Sonia Sanajou - Academia.edu (original) (raw)

Papers by Sonia Sanajou

Research paper thumbnail of Role of aluminum exposure on Alzheimer’s disease and related glycogen synthase kinase pathway

Drug and Chemical Toxicology, Apr 21, 2022

Aluminum (Al) is an environmentally abundant metal that is not essential for life. There is consi... more Aluminum (Al) is an environmentally abundant metal that is not essential for life. There is considerable evidence that Al as a neurotoxic xenobiotic may play a role in the pathogenesis of neurodegenerative diseases like Alzheimer's disease (AD). Exposure to aluminum has been shown to cause neuronal damage that resembles the symptoms of AD. In this review, we will summarize recent data about Al as the possible risk of incidence of AD. Then glycogen synthase kinase-3 beta (GSK3β) contributes to the hyperphosphorylation of Tau protein, the main component of neurofibrillary tangles, one of the hallmarks of AD as one of the mechanisms behind Al neurotoxicity will be covered. Overall, there is still a need for epidemiological studies and more in vivo and in vitro studies to determine the exact mechanisms of its neurotoxicity and the role of GSK3β in both Al toxic effect and AD.

Research paper thumbnail of Biosensors and Their Areas of Application: Traditional Review

Literatür eczacılık bilimleri dergisi, 2022

Sensör, amacı ortamdaki değişiklikleri tespit etmek ve bu değişiklikleri bilgisayar gibi elektron... more Sensör, amacı ortamdaki değişiklikleri tespit etmek ve bu değişiklikleri bilgisayar gibi elektronik cihazlara göndererek veri elde etmek olan bir cihaz-dır. Sensörler; bir moleküler tanıma sistemi (reseptör), bir fizikokimyasal dönüştürücü ve sinyal işlemcisinden oluşur. Sensörlerin yapısındaki reseptör

Research paper thumbnail of Effect of Carbamates Pesticide on Instar I-II larvae and Adult Artemia urumiana

Annals of Biological Research, 2011

The purpose of this assessment was to evaluate potential direct effects of acute and chronic toxi... more The purpose of this assessment was to evaluate potential direct effects of acute and chronic toxicity of Maneb (Dithane-M22) and Carbaryl (Sevin) in Artimia urmiana. A study was conducted to determine the concentration incorporated in the contamination treatment of instar I-II larvae and Adult Artemia urumiana for 24 hr.and 48 hr. Nine-hundred Artemia urumiana were used in a 2 factorial experiments(time and concentration).Mortality was recorded during the different times as well as variable concentration.Acute intoxication of Maneb and Carbaryl were able to be induced at >33 ppm concentration, Carbaryl was more lethal than Maneb. Histopathological observations made from hematoxylin-eosin stained sections of Maneb and Carbaryl treated Artemia showed significant lesions which were found to be more extensive in Carbaryl treated Artemia than in those Maneb treated Artemia.Results of this study showed the potential of Carbaryl pesticide to cause serious damage of the nervous system of the Adult Artemia urumiana.On the other hand,Maneb pesticides was primarily highly toxic on instar I-II larvae.

Research paper thumbnail of Nanomaterials in Construction and Their Potential Impacts on Human Health and the Environment

Environmental Engineering and Management Journal, 2019

Over the last few years, the use of nanomaterials in the construction industry has grown prominen... more Over the last few years, the use of nanomaterials in the construction industry has grown prominently. Nanomaterials can considerably modify the properties of construction materials and even improve their performance. Despite their merits, considerable research has reported that nanomaterials pose a potential risk to human health. For this reason, it is important to fully comprehend the effects of nanomaterials on human health and the environment throughout all phases of their life cycle, including manufacturing, construction use, and recycling, in order to ensure their responsible usage. This research reviews the use of nanomaterials to enhance the properties of conventional construction materials as well as the possible adverse exposure scenarios for humans and the environment. Moreover, the potential risks and negative biological effects of these materials on human health are debated. This study serves to raise awareness of the potential hazards of nanomaterials, especially on human health and the environment.

