Mustafa Özyurt - Academia.edu (original) (raw)
Papers by Mustafa Özyurt
marmaramedicaljournal.org
Fusaria are major opportunist pathogens for immunocompromised patients. In this study, it was con... more Fusaria are major opportunist pathogens for immunocompromised patients. In this study, it was concluded as a result of both conventional and molecular identification techniques that the isolate obtained from the patient's diabetic foot was Fusarium sporotrichioides. T-2 toxin production of the pathogen was investigated using HPLC and no toxin was determined. For this reason, in laboratory diagnosis, Fusaria should not be considered solely as an environmental contaminant.
Türkiye Klinikleri COVID - 19, 2020
Turkish Journal of Infection, 2000
Gülhane tıp dergisi, 2015
DOAJ (DOAJ: Directory of Open Access Journals), Sep 1, 1998
Son 50 yıl içerisinde beta-laktam antibiyotikler dar spektrumlu benzil penisilinlerden oldukça ge... more Son 50 yıl içerisinde beta-laktam antibiyotikler dar spektrumlu benzil penisilinlerden oldukça geniş spektrumlu karbapenemlere kadar büyük bir değişim göstermiştir. Meropenem, karbapenem grubunda yer alan geniş spektrumlu bir antibiyotiktir. Bu antibiyotiğin önemli özelliği tüm beta-laktamazlara karşı stabil olması ve imipenemin aksine insan böbrek dehidropeptidaz I (DHP-I) enzimine karşı çok yüksek stabilite göstermesidir [1,6]. Bugün için, oldukça geniş spektrumlu antibakteriyel etkinlikleri ile beta-laktamazlara karşı stabiliteleri, karbapenem grubu antibiyotikleri, diğer beta-laktamlardan ayıran önemli bir özelliktir [3]. Meropenemin, plazmid veya kromozomal kaynaklı beta-laktamaz aktivitesi gösteren stafilokok, enterobakter ve Pseudomonas izolatlarına karşı mükemmel bir etkinlik gösterdiği bildirilmiştir [7,9]. Karbapenemlerden imipenem gram pozitif organizmalara karşı daha etkili gözükürken meropenem gram negatiflere özellikle de Pseudomonas aeruginosa'ya daha etkilidir [4] .
Flora infeksiyon hastalıkları ve klinik mikrobiyoloji dergisi, Jun 1, 2002
Türkiye Klinikleri COVID - 19, 2020
Erciyes tıp dergisi, Feb 17, 2015
Objective: Automated blood culture systems are the most preferred and reliable methods. It is ver... more Objective: Automated blood culture systems are the most preferred and reliable methods. It is very important and also difficult to distinguish whether the microorganism is causative or a contaminant in blood cultures. The aim of this study is to evaluate blood culture results between January 1, 2012 and January 1, 2013. Materials and Methods: Blood samples were cultured by using the BACTEC 9120 automated system. The decision about the growth being a pathogen or contamination was made through clinical findings, laboratory results, and identification of the same microorganism with the same antibiotic susceptibility patterns from blood samples. Results: Of the blood cultures, 43.8% yielded positive results, and 30.4% of them were identified as pathogens, while 13.4% was evaluated as contaminants. The highest contamination rate of 29.8% was observed in the department of cardiology, and the lowest contamination rate of 1.2% was observed in the department of pediatrics. Methicillin-resistant coagulase-negative staphylococci were the most common organisms (19.4%) isolated from blood cultures and assumed as pathogens. Conclusion: Every laboratory should control contamination rates at least once a year and check the results on whether contamination rates are less than 3% or not. If the rates are more than 3%, necessary measures should be taken. The most important measure is to establish phlebotomy teams or to educate all personnel, if this establishment not possible.
