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Papers by Marcelo Valente

JBNC - JORNAL BRASILEIRO DE NEUROCIRURGIA

O presente artigo relata um caso de fístula carótido-cavernosa direta (FCCD) pós-traumática em um... more O presente artigo relata um caso de fístula carótido-cavernosa direta (FCCD) pós-traumática em uma criança, tratada por via endovascular com balões destacáveis. A grande laceração da carótida e o refluxo cortical obrigou à oclusão da fístula e da artéria carótida interna com único balão. O resultado clínico após o tratamento foi excelente, mas o controle tardio com ecodoppler demonstrou revascularização da carótida interna e/ou recidiva da FCCD. A angiografia evidenciou repermeabilização da artéria carótida interna e esvaziamento do balão para dentro da FCCD que permaneceu trombosada. Essa observação demonstra que a protrusão de um balão de uma FCCD para dentro da artéria carótida interna nem sempre implica na sua oclusão a longo prazo.

Revista da Associação Médica Brasileira, 2016

Geriatrics, Gerontology and Aging, 2016

Identificar a prevalência de polifarmácia e o uso de medicamentos inapropriados em idosos interna... more Identificar a prevalência de polifarmácia e o uso de medicamentos inapropriados em idosos internados em uma instituição de longa permanência. MÉTODOS: Trata-se de um estudo descritivo transversal. Foram analisadas as prescrições médicas de idosos internados há pelo menos um mês em uma instituição de longa permanência. Para a coleta de dados utilizou-se um roteiro contendo as seguintes variáveis: idade, gênero, tempo de institucionalização, medicamentos prescritos, presença de medicamentos inapropriados para idosos e prática da polifarmácia. RESULTADOS: Foram analisadas 253 prescrições médicas. Dentre os idosos estudados, 149 (59%) eram do gênero masculino. A média de idade foi de 74 ± 9 anos. A mediana do tempo de institucionalização foi de 62 (1-942) meses. Dentre as prescrições médicas analisadas, a média era de 7 ± 3 medicamentos, e 68 (27%) continham pelo menos 1 medicamento inapropriado para idosos. A prática de polifarmácia foi verificada em 197 (78%) prescrições. CONCLUSÃO: Os resultados revelam uma alta prevalência de medicamentos inapropriados e prática de polifarmácia, elevando os riscos aos idosos institucionalizados. PALAVRAS-CHAVE: idoso; polimedicação; instituição de longa permanência para idosos.

Arquivos De Neuro Psiquiatria, 2003

Revista Aidis De Ingenieria Y Ciencias Ambientales Investigacion Desarrollo Y Practica, Jun 12, 2012

Revista brasileira de reumatologia

The objective of the present study was to evaluate radiographic changes of the temporomandibular ... more The objective of the present study was to evaluate radiographic changes of the temporomandibular joint (TMJ) in patients with juvenile systemic lupus erythematosus (JSLE) and a control group. Panoramic radiographies of the TMJ of 26 JSLE patients and 28 healthy individuals were evaluated. Multislice computed tomography (MCT) was performed on those patients who presented flattening and/or destruction of mandibular condyles. Demographic data, oral health indices, clinical manifestations, laboratory exams, and treatment were evaluated. Important radiographic changes consistent with osteonecrosis of the mandible, confirmed by MCT of the TMJ, were observed in 2/26 (8%) JSLE patients versus 0% in the control group (P = 0.22). Mild clinical dysfunction and abnormal TMJ mobility were observed in 67% and 54% of the patients, respectively. Age of onset, disease duration, and current age were similar in JSLE patients with and without severe radiographic changes of TMJ (9.3 versus 10.8 years, P...

AJNR. American journal of neuroradiology

Vascular and cortical anomalies have been found in a family with parietal foramina type 2 (PFM2),... more Vascular and cortical anomalies have been found in a family with parietal foramina type 2 (PFM2), which is determined by the ALX4 gene. It is believed that ALX4 has a bone-restricted expression. We report a case of PFM with age-related size variation in a 4-year-old boy, as well as in his mother, aunt and grandfather. MR imaging of the child demonstrates prominent malformations of cortical (polymicrogyric cortex with an unusual infolding pattern) and vascular development (persistence median prosencephalic vein), associated with high tentorial incisure periatrial white matter changes.

