides and their capacity to interact with BCDP was elucidated by stepwise regression analysis. BCDP decreased the lipophilicity of the majority of pesticides probably by the formation of inclusion complexes. Significant quadratic relationships were found between the relative strength of interaction and the polar surface area and polar surface energy of pesticides emphasizing the impact of surface characteristics on the relative strength of interaction. The result suggests that the agrochemical properties (adsorption, uptake, half-life, etc.) of pesticide - BCDP complex may be different from those of uncomplexed compounds resulting in modified effectivity.
Environment International, Nov 1, 2002
The newest results concerning the biological activity and environmental fate of anionic surfactan... more The newest results concerning the biological activity and environmental fate of anionic surfactants are collected and critically evaluated. The chemical and physicochemical parameters related to the biological activity and the field of application are briefly discussed. Examples on the effect of anionic surfactants on the cell membranes, on the activity of enzymes, on the binding to various proteins and to other cell components and on their human toxicity are presented and the possible mode of action is elucidated. The sources of environmental pollution caused by anionic surfactants are listed and the methods developed for their removal from liquid, semiliquid and solid matrices are collected. Both the beneficial and adversary effects of anionic surfactants on the environment are reported and critically discussed. It was concluded that the role of anionic surfactants in the environment is ambiguous: they can cause serious environmental pollution with toxic effect on living organisms; otherwise, they can promote the decomposition and/or removal of other inorganic and organic pollutants from the environment. The relationship between their chemical structure, physicochemical parameters, biological activity and environmental impact is not well understood. A considerable number of data are needed for the development of new anionic surfactants and for the successful application of the existing ones to reduce the adversary and to promote beneficial effects.
Advances in Bioscience and Biotechnology, 2021
The dynamics of ethanol production of local strains of three yeast species and their ternary mixt... more The dynamics of ethanol production of local strains of three yeast species and their ternary mixtures was examined in two Tokaj vineries. Although, the performance of them diverged significantly in first etaps of vinification-up to the utilization of half of the sugar content of grape juice-the variations vintages per vintages surpassed the strain-dependent alterations. The divergence in the latter aspect diminished during the last etap, and the ethanol concentration in young wines fermented by Saccharomyces cerevisiae, S. uvarum and Starmerella bacillaris (2 local strains of each) and their mixtures did not vary considerably (c.v. 4.2%). The vinification of grape juice performed more rapidly in fermentors inoculated with strains of S. cerevisiae, S. uvarum and St. bacillaris as well as with their mixtures than in spontaneously How to cite this paper: Kállai, Z. and Oros, G. (2021) Vintage Effect on the Strain Dependent Dynamics of Ethanol Production in Vineries of Tokaj. Advances in Bioscience and Biotechnology, 12, 31-44.
Global Journal of Science Frontier Research, Jul 31, 2020
The dynamics of ethanol production of wine yeasts were examined in model experiments as well as i... more The dynamics of ethanol production of wine yeasts were examined in model experiments as well as in the winery. The ethanol concentration in young wines fermented by local strains of Saccharomyces cerevisiae, S. uvarum or Starmerella bacillaris (21, 2 and 2, respectively) did not vary considerably (c.v. 1.9 %). All of them produced significantly higher amount of ethanol than the type strain [ATCC 26108] of S. cerevisiae. However, their performance during the fermentation process diverged significantly. Thus the lag phase varied between 33 and 123 hours, while the time requested to produce half of the final ethanol concentration varied between 67 and 294 hours.