Research paper thumbnail of Mechanistic Biomarkers in Toxicology

Turkish journal of pharmaceutical sciences, Jun 18, 2021

Biyobelirteçler önemli, güvenilir, uygulanabilir, tekrarlanabilir ve genelikle maliyeti uygun par... more Biyobelirteçler önemli, güvenilir, uygulanabilir, tekrarlanabilir ve genelikle maliyeti uygun parametrelerdir. Biyobelirteçlerin insan sağlığı açısından önemli rolü olmakla birlikte özellikle mekanistik biyobelirteçlerin toksik etki ve hastalıklardan korunmada önemi büyüktür. Biyobelirteçler hastalıkların tanısını, gidişatını, tekrarlama ve yayılma olasılığını, tedavinin etkinliğini gösterebilir. İlave olarak birçok kimyasal, biyolojik ve fiziksel ajanlara maruz kalma düzeyini gösterir. Bugün biyobelirteç geliştirilmesi ve uygulanması, bunların oluşumunun altında yatan mekanizma bilgilerini gerektirir. Bu nedenle bu yazıda olası mekanistik biyobelirteçler üzerinde yoğunlaşılmıştır.

Research paper thumbnail of Adsorption of iron, lead, paracetamol, imipramine on natural polymers

Poisoning results from many reasons such as misuse or overdose of drugs. Suicidal and murder purp... more Poisoning results from many reasons such as misuse or overdose of drugs. Suicidal and murder purposes are mostly severe, serious and life-threatening cases which require immediate intervention and treatment. Among lifesaving methods external and/or internal decontamination is the most important. Internal decontamination (gastrointestinal) is an effective process for intoxication control that can be done by adsorptive materials. Activated charcoal is used as unique local antidote for adsorption of causative agent. Considering their significance and effectiveness, adsorptive materials are necessary to be developed. In the present study, starch and naturally extracted pectin from citrus, in the presence of trace amount of potassium per sulphate as initiator, were thermally grafted to chitosan to form natural, inert, and highly adsorptive polymeric surfaces. This polymer is convenient for biomedical purposes. Upon drying at 37°C for 48 hours, thermally cross-linked products were obtained. FTIR, UV-Visible spectrophotometer and SEM analyses were applied in order to characterize the products. To evaluate the adsorption potency of new adsorptive material, lead and iron which cause common poisoning were applied on the polymers. The results showed that adsorption degree of lead and iron were maximum 50% and 30% respectively. Desorption amounts can be a sign of adsorption potency. In this study, paracetamol and imipramine, which are commonly used drugs that can and caused intoxication in case they are misused or use for suicidal purpose were applied onto two polymers which contain pectin desorption amount for two drugs were determined. SEM pictures taken before and after blood/polymer contact didn't reveal any significant blood component attachment on the chitosan-graft-(starch; pectin) film surface. Indicating no hemocompatibility.

Research paper thumbnail of Evaluation of neopterin levels and kynurenine pathway in patients with acute coronary syndrome

Acute and Critical Care

Background: Coronary atherosclerosis is the leading cause of coronary artery disease. Several inv... more Background: Coronary atherosclerosis is the leading cause of coronary artery disease. Several investigations have indicated that tear-sensitive plaques contain macrophages and T cells. Neopterin is an essential cellular immune response biomarker. The main goal of this study was to see if there were any changes in biomarkers like unconjugated pteridines, neopterin, and biopterin, as well as kynurenine pathway enzymes like indolamine 2,3-dioxygenase (IDO), which catalyzes the rate-limiting step in tryptophan degradation, in patients with the acute coronary syndrome (ACS) caused by angiographic atherosclerosis.Methods: High-performance liquid chromatography was used to determine the amounts of neopterin, biopterin, and creatinine in urine samples, as well as tryptophan and kynurenine in serum samples. The enzyme-linked immunosorbent assay was used to assess the amounts of neopterin in serum samples. The measured parameters were evaluated between ACS patients and controls.Results: The m...

Research paper thumbnail of Effect of NB-UVB therapy on IL-6 and neopterin levels in patients with psoriasis

Pteridines

Background Psoriasis is a chronic and non-transient disease with increased epidermal proliferatio... more Background Psoriasis is a chronic and non-transient disease with increased epidermal proliferation in the skin. Dysregulation of the immune system is an important factor in this pathology. Inflammation markers, pro-inflammatory cytokines, and immune cells are reported to be changed in psoriasis. Study design In the current cohort study, the possible changes in interleukin-6 (IL-6), neopterin levels, and kynurenine (Kyn) pathway in 42 psoriasis patients compared to 30 controls, and their change with narrow-band (NB) UVB treatment were investigated. Methodology IL-6 and serum neopterin levels were analyzed with ELISA kits. HPLC analyses were performed to detect urinary neopterin, serum Kyn, and tryptophan (Trp) levels. Results IL-6 levels were lower, while Kyn levels and the Kyn-to-Trp ratio were higher in psoriasis patients compared to control subjects (p < 0.01, all). Conclusion Narrow-band ultraviolet B (NB-UVB) treatment decreased Psoriasis Area and Severity Index (PASI) scores...

