Reenoo Jauhari - Academia.edu (original) (raw)

Papers by Reenoo Jauhari

Tropical Doctor, Jul 1, 1998

Journal of applied pharmaceutical sciences and research, Jan 8, 2022

HIV/AIDS is one of the fatal diseases within the world and is caused by human immunodeficiency vi... more HIV/AIDS is one of the fatal diseases within the world and is caused by human immunodeficiency virus. Aids initially cause immune system failure resulting in infection and risk of cancers. HIV infection caused by blood transfusion and by using contaminated syringes, HIV is present in body in 2 forms-Free virus & within infected immune cells. CD4 T-cells are infected by HIV and reduce its numbers by breaking down T-cells. Most of the symptoms of HIV are opportunistically caused by bacteria, virus, fungi etc. The infection is smaller than 1% per annum in couples who used condoms. Female condoms may provide equal level of protection. The treatment of antiretroviral drugs has changed AIDS from a life-threatening disease to a feasible disease. Research has known how the virus replicates, manipulates, and hides in infected persons. Although our understanding is increased about the virus yet, a cure and vaccine remain tough.

International journal of pharmaceutical sciences review and research, Jan 15, 2022

Urinary tract infections (UTIs) are the inflammatory disorders of the urinary tract caused by the... more Urinary tract infections (UTIs) are the inflammatory disorders of the urinary tract caused by the abnormal growth of pathogens. Urinary tract infections can be community acquired or nosocomial. Symptoms of UTIs such as fever, burning sensations while urinating, LAP, itching, formation of blisters and ulcers in the genital area, genital and supra pubic pain, and pyuria generally depend on the age of the person infected the location of the urinary tract infected. E.coli is the major etiologic agent in causing UTI, which accounts for up to 75%-90% of cases whereas Staphylococcus saprophyticus causes an estimated 5-1 5% of UTIs frequently in younger women. P. mirabilis, Klebsiella species, P. aeruginosa and Enterobacter species are less frequent offenders. Less commonly, Enterococci, G. vaginalis and U. urealyticum are also known agents in UTIs. Due to the rapidly evolving adaptive strategies of bacteria, the etiology of UTI and antibiotic resistance profile of bacterial uropathogens have changed considerably over the past years, both in community and nosocomial infections. Treatment of UTIs cases is often started empirically and therapy is based on information determined from the antimicrobial resistance pattern of the urinary pathogens.

Journal of Drug Delivery and Therapeutics, Oct 15, 2019

Background: Assessing Quality of life of Migraine patients is important so as to manage the Heada... more Background: Assessing Quality of life of Migraine patients is important so as to manage the Headache and to implement some interventional programs in order to improve the quality of life of these patients. The study aims to find out the impact of Migraine on qual ity of life of Migraine patients. Material and method: This was a Prospective, Observational and questionnaire-based study, conducted from March to August 2019 for a period of 6 months, after approval from Institutional Ethics Committee. Data was analysed using Statistical Package for Social Sciences (SPSS) version 25. The quality of life in Migraine (HIT-6) was used for collecting data on Quality of Life. Results: Among 100 patients 81 were Females accounting for 81% of total study population and 19 were Males accounting for 19% of total study population. Majority of the patients were in the age range of 33-39 (30%). These were the Social History of the Patients among which 16(16%) patients were smokers, 20(20%) consumed alcohol, 21(21%) smoke and consumed alcohol and 43 (43%) did not smoke nor consumed alcohol. 44 patients were from nuclear family and 56 were from joint family. The age of onset of migraine was more i n the age of 21-30 that is (33%) as compared to other age groups. In this study the patients were to drug therapy planned to be given to them-amitriptyline and propranolol. The mean value for quality of life (QOL) before amitriptyline treatment was found to be 78.32 and the mean value for quality of life (QOL) before propranolol treatment was found to be 73.60 which comes under the score of ≥60 in accordance of HIT-6 that indicates severe impact on migraine patients. The HIT score after amitriptyline was found to be 46.5 and HIT score of propranolol was recorded to be 60.5. The score with amitriptyline falls under scoring 49 or less which indicates that the headache have little or no impact on QOL. And score of 60.5 with propranolol indicates that still headache have severe impact on QOL of the patient. Conclusion: Migraine patients had poor Quality of Life, which affected their pain and role functioning. It is very important to improve their Quality of life so that they can enjoy their day to day life.

