J. Boulloche - Academia.edu (original) (raw)
Papers by J. Boulloche
Journal de Pédiatrie et de Puériculture, 1995
Archives françaises de pédiatrie, 1991
Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie, 2000
Hepatic hemangioendothelioma can have a fatal outcome. After failure of classic therapies, and wh... more Hepatic hemangioendothelioma can have a fatal outcome. After failure of classic therapies, and when surgery or arterial embolization are not possible, those benign tumours may benefit from interferon alpha treatment. We report a case of a 14-month-old infant who presented with hepatic hemangiomatosis and cardiac failure. The disease can neither be controlled by steroids nor by radiotherapy associated with digitalo-diuretic treatment. Due to the important vascular volume of the tumour, neither surgical care nor arterial embolization were possible. Thus this infant was treated for ten months by interferon alpha. The evolution was favourable: cardiac failure, calcifications and volume of the angiomatosis were regressive. Interferon alpha treatment helps to control cardiac failure and the course of hepatic hemangioma in childhood.
Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie, 1995
Prevalence of asthma is influenced by environmental factors which may be different from area to a... more Prevalence of asthma is influenced by environmental factors which may be different from area to area. A cross-sectional epidemiological survey was carried out among 1,395 children attending primary schools in the city of Le Havre and the canton of Fécamp (Haute-Normandie). Questionnaires including data about the disease, family history, environmental and socio-economic factors were completed by the school physician in presence of the parents. Prevalence rate of asthma calculated from 1,193 questionnaires was 7.8%. The logistic regression curves pointed out four risk factors: family history of asthma (odds ratio: 2.52) or hay fever (OR: 1.98), atopic dermatitis (OR: 3.96), and parental smoking (OR: 1.79). Sex, socioeconomic status of parents, type of housing, presence of pets in the house were not related to prevalence of asthma. Frequency of cough during the day was only significantly different between both areas. The high level of school absence (21.1%) and frequency of hospitaliza...
Médecine et Maladies Infectieuses, 1995
La possibilit6 d'un d6ficit en composant du compl6ment doit 8tre 6voqu6e devant la survenue de m6... more La possibilit6 d'un d6ficit en composant du compl6ment doit 8tre 6voqu6e devant la survenue de m6ningite 7t r6p6tition. Nous rapportons deux observations r6v61atrices, l'une d'un d6ficit en C2, l'autre en C5. La survenue d'une r6cidive de m6ningite doit faire rechercher une br6che m6ning6e (surtout s'il s'agit d'une m6ningite h pneumocoque), une aspl6nie, un d6ficit en immunoglobuline et un d6ficit du systSme compl6mentaire. Dans ce cadre, il s'agit de la voie principale (C1, C2, C4) dans 12 %, de la voie alterne dans 42 %, de la voie terminale (C5 h C9) dans 46 %. Devant l'absence de traitement sp6cifique de ces d6ficits, une prophylaxie des infections est r6alis6e par la p6nicilline V, et par les vaccinations (pneumo 23, m6ningocoque A C, Haemophilus influenzae ).
European Journal of Paediatric Neurology, 1999
All5 cause increased plasma creatine kinase after 3 weeks was proper, three items were inspected:... more All5 cause increased plasma creatine kinase after 3 weeks was proper, three items were inspected: duration of feeding with a special diet, age feeding started and the need to omit magnesium (Mg) from the diet.