Research paper thumbnail of Evaluation of the effects of herpes simplex glycoprotein B on complement system and cytokines in in vitro models of Alzheimer's disease

Journal of Applied Toxicology

Alzheimer's disease (AD) is a neurodegenerative disorder that causes memory loss and dementia... more Alzheimer's disease (AD) is a neurodegenerative disorder that causes memory loss and dementia and is characterized by a decline in cognitive functions. Brain infections, especially induced by herpes simplex virus type‐1 (HSV‐1), are suggested to play a key role in the pathogenesis of AD. Within the scope of this study, two different AD models (Tau model and amyloid beta [Aβ]) were created in the SH‐SY5Y cell line, and HSV glycoprotein B (gB) was applied to the cell line and on the generated AD models. Study groups (n = 3) were designed as (1) control, (2) HSV‐gB group, (3) retinoic acid (RA) and brain derived neurotrophic factor (BDNF) induced Alzheimer's model (AD), (4) RA and BDNF induced Alzheimer's model + HSV‐gB (ADH), (5) Aβ 1‐42 peptide‐induced Alzheimer's model (Aβ), and (6) Aβ 1‐42 peptide‐induced Alzheimer's model + HSV‐gB (AβH). Levels of complement proteins and cytokines were determined comparatively. In addition, specific markers of AD (hyperphosphor...

Research paper thumbnail of Antioxidant dihydrolipolic acid protects against aluminum-induced toxicity in Alzheimer's model

Dihydrolipoic acid (DHLA) is a natural antioxidant that is recognized as being useful in combatin... more Dihydrolipoic acid (DHLA) is a natural antioxidant that is recognized as being useful in combating metal toxicity and oxidative stress. It can protect cells from environmental contaminants and may be beneficial in treating neurodegenerative diseases by protecting against oxidative damage and chronic inflammation. Therefore, this study aimed to investigate the possible neuroprotective effects of DHLA against aluminum-induced toxicity in an in vitro Alzheimer’s disease (AD) model. The study focused on the glycogen synthase kinase3 (GSK3) pathway, and the Wnt signaling. A differentiated SH-SY5Y cell line model of AD was developed, and the study groups were as follows: control, Al, DHLA, Al-DHLA, AD, AD-Al, AD-DHLA, and AD-Al-DHLA. The impact of DHLA on oxidative stress parameters was evaluated, and GSK3 pathway was evaluated by measuring GSK3-β, human serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PPP1CA), protein phosphatase 2A (PP2A) levels, and human RAC-alpha ser...

Research paper thumbnail of Analgesic Nephropathy

Research paper thumbnail of Dental Implants and Implant Coatings: A Focus on Their Toxicity and Safety

Journal of Environmental Pathology, Toxicology and Oncology

Research paper thumbnail of Safety Usage of Essential Oils in Cosmetics-National Orientations: Traditional Review

Journal of Literature Pharmacy Sciences

Research paper thumbnail of Biosensors and Their Areas of Application: Traditional Review

Journal of Literature Pharmacy Sciences, 2022

Research paper thumbnail of The Investigation of the Interaction of Several Antipsychotic Drugs with Human Cholinesterase Enzymes

EMU Journal of Pharmaceutical Sciences, Jun 1, 2018

Research paper thumbnail of Evaluation of the Annual Sales of Acetylsalicylic Acid, Metamizole and Paracetamol in North Cyprus: Emphasizing the Wide Paracetamol Use

Background: Among the analgesic-antipyretic agents acetylsalicylic acid, metamizole and paracetam... more Background: Among the analgesic-antipyretic agents acetylsalicylic acid, metamizole and paracetamol are commonly used. Objective: The aim of this study was to analyse the sales of acetylsalicylic acid, metamizole and paracetamol in Northern Cyprus from the pharmaceutical wholesale companies during one year period. Methods: We collected the data of annual drug delivery to hospitals and community pharmacy stores between 1st September 2013 and 31st August 2014 from the five most prevalent pharmaceutical wholesale companies that serve in North Cyprus. Results: We noticed that oral administration routes of these three molecules were very dominant with 92.88%. Paracetamol was the most preferred with a total annual sale of 117668 boxes (65.25%). 500 mg paracetamol with 65 mg caffeine was the highest among the combined drug formulations of paracetamol (45236 boxes). Metamizole was ranked the second with 18.65%. Drug formulations containing only acetylsalicylic acid were dispensed 24909 boxe...