The Pharma Innovation Journal, Jul 1, 2017

Asthma is an airway inflammation disease which has series of generative, provoking, persuading an... more Asthma is an airway inflammation disease which has series of generative, provoking, persuading and irritating factors which define its constitution and helps to correlate with genetic expression. Since it is both, genetic and atmospheric disease. In India the prevalence of asthma in increased 10-15% in 5-11 year old children. It took place due to hyper responsiveness of helper T-cells with the release of leukotrines, histamines, cytokines, causing inflammation and bronchoconstriction. Several supplements like vitamins A, B, C; D and E have beneficial effect in bronchoconstriction, wheeze and inflammation. Alcohol and smoking habits have adverse effects in asthma. BMI have the potential effect on Asthma. BMI shows potential effects with increase BMI wheezing and panting symptoms are increased. Fast food i.e. burgers and pizza mark as the increase in wheezing and asthmatic symptoms. Fish and several nutrients like selenium, magnesium, sodium etc have beneficial effect in asthmatic and wheezing symptoms.

Journal of pharmaceutical research international, Dec 8, 2021

Polycystic ovarian syndrome (PCOS) is the commonest cause of anovulatory infertility. Depending o... more Polycystic ovarian syndrome (PCOS) is the commonest cause of anovulatory infertility. Depending on the population studied between 5 and 18% of women of reproductive age suffer from PCOS, however not all of them are anovulatory or experience subfertility. PCOS has been associated with numerous reproductive and metabolic abnormalities. Despite enormous advances in the management of reproductive dysfunction, insight into the metabolic implications of PCOS is limited by the lack of uniform diagnostic criteria, the heterogeneity of the condition and the presence of confounders including obesity. Obesity clearly has a role in long term health and may best predict both reproductive and metabolic dysfunction as well as negatively affect the response to treatment in women with PCOS. Diabetes, cardiovascular disease and cancer are also at the forefront of any risk assessment or comprehensive treatment strategy for these women. Lifestyle modifications including dietary changes, increased exercise and weight loss are appropriate first line interventions for many women with PCOS. Pharmaceuticals including metformin, lipid lowering agents and oral contraceptives should be tailored to the individual's risk profile and treatment goals. The fertility treatment in women with subfertility and PCOS aimed to safely induce monofollicular ovulation resulting in the birth of a singleton child. Women with PCOS undergoing fertility treatment

Journal of Drug Delivery and Therapeutics, Oct 15, 2019

Background: Estimation of Quality of life is a useful outcome measure to know about epilepsy care... more Background: Estimation of Quality of life is a useful outcome measure to know about epilepsy care from patient's perspective. Assessing QOL of epileptic patients is important so as to manage the epilepsy and to implement some interventional programs in order to improve the quality of life of these patients. The study aims to find out the impact of epilepsy on quality of life of epileptic patients Material and method: This was a cross-sectional, questionnaire-based study, conducted from March to August 2019 for a period of 6 months, after approval from Institutional Ethics Committee. Data was analyzed using Statistical Package for Social Sciences (SPSS) version 25. The quality of life in epilepsy (QOLIE-31) was used for collecting data on health-related QOL. Result: The study group consisted of 65 patients of whom 48 were males (73.84%) and 17 were females (26.15%). Their ages ranged from 19 to 60 years. (mean age: 35.65). Majority of the patients were in the age range of 30-41 (40%). 50.8% participants were from nuclear family and 49.2% were from joint family system. Most of the patients had lower class socioeconomic status (61.5%). As regard to the employment status, 38.4% of patients were full time employed, 13.8% were part time employed. 29.2% were unemployed and 9.23% were retired and 9.23% were students. The medication analysis revealed that 30.6% of the participants were on monotherapy whereas 69.0% were on polyther apy. The mean total QOLIE-31 score was 39.12 (SD-5.00). Conclusion: Epileptic patients had poor QOL with low total QOLIE-31 score, unemployment, use of combination therapy and people belonging to lower class were associated with lower quality of life in individuals with epilepsy.