Archives de Pédiatrie, 2003
Archives de Pédiatrie, 2000
Certains hémangio-endothéliomes hépatiques mettent en jeu le pronostic vital. Après échec des tra... more Certains hémangio-endothéliomes hépatiques mettent en jeu le pronostic vital. Après échec des traitements classiques, en cas de non-accessibilité à la chirurgie et à l'embolisation artérielle, ces tumeurs bénignes peuvent bénéficier d'un traitement par interféron α. Observation. -Nous rapportons l'observation d'un nourrisson de 14 mois atteint d'une angiomatose diffuse néonatale sévère avec une localisation hépatique et une insuffisance cardiaque. Aucun traitement chirurgical ou par embolisation artérielle n'étant possible, un traitement par interféron α a été proposé pendant dix mois. L'évolution, favorable, a été marquée par la régression de l'insuffisance cardiaque, et par la calcification et la régression de l'angiomatose. Conclusion. -Un traitement par interféron α permet de contrôler une insuffisance cardiaque et l'évolution d'un hémangiome hépatique. © 2000 Éditions scientifiques et médicales Elsevier SAS hémangioendothéliome hépatique / foie / interféron α Summary -A case of hepatic hemangioendothelioma management: by interferon α. Hepatic hemangioendothelioma can have a fatal outcome. After failure of classic therapies, and when surgery or arterial embolization are not possible, those benign tumours may benefit from interferon α treatment. Case report. -We report a case of a 14-month-old infant who presented with hepatic hemangiomatosis and cardiac failure. The disease can neither be controlled by steroids nor by radiotherapy associated with digitalo-diuretic treatment. Due to the important vascular volume of the tumour, neither surgical care nor arterial embolization were possible. Thus this infant was treated for ten months by interferon α. The evolution was favourable: cardiac failure, calcifications and volume of the angiomatosis were regressive. Conclusion. -Interferon α treatment helps to control cardiac failure and the course of hepatic hemangioma in childhood. © 2000 Éditions scientifiques et médicales Elsevier SAS hemangioendothelioma / liver / interferon α / infant Les angiomes hépatiques du nourrisson sont des affections rares qui peuvent mettre en jeu le pronostic vital du fait d'une coagulopathie de consomma-tion, d'hémorragies graves, d'insuffisance cardiaque [1]. L'abord thérapeutique médical fait appel aux corticostéroïdes [2], à la radiothérapie et aux agents
Archives de Pédiatrie, 1995
P Le Roux', D Hourderont3, I Loise12, A Collet4, J Boullochez. MT BriqueV, B Le Luyerz L'astbme. ... more P Le Roux', D Hourderont3, I Loise12, A Collet4, J Boullochez. MT BriqueV, B Le Luyerz L'astbme. chez I'enfant est un problhe de sant.5 publique. par sa fr6quence et sa motbiditc. Lc but de ce travail est de dctclnioer sa pf&akttcc ditns ?? nc f&on fmn@c au &mat maritime. cxpos& B la pok&nt irdustrklk, u ddvalocr ks factaws de tisqucs associts. P0puWOn e2 m&h&h. -L'coqu&e a # mt f&e aup& de 13% cnfants scokfiscS en cow3 Prcparatoite. Un questioimaire a Cti rcm~~Ji par k m&l&n scokirc en prhence des parents. Les items envisagCs ant port6 SIN la notion d'asthme diagaostiquC. les tmt&6dcnts pemomlels et familiaus I'env ironncmeIlt,hpriseCllChageClIn~. Msw/Ms. -Millc cent-quatrc-viogt-treize dossiers ottt &C attttlysh. La prdvalence cumultc de I'astbme a Ctd dc 7.8%. Aucunc diff&cncc a'a W rctnnw6c ctttn ~GWS mrale et urbainc. L'&udc de r&es&o h-gistique a moot& qtmtre factatts de dsqt~~: ks antccC&nts pcrsotmels de ckrmatite atopique (RR = 3.%). ka ant&&N familiaux d'asthme(RR=2.52)a&wllinose~~=1.98)ainsiqoekUbogismeplwif(RR= 1.79). Le mode de logemeat. la protess;on do chef de familk. k mode de garde. I'anciennet6 de rhideoce. la pr&cnce d'animaux domestiqucs, le sexe n'ont pas CtC retcnus commc facteurs de risque sigaificatifs. Seule. la toux diurnc chcz ICS asthmatiqws dit%e entre La Hwre et F& (21.8% vs 4.6%. p c OJIS). L'astbme a ctc rcsponsable de 21.1% d'absent6iimc sc&im da113 ks 12 mok prcctaents et de 20.4% d'hospitaiisation. Uo enfattt sut tkux (49.1%) avait un trhmatt ad8@. CORChUfO~S. -La prhdence 6levCe de I'asthme s'accompagnattt d'unc motkiditb importante, d'absent&me et d'hospitalisatioo, rend n&em&e uth? meilleun hformstkn et Mucation des famillcs. du corps enseignaot et des pmfcssio~~ls & saot6.
Médecine et Maladies Infectieuses
Helvetica paediatrica acta
The authors examine 18 cases of early dystonic syndromes and review all the pediatric cases publi... more The authors examine 18 cases of early dystonic syndromes and review all the pediatric cases published previously in order to determine the evolutive and epidemiological characters of these intolerance reactions. These unrecognized manifestations normally occur within the first 24 hours of treatment and disappear within a few hours when the treatment is discontinued. The use of diazepam and trihexyphenidyl accelerates the regression of the disorders. The doses of metoclopramide were mostly above the recommended doses, 60% of the cases correspond to doses in excess of 0.5 mg/kg per day or 0.2 mg/kg in a single dose. In the absence of overdosage, dystonic reactions occur essentially in female subjects aged over 9 years. For this part of the population, the possible occurrence of such a reaction should be mentioned to the family when the drug is prescribed.