Research paper thumbnail of Feedback of pharmacy students toward teaching-learning pharmacology in Northern Cyprus

This study explores pharmacy students’ feedback on teaching–learning methods of pharmacology in f... more This study explores pharmacy students’ feedback on teaching–learning methods of pharmacology in faculties of pharmacy in Northern Cyprus universities. 150 students randomly selected and participated by filling self-administered questionnaires. The majority of participants were female and most of them were in the 4th year of their study. The results showed that high percentage of students had good understanding and grasping of pharmacology subjects in class, and the pharmacology is the most favored course in comparison with others. Moreover, participants taught that pharmacology course will have most usage in their future pharmacy practice. It can be concluded that the general attitude of students toward pharmacology were positive; however, some changes in curriculum are still required in order to make the pharmacology courses more interesting.

Research paper thumbnail of Nanomaterials in Construction and Their Potential Impacts on Human Health and the Environment

Environmental Engineering and Management Journal, 2019

Over the last few years, the use of nanomaterials in the construction industry has grown prominen... more Over the last few years, the use of nanomaterials in the construction industry has grown prominently. Nanomaterials can considerably modify the properties of construction materials and even improve their performance. Despite their merits, considerable research has reported that nanomaterials pose a potential risk to human health. For this reason, it is important to fully comprehend the effects of nanomaterials on human health and the environment throughout all phases of their life cycle, including manufacturing, construction use, and recycling, in order to ensure their responsible usage. This research reviews the use of nanomaterials to enhance the properties of conventional construction materials as well as the possible adverse exposure scenarios for humans and the environment. Moreover, the potential risks and negative biological effects of these materials on human health are debated. This study serves to raise awareness of the potential hazards of nanomaterials, especially on human health and the environment.

Research paper thumbnail of Effect of Carbamates Pesticides on Instar I-II Larvae and Adult Artemia urumiana

The purpose of this assessment was to evaluate potential direct effects of acute and chronic toxi... more The purpose of this assessment was to evaluate potential direct effects of acute and chronic toxicity of Maneb (Dithane-M22) and Carbaryl (Sevin) in Artimia urmiana. A study was conducted to determine the concentration incorporated in the contamination treatment of instar I-II larvae and Adult Artemia urumiana for 24 hr.and 48 hr. Nine-hundred Artemia urumiana were used in a 2 factorial experiments(time and concentration).Mortality was recorded during the different times as well as variable concentration.Acute intoxication of Maneb and Carbaryl were able to be induced at >33 ppm concentration, Carbaryl was more lethal than Maneb. Histopathological observations made from hematoxylin-eosin stained sections of Maneb and Carbaryl treated Artemia showed significant lesions which were found to be more extensive in Carbaryl treated Artemia than in those Maneb treated Artemia.Results of this study showed the potential of Carbaryl pesticide to cause serious damage of the nervous system of...

Research paper thumbnail of Effect of Carbamates Pesticide on Instar I-II larvae and Adult Artemia urumiana

Annals of Biological Research, 2011

The purpose of this assessment was to evaluate potential direct effects of acute and chronic toxi... more The purpose of this assessment was to evaluate potential direct effects of acute and chronic toxicity of Maneb (Dithane-M22) and Carbaryl (Sevin) in Artimia urmiana. A study was conducted to determine the concentration incorporated in the contamination treatment of instar I-II larvae and Adult Artemia urumiana for 24 hr.and 48 hr. Nine-hundred Artemia urumiana were used in a 2 factorial experiments(time and concentration).Mortality was recorded during the different times as well as variable concentration.Acute intoxication of Maneb and Carbaryl were able to be induced at >33 ppm concentration, Carbaryl was more lethal than Maneb. Histopathological observations made from hematoxylin-eosin stained sections of Maneb and Carbaryl treated Artemia showed significant lesions which were found to be more extensive in Carbaryl treated Artemia than in those Maneb treated Artemia.Results of this study showed the potential of Carbaryl pesticide to cause serious damage of the nervous system of...