The Pharma Innovation Journal, 2019

WHO (World Health Organization) defines health as a complete state of physical and mental wellbei... more WHO (World Health Organization) defines health as a complete state of physical and mental wellbeing, and not merely the absence of disease or weakness. Traditional healing is used for the health treatment, dealing with the health problem, knowledge related the traditional healing and faith. Traditional healers plays the important role in the traditional therapy. It is found that the traditional therapy depends upon the faith and believe on the traditional healer. Aim of this study was to find out the existence and there future aspect of the traditional healing in the societies of developing countries. Some countries are focusing on the development and research framework for traditional therapy. After the study it was concluded that most of the developing countries including India, peoples believes in traditional therapies. If they are suffering from any disease they choose to prefer the traditional healer after that they prefer to go to the medical practitioner. Although there is no side effect of traditional therapy, so it is important that traditional healing should be incorporated with western medical therapy. Some rule regulation and education framework should be created for the therapy by the government of respective countries.

Journal of Drug Delivery and Therapeutics, Sep 10, 2019

Glaucoma is a condition in which distinctive changes occur in the optic nerve and visual field. I... more Glaucoma is a condition in which distinctive changes occur in the optic nerve and visual field. In glaucoma intraocular pressure (IOP) is raised that compresses and damages the optic nerve. As the optic nerve is damaged, it fails to carry the visual information to the brain which induce clinically progressive loss of peripheral visual field and ultimately loss of vision. Aims and Objectives: To Evaluate the drug utilization and prescribing pattern of drugs used for treatment of glaucoma, to analyze current prescribing trends in anti-glaucoma drugs, to perform a drug utilization study, to identify drugs per prescription, category wise identification of drugs prescribed, mono therapy vs combination therapy. Materials and Methods: The present study was a prospective, observational study carried out in 105 patients at

Journal of Applied Pharmaceutical Sciences and Research

Obesity is a major public health problem in the world. This growing rate represents an epidemic t... more Obesity is a major public health problem in the world. This growing rate represents an epidemic that requires immediate attention. Oral Semaglutide is a semaglutide compound with an absorption enhancer, a sodium N- (8 - [2-hydroxybenzoyl] amino) caprylate (SNAC). The mechanism of action simply produces Glucagon-like peptide-1 (GLP-1) as a food-based digestive hormone that acts as an appetite signal, stimulates insulin release, inhibits glucagon production, and regulates diarrhea. This article shows the correlation of GLP-1 association with motivation to feed and Semaglutide’s anorectic effect and relation to cravings. We have performed complete searches from PubMed, Cochrane, Scopus, Medline, Medscape, and Wiley online library from 2015 to 2022. The trial data (SUSTAIN, PIONEER, STEP) suggested a major decrease in weight and HbA 1c. SELECT trial data showed cardiovascular safety of semaglutide over other anti-diabetic drugs. This review article summarized semaglutide trial data as a...

Journal of Applied Pharmaceutical Sciences and Research

Melatonin and migraine have been linked in most ways, from mechanisms to treatment. Migraine is o... more Melatonin and migraine have been linked in most ways, from mechanisms to treatment. Migraine is one of the common neurological diseases and it is characterized by throbbing unilateral headache attacks. Migraine is an issue for both individuals and society. Migraine can lead to reduced work productivity and a flawed family and social life. It has been suggested that melatonin plays a key therapeutic role in treating migraines and several other types of headaches. Early and exact diagnosis is essential in enhancing treatment and in preventing progression. This review aimed to evaluate the available evidence related to the efficacy and safety of melatonin in the prophylaxis and prevention of migraine. Research in regard the administration of melatonin found it safe in migraine patients, with few or no side effects. This review concluded that Melatonin can be considered a safe integrative prophylactic treatment for children, adults and menstrual-related migraines, thus improving outcome...

Journal of Applied Pharmaceutical Sciences and Research

BACKGROUND: Methylcobalamin or Vitamin B12 is a coenzyme involved in the synthesis of methionine,... more BACKGROUND: Methylcobalamin or Vitamin B12 is a coenzyme involved in the synthesis of methionine, pyrimidine and purine bases. Type 2 diabetes is associated with oxidative stress; Vitamin B12 deficiency in diabetic patients taking metformin has been linked with oxidative stress. Because of these associations, it is implied that Vitamin B12 deficiency must be considered a risk factor for complications related to diabetes. However, several studies also suggest that deficiency of Vitamin B12 starts from the early stages of Diabetes. It has also been suggested that Vitamin B12 supplementation may help in reducing the complications related to diabetes. Although, the use of prophylactic Vitamin B12 to reduce complications related to diabetes remains controversial. Objective: This study aimed to explore the clinical relevance of Vitamin B12 in newly diagnosed T2DM patients. This study measured Vitamin B12 levels in newly diagnosed patients with type 2 diabetes (T2DM) and explored the corre...