Revue Française d'Allergologie et d'Immunologie Clinique, 1997
Archives De Pediatrie, 1999
Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie, 2000
This study presents the results of a hospital survey on Lyme disease in children living in upper ... more This study presents the results of a hospital survey on Lyme disease in children living in upper Normandy, a region that is quite densely wooded (with 18% forest areas and woods). The aim of this survey was to assess the prevalence of this disease in children from the Seine-Maritime and L'Eure, hospitalized in pediatric wards in the Seine-Maritime department, which includes Rouen, Dieppe, Fécamp, Elbeuf, and Le Havre. Fifteen cases of Lyme disease were diagnosed between September 1988 and June 1997. The children (6 girls and 9 boys) were aged between 5 and 14 years old. Only 7 subjects showed primary symptoms, while secondary symptoms were observed in 12 children. In the study population, a high prevalence (11 out of the 15 children) of neurological disorders was found. The following secondary symptoms were noted: 5 cases of erythema migrans, 2 cases of non-malignant cutaneous lymphocytoma, and 4 cases which in fact had previously displayed primary clinical signs (3 subjects wit...
Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie, 1999
Benign infantile non febrile seizures are not well known, leading us to study their clinical and ... more Benign infantile non febrile seizures are not well known, leading us to study their clinical and EEG characteristics. Between 1981 and 1994, we assembled 34 patients with the following inclusion criteria: non febrile seizures between 1 month and 2 years of age, normal personal history, no abnormality on clinical, biological and radiological investigations, normal developmental outcome with at least 1 year follow-up. These 34 patients were recognized as 14 familial cases (identical seizures affecting parents) and 11 non familial cases. The other nine cases had different or undefined epilepsy in the family. The clinical and EEG characteristics were the same: at the mean age of 6 months, brief partial seizures (often secondarily or apparently generalized) occurring in a cluster of two to 12 episodes a day for a mean duration of 2.5 days, with ictal EEG showing focal discharge, often slow waves or focal spikes on post-ictal tracing and normal interictal EEG. The clinical and EEG charact...
Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie, 1998
Neonatal myoclonic encephalopathy is of lesional or metabolic origin; non ketotic hyperglycinemia... more Neonatal myoclonic encephalopathy is of lesional or metabolic origin; non ketotic hyperglycinemia is one of its causes. A girl, born from consanguineous parents, died from myoclonic epileptic encephalopathy at the age of 3 months. Screening for metabolic disease was negative, except for increased levels of urine serotonin and 5-hydroxyindol-acetic in cerebrospinal fluid, blood and urine. Two sisters died with non ketotic hyperglycinemia, corpus callosum agenesis and clubfoot. Familial occurrence of non ketotic hyperglycinemia and early myoclonic epileptic encephalopathy is uncommon.
Archives françaises de pédiatrie, 1993
As facial nerve palsy is usually of sudden onset and of obscure etiology, a survey of large serie... more As facial nerve palsy is usually of sudden onset and of obscure etiology, a survey of large series may provide new information. The files of 40 children suffering from acute facial nerve palsy seen in 3 pediatric and 1 otorhinolaryngologic (ORL) departments between 1980 and 1990 were analysed. Patients with congenital palsy and those with paralysis that appeared after injury or in the course of acute or chronic disease (otitis media, tumor) were excluded from the study. The children were 9 months-16 years old (mean: 7 year 1 month). There were 22 left and 18 right facial nerve palsies. The palsy was moderate in 17 children, severe in 15, and total in 5. Etiologic factors (viral serologic studies, CSF examination), ORL studies and electromyogram of the facial nerve were analyzed in the majority of cases. Corticosteroids were used in 30 patients. A viral etiology was suspected and/or confirmed in 13 children; abnormalities were seen in 6 of the patients who underwent lumbar puncture. ...
Revue des maladies respiratoires, 1995
The authors report an original case of Crohn's disease in a teenager with breathlessness and ... more The authors report an original case of Crohn's disease in a teenager with breathlessness and alveolar lymphocytosis. This respiratory involvement is uncommon in pediatric. About the literature, the authors review the significant and the prognostic value of alveolitis in Crohn's disease.
Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie, 1995
Journal de Pédiatrie et de Puériculture, 1995
Archives françaises de pédiatrie, 1991
Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie, 2000
Hepatic hemangioendothelioma can have a fatal outcome. After failure of classic therapies, and wh... more Hepatic hemangioendothelioma can have a fatal outcome. After failure of classic therapies, and when surgery or arterial embolization are not possible, those benign tumours may benefit from interferon alpha treatment. We report a case of a 14-month-old infant who presented with hepatic hemangiomatosis and cardiac failure. The disease can neither be controlled by steroids nor by radiotherapy associated with digitalo-diuretic treatment. Due to the important vascular volume of the tumour, neither surgical care nor arterial embolization were possible. Thus this infant was treated for ten months by interferon alpha. The evolution was favourable: cardiac failure, calcifications and volume of the angiomatosis were regressive. Interferon alpha treatment helps to control cardiac failure and the course of hepatic hemangioma in childhood.
Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie, 1995
Prevalence of asthma is influenced by environmental factors which may be different from area to a... more Prevalence of asthma is influenced by environmental factors which may be different from area to area. A cross-sectional epidemiological survey was carried out among 1,395 children attending primary schools in the city of Le Havre and the canton of Fécamp (Haute-Normandie). Questionnaires including data about the disease, family history, environmental and socio-economic factors were completed by the school physician in presence of the parents. Prevalence rate of asthma calculated from 1,193 questionnaires was 7.8%. The logistic regression curves pointed out four risk factors: family history of asthma (odds ratio: 2.52) or hay fever (OR: 1.98), atopic dermatitis (OR: 3.96), and parental smoking (OR: 1.79). Sex, socioeconomic status of parents, type of housing, presence of pets in the house were not related to prevalence of asthma. Frequency of cough during the day was only significantly different between both areas. The high level of school absence (21.1%) and frequency of hospitaliza...
Médecine et Maladies Infectieuses, 1995
La possibilit6 d'un d6ficit en composant du compl6ment doit 8tre 6voqu6e devant la survenue de m6... more La possibilit6 d'un d6ficit en composant du compl6ment doit 8tre 6voqu6e devant la survenue de m6ningite 7t r6p6tition. Nous rapportons deux observations r6v61atrices, l'une d'un d6ficit en C2, l'autre en C5. La survenue d'une r6cidive de m6ningite doit faire rechercher une br6che m6ning6e (surtout s'il s'agit d'une m6ningite h pneumocoque), une aspl6nie, un d6ficit en immunoglobuline et un d6ficit du systSme compl6mentaire. Dans ce cadre, il s'agit de la voie principale (C1, C2, C4) dans 12 %, de la voie alterne dans 42 %, de la voie terminale (C5 h C9) dans 46 %. Devant l'absence de traitement sp6cifique de ces d6ficits, une prophylaxie des infections est r6alis6e par la p6nicilline V, et par les vaccinations (pneumo 23, m6ningocoque A C, Haemophilus influenzae ).
European Journal of Paediatric Neurology, 1999
All5 cause increased plasma creatine kinase after 3 weeks was proper, three items were inspected:... more All5 cause increased plasma creatine kinase after 3 weeks was proper, three items were inspected: duration of feeding with a special diet, age feeding started and the need to omit magnesium (Mg) from the diet.