Research paper thumbnail of Role of aluminum exposure on Alzheimer’s disease and related glycogen synthase kinase pathway

Drug and Chemical Toxicology, Apr 21, 2022

Aluminum (Al) is an environmentally abundant metal that is not essential for life. There is consi... more Aluminum (Al) is an environmentally abundant metal that is not essential for life. There is considerable evidence that Al as a neurotoxic xenobiotic may play a role in the pathogenesis of neurodegenerative diseases like Alzheimer's disease (AD). Exposure to aluminum has been shown to cause neuronal damage that resembles the symptoms of AD. In this review, we will summarize recent data about Al as the possible risk of incidence of AD. Then glycogen synthase kinase-3 beta (GSK3β) contributes to the hyperphosphorylation of Tau protein, the main component of neurofibrillary tangles, one of the hallmarks of AD as one of the mechanisms behind Al neurotoxicity will be covered. Overall, there is still a need for epidemiological studies and more in vivo and in vitro studies to determine the exact mechanisms of its neurotoxicity and the role of GSK3β in both Al toxic effect and AD.

Research paper thumbnail of Biosensors and Their Areas of Application: Traditional Review

Literatür eczacılık bilimleri dergisi, 2022

Sensör, amacı ortamdaki değişiklikleri tespit etmek ve bu değişiklikleri bilgisayar gibi elektron... more Sensör, amacı ortamdaki değişiklikleri tespit etmek ve bu değişiklikleri bilgisayar gibi elektronik cihazlara göndererek veri elde etmek olan bir cihaz-dır. Sensörler; bir moleküler tanıma sistemi (reseptör), bir fizikokimyasal dönüştürücü ve sinyal işlemcisinden oluşur. Sensörlerin yapısındaki reseptör

Research paper thumbnail of Effect of Carbamates Pesticide on Instar I-II larvae and Adult Artemia urumiana

Annals of Biological Research, 2011

The purpose of this assessment was to evaluate potential direct effects of acute and chronic toxi... more The purpose of this assessment was to evaluate potential direct effects of acute and chronic toxicity of Maneb (Dithane-M22) and Carbaryl (Sevin) in Artimia urmiana. A study was conducted to determine the concentration incorporated in the contamination treatment of instar I-II larvae and Adult Artemia urumiana for 24 hr.and 48 hr. Nine-hundred Artemia urumiana were used in a 2 factorial experiments(time and concentration).Mortality was recorded during the different times as well as variable concentration.Acute intoxication of Maneb and Carbaryl were able to be induced at >33 ppm concentration, Carbaryl was more lethal than Maneb. Histopathological observations made from hematoxylin-eosin stained sections of Maneb and Carbaryl treated Artemia showed significant lesions which were found to be more extensive in Carbaryl treated Artemia than in those Maneb treated Artemia.Results of this study showed the potential of Carbaryl pesticide to cause serious damage of the nervous system of the Adult Artemia urumiana.On the other hand,Maneb pesticides was primarily highly toxic on instar I-II larvae.

Research paper thumbnail of Nanomaterials in Construction and Their Potential Impacts on Human Health and the Environment

Environmental Engineering and Management Journal, 2019

Over the last few years, the use of nanomaterials in the construction industry has grown prominen... more Over the last few years, the use of nanomaterials in the construction industry has grown prominently. Nanomaterials can considerably modify the properties of construction materials and even improve their performance. Despite their merits, considerable research has reported that nanomaterials pose a potential risk to human health. For this reason, it is important to fully comprehend the effects of nanomaterials on human health and the environment throughout all phases of their life cycle, including manufacturing, construction use, and recycling, in order to ensure their responsible usage. This research reviews the use of nanomaterials to enhance the properties of conventional construction materials as well as the possible adverse exposure scenarios for humans and the environment. Moreover, the potential risks and negative biological effects of these materials on human health are debated. This study serves to raise awareness of the potential hazards of nanomaterials, especially on human health and the environment.