Retention Behavior of Some Thiophosphorylglycinamide Fungicides in Adsorption and Reversed‐Phase Thin‐Layer Chromatography
Journal of Liquid Chromatography & Related Technologies, Aug 1, 2006
The free energy of adsorption, the surface area of adsorption on silica and alumina surfaces, and... more The free energy of adsorption, the surface area of adsorption on silica and alumina surfaces, and the molecular lipophilicity of 37 thiophosphorylglycinamide (TPGA) derivatives was determined by thin layer chromatography using silica and alumina supports and silica support impregnated with paraffin oil. The relationships between the physicochemical characteristics of analytes were elucidated by stepwise regression analysis. It was found that
Chemometrics and Intelligent Laboratory Systems, Nov 1, 1997
The biological activity of 27 nonionic surfactants with different hydrophobic moiety and with dif... more The biological activity of 27 nonionic surfactants with different hydrophobic moiety and with different length of ethylene oxide chain was determined on 10 microbiological objects. Spectral mapping technique and stepwise regression analysis were used for the separation of the strength and selectivity of the biological effect of surfactants, and for the elucidation of the relationship between molecular structure and activity. It was found that both the strength and selectivity of the biological effect of surfactants differ considerably from each other and considerably depend on the molecular structure. It was established that the strength of the effect mainly depends on the hydrophobicity of surfactants whereas both the hydrophobicity and the length of polar ethylene oxide chain exert a significant influence on the selectivity indicating the involvement of hydrophobic and hydrophilic forces in the surfactant-target interaction. 0 1997 Elsevier Science B.V.
Environmental Toxicology and Chemistry, 2002
The fungicidal activity of 10 trityl dyes and six reference compounds was determined on 36 fungal... more The fungicidal activity of 10 trityl dyes and six reference compounds was determined on 36 fungal strains, and the data matrix was evaluated separately by principal component analysis (PCA) and by spectral mapping technique (SPM). The dimensionality of the maps of the principle component loadings and variables and the selectivity maps were reduced to two by varimax rotation and by nonlinear mapping. Calculations proved that both the strength and selectivity of the fungicidal activity of trityl dyes considerably depended on the chemical structure of the dye and on the type of fungi. Both PCA and SPM were suitable for evaluation of the antifungal activity of dyes; however, the strength and selectivity of the fungicidal effect can be separated only by SPM. Due to its advantageous application parameters, use of SPM in future quantitative structure-activity relationship studies is highly recommended.
Combination of Tucker3 model with cluster analysis for the assessment of the microbiological activity on benzimidazolium salts
Chemometrics and Intelligent Laboratory Systems, Mar 1, 2009
The antimicrobial effect of 7 benzimidazolium salts (base, chloride, sulfate, phosphate and nitra... more The antimicrobial effect of 7 benzimidazolium salts (base, chloride, sulfate, phosphate and nitrate forms) was determined on 15 microorganisms. The similarities and dissimilarities among the data consisting of the benzimidazolium salts and microorganisms were elucidated by using the Tucker model combined with cluster analysis. The calculations demonstrated that the combined method can be successfully employed for the separation of the impact of the molecular structure and cation type on the antimicrobial activity of the base and benzimidazolium salts.
Journal of Separation Science, Apr 1, 2008
Short Communication A quantitative peptide structure vs. retention relationship study The quantit... more Short Communication A quantitative peptide structure vs. retention relationship study The quantitative relationship between the TLC retention parameters of 28 short peptides and their physicochemical characteristics was calculated using linear regression analysis. It was established that surface parameters exert a significant impact on the retention of peptides and the ratio of non-polar surface area/polar surface area exerts the highest influence on the retention. This result may be due to the fact that peptides turn towards the apolar surface of the stationary phase with their non-polar substructures while the polar molecular parts point into the hydrophilic mobile phase.
Journal of inclusion phenomena, 1984
Cross-linked fl-cyclodextrin with a molecular weight of less than 10000 has good solubility in wa... more Cross-linked fl-cyclodextrin with a molecular weight of less than 10000 has good solubility in water, and it is a better inclusion complexing agent than the parent fl-cyclodextrin. By including lipophilic guest molecules into the apolar cyclodextrin cavity, their apparent lipophilicity is reduced because the outer surface of the molecular 'wrapping' (the crosslinked fl-CD) is highly hydrophilic. The relative stability of the inclusion complexes can be rapidly determined by reversed-phase thin-layer chromatography. The reversed-phase TLC behaviour of 25 triphenylmethane derivatives and analogues were studied in the presence of fl-cyclodextrin polymers containing neutral and carboxyl groups. Increasing the molecular weight results in an increased complex-forming capacity. The carboxyl group modifies the accessibility of the CD cavity which in turn results in increased or decreased complex stability, depending on the guest molecule. The presence of organic solvents diminishes the stability of the CD complexes:
Environment International, Sep 1, 2004
The more recent methods for the removal of synthetic dyes from waters and wastewater are complied... more The more recent methods for the removal of synthetic dyes from waters and wastewater are complied. The various methods of removal such as adsorption on various sorbents, chemical decomposition by oxidation, photodegradation, and microbiological decoloration, employing activated sludge, pure cultures and microbe consortiums are described. The advantages and disadvantages of the various methods are discussed and their efficacies are compared.