The Internet Journal of Infectious Diseases, 2005
In this study, HHV-6 presence was investigated in immunosupressed individuals. Forty-five (45) re... more In this study, HHV-6 presence was investigated in immunosupressed individuals. Forty-five (45) renal-transplante-patients, 35 chemotherapy-patients and 60 healthy control group were included in the study. Anti-HHV-6 IgM and IgG by indirect immunoflourescence technique, HHV-6 DNA by polymerase chin reaction, anti-CMV IgM and IgG by microparticule enzyme immunoassay were analyzed. The HHV-6 DNA positivity rates in the renal transplant group, chemotherapy group and the control group were respectively 20%, 11.4% and 1.6%; whereas anti-HHV-G IgM rates were 17.7%, 14.2% and 3.3%; and the anti-HHV-6 IgG rates were 95.5%, 88.5% and 91.6% respectively. Anti-CMV IgM was found to be 11%, 14.2% and 10% in the same groups and anti-CMV IgG rates were 91%, 91.4% and 86%. In the renal transplant group, HHV-6 DNA and anti-HHV-6 IgM positivity was statistically significant both alone (p=0.002 and p=0.04 respectively) or together (p=0.001). In the chemotherapy group anti-HHV-6 IgM alone (p=0.036) and anti-HHV-6 IgM together with HHV-6 DNA (p=0.007) positivity was significant; HHV-6 DNA positivity alone (p=0.099) was not significant. Conclusively, HHV-6 may be related with some malignant diseases and may play a role in the rejection in some renal transplanted patients.
PubMed, Jul 1, 2005
Much international business and tourism travels occur, as well as the deployment of soldiers to o... more Much international business and tourism travels occur, as well as the deployment of soldiers to other places. The aim of this study was both to determine incidence of malaria in the military hospital, Diyarbakir, southeast region of Turkey, and to point out the incidence of this disease. During the study period (1997-2004), 609 cases were found in a military hospital, which is in an endemic area for vivax malaria. This article review trends in current malaria status as well as possible factors for the decreasing prevalence throughout the study period.
Üçüncü basamak bir hastanede dispeptik yakınmaları olan hastaların dışkı örneklerinde Helicobacte... more Üçüncü basamak bir hastanede dispeptik yakınmaları olan hastaların dışkı örneklerinde Helicobacter pylori antijen pozitifliğinin değerlendirilmesi Evaluation of Helicobacter pylori antigen positivity in stool samples of patients with dyspeptic complaints in a tertiary care hospital
PubMed, Aug 6, 2004
Infections caused by Vibrio alginolyticus is generally disregarded because of the fact that it is... more Infections caused by Vibrio alginolyticus is generally disregarded because of the fact that it is an unusual pathogen for humans. In this report, a 57 years old male patient with otitis media has been presented. Intense and pure isolation of V. alginolyticus was achieved from the ear discharge sample. According to the history, it was detected that he was on vacation at Mediterranean coast three weeks ago, thus the transmission of the bacteria is possibly via seawater. The isolate was found sensitive to all of the tested antibiotics, and the patient was treated successfully with the combination of ciprofloxacin and amoxicillin-clavulanate. This case was presented to withdraw attention to V. alginolyticus infections which are very rarely seen, but should be taken into consideration in related cases.
PubMed, Oct 1, 2009
Although in certain countries in Europe fosfomycin trometamol (FT) has been used for many years, ... more Although in certain countries in Europe fosfomycin trometamol (FT) has been used for many years, in Turkey FT has become available in recent years. FT has a broad-spectrum activity against most of gram-positive and gram-negative bacteria. In this study, we aimed to evaluate the effect of FT, a new alternative antimicrobial agent in the treatment of patients with Escherichia coli related uncomplicated lower urinary tract infection (UTI). For this purpose, between May 2007-July 2008, FT susceptibility of 771 nonduplicate E. coli strains, isolated from urine samples of patients with uncomplicated lower UTI (bacteria > or = 10(5) cfu/mL), was determined by disk diffusion method according to Clinical and Laboratory Standarts Institute (CLSI) criteria. Simultaneously, extended-spectrum beta-lactamase (ESBL) detection was performed by double disk synergy test in all isolates. Among all E. coli isolates, FT resistance rate was 0.4% (3/771) and ESBL positivity was 19.5% (150/771). The rates of ESBL producing strains isolated from inpatients and outpatients were 34.1% (70/205) and 14.1% (80/566), respectively, and the difference was found statistically significant (p = 0.0001). Although resistance to FT was not detected in non-ESBL producing E. coli isolates (n = 621), FT resistance rate was 2% (3/150) in ESBL producers. As far as the current literature was concerned this was the largest scale study investigating the activity of FT in Turkey. Resistance to antimicrobials that had been used frequently as therapeutic options for the treatment of E. coli related UTIs, has been increasing. In the present study high susceptibility rates to FT was determined for urinary E. coli isolates. In conclusion, these data suggest that FT may be a good alternative for the treatment of uncomplicated UTIs as a first line antimicrobial agent.