Research paper thumbnail of Mechanistic Biomarkers in Toxicology

Turkish journal of pharmaceutical sciences, Jun 18, 2021

Biyobelirteçler önemli, güvenilir, uygulanabilir, tekrarlanabilir ve genelikle maliyeti uygun par... more Biyobelirteçler önemli, güvenilir, uygulanabilir, tekrarlanabilir ve genelikle maliyeti uygun parametrelerdir. Biyobelirteçlerin insan sağlığı açısından önemli rolü olmakla birlikte özellikle mekanistik biyobelirteçlerin toksik etki ve hastalıklardan korunmada önemi büyüktür. Biyobelirteçler hastalıkların tanısını, gidişatını, tekrarlama ve yayılma olasılığını, tedavinin etkinliğini gösterebilir. İlave olarak birçok kimyasal, biyolojik ve fiziksel ajanlara maruz kalma düzeyini gösterir. Bugün biyobelirteç geliştirilmesi ve uygulanması, bunların oluşumunun altında yatan mekanizma bilgilerini gerektirir. Bu nedenle bu yazıda olası mekanistik biyobelirteçler üzerinde yoğunlaşılmıştır.

Research paper thumbnail of Adsorption of iron, lead, paracetamol, imipramine on natural polymers

Poisoning results from many reasons such as misuse or overdose of drugs. Suicidal and murder purp... more Poisoning results from many reasons such as misuse or overdose of drugs. Suicidal and murder purposes are mostly severe, serious and life-threatening cases which require immediate intervention and treatment. Among lifesaving methods external and/or internal decontamination is the most important. Internal decontamination (gastrointestinal) is an effective process for intoxication control that can be done by adsorptive materials. Activated charcoal is used as unique local antidote for adsorption of causative agent. Considering their significance and effectiveness, adsorptive materials are necessary to be developed. In the present study, starch and naturally extracted pectin from citrus, in the presence of trace amount of potassium per sulphate as initiator, were thermally grafted to chitosan to form natural, inert, and highly adsorptive polymeric surfaces. This polymer is convenient for biomedical purposes. Upon drying at 37°C for 48 hours, thermally cross-linked products were obtained. FTIR, UV-Visible spectrophotometer and SEM analyses were applied in order to characterize the products. To evaluate the adsorption potency of new adsorptive material, lead and iron which cause common poisoning were applied on the polymers. The results showed that adsorption degree of lead and iron were maximum 50% and 30% respectively. Desorption amounts can be a sign of adsorption potency. In this study, paracetamol and imipramine, which are commonly used drugs that can and caused intoxication in case they are misused or use for suicidal purpose were applied onto two polymers which contain pectin desorption amount for two drugs were determined. SEM pictures taken before and after blood/polymer contact didn't reveal any significant blood component attachment on the chitosan-graft-(starch; pectin) film surface. Indicating no hemocompatibility.

Research paper thumbnail of Evaluation of neopterin levels and kynurenine pathway in patients with acute coronary syndrome

Acute and Critical Care

Background: Coronary atherosclerosis is the leading cause of coronary artery disease. Several inv... more Background: Coronary atherosclerosis is the leading cause of coronary artery disease. Several investigations have indicated that tear-sensitive plaques contain macrophages and T cells. Neopterin is an essential cellular immune response biomarker. The main goal of this study was to see if there were any changes in biomarkers like unconjugated pteridines, neopterin, and biopterin, as well as kynurenine pathway enzymes like indolamine 2,3-dioxygenase (IDO), which catalyzes the rate-limiting step in tryptophan degradation, in patients with the acute coronary syndrome (ACS) caused by angiographic atherosclerosis.Methods: High-performance liquid chromatography was used to determine the amounts of neopterin, biopterin, and creatinine in urine samples, as well as tryptophan and kynurenine in serum samples. The enzyme-linked immunosorbent assay was used to assess the amounts of neopterin in serum samples. The measured parameters were evaluated between ACS patients and controls.Results: The m...

Research paper thumbnail of Effect of NB-UVB therapy on IL-6 and neopterin levels in patients with psoriasis

Pteridines

Background Psoriasis is a chronic and non-transient disease with increased epidermal proliferatio... more Background Psoriasis is a chronic and non-transient disease with increased epidermal proliferation in the skin. Dysregulation of the immune system is an important factor in this pathology. Inflammation markers, pro-inflammatory cytokines, and immune cells are reported to be changed in psoriasis. Study design In the current cohort study, the possible changes in interleukin-6 (IL-6), neopterin levels, and kynurenine (Kyn) pathway in 42 psoriasis patients compared to 30 controls, and their change with narrow-band (NB) UVB treatment were investigated. Methodology IL-6 and serum neopterin levels were analyzed with ELISA kits. HPLC analyses were performed to detect urinary neopterin, serum Kyn, and tryptophan (Trp) levels. Results IL-6 levels were lower, while Kyn levels and the Kyn-to-Trp ratio were higher in psoriasis patients compared to control subjects (p < 0.01, all). Conclusion Narrow-band ultraviolet B (NB-UVB) treatment decreased Psoriasis Area and Severity Index (PASI) scores...

