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Papers by Shirley Pettit

Lancet (London, England), Jan 26, 2015

Cardiopulmonary bypass initiates a systemic inflammatory response syndrome that is associated wit... more Cardiopulmonary bypass initiates a systemic inflammatory response syndrome that is associated with postoperative morbidity and mortality. Steroids suppress inflammatory responses and might improve outcomes in patients at high risk of morbidity and mortality undergoing cardiopulmonary bypass. We aimed to assess the effects of steroids in patients at high risk of morbidity and mortality undergoing cardiopulmonary bypass. The Steroids In caRdiac Surgery (SIRS) study is a double-blind, randomised, controlled trial. We used a central computerised phone or interactive web system to randomly assign (1:1) patients at high risk of morbidity and mortality from 80 hospital or cardiac surgery centres in 18 countries undergoing cardiac surgery with the use of cardiopulmonary bypass to receive either methylprednisolone (250 mg at anaesthetic induction and 250 mg at initiation of cardiopulmonary bypass) or placebo. Patients were assigned with block randomisation with random block sizes of 2, 4, or...

JAMA, 2012

Of the 200 million adults worldwide who undergo noncardiac surgery each year, more than 1 million... more Of the 200 million adults worldwide who undergo noncardiac surgery each year, more than 1 million will die within 30 days.

Anesthesiology, 2014

Myocardial injury after noncardiac surgery (MINS) was defined as prognostically relevant myocardi... more Myocardial injury after noncardiac surgery (MINS) was defined as prognostically relevant myocardial injury due to ischemia that occurs during or within 30 days after noncardiac surgery. The…

Supplemental digital content 2, Table 1. Cox model exploring independent association between pote... more Supplemental digital content 2, Table 1. Cox model exploring independent association between potential MINS diagnostic criteria of a peak Troponin T ≥0.04 ng/mL with and without an ischemic feature and 30-day mortality Potential diagnostic criteria Adjusted HR (95% CI) p-value Peak TnT ≥0.04 ng/mL with 1 ischemic feature Peak TnT ≥0.04 ng/mL without an ischemic feature TnT ≤0.01 ng/mL 5.06 (3.55-7.21) 3.33 (2.28-4.87) 1.00 <0.001 <0.001 -CI = confidence intervals; HR = hazard ratio; MINS = myocardial injury after noncardiac surgery; % = percentage; TnT = 4 th generation Troponin T Supplemental digital content 2, Table 2. Cox model exploring the independent association between all considered MINS diagnostic criteria and 30-day mortality Potential diagnostic criteria Number of Patients (%) Adjusted HR (95% CI) p-value Peak TnT ≥0.04 ng/mL with 1 ischemic feature Peak TnT ≥0.04 ng/mL without an ischemic feature Peak TnT = 0.03 ng/mL Peak TnT = 0.02 ng/mL TnT ≤0.01 ng/mL 401 (2.7) 540 (3.6) 259 (1.7) 479 (3.2) 13,386 (88.9) 4.82 (3.40-6.84) 3.30 (2.26-4.81) 4.30 (2.68-6.91) 1.61 (0.91-2.86)

New England Journal of Medicine, 2014

Marked activation of the sympathetic nervous system occurs during and after noncardiac surgery. L... more Marked activation of the sympathetic nervous system occurs during and after noncardiac surgery. Low-dose clonidine, which blunts central sympathetic outflow, may prevent perioperative myocardial infarction and death without inducing hemodynamic instability.

Clinical Biochemistry, 2011

abusing mothers. FA requires folate for detoxification. We hypothesize FA produced in the materna... more abusing mothers. FA requires folate for detoxification. We hypothesize FA produced in the maternal circulation will cross the placenta and will be toxic to both the placenta and fetus.

by Sergio Mazzadi, Daniel Sessler, Edyta Niebrzegowska, Theroshnie Kisten, Shirley Pettit, Michelle Graham, Hooman Honar, Atiya Faruqui, Sebastian Ribas, Amal Bessissow, and Giovanna Luratibuse