Sam Munro - Academia.edu (original) (raw)

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Eberhard Crailsheim

CSIC (Consejo Superior de Investigaciones Científicas-Spanish National Research Council)

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Papers by Sam Munro

Developmental Medicine & Child Neurology, 2022

The Journal of Laryngology & Otology, 2021

ObjectiveTo examine the patterns of care for octogenarian head and neck cancer patients.MethodsAl... more ObjectiveTo examine the patterns of care for octogenarian head and neck cancer patients.MethodsAll newly diagnosed patients aged 80 years or older, who presented at our centre between June 2018 and October 2020, were included.ResultsThe total number of patients was 42. The median Charlson Comorbidity Index was 5 (range, 4–9). The larynx was the most common subsite (n = 12). Twenty-nine patients (66 per cent) were diagnosed at disease stage IV. Squamous cell carcinoma was the most common histology (86 per cent). Twenty-six patients (62 per cent) had radical treatment and 16 (38 per cent) had palliative treatment. The estimated six-month and one-year overall survival rates for the radical and palliative treatment cohorts were 92.3 per cent and 42.9 per cent (p = 0.001) and 65.4 per cent and 15.4 per cent (p = 0.003), respectively.ConclusionThis study provides useful information on octogenarian patients with head and neck cancer. This information may help in conducting prospective studies, especially those focusing on older patients with head and neck cancer, in order to define the ideal care of this patient population.

Clinical Otolaryngology, 2021

Renewable and Sustainable Energy Reviews, 2016

Resource strategy concerns and the need for mitigation of environmental impacts associated with e... more Resource strategy concerns and the need for mitigation of environmental impacts associated with energy generation from fossil fuels have increased the deployment of renewable energy carriers such as biogas. Biogas has beneficial environmental aspects such as waste treatment, production of energy from waste and general substrates and a better way to spread the fermented residues through improved nutrient and flow abilities. The objective of this study was to assess the status of biogas production and its effects on the environment due to greenhouse gases (GHG) and other environmental impacts. In this work, 15 life cycle assessment (LCA) studies of biogas systems from around Europe were reviewed. Biogas scenarios in all the studies had lower GHG intensities than their reference systems.

Global Change Biology, 2015

Journal of Neuroimmunology, 1985

An extensive analysis of the relationship between immunological parameters and clinical responses... more An extensive analysis of the relationship between immunological parameters and clinical responses and biochemical loss of muscle acetylcholine receptors (AChR) was performed in murine experimental autoimmune myasthenia gravis. The onset of clinical muscle weakness correlated strongly with the onset of significant muscle AChR loss. Mice with clinical muscle weakness had greater amount of muscle AChR loss. There was no correlation between the concentration of anti-AChR antibodies and the presence of clinical muscle weakness or amount of muscle AChR loss. However, the kinetics of autoantibody response correlated well with that of muscle AChR loss.

Developmental Medicine & Child Neurology, 2022

The Journal of Laryngology & Otology, 2021

ObjectiveTo examine the patterns of care for octogenarian head and neck cancer patients.MethodsAl... more ObjectiveTo examine the patterns of care for octogenarian head and neck cancer patients.MethodsAll newly diagnosed patients aged 80 years or older, who presented at our centre between June 2018 and October 2020, were included.ResultsThe total number of patients was 42. The median Charlson Comorbidity Index was 5 (range, 4–9). The larynx was the most common subsite (n = 12). Twenty-nine patients (66 per cent) were diagnosed at disease stage IV. Squamous cell carcinoma was the most common histology (86 per cent). Twenty-six patients (62 per cent) had radical treatment and 16 (38 per cent) had palliative treatment. The estimated six-month and one-year overall survival rates for the radical and palliative treatment cohorts were 92.3 per cent and 42.9 per cent (p = 0.001) and 65.4 per cent and 15.4 per cent (p = 0.003), respectively.ConclusionThis study provides useful information on octogenarian patients with head and neck cancer. This information may help in conducting prospective studies, especially those focusing on older patients with head and neck cancer, in order to define the ideal care of this patient population.

Clinical Otolaryngology, 2021

Renewable and Sustainable Energy Reviews, 2016

Resource strategy concerns and the need for mitigation of environmental impacts associated with e... more Resource strategy concerns and the need for mitigation of environmental impacts associated with energy generation from fossil fuels have increased the deployment of renewable energy carriers such as biogas. Biogas has beneficial environmental aspects such as waste treatment, production of energy from waste and general substrates and a better way to spread the fermented residues through improved nutrient and flow abilities. The objective of this study was to assess the status of biogas production and its effects on the environment due to greenhouse gases (GHG) and other environmental impacts. In this work, 15 life cycle assessment (LCA) studies of biogas systems from around Europe were reviewed. Biogas scenarios in all the studies had lower GHG intensities than their reference systems.

Global Change Biology, 2015

Journal of Neuroimmunology, 1985

An extensive analysis of the relationship between immunological parameters and clinical responses... more An extensive analysis of the relationship between immunological parameters and clinical responses and biochemical loss of muscle acetylcholine receptors (AChR) was performed in murine experimental autoimmune myasthenia gravis. The onset of clinical muscle weakness correlated strongly with the onset of significant muscle AChR loss. Mice with clinical muscle weakness had greater amount of muscle AChR loss. There was no correlation between the concentration of anti-AChR antibodies and the presence of clinical muscle weakness or amount of muscle AChR loss. However, the kinetics of autoantibody response correlated well with that of muscle AChR loss.

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