Archives de Pédiatrie, 2003
Archives de Pédiatrie, 2000
Certains hémangio-endothéliomes hépatiques mettent en jeu le pronostic vital. Après échec des tra... more Certains hémangio-endothéliomes hépatiques mettent en jeu le pronostic vital. Après échec des traitements classiques, en cas de non-accessibilité à la chirurgie et à l'embolisation artérielle, ces tumeurs bénignes peuvent bénéficier d'un traitement par interféron α. Observation. -Nous rapportons l'observation d'un nourrisson de 14 mois atteint d'une angiomatose diffuse néonatale sévère avec une localisation hépatique et une insuffisance cardiaque. Aucun traitement chirurgical ou par embolisation artérielle n'étant possible, un traitement par interféron α a été proposé pendant dix mois. L'évolution, favorable, a été marquée par la régression de l'insuffisance cardiaque, et par la calcification et la régression de l'angiomatose. Conclusion. -Un traitement par interféron α permet de contrôler une insuffisance cardiaque et l'évolution d'un hémangiome hépatique. © 2000 Éditions scientifiques et médicales Elsevier SAS hémangioendothéliome hépatique / foie / interféron α Summary -A case of hepatic hemangioendothelioma management: by interferon α. Hepatic hemangioendothelioma can have a fatal outcome. After failure of classic therapies, and when surgery or arterial embolization are not possible, those benign tumours may benefit from interferon α treatment. Case report. -We report a case of a 14-month-old infant who presented with hepatic hemangiomatosis and cardiac failure. The disease can neither be controlled by steroids nor by radiotherapy associated with digitalo-diuretic treatment. Due to the important vascular volume of the tumour, neither surgical care nor arterial embolization were possible. Thus this infant was treated for ten months by interferon α. The evolution was favourable: cardiac failure, calcifications and volume of the angiomatosis were regressive. Conclusion. -Interferon α treatment helps to control cardiac failure and the course of hepatic hemangioma in childhood. © 2000 Éditions scientifiques et médicales Elsevier SAS hemangioendothelioma / liver / interferon α / infant Les angiomes hépatiques du nourrisson sont des affections rares qui peuvent mettre en jeu le pronostic vital du fait d'une coagulopathie de consomma-tion, d'hémorragies graves, d'insuffisance cardiaque [1]. L'abord thérapeutique médical fait appel aux corticostéroïdes [2], à la radiothérapie et aux agents
Archives de Pédiatrie, 1995
P Le Roux', D Hourderont3, I Loise12, A Collet4, J Boullochez. MT BriqueV, B Le Luyerz L'astbme. ... more P Le Roux', D Hourderont3, I Loise12, A Collet4, J Boullochez. MT BriqueV, B Le Luyerz L'astbme. chez I'enfant est un problhe de sant.5 publique. par sa fr6quence et sa motbiditc. Lc but de ce travail est de dctclnioer sa pf&akttcc ditns ?? nc f&on fmn@c au &mat maritime. cxpos& B la pok&nt irdustrklk, u ddvalocr ks factaws de tisqucs associts. P0puWOn e2 m&h&h. -L'coqu&e a # mt f&e aup& de 13% cnfants scokfiscS en cow3 Prcparatoite. Un questioimaire a Cti rcm~~Ji par k m&l&n scokirc en prhence des parents. Les items envisagCs ant port6 SIN la notion d'asthme diagaostiquC. les tmt&6dcnts pemomlels et familiaus I'env ironncmeIlt,hpriseCllChageClIn~. Msw/Ms. -Millc cent-quatrc-viogt-treize dossiers ottt &C attttlysh. La prdvalence cumultc de I'astbme a Ctd dc 7.8%. Aucunc diff&cncc a'a W rctnnw6c ctttn ~GWS mrale et urbainc. L'&udc de r&es&o h-gistique a moot& qtmtre factatts de dsqt~~: ks antccC&nts pcrsotmels de ckrmatite atopique (RR = 3.%). ka ant&&N familiaux d'asthme(RR=2.52)a&wllinose~~=1.98)ainsiqoekUbogismeplwif(RR= 1.79). Le mode de logemeat. la protess;on do chef de familk. k mode de garde. I'anciennet6 de rhideoce. la pr&cnce d'animaux domestiqucs, le sexe n'ont pas CtC retcnus commc facteurs de risque sigaificatifs. Seule. la toux diurnc chcz ICS asthmatiqws dit%e entre La Hwre et F& (21.8% vs 4.6%. p c OJIS). L'astbme a ctc rcsponsable de 21.1% d'absent6iimc sc&im da113 ks 12 mok prcctaents et de 20.4% d'hospitaiisation. Uo enfattt sut tkux (49.1%) avait un trhmatt ad8@. CORChUfO~S. -La prhdence 6levCe de I'asthme s'accompagnattt d'unc motkiditb importante, d'absent&me et d'hospitalisatioo, rend n&em&e uth? meilleun hformstkn et Mucation des famillcs. du corps enseignaot et des pmfcssio~~ls & saot6.
Médecine et Maladies Infectieuses
Helvetica paediatrica acta
The authors examine 18 cases of early dystonic syndromes and review all the pediatric cases publi... more The authors examine 18 cases of early dystonic syndromes and review all the pediatric cases published previously in order to determine the evolutive and epidemiological characters of these intolerance reactions. These unrecognized manifestations normally occur within the first 24 hours of treatment and disappear within a few hours when the treatment is discontinued. The use of diazepam and trihexyphenidyl accelerates the regression of the disorders. The doses of metoclopramide were mostly above the recommended doses, 60% of the cases correspond to doses in excess of 0.5 mg/kg per day or 0.2 mg/kg in a single dose. In the absence of overdosage, dystonic reactions occur essentially in female subjects aged over 9 years. For this part of the population, the possible occurrence of such a reaction should be mentioned to the family when the drug is prescribed.