Research paper thumbnail of Evaluation of the effects of herpes simplex glycoprotein B on complement system and cytokines in in vitro models of Alzheimer's disease

Journal of Applied Toxicology

Alzheimer's disease (AD) is a neurodegenerative disorder that causes memory loss and dementia... more Alzheimer's disease (AD) is a neurodegenerative disorder that causes memory loss and dementia and is characterized by a decline in cognitive functions. Brain infections, especially induced by herpes simplex virus type‐1 (HSV‐1), are suggested to play a key role in the pathogenesis of AD. Within the scope of this study, two different AD models (Tau model and amyloid beta [Aβ]) were created in the SH‐SY5Y cell line, and HSV glycoprotein B (gB) was applied to the cell line and on the generated AD models. Study groups (n = 3) were designed as (1) control, (2) HSV‐gB group, (3) retinoic acid (RA) and brain derived neurotrophic factor (BDNF) induced Alzheimer's model (AD), (4) RA and BDNF induced Alzheimer's model + HSV‐gB (ADH), (5) Aβ 1‐42 peptide‐induced Alzheimer's model (Aβ), and (6) Aβ 1‐42 peptide‐induced Alzheimer's model + HSV‐gB (AβH). Levels of complement proteins and cytokines were determined comparatively. In addition, specific markers of AD (hyperphosphor...

Research paper thumbnail of Antioxidant dihydrolipolic acid protects against aluminum-induced toxicity in Alzheimer's model

Dihydrolipoic acid (DHLA) is a natural antioxidant that is recognized as being useful in combatin... more Dihydrolipoic acid (DHLA) is a natural antioxidant that is recognized as being useful in combating metal toxicity and oxidative stress. It can protect cells from environmental contaminants and may be beneficial in treating neurodegenerative diseases by protecting against oxidative damage and chronic inflammation. Therefore, this study aimed to investigate the possible neuroprotective effects of DHLA against aluminum-induced toxicity in an in vitro Alzheimer’s disease (AD) model. The study focused on the glycogen synthase kinase3 (GSK3) pathway, and the Wnt signaling. A differentiated SH-SY5Y cell line model of AD was developed, and the study groups were as follows: control, Al, DHLA, Al-DHLA, AD, AD-Al, AD-DHLA, and AD-Al-DHLA. The impact of DHLA on oxidative stress parameters was evaluated, and GSK3 pathway was evaluated by measuring GSK3-β, human serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PPP1CA), protein phosphatase 2A (PP2A) levels, and human RAC-alpha ser...

Research paper thumbnail of Analgesic Nephropathy

Research paper thumbnail of Dental Implants and Implant Coatings: A Focus on Their Toxicity and Safety

Journal of Environmental Pathology, Toxicology and Oncology

Research paper thumbnail of Safety Usage of Essential Oils in Cosmetics-National Orientations: Traditional Review

Journal of Literature Pharmacy Sciences

Research paper thumbnail of Biosensors and Their Areas of Application: Traditional Review

Journal of Literature Pharmacy Sciences, 2022

Research paper thumbnail of The Investigation of the Interaction of Several Antipsychotic Drugs with Human Cholinesterase Enzymes

EMU Journal of Pharmaceutical Sciences, Jun 1, 2018

Research paper thumbnail of Evaluation of the Annual Sales of Acetylsalicylic Acid, Metamizole and Paracetamol in North Cyprus: Emphasizing the Wide Paracetamol Use

Background: Among the analgesic-antipyretic agents acetylsalicylic acid, metamizole and paracetam... more Background: Among the analgesic-antipyretic agents acetylsalicylic acid, metamizole and paracetamol are commonly used. Objective: The aim of this study was to analyse the sales of acetylsalicylic acid, metamizole and paracetamol in Northern Cyprus from the pharmaceutical wholesale companies during one year period. Methods: We collected the data of annual drug delivery to hospitals and community pharmacy stores between 1st September 2013 and 31st August 2014 from the five most prevalent pharmaceutical wholesale companies that serve in North Cyprus. Results: We noticed that oral administration routes of these three molecules were very dominant with 92.88%. Paracetamol was the most preferred with a total annual sale of 117668 boxes (65.25%). 500 mg paracetamol with 65 mg caffeine was the highest among the combined drug formulations of paracetamol (45236 boxes). Metamizole was ranked the second with 18.65%. Drug formulations containing only acetylsalicylic acid were dispensed 24909 boxe...