Journal of pharmaceutical research international, Dec 17, 2021

Objective: To compare vitamin D status in, women with PCOS & fertile women without PCOS and its s... more Objective: To compare vitamin D status in, women with PCOS & fertile women without PCOS and its subsequent evaluation. Introduction: PCOS is an endocrine disorder of women in reproductive age, characterised by obesity, hyperandrogenaemia and insulin resistance. Women with PCOS tend to be overweight and have increased risk of development of Type II Diabetes and cardiovascular disease. Exact Etiology of PCOS still remain an enigmatic dilemma however various studies conducted till date include diet and lifestyle modification as the key factor to promote health, BMI, reduced hyperinsulinemia and reduce the risk of development of PCOS. Main aim of our study was to compare vitamin D status in women having PCOS, with fertile women in a tertiary care hospital in Uttarakhand. Methodology: The conducted study was cross sectional, involving the enrolment of 100 women comprising of 50 women with PCOS and 50 fertile women without PCOS. Participants were selected from gynaecological OPD at Shri Mahant Indiresh Hospital, associated with Shri Guru Ram Rai Institute of Medical Sciences, Dehradun from July 2019 to January 2020. The diagnostic criteria of PCOS used was the Rotterdam criteria. The serum 25-hydroxy vitamin D and other metabolic markers were measured. Vitamin D deficiency was defined as serum 25 (OH) D concentrations less than 20 ng/ml measured on an instrument named as miniVidas (BioMerieux, Germany) based on ELFA (enzyme linked fluorescent assay).

IOSR Journal of Dental and Medical Sciences, Jul 1, 2016

Background: Urinary tract infection (UTI) is one of the most common infections encountered and tr... more Background: Urinary tract infection (UTI) is one of the most common infections encountered and treated worldwide. The spectrum of etiologic agents causing urinary tract infections and their antimicrobial resistance pattern has been continuously changing over the years, both in community and in hospitals. No data concerning the antimicrobial resistance of bacteria isolated from UTI in and around Dehradun region of Uttarakhand has been published to date. Hence an evaluation may also be useful to detect emerging trends of antimicrobial resistance and serve as an indicator for change in antimicrobial prescriptions. Material & Methods: Study was conducted on all patients who came to the laboratory for urine culture & sensitivity and 100 Escherichia coli isolates were included in the study over a period of 10 months. Minimal inhibitory concentrations were calculated on Vitek 2 compact automated system with emphasis on different enzyme resistance mechanisms. Results: These isolates had predilection primarily for females except in older age group wherein males were more affected. Different enzyme resistance mechanisms responsible for antibiotic resistance included ESBL, carbapenemase, etc were statistically evaluated. Conclusion: Importance of excessive water intake and alkalisers should be stressed upon before starting the antibiotic therapy to minimize the emergence of multidrug resistance.

Journal of Applied Pharmaceutical Sciences and Research

All around the world, the profession of pharmacy and the notion of pharmaceutical care are quickl... more All around the world, the profession of pharmacy and the notion of pharmaceutical care are quickly evolving. In addition, the pharmacist's role in promoting logical and cautious use of medicine is becoming more important as a result of his technical and professional understanding. It is clearly known that patients who are adequately informed about medications and how to take them receive safe and effective treatment. Therapeutic pharmacists interact with patients on a frequent basis and assist with clinical treatments in addition to the numerous technical activities performed behind the counter. It is not enough to simply hand over a medicine kit to the patient or their representative; it is also necessary to hand over the correct drug to the correct person with the correct information. The act of assisting a client in seeing everything clearly, potentially from a different perspective. This might assist the client in focusing on feelings, experiences, or behaviour with the goal...

Journal of Applied Pharmaceutical Sciences and Research

Parkinson’s disease is a progressive, neurodegenerative disorder of the extrapyramidal nervous sy... more Parkinson’s disease is a progressive, neurodegenerative disorder of the extrapyramidal nervous system affecting the mobility and control of the skeletal muscular system. Although PD can develop at any age, it begins most commonly in older adults, with a peak age at the onset of around 60 years. Levodopa and dopamine agonists such as ropinirole are used in Parkinson’s treatment. This complete literature search was done using Google Scholar and PubMed. This review is to compare the safety and efficacy of ropinirole with that of Levodopa.