Interaction of some antibiotics with hydroxypropyl-?-cyclodextrin
Journal of Inclusion Phenomena and Macrocyclic Chemistry, 1994
The interaction between 19 antibiotics and hydroxypropyl-β-cyclodextrin (HPβCD) was studied by re... more The interaction between 19 antibiotics and hydroxypropyl-β-cyclodextrin (HPβCD) was studied by reversed-phase thin-layer chromatography. HPβCD formed inclusion complexes with 16 compounds, the complex always being more hydrophilic than the uncomplexed drug. The intensity of interaction significantly increased with increasing specific hydrophobic surface area of the guest molecule proving the preponderant role of hydrophobic interactions in inclusion complex formation. The intensity of the HPβCD-drug interaction significantly decreased with increasing concentration of methanol in the environment indicating that methanol can also enter the cyclodextrin cavity and inhibits competitively the inclusion complex formation or the free energy of transfer from water to the HPβCD cavity should be less negative at higher concentration of methanol in the aqueous medium.
European Chemical Bulletin, Jul 22, 2013
The objectives of the reviews are the collection, concise description, comparison and evaluation ... more The objectives of the reviews are the collection, concise description, comparison and evaluation of the various chromatographic technologies using natural and modified cyclodextrins for the increase the seperation capacity of various chromatographic separation systems.
Use of principal component analysis and a spectral mapping technique for the evaluation of the antifungal activity of anthracene-based synthetic dyes
Sar and Qsar in Environmental Research, Apr 1, 2009
The antifungal activity of 14 anthracene-based synthetic dyes and 6 reference compounds was measu... more The antifungal activity of 14 anthracene-based synthetic dyes and 6 reference compounds was measured on 36 fungal strains and the data matrix was evaluated separately by principal component analysis (PCA) and using a spectral mapping technique (SPM). The dimensionality of the maps of principal component loadings and variables and the selectivity maps was reduced to two by non-linear mapping. Except for two compounds, the dyes showed marked antifungal activity. Calculations proved that both the strength and selectivity of the biological effect of anthracene-based dyes were highly dependent on the chemical structure of the dye and on the type of fungi. PCA and SPM revealed different aspects of the antifungal activity, therefore, their simultaneous application in future quantitative structure-activity relationship studies is highly recommended.
Springer eBooks, 2019
Present control technologies of plant pathogenic fungi decouple the pathogen’s life cycle mainly ... more Present control technologies of plant pathogenic fungi decouple the pathogen’s life cycle mainly in two points of ontogeny, either by destroying spores prevent the infection or inhibit the biotrophic thallus, thus anticipating the formation of new infective propagules. Although, nowadays, the only tool for credible control of cultivated plants is the use of synthetic chemicals, the calculability of yield sureness has been worldwide threatened by the emergence of acquired tolerance to this group of pesticides as well as anxious feelings for their undesirable side effects. This situation urges the development of efficient alternative control agents, as threatening the net return even 10% disease incidence can cause economic loss. One approach to discover newer antimicrobial compounds is to search for their presence in natural sources exploiting the defense strategies of plants against their pathogens. Contrary to phytoalexins that are synthesized de novo after the plant is exposed to microbial attack, i.e., being produced in response of elicitors or stressors, the phytoanticipins are not formed in the tissue or released from preexisting plant constituents. These substances are plant antibiotics presented in tissue prior to infection, serving as the basis of pest tolerance. Several thousands of such molecules of different structure have been identified; however, few of them met practical application. In this chapter, we focus on constitutive mechanisms that might be used for controlling phytopathogenic fungi with special regard to organic substances, which might serve either as botanical fungicides or as lead compounds for molecular design. Consequently, the introduction of alien phytoanticipins and precursors of phytoalexins into the proper host/parasite system can represent a prospective tool for disease management. We summarized the results and experiences of past three decades searching for candidates for biofungicides useful in pest management practices. The efficacy of over 100 plant species used as either spices or preparations in traditional medicine or culinary was demonstrated in vitro against 25 phytopathogenic fungi, and possible use of promising candidates was discussed.