Research paper thumbnail of Feedback of pharmacy students toward teaching-learning pharmacology in Northern Cyprus

This study explores pharmacy students’ feedback on teaching–learning methods of pharmacology in f... more This study explores pharmacy students’ feedback on teaching–learning methods of pharmacology in faculties of pharmacy in Northern Cyprus universities. 150 students randomly selected and participated by filling self-administered questionnaires. The majority of participants were female and most of them were in the 4th year of their study. The results showed that high percentage of students had good understanding and grasping of pharmacology subjects in class, and the pharmacology is the most favored course in comparison with others. Moreover, participants taught that pharmacology course will have most usage in their future pharmacy practice. It can be concluded that the general attitude of students toward pharmacology were positive; however, some changes in curriculum are still required in order to make the pharmacology courses more interesting.

Research paper thumbnail of Nanomaterials in Construction and Their Potential Impacts on Human Health and the Environment

Environmental Engineering and Management Journal, 2019

Over the last few years, the use of nanomaterials in the construction industry has grown prominen... more Over the last few years, the use of nanomaterials in the construction industry has grown prominently. Nanomaterials can considerably modify the properties of construction materials and even improve their performance. Despite their merits, considerable research has reported that nanomaterials pose a potential risk to human health. For this reason, it is important to fully comprehend the effects of nanomaterials on human health and the environment throughout all phases of their life cycle, including manufacturing, construction use, and recycling, in order to ensure their responsible usage. This research reviews the use of nanomaterials to enhance the properties of conventional construction materials as well as the possible adverse exposure scenarios for humans and the environment. Moreover, the potential risks and negative biological effects of these materials on human health are debated. This study serves to raise awareness of the potential hazards of nanomaterials, especially on human health and the environment.

Research paper thumbnail of Effect of Carbamates Pesticides on Instar I-II Larvae and Adult Artemia urumiana

The purpose of this assessment was to evaluate potential direct effects of acute and chronic toxi... more The purpose of this assessment was to evaluate potential direct effects of acute and chronic toxicity of Maneb (Dithane-M22) and Carbaryl (Sevin) in Artimia urmiana. A study was conducted to determine the concentration incorporated in the contamination treatment of instar I-II larvae and Adult Artemia urumiana for 24 hr.and 48 hr. Nine-hundred Artemia urumiana were used in a 2 factorial experiments(time and concentration).Mortality was recorded during the different times as well as variable concentration.Acute intoxication of Maneb and Carbaryl were able to be induced at >33 ppm concentration, Carbaryl was more lethal than Maneb. Histopathological observations made from hematoxylin-eosin stained sections of Maneb and Carbaryl treated Artemia showed significant lesions which were found to be more extensive in Carbaryl treated Artemia than in those Maneb treated Artemia.Results of this study showed the potential of Carbaryl pesticide to cause serious damage of the nervous system of...

Research paper thumbnail of Effect of Carbamates Pesticide on Instar I-II larvae and Adult Artemia urumiana

Annals of Biological Research, 2011

The purpose of this assessment was to evaluate potential direct effects of acute and chronic toxi... more The purpose of this assessment was to evaluate potential direct effects of acute and chronic toxicity of Maneb (Dithane-M22) and Carbaryl (Sevin) in Artimia urmiana. A study was conducted to determine the concentration incorporated in the contamination treatment of instar I-II larvae and Adult Artemia urumiana for 24 hr.and 48 hr. Nine-hundred Artemia urumiana were used in a 2 factorial experiments(time and concentration).Mortality was recorded during the different times as well as variable concentration.Acute intoxication of Maneb and Carbaryl were able to be induced at >33 ppm concentration, Carbaryl was more lethal than Maneb. Histopathological observations made from hematoxylin-eosin stained sections of Maneb and Carbaryl treated Artemia showed significant lesions which were found to be more extensive in Carbaryl treated Artemia than in those Maneb treated Artemia.Results of this study showed the potential of Carbaryl pesticide to cause serious damage of the nervous system of...