Pancreas, Oct 1, 2001
ABSTRACT Translocation of bacteria from the gut into pancreatic necrosis is an important factor i... more ABSTRACT Translocation of bacteria from the gut into pancreatic necrosis is an important factor in the development of septic complications and mortality in acute pancreatitis. S-methylisothiourea (SMT) is an inducible nitric oxide synthase inhibitor that has been shown to decrease bacteria] translocation in sepsis and thermal injury. To investigate whether SMT could affect bacterial translocation in acute necrotizing pancreatitis. Forty-five Sprague-Dawley rats were studied. Acute pancreatitis was induced in Group I and Group II by injection of taurocholate and trypsin into the common biliopancreatic duct. Group III underwent laparotomy with the manipulation (but not cannulation) of the pancreas and received saline injection. Group I rats received normal saline as a placebo, and Group II rats received SMT after surgery for 2 days. At 48 hours, blood was drawn for serum amylase determinations. Bacterial translocation to mesenteric lymph nodes and distant sites (pancreas, liver, and peritoneum) were examined. A point scoring system of histologic features was used to evaluate the severity of pancreatitis. Plasma amylase levels and pancreatic histologic score were significantly reduced in Group II rats given SMT compared with those in Group I rats given saline (p < 0.01, p < 0.05, respectively). All Group I rats had bacterial translocation to mesenteric lymph nodes compared with 7 of 12 rats in Group II (p < 0.05). There was no difference in bacterial translocation to distant organs between the two groups, although rates tended to be lower in Group II compared with Group I (p > 0.05). Bacterial counts in the pancreas were significantly reduced in Group II rats compared with those in Group I rats (p < 0.05). Treatment with SMT appears to have ameliorated the course of acute pancreatitis; however, mortality was not affected.
Türkderm-Deri Hastalıkları ve Frengi Arşivi, 2017
marmaramedicaljournal.org
Fusaria are major opportunist pathogens for immunocompromised patients. In this study, it was con... more Fusaria are major opportunist pathogens for immunocompromised patients. In this study, it was concluded as a result of both conventional and molecular identification techniques that the isolate obtained from the patient's diabetic foot was Fusarium sporotrichioides. T-2 toxin production of the pathogen was investigated using HPLC and no toxin was determined. For this reason, in laboratory diagnosis, Fusaria should not be considered solely as an environmental contaminant.
Türkiye Klinikleri COVID - 19, 2020
Turkish Journal of Infection, 2000
Gülhane tıp dergisi, 2015
DOAJ (DOAJ: Directory of Open Access Journals), Sep 1, 1998
Son 50 yıl içerisinde beta-laktam antibiyotikler dar spektrumlu benzil penisilinlerden oldukça ge... more Son 50 yıl içerisinde beta-laktam antibiyotikler dar spektrumlu benzil penisilinlerden oldukça geniş spektrumlu karbapenemlere kadar büyük bir değişim göstermiştir. Meropenem, karbapenem grubunda yer alan geniş spektrumlu bir antibiyotiktir. Bu antibiyotiğin önemli özelliği tüm beta-laktamazlara karşı stabil olması ve imipenemin aksine insan böbrek dehidropeptidaz I (DHP-I) enzimine karşı çok yüksek stabilite göstermesidir [1,6]. Bugün için, oldukça geniş spektrumlu antibakteriyel etkinlikleri ile beta-laktamazlara karşı stabiliteleri, karbapenem grubu antibiyotikleri, diğer beta-laktamlardan ayıran önemli bir özelliktir [3]. Meropenemin, plazmid veya kromozomal kaynaklı beta-laktamaz aktivitesi gösteren stafilokok, enterobakter ve Pseudomonas izolatlarına karşı mükemmel bir etkinlik gösterdiği bildirilmiştir [7,9]. Karbapenemlerden imipenem gram pozitif organizmalara karşı daha etkili gözükürken meropenem gram negatiflere özellikle de Pseudomonas aeruginosa'ya daha etkilidir [4] .