Calixin treatment of Corynebacterium michiganense [tomato seeds]
Novenyvedelem (Hungary), 1984
... ISSN, 0133-0829. Vol. No. v. 20(6) p. 262. Submitted by: National Agricultural Library and Do... more ... ISSN, 0133-0829. Vol. No. v. 20(6) p. 262. Submitted by: National Agricultural Library and Documentation Centre (Hungary). Attila Ut 93. 1012 Budapest 1. Tel: 36-1-489-4900. Fax: +36 1 1569928. Email: omgkref@omgk.hu; URL: http://www.omgk.hu/ujEnglish/Eindex.htm. ...
Removal of Synthetic Dyes from Wastewaters Hydroxide Sludge as Adsorbent: A Review
Determination of Hydrophobicity Parameters of Antibiotics by Reversed-Phase Chromatography. The Effect of Support
Biomedical Chromatography, May 1, 1996
The hydrophobicity and specific hydrophilic surface area of 29 antibiotics were determined by rev... more The hydrophobicity and specific hydrophilic surface area of 29 antibiotics were determined by reversed-phase thin-layer chromatography using impregnated silica and alumina supports and methanol:water mixtures as eluents. It was found that the supports retain their original retention characteristics even after impregnation influencing the reversed-phase retention of antibiotics. It was established that the hydrophobicity parameters are intercorrelated both on impregnated silica and alumina layers, indicating that antibiotics behave as a homologous series of solutes. However, the correlations were not strong enough to substitute the parameters with each other in quantitative structure-activity relationship studies. The specific hydrophobic surface areas determined on impregnated silica and alumina showed no significant correlation, proving the decisive role of support characteristics in the determination of this parameter.
De Gruyter eBooks, Dec 31, 1982
Calixin exhibited high activity against some phytopathogenic bacteria (Corynebacterium michiganen... more Calixin exhibited high activity against some phytopathogenic bacteria (Corynebacterium michiganense, C. fascians). In this report we try to show its possible antibacterial mode of action.
Effect of some new crown ethers on plant-related bacteria and their possible mode of action
PubMed, 1986
Binding Characteristics of a Water-Soluble Β-Cyclodextrin Polymer
Journal of Liquid Chromatography & Related Technologies, Jan 18, 2000
The interaction of 18 commercial pesticides with a water-soluble β-cyclodextrin polymer (BCDP) wa... more The interaction of 18 commercial pesticides with a water-soluble β-cyclodextrin polymer (BCDP) was determined by charge-transfer reversed phase thin layer chromatography and the relative strength of interaction was calculated. The relationship between the calculated surface parameters of pesticides and their capacity to interact with BCDP was elucidated by stepwise regression analysis. BCDP decreased the lipophilicity of the majority of pesticides probably by the formation of inclusion complexes. Significant quadratic relationships were found between the relative strength of interaction and the polar surface area and polar surface energy of pesticides emphasizing the impact of surface characteristics on the relative strength of interaction. The result suggests that the agrochemical properties (adsorption, uptake, half-life, etc.) of pesticide - BCDP complex may be different from those of uncomplexed compounds resulting in modified effectivity.
