Renu Thambi - Academia.edu (original) (raw)

Papers by Renu Thambi

Indian Journal of Pathology & Microbiology, 2016

Minimal deviation adenocarcinoma (MDA) of endometrium is considered a differentiated state of end... more Minimal deviation adenocarcinoma (MDA) of endometrium is considered a differentiated state of endometrioid adenocarcinoma. It is a low-grade tumor associated with areas histologically typical of endometrioid adenocarcinoma in the majority of the cases. Due to deceptively benign microscopy, MDA may be overlooked leading to incorrect assessment of tumor extend and staging.

International Journal of Research in Medical Sciences, May 27, 2022

The leading causes of death during perinatal period includes congenital anomalies, prematurity, l... more The leading causes of death during perinatal period includes congenital anomalies, prematurity, low birth weight,infections, maternal risk factors. 2 The most common cause of fetal and perinatal mortality in developed countries is congenital anomaly. In addition to fetal problems, obstetric complications are also implicated in more than half of perinatal and neonatal deaths. So adequate maternal health and antenatal care

Indian Journal of Cancer, 2015

Indian Journal of Pathology and Microbiology, 2022

Background: Cystic Hypersecretory Carcinoma (CHC) is a rare subset of breast carcinoma. It is par... more Background: Cystic Hypersecretory Carcinoma (CHC) is a rare subset of breast carcinoma. It is part of a spectrum of cystic hypersecretory lesions which includes cystic hypersecretory hyperplasia (CHH), CHH with atypia, CHC in situ and CHC with invasion. Approximately 65 cases of cystic hypersecretory lesions have been reported; most of them were CHC in situ and only 19 cases of CHC with invasion have been reported so far. Case Presentation: We are reporting 2 cases of 47 and 62 year old women with a palpable breast mass for 6 and 1 month duration respectively. Trucut biopsy was carried out for both which showed high grade ductal carcinoma in situ with microinvasion in the first patient and the latter showed a tiny focus of invasive carcinoma. Simple mastectomy and modified radical mastectomy (MRM) were done for the respective cases; both showed dilated cystic spaces filled with eosinophilic secretions (thyroid colloid-like), lining neoplastic cells that showed variable degrees of pr...

National Journal of Laboratory Medicine, 2015

Gout is caused by persistent chronic hyperuricemia and is characterised clinically by relapsing a... more Gout is caused by persistent chronic hyperuricemia and is characterised clinically by relapsing and remitting attacks of joint pain. The deposition of monosodium urate crystals in and around joints, skin and soft tissue produces masses commonly referred to as tophi. Rare cases can present initially as tophaceous gout without features of arthritis. Below we report two cases clinically suspicious of neoplastic process; where cytology was diagnostic of gouty tophi. One of our cases presented as lytic lesion of bone without features of arthritis. The use of fine needle aspiration (FNA) cytology in periarticular and soft tissue nodules is highlighted.

JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH, 2016

National Journal of Laboratory Medicine, 2016

Indian journal of pathology & microbiology

Indian Journal of Sexually Transmitted Diseases and AIDS, 2014

Journal of Cytology, 2012

We report a case of primary actinomycosis of breast diagnosed by fine needle aspiration cytology ... more We report a case of primary actinomycosis of breast diagnosed by fine needle aspiration cytology (FNAC) in a postmenopausal lady who presented with a clinical impression of malignancy. Resolution of infection while conserving the breast was achieved by timely diagnosis and effective antibiotic therapy. The literature reports that primary actinomycosis of the breast is very rare after menopause, with only very few cases found after extensive search. It is imperative that this condition should be considered in the differential diagnosis of malignancy. The effectiveness of cell block sections in the final diagnosis is also highlighted.

Journal of Cytology, 2013

Extramedullary hematopoiesis (EMH) evidenced by erythropoietic cells and megakaryocytes is a char... more Extramedullary hematopoiesis (EMH) evidenced by erythropoietic cells and megakaryocytes is a characteristic feature of hepatoblastoma (HB). The typical cytomorphology, the presence of EMH and associated clinical and radiological findings offer a reliable diagnosis of hepatoblastoma by fine-needle aspiration cytology (FNAC). We describe the cytologic features of hepatoblastomas and discuss the differential diagnosis in two children, aged 53 days and 19 years. The usefulness of EMH in differentiating HB from other small round cell tumors and well differentiated hepatocellular carcinoma (HCC) on cytology is highlighted.

Indian Journal of Pathology and Microbiology, 2012

International Journal of Research in Medical Sciences, 2022

Background: Fine needle aspiration cytology (FNAC) is a relatively safe diagnostic tool with high... more Background: Fine needle aspiration cytology (FNAC) is a relatively safe diagnostic tool with high sensitivity and specificity. Due to lesion inherent properties and lack of proper technique, adequate cellularity is not yielded in some instances, resulting in an inconclusive report. In such instances we have to go for repeat FNA to make a proper diagnosis. Repeat aspirations impose unnecessary workload on the lab and are distressful to the patients. The issue of repeat aspiration is largely unaddressed. Objectives were to identify the proportion of repeated fine needle aspirations in breast and thyroid lesions turning out to be diagnostic and to identify and describe the common factors leading to repeat fine needle aspiration.Methods: 190 cases of repeated FNA including both thyroid and breast lesions are included in the study. FNA done after an initial aspiration with inconclusive smear is considered as repeated FNA. History, clinical examination findings, findings in imaging studie...