Flora infeksiyon hastalıkları ve klinik mikrobiyoloji dergisi, Jun 1, 2002
Türkiye Klinikleri COVID - 19, 2020
Erciyes tıp dergisi, Feb 17, 2015
Objective: Automated blood culture systems are the most preferred and reliable methods. It is ver... more Objective: Automated blood culture systems are the most preferred and reliable methods. It is very important and also difficult to distinguish whether the microorganism is causative or a contaminant in blood cultures. The aim of this study is to evaluate blood culture results between January 1, 2012 and January 1, 2013. Materials and Methods: Blood samples were cultured by using the BACTEC 9120 automated system. The decision about the growth being a pathogen or contamination was made through clinical findings, laboratory results, and identification of the same microorganism with the same antibiotic susceptibility patterns from blood samples. Results: Of the blood cultures, 43.8% yielded positive results, and 30.4% of them were identified as pathogens, while 13.4% was evaluated as contaminants. The highest contamination rate of 29.8% was observed in the department of cardiology, and the lowest contamination rate of 1.2% was observed in the department of pediatrics. Methicillin-resistant coagulase-negative staphylococci were the most common organisms (19.4%) isolated from blood cultures and assumed as pathogens. Conclusion: Every laboratory should control contamination rates at least once a year and check the results on whether contamination rates are less than 3% or not. If the rates are more than 3%, necessary measures should be taken. The most important measure is to establish phlebotomy teams or to educate all personnel, if this establishment not possible.
The Internet Journal of Infectious Diseases, 2005
In this study, HHV-6 presence was investigated in immunosupressed individuals. Forty-five (45) re... more In this study, HHV-6 presence was investigated in immunosupressed individuals. Forty-five (45) renal-transplante-patients, 35 chemotherapy-patients and 60 healthy control group were included in the study. Anti-HHV-6 IgM and IgG by indirect immunoflourescence technique, HHV-6 DNA by polymerase chin reaction, anti-CMV IgM and IgG by microparticule enzyme immunoassay were analyzed. The HHV-6 DNA positivity rates in the renal transplant group, chemotherapy group and the control group were respectively 20%, 11.4% and 1.6%; whereas anti-HHV-G IgM rates were 17.7%, 14.2% and 3.3%; and the anti-HHV-6 IgG rates were 95.5%, 88.5% and 91.6% respectively. Anti-CMV IgM was found to be 11%, 14.2% and 10% in the same groups and anti-CMV IgG rates were 91%, 91.4% and 86%. In the renal transplant group, HHV-6 DNA and anti-HHV-6 IgM positivity was statistically significant both alone (p=0.002 and p=0.04 respectively) or together (p=0.001). In the chemotherapy group anti-HHV-6 IgM alone (p=0.036) and anti-HHV-6 IgM together with HHV-6 DNA (p=0.007) positivity was significant; HHV-6 DNA positivity alone (p=0.099) was not significant. Conclusively, HHV-6 may be related with some malignant diseases and may play a role in the rejection in some renal transplanted patients.
PubMed, Jul 1, 2005
Much international business and tourism travels occur, as well as the deployment of soldiers to o... more Much international business and tourism travels occur, as well as the deployment of soldiers to other places. The aim of this study was both to determine incidence of malaria in the military hospital, Diyarbakir, southeast region of Turkey, and to point out the incidence of this disease. During the study period (1997-2004), 609 cases were found in a military hospital, which is in an endemic area for vivax malaria. This article review trends in current malaria status as well as possible factors for the decreasing prevalence throughout the study period.
Üçüncü basamak bir hastanede dispeptik yakınmaları olan hastaların dışkı örneklerinde Helicobacte... more Üçüncü basamak bir hastanede dispeptik yakınmaları olan hastaların dışkı örneklerinde Helicobacter pylori antijen pozitifliğinin değerlendirilmesi Evaluation of Helicobacter pylori antigen positivity in stool samples of patients with dyspeptic complaints in a tertiary care hospital
PubMed, Aug 6, 2004
Infections caused by Vibrio alginolyticus is generally disregarded because of the fact that it is... more Infections caused by Vibrio alginolyticus is generally disregarded because of the fact that it is an unusual pathogen for humans. In this report, a 57 years old male patient with otitis media has been presented. Intense and pure isolation of V. alginolyticus was achieved from the ear discharge sample. According to the history, it was detected that he was on vacation at Mediterranean coast three weeks ago, thus the transmission of the bacteria is possibly via seawater. The isolate was found sensitive to all of the tested antibiotics, and the patient was treated successfully with the combination of ciprofloxacin and amoxicillin-clavulanate. This case was presented to withdraw attention to V. alginolyticus infections which are very rarely seen, but should be taken into consideration in related cases.