Pediatric Rheumatology, 2014

Revista Brasileira de Reumatologia, 2010

Juvenile systemic lupus erythematosus (JSLE) is an autoimmune disorder affecting several organs a... more Juvenile systemic lupus erythematosus (JSLE) is an autoimmune disorder affecting several organs and systems, with a wide range of manifestations that can involve the masticatory system and oral mucosa. 1,2 Orofacial involvement in JSLE has not been the focus of a large number of studies. In a recent study, we evaluated 48 patients with JSLE versus 48 age-and gender-matched healthy individuals, and we identified higher incidence of bacterial plaque and gingival bleeding in lupus patients. 3

Radiologia Brasileira, 2012

Anais do Congresso Internacional de Humanidades & Humanização em Saúde, 2014

Pediatric Neurology, 2004

The purpose of the present report is to document a 20-year-old woman with glycogenosis type III w... more The purpose of the present report is to document a 20-year-old woman with glycogenosis type III who presented a malformation of cortical development, in this case a polymicrogyria over bilateral perisylvian regions. Association of a malformation of cortical development in this type of glycogenosis has not been previously reported. The existence of previous cases of glycogenosis associated with malformations of cortical development led us to believe that glycogen storage during pregnancy may act as a harmful prenatal event. On the other hand, the presence of a lesion associated with severe neurologic deficits in one patient with a milder form of glycogenosis is in disagreement with the idea that there is a strong correlation between the severity of the central nervous system lesion and that of the disease.

Radiation Research, 2013

Rapid biodosimetry tools are required to assist with triage in the case of a large-scale radiatio... more Rapid biodosimetry tools are required to assist with triage in the case of a large-scale radiation incident. Here, we aimed to determine the dose-assessment accuracy of the well-established dicentric chromosome assay (DCA) and cytokinesis-block micronucleus assay (CBMN) in comparison to the emerging γ-H2AX foci and gene expression assays for triage mode biodosimetry and radiation injury assessment. Coded blood samples exposed to 10 X-ray doses (240 kVp, 1 Gy/min) of up to 6.4 Gy were sent to participants for dose estimation. Report times were documented for each laboratory and assay. The mean absolute difference (MAD) of estimated doses relative to the true doses was calculated. We also merged doses into binary dose

Pediatric Critical Care Medicine, 2013

Medical Physics, 2011

The calculation of patient-specific dose distribution can be achieved by Monte Carlo simulations ... more The calculation of patient-specific dose distribution can be achieved by Monte Carlo simulations or by analytical methods. In this study, FLUKA Monte Carlo code has been considered for use in nuclear medicine dosimetry. Up to now, FLUKA has mainly been dedicated to other fields, namely high energy physics, radiation protection, and hadrontherapy. When first employing a Monte Carlo code for nuclear medicine dosimetry, its results concerning electron transport at energies typical of nuclear medicine applications need to be verified. This is commonly achieved by means of calculation of a representative parameter and comparison with reference data. Dose point kernel (DPK), quantifying the energy deposition all around a point isotropic source, is often the one. FLUKA DPKS have been calculated in both water and compact bone for monoenergetic electrons (10-3 MeV) and for beta emitting isotopes commonly used for therapy (89Sr, 90Y, 131I 153Sm, 177Lu, 186Re, and 188Re). Point isotropic sources have been simulated at the center of a water (bone) sphere, and deposed energy has been tallied in concentric shells. FLUKA outcomes have been compared to PENELOPE v.2008 results, calculated in this study as well. Moreover, in case of monoenergetic electrons in water, comparison with the data from the literature (ETRAN, GEANT4, MCNPX) has been done. Maximum percentage differences within 0.8.RCSDA and 0.9.RCSDA for monoenergetic electrons (RCSDA being the continuous slowing down approximation range) and within 0.8.X90 and 0.9.X90 for isotopes (X90 being the radius of the sphere in which 90% of the emitted energy is absorbed) have been computed, together with the average percentage difference within 0.9.RCSDA and 0.9.X90 for electrons and isotopes, respectively. Concerning monoenergetic electrons, within 0.8.RCSDA (where 90%-97% of the particle energy is deposed), FLUKA and PENELOPE agree mostly within 7%, except for 10 and 20 keV electrons (12% in water, 8.3% in bone). The discrepancies between FLUKA and the other codes are of the same order of magnitude than those observed when comparing the other codes among them, which can be referred to the different simulation algorithms. When considering the beta spectra, discrepancies notably reduce: within 0.9.X90, FLUKA and PENELOPE differ for less than 1% in water and less than 2% in bone with any of the isotopes here considered. Complete data of FLUKA DPKS are given as Supplementary Material as a tool to perform dosimetry by analytical point kernel convolution. FLUKA provides reliable results when transporting electrons in the low energy range, proving to be an adequate tool for nuclear medicine dosimetry.