Environment International, Nov 1, 2002
The newest results concerning the biological activity and environmental fate of anionic surfactan... more The newest results concerning the biological activity and environmental fate of anionic surfactants are collected and critically evaluated. The chemical and physicochemical parameters related to the biological activity and the field of application are briefly discussed. Examples on the effect of anionic surfactants on the cell membranes, on the activity of enzymes, on the binding to various proteins and to other cell components and on their human toxicity are presented and the possible mode of action is elucidated. The sources of environmental pollution caused by anionic surfactants are listed and the methods developed for their removal from liquid, semiliquid and solid matrices are collected. Both the beneficial and adversary effects of anionic surfactants on the environment are reported and critically discussed. It was concluded that the role of anionic surfactants in the environment is ambiguous: they can cause serious environmental pollution with toxic effect on living organisms; otherwise, they can promote the decomposition and/or removal of other inorganic and organic pollutants from the environment. The relationship between their chemical structure, physicochemical parameters, biological activity and environmental impact is not well understood. A considerable number of data are needed for the development of new anionic surfactants and for the successful application of the existing ones to reduce the adversary and to promote beneficial effects.
Advances in Bioscience and Biotechnology, 2021
The dynamics of ethanol production of local strains of three yeast species and their ternary mixt... more The dynamics of ethanol production of local strains of three yeast species and their ternary mixtures was examined in two Tokaj vineries. Although, the performance of them diverged significantly in first etaps of vinification-up to the utilization of half of the sugar content of grape juice-the variations vintages per vintages surpassed the strain-dependent alterations. The divergence in the latter aspect diminished during the last etap, and the ethanol concentration in young wines fermented by Saccharomyces cerevisiae, S. uvarum and Starmerella bacillaris (2 local strains of each) and their mixtures did not vary considerably (c.v. 4.2%). The vinification of grape juice performed more rapidly in fermentors inoculated with strains of S. cerevisiae, S. uvarum and St. bacillaris as well as with their mixtures than in spontaneously How to cite this paper: Kállai, Z. and Oros, G. (2021) Vintage Effect on the Strain Dependent Dynamics of Ethanol Production in Vineries of Tokaj. Advances in Bioscience and Biotechnology, 12, 31-44.
Global Journal of Science Frontier Research, Jul 31, 2020
The dynamics of ethanol production of wine yeasts were examined in model experiments as well as i... more The dynamics of ethanol production of wine yeasts were examined in model experiments as well as in the winery. The ethanol concentration in young wines fermented by local strains of Saccharomyces cerevisiae, S. uvarum or Starmerella bacillaris (21, 2 and 2, respectively) did not vary considerably (c.v. 1.9 %). All of them produced significantly higher amount of ethanol than the type strain [ATCC 26108] of S. cerevisiae. However, their performance during the fermentation process diverged significantly. Thus the lag phase varied between 33 and 123 hours, while the time requested to produce half of the final ethanol concentration varied between 67 and 294 hours.
Retention Behavior of Some Thiophosphorylglycinamide Fungicides in Adsorption and Reversed‐Phase Thin‐Layer Chromatography
Journal of Liquid Chromatography & Related Technologies, Aug 1, 2006
The free energy of adsorption, the surface area of adsorption on silica and alumina surfaces, and... more The free energy of adsorption, the surface area of adsorption on silica and alumina surfaces, and the molecular lipophilicity of 37 thiophosphorylglycinamide (TPGA) derivatives was determined by thin layer chromatography using silica and alumina supports and silica support impregnated with paraffin oil. The relationships between the physicochemical characteristics of analytes were elucidated by stepwise regression analysis. It was found that
Chemometrics and Intelligent Laboratory Systems, Nov 1, 1997
The biological activity of 27 nonionic surfactants with different hydrophobic moiety and with dif... more The biological activity of 27 nonionic surfactants with different hydrophobic moiety and with different length of ethylene oxide chain was determined on 10 microbiological objects. Spectral mapping technique and stepwise regression analysis were used for the separation of the strength and selectivity of the biological effect of surfactants, and for the elucidation of the relationship between molecular structure and activity. It was found that both the strength and selectivity of the biological effect of surfactants differ considerably from each other and considerably depend on the molecular structure. It was established that the strength of the effect mainly depends on the hydrophobicity of surfactants whereas both the hydrophobicity and the length of polar ethylene oxide chain exert a significant influence on the selectivity indicating the involvement of hydrophobic and hydrophilic forces in the surfactant-target interaction. 0 1997 Elsevier Science B.V.