PubMed, Oct 1, 2009
Although in certain countries in Europe fosfomycin trometamol (FT) has been used for many years, ... more Although in certain countries in Europe fosfomycin trometamol (FT) has been used for many years, in Turkey FT has become available in recent years. FT has a broad-spectrum activity against most of gram-positive and gram-negative bacteria. In this study, we aimed to evaluate the effect of FT, a new alternative antimicrobial agent in the treatment of patients with Escherichia coli related uncomplicated lower urinary tract infection (UTI). For this purpose, between May 2007-July 2008, FT susceptibility of 771 nonduplicate E. coli strains, isolated from urine samples of patients with uncomplicated lower UTI (bacteria > or = 10(5) cfu/mL), was determined by disk diffusion method according to Clinical and Laboratory Standarts Institute (CLSI) criteria. Simultaneously, extended-spectrum beta-lactamase (ESBL) detection was performed by double disk synergy test in all isolates. Among all E. coli isolates, FT resistance rate was 0.4% (3/771) and ESBL positivity was 19.5% (150/771). The rates of ESBL producing strains isolated from inpatients and outpatients were 34.1% (70/205) and 14.1% (80/566), respectively, and the difference was found statistically significant (p = 0.0001). Although resistance to FT was not detected in non-ESBL producing E. coli isolates (n = 621), FT resistance rate was 2% (3/150) in ESBL producers. As far as the current literature was concerned this was the largest scale study investigating the activity of FT in Turkey. Resistance to antimicrobials that had been used frequently as therapeutic options for the treatment of E. coli related UTIs, has been increasing. In the present study high susceptibility rates to FT was determined for urinary E. coli isolates. In conclusion, these data suggest that FT may be a good alternative for the treatment of uncomplicated UTIs as a first line antimicrobial agent.
Pancreas, Oct 1, 2001
ABSTRACT Translocation of bacteria from the gut into pancreatic necrosis is an important factor i... more ABSTRACT Translocation of bacteria from the gut into pancreatic necrosis is an important factor in the development of septic complications and mortality in acute pancreatitis. S-methylisothiourea (SMT) is an inducible nitric oxide synthase inhibitor that has been shown to decrease bacteria] translocation in sepsis and thermal injury. To investigate whether SMT could affect bacterial translocation in acute necrotizing pancreatitis. Forty-five Sprague-Dawley rats were studied. Acute pancreatitis was induced in Group I and Group II by injection of taurocholate and trypsin into the common biliopancreatic duct. Group III underwent laparotomy with the manipulation (but not cannulation) of the pancreas and received saline injection. Group I rats received normal saline as a placebo, and Group II rats received SMT after surgery for 2 days. At 48 hours, blood was drawn for serum amylase determinations. Bacterial translocation to mesenteric lymph nodes and distant sites (pancreas, liver, and peritoneum) were examined. A point scoring system of histologic features was used to evaluate the severity of pancreatitis. Plasma amylase levels and pancreatic histologic score were significantly reduced in Group II rats given SMT compared with those in Group I rats given saline (p < 0.01, p < 0.05, respectively). All Group I rats had bacterial translocation to mesenteric lymph nodes compared with 7 of 12 rats in Group II (p < 0.05). There was no difference in bacterial translocation to distant organs between the two groups, although rates tended to be lower in Group II compared with Group I (p > 0.05). Bacterial counts in the pancreas were significantly reduced in Group II rats compared with those in Group I rats (p < 0.05). Treatment with SMT appears to have ameliorated the course of acute pancreatitis; however, mortality was not affected.
Türkderm-Deri Hastalıkları ve Frengi Arşivi, 2017