Revue Française d'Allergologie et d'Immunologie Clinique, 1997
Archives De Pediatrie, 1999
Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie, 2000
This study presents the results of a hospital survey on Lyme disease in children living in upper ... more This study presents the results of a hospital survey on Lyme disease in children living in upper Normandy, a region that is quite densely wooded (with 18% forest areas and woods). The aim of this survey was to assess the prevalence of this disease in children from the Seine-Maritime and L'Eure, hospitalized in pediatric wards in the Seine-Maritime department, which includes Rouen, Dieppe, Fécamp, Elbeuf, and Le Havre. Fifteen cases of Lyme disease were diagnosed between September 1988 and June 1997. The children (6 girls and 9 boys) were aged between 5 and 14 years old. Only 7 subjects showed primary symptoms, while secondary symptoms were observed in 12 children. In the study population, a high prevalence (11 out of the 15 children) of neurological disorders was found. The following secondary symptoms were noted: 5 cases of erythema migrans, 2 cases of non-malignant cutaneous lymphocytoma, and 4 cases which in fact had previously displayed primary clinical signs (3 subjects wit...
Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie, 1999
Benign infantile non febrile seizures are not well known, leading us to study their clinical and ... more Benign infantile non febrile seizures are not well known, leading us to study their clinical and EEG characteristics. Between 1981 and 1994, we assembled 34 patients with the following inclusion criteria: non febrile seizures between 1 month and 2 years of age, normal personal history, no abnormality on clinical, biological and radiological investigations, normal developmental outcome with at least 1 year follow-up. These 34 patients were recognized as 14 familial cases (identical seizures affecting parents) and 11 non familial cases. The other nine cases had different or undefined epilepsy in the family. The clinical and EEG characteristics were the same: at the mean age of 6 months, brief partial seizures (often secondarily or apparently generalized) occurring in a cluster of two to 12 episodes a day for a mean duration of 2.5 days, with ictal EEG showing focal discharge, often slow waves or focal spikes on post-ictal tracing and normal interictal EEG. The clinical and EEG charact...
Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie, 1998
Neonatal myoclonic encephalopathy is of lesional or metabolic origin; non ketotic hyperglycinemia... more Neonatal myoclonic encephalopathy is of lesional or metabolic origin; non ketotic hyperglycinemia is one of its causes. A girl, born from consanguineous parents, died from myoclonic epileptic encephalopathy at the age of 3 months. Screening for metabolic disease was negative, except for increased levels of urine serotonin and 5-hydroxyindol-acetic in cerebrospinal fluid, blood and urine. Two sisters died with non ketotic hyperglycinemia, corpus callosum agenesis and clubfoot. Familial occurrence of non ketotic hyperglycinemia and early myoclonic epileptic encephalopathy is uncommon.
Archives françaises de pédiatrie, 1993
As facial nerve palsy is usually of sudden onset and of obscure etiology, a survey of large serie... more As facial nerve palsy is usually of sudden onset and of obscure etiology, a survey of large series may provide new information. The files of 40 children suffering from acute facial nerve palsy seen in 3 pediatric and 1 otorhinolaryngologic (ORL) departments between 1980 and 1990 were analysed. Patients with congenital palsy and those with paralysis that appeared after injury or in the course of acute or chronic disease (otitis media, tumor) were excluded from the study. The children were 9 months-16 years old (mean: 7 year 1 month). There were 22 left and 18 right facial nerve palsies. The palsy was moderate in 17 children, severe in 15, and total in 5. Etiologic factors (viral serologic studies, CSF examination), ORL studies and electromyogram of the facial nerve were analyzed in the majority of cases. Corticosteroids were used in 30 patients. A viral etiology was suspected and/or confirmed in 13 children; abnormalities were seen in 6 of the patients who underwent lumbar puncture. ...
Revue des maladies respiratoires, 1995
The authors report an original case of Crohn's disease in a teenager with breathlessness and ... more The authors report an original case of Crohn's disease in a teenager with breathlessness and alveolar lymphocytosis. This respiratory involvement is uncommon in pediatric. About the literature, the authors review the significant and the prognostic value of alveolitis in Crohn's disease.
Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie, 1995