Environmental Toxicology and Chemistry, 2002
The fungicidal activity of 10 trityl dyes and six reference compounds was determined on 36 fungal... more The fungicidal activity of 10 trityl dyes and six reference compounds was determined on 36 fungal strains, and the data matrix was evaluated separately by principal component analysis (PCA) and by spectral mapping technique (SPM). The dimensionality of the maps of the principle component loadings and variables and the selectivity maps were reduced to two by varimax rotation and by nonlinear mapping. Calculations proved that both the strength and selectivity of the fungicidal activity of trityl dyes considerably depended on the chemical structure of the dye and on the type of fungi. Both PCA and SPM were suitable for evaluation of the antifungal activity of dyes; however, the strength and selectivity of the fungicidal effect can be separated only by SPM. Due to its advantageous application parameters, use of SPM in future quantitative structure-activity relationship studies is highly recommended.
Combination of Tucker3 model with cluster analysis for the assessment of the microbiological activity on benzimidazolium salts
Chemometrics and Intelligent Laboratory Systems, Mar 1, 2009
The antimicrobial effect of 7 benzimidazolium salts (base, chloride, sulfate, phosphate and nitra... more The antimicrobial effect of 7 benzimidazolium salts (base, chloride, sulfate, phosphate and nitrate forms) was determined on 15 microorganisms. The similarities and dissimilarities among the data consisting of the benzimidazolium salts and microorganisms were elucidated by using the Tucker model combined with cluster analysis. The calculations demonstrated that the combined method can be successfully employed for the separation of the impact of the molecular structure and cation type on the antimicrobial activity of the base and benzimidazolium salts.
Journal of Separation Science, Apr 1, 2008
Short Communication A quantitative peptide structure vs. retention relationship study The quantit... more Short Communication A quantitative peptide structure vs. retention relationship study The quantitative relationship between the TLC retention parameters of 28 short peptides and their physicochemical characteristics was calculated using linear regression analysis. It was established that surface parameters exert a significant impact on the retention of peptides and the ratio of non-polar surface area/polar surface area exerts the highest influence on the retention. This result may be due to the fact that peptides turn towards the apolar surface of the stationary phase with their non-polar substructures while the polar molecular parts point into the hydrophilic mobile phase.
Journal of inclusion phenomena, 1984
Cross-linked fl-cyclodextrin with a molecular weight of less than 10000 has good solubility in wa... more Cross-linked fl-cyclodextrin with a molecular weight of less than 10000 has good solubility in water, and it is a better inclusion complexing agent than the parent fl-cyclodextrin. By including lipophilic guest molecules into the apolar cyclodextrin cavity, their apparent lipophilicity is reduced because the outer surface of the molecular 'wrapping' (the crosslinked fl-CD) is highly hydrophilic. The relative stability of the inclusion complexes can be rapidly determined by reversed-phase thin-layer chromatography. The reversed-phase TLC behaviour of 25 triphenylmethane derivatives and analogues were studied in the presence of fl-cyclodextrin polymers containing neutral and carboxyl groups. Increasing the molecular weight results in an increased complex-forming capacity. The carboxyl group modifies the accessibility of the CD cavity which in turn results in increased or decreased complex stability, depending on the guest molecule. The presence of organic solvents diminishes the stability of the CD complexes:
Environment International, Sep 1, 2004
The more recent methods for the removal of synthetic dyes from waters and wastewater are complied... more The more recent methods for the removal of synthetic dyes from waters and wastewater are complied. The various methods of removal such as adsorption on various sorbents, chemical decomposition by oxidation, photodegradation, and microbiological decoloration, employing activated sludge, pure cultures and microbe consortiums are described. The advantages and disadvantages of the various methods are discussed and their efficacies are compared.