Tumorlets are collections of neuroendocrine cells seen in the lungs. They may be incidentally det... more Tumorlets are collections of neuroendocrine cells seen in the lungs. They may be incidentally detected and are usually seen associated with chronic lung diseases like bronchiectasis, bronchial asthma and sequestration. It is important to identify tumorlets especially in patients with prior history of carcinoma breast, since they mimic metastatic disease. Our patient was a 49 year lady who presented with cough and dyspnea of 6 months duration. Radiology revealed a large cavitatary lesion occupying the entire lower lobe of right lung. A lobectomy was done and gross examination revealed a large cavity with thickened wall, bronchioles were also thickened and reached up to the pleural surface. Histology confirmed the diagnosis of bronchiectasis with cavity formation. Adjacent lung showed granulomatous reaction but there was no caseation necrosis. One of the sections had a minute (1mm) focus showing a group of cells with neuroendocrine features. Further bits were taken and sections studie...

Teratomas are the most common germ cell tumors derived from embryonic tissue composed of cells fr... more Teratomas are the most common germ cell tumors derived from embryonic tissue composed of cells from two or more germ cell layers. These tumors arise in gonads and extragonadal sites such as midline, mediastinum, sacrococcygeal region, and retroperitoneum. Retroperitoneum is an unusual site in adults. Malignant transformation in teratomas is rarely seen only in 1% cases. We present the case of a 57-year-old female patient who presented with abdominal pain and swelling and was diagnosed as adenocarcinoma in a retroperitoneal teratoma. Adenocarcinoma is a rare somatic malignancy arising in a retroperitoneal teratoma. Extensive literature search revealed <20 cases and our patient was unique in presenting at a later age. A review of the current literature is also done.

Journal of Medical Science And clinical Research

Background: Multiple myeloma is a malignant plasma cell dyscrasia which is characterised by bone ... more Background: Multiple myeloma is a malignant plasma cell dyscrasia which is characterised by bone marrow plasmacytosis. Multiple myeloma causes 1 % of all cancer deaths in western population. Objectives 1. To describe the various morphological types of myeloma in bone marrow examination and its kappa and lambda expression 2. To assess the microvessel density using CD 34 in the bone marrow biopsy of patients with multiple myeloma Methods Study Design: Descriptive study Study Population: Study sample includes all the cases of multiple myeloma received in the Department of Pathology during the study period. Sample Size: 64 Sampling Procedure: Continuous sampling Results: In our study, myeloma with plasma cell morphology constituted 57.82% and plasmablastic morphology constituted 42.18 %. A high microvessel density above the cut off value was seen in 28 cases (43.75 %) and a low MVD in 36 cases (56.25 %).In all the cases monoclonality was proved by kappa and lambda light chain restriction. In the present study, plasmablastic morphology was found to have a higher microvessel density compared to plasmacytic type. It was also suggested that a higher microvessel density was seen in cases with plasma cell percentage of more than 50 % and diffuse plasma cell infiltration in the bone marrow. Conclusion: Statistically significant association was detected between microvessel density and the plasma cell morphology. Microvessel density was found to be higher with plasma cell morphology.

International Journal of Research in Medical Sciences, 2021

Background: Blood transfusion is a routine lifesaving medical intervention which is generally reg... more Background: Blood transfusion is a routine lifesaving medical intervention which is generally regarded as safe when done appropriately. Without blood transfusion, many medical and surgical conditions like anemia, road traffic accidents, obstetric hemorrhage, cardiothoracic surgeries are nearly impossible to manage. However, this life-saving procedure is often associated with adverse effects ranging from minor chills and rigors to life-threatening anaphylaxis. Incidence of transfusion reactions is estimated at 0.001% -10%. The knowledge about the adverse transfusion reaction (ATRs) will help in early identification, management, and prevention of adverse transfusion reactions. Methods: Descriptive cross-sectional study done in 1047 patients, admitted and received at least one unit of whole blood and blood components in the surgery department, Government Medical College, Kottayam during the study period. Information regarding the issue of blood component collected from the transfusion ...

Indian Journal of Pathology and Oncology

Tropical Journal of Pathology and Microbiology

Introduction: Fine Needle Biopsy of head and neck masses as a minimally invasive technique is par... more Introduction: Fine Needle Biopsy of head and neck masses as a minimally invasive technique is particularly suitable in this sensitive area where an incisional biopsy can cause problems. A cytological diagnosis of a non-neoplastic lesion or confirming suspected metastatic or recurrent tumor can obviate the need for surgery. FNAC can effectively distinguish between benign and malignant cystic lesions of the head and neck. Aim: The aim of this study is to categorise the various head and neck lesions diagnosed by cytology and to assess the diagnostic utility of FNAC. Materials and Methods: All the cases of head and neck masses diagnosed by cytology during the period of one year were analysed. Age and sex distribution was noted. Lesions were mainly categorised into lesions of thyroid, salivary gland and lymph node. Each group were then subcategorised into various groups depending upon the neoplastic and nonneoplastic nature. In some cases histopathologic correlation was done. Results: Thyroid lesions formed 61.5% (475) of the total number of head and neck masses. 99% of the cases were benign lesions. Lymphadenopathies formed 34% (262) of the total number of head and neck masses. Most common diagnoses were reactive lymphadenitis (43.5%) followed by granulomatous lymphadenitis (12.5%). Salivary gland lesions formed 4.5% (35) of the total number of head and neck masses. Sialadenitis was the most common among the benign lesions (40%) and pleomorphic adenoma was commonest among neoplasms (37%). Conclusion: FNAC is a reliable, safe, cost-effective and minimally invasive procedure. FNAC can be advised as a primary diagnostic tool.