Interaction of some antibiotics with hydroxypropyl-?-cyclodextrin
Journal of Inclusion Phenomena and Macrocyclic Chemistry, 1994
The interaction between 19 antibiotics and hydroxypropyl-β-cyclodextrin (HPβCD) was studied by re... more The interaction between 19 antibiotics and hydroxypropyl-β-cyclodextrin (HPβCD) was studied by reversed-phase thin-layer chromatography. HPβCD formed inclusion complexes with 16 compounds, the complex always being more hydrophilic than the uncomplexed drug. The intensity of interaction significantly increased with increasing specific hydrophobic surface area of the guest molecule proving the preponderant role of hydrophobic interactions in inclusion complex formation. The intensity of the HPβCD-drug interaction significantly decreased with increasing concentration of methanol in the environment indicating that methanol can also enter the cyclodextrin cavity and inhibits competitively the inclusion complex formation or the free energy of transfer from water to the HPβCD cavity should be less negative at higher concentration of methanol in the aqueous medium.
European Chemical Bulletin, Jul 22, 2013
The objectives of the reviews are the collection, concise description, comparison and evaluation ... more The objectives of the reviews are the collection, concise description, comparison and evaluation of the various chromatographic technologies using natural and modified cyclodextrins for the increase the seperation capacity of various chromatographic separation systems.
Use of principal component analysis and a spectral mapping technique for the evaluation of the antifungal activity of anthracene-based synthetic dyes
Sar and Qsar in Environmental Research, Apr 1, 2009
The antifungal activity of 14 anthracene-based synthetic dyes and 6 reference compounds was measu... more The antifungal activity of 14 anthracene-based synthetic dyes and 6 reference compounds was measured on 36 fungal strains and the data matrix was evaluated separately by principal component analysis (PCA) and using a spectral mapping technique (SPM). The dimensionality of the maps of principal component loadings and variables and the selectivity maps was reduced to two by non-linear mapping. Except for two compounds, the dyes showed marked antifungal activity. Calculations proved that both the strength and selectivity of the biological effect of anthracene-based dyes were highly dependent on the chemical structure of the dye and on the type of fungi. PCA and SPM revealed different aspects of the antifungal activity, therefore, their simultaneous application in future quantitative structure-activity relationship studies is highly recommended.
Prime Archives in Plant Sciences, 2020
This study aimed to examine whether Trichoderma species might have potential as a biological cont... more This study aimed to examine whether Trichoderma species might have potential as a biological control agent against another Trichoderma spp. possibly residing in the local environment. Metabolites of thirty Trichoderma isolates were screened for growth moderating activity against test fungi in dual cultures using the vertical diffusion technique. Most of the different Trichoderma isolates as producers demonstrated strain-dependent growth moderating activities either stimulating or completely inhibiting the exposed fungi, while some isolates showed no activity.
The examined Trichoderma spp. showed high natural variation in sensitivity responses to metabolites released to the medium by other Trichoderma strains, depending on traits related to their adaptation to ecological niches, thus the suspected mycoparasitic strains significantly differed of those habiting in soil. The released complex set of metabolites with broad intrageneric spectrum of growth moderating activity exhibited broad spectrum of activity against phytopathogenic fungi as well, however, the strength of the effect could not be predicted.
Few common factors were revealed by comparing growth responses of Trichoderma and phytopathogens (their possible hosts) to released metabolites by examined Trichoderma strains. Seemingly, some genus-specific traits regulate the character of intrageneric connections among various Trichoderma strains. These properties might influence the performance of Trichoderma-based eubiotic preparations in pest management practices.
Present control technologies of plant pathogenic fungi decouple the pathogen's life cycle mainly ... more Present control technologies of plant pathogenic fungi decouple the pathogen's life cycle mainly in two points of ontogeny, either by destroying spores prevent the infection or inhibit the biotrophic thallus, thus anticipating the formation of new infective propagules. Although, nowadays, the only tool for credible control of cultivated plants is the use of synthetic chemicals, the calculability of yield sureness has been worldwide threatened by the emergence of acquired tolerance to this group of pesticides as well as anxious feelings for their undesirable side effects. This situation urges the development of efficient alternative control agents, as threatening the net return even 10% disease incidence can cause economic loss. One approach to discover newer antimicrobial compounds is to search for their presence in natural sources exploiting the defense strategies of plants against their pathogens. Contrary to phytoalexins that are synthesized de novo after the plant is exposed to microbial attack, i.e., being produced in response of elicitors or stressors, the phytoanticipins are not formed in the tissue or released from preexisting plant constituents. These substances are plant antibiotics presented in tissue prior to infection, serving as the basis of pest tolerance. Several thousands of such molecules of different structure have been identified; however, few of them met practical application. In this chapter, we focus on constitutive mechanisms that might be used for controlling phytopathogenic fungi with special regard to organic substances, which might serve either as botanical fungicides or as lead compounds for molecular design. Consequently, the introduction of alien phytoanticipins and precursors of phytoalexins into the proper host/ parasite system can represent a prospective tool for disease management. We summarized the results and experiences of past three decades searching for candidates for biofungicides useful in pest management practices. The efficacy of over 100 plant species used as either spices or preparations in traditional medicine or culinary was demonstrated in vitro against 25 phytopathogenic fungi, and possible use of promising candidates was discussed.
In this study, we identified that rice seeds grown in radionuclide contaminated soil respond by w... more In this study, we identified that rice seeds grown in radionuclide contaminated soil respond by well-coordinated defense responses against low- level gamma radiation by using Agilent’s multi- omic solutions. • The combined multi-omics analysis of metabolite and gene expression data using MOA module of GeneSpring 13 showed significant differentials in phenylalanine/phenylpropanoid, unsaturated fatty acid biosynthesis, fatty acid biosynthesis etc pathway. All these events are related to stress responses of plants to harmful environmental factors such as gamma radiation. • Further, the well-known antagonistic effect between jasmonic acid and salicylic acid signal transduction pathways were also documented in this study. • These results are useful for taking decisions on the food quality.
7th Recent Advances in Food Analysis, 2015
The exposure of plants to ionizing radiation (IR) is known to trigger a wide range of responses b... more The exposure of plants to ionizing radiation (IR) is known to trigger a wide range of responses between initial absorption of energy and final biological injury. In this study, we performed multi-omic study to investigate the effects of gamma radiation on seeds of rice plants (cv. Koshihikari) grown in radionuclide contaminated soil at Iitate farm located in Iitate village consequent to the nuclear power plant disaster of March 2011, Fukushima prefecture. Seeds from rice plants (cv. Koshihikari) grown in clean soil served as control. The gene expression analysis was conducted using rice 4 × 44 k microarrays and metabolite analysis was done by using LC/MS and GC/MS followed by combined data analysis using GeneSpring software. Gene expression microarray analysis revealed 1891 and 440 genes as gamma ray inducible and repressible genes, respectively (P<0.05). The metabolite analysis using LC/MS and GC/MS revealed 50 differential metabolites (P<0.05). The combined multi-omics analysis revealed modulation of several metabolic and defense pathways related to stress response of plants. Interconnectivity between upstream and downstream pathways at gene and metabolite levels were also observed. Our results suggest that the rice plants grown up in radionuclide contaminated soils form seeds with elevated capability to defend well by eliciting appropriate stress responses.
Cite as: G Hayashi, J Shibato , A Kubo, M Fukumoto, S Shioda, G Oros, R Rakwal, SA Deepak (2015): Multi-Omic Approach to Reveal the Effect of Low-Level Gamma Radiation on Rice Seeds. Book of Abstracts (Editors Jana Hajšlová and Michel Nielen) of the 7th Recent Advances in Food Analysis · RAFA 2015, November 3–6, 2015, Prague, Czech Republic, Published by the University of Chemistry and Technology, Prague, p. 284. ISBN 978-80-7080-934-1