Toomas Paalme - Academia.edu (original) (raw)

Toomas Paalme

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Tallinn University of Technology

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Papers by Toomas Paalme

Research paper thumbnail of Stochastic Control of Growth in Fed-Batch Culture of Bacteria

Eesti NSV Teaduste Akadeemia toimetised, 1988

STOCHASTIC CONTROL OF GROWTH IN FED-BATCH CULTURE OF BACTERIA (Presented by E. Lippmaa) Using the... more STOCHASTIC CONTROL OF GROWTH IN FED-BATCH CULTURE OF BACTERIA (Presented by E. Lippmaa) Using the stoichiometric equation of growth and Monod type kinetic equation, a deterministic model of growth of microorganisms in fed-batch culture was built. A stochastic model of the process was developed on the basis of the deterministic description. A stochastic control algorithm which is using filtered data was developed.

Research paper thumbnail of Metabolic Flux Analysis of Compartmentalized Systems using Dynamic Isotopologue Modeling. Isotopoloogilise modelleerimise rakendamine heterogeensete bioloogiliste süsteemide ainevahetusvoo analüüsis

Research paper thumbnail of Identification and Characterization of Bioactive Peptides with Antimicrobial and Immunoregulating Properties Derived from Bovine Colostrum and Milk. Antimikroobsete ja immuunsüsteemi stimuleerivate omadustega bioaktiivsete peptiidide identifitseerimine ja karakteriseerimine lehma piimast ja kolos...

Research paper thumbnail of Spice-Cured Sprats Ripening, Sensory Parameters Development, and Quality Indicators. Vürtsikilu valmimine, sensoorsete omaduste kujunemine ja kvaliteediindikaatorid

kokkuvõte vii list of publications xi list of conference presentations xii additional publication... more kokkuvõte vii list of publications xi list of conference presentations xii additional publications & conference presentations xiii acknowledgments xiv acronyms xv chemicals and enzymes xvi thesis 19

Research paper thumbnail of Application of isothermic calorymetry and dynamic viscosimetry in studies of rye bread staling

Research paper thumbnail of The effects of apple variety, ripening stage, and yeast strain on the volatile composition of apple cider

Heliyon, Jun 1, 2019

This work examined the degree of influence of apple variety, apple ripening stage, and yeast stra... more This work examined the degree of influence of apple variety, apple ripening stage, and yeast strain on the volatile composition of apple cider. Four apple varieties grown in Estonia were selected for the study-Antei, Melba, Kulikovskoye, and Orlovski Sinap. The must from the apples at various stages of ripening (unripe, ripe, overripe) underwent alcoholic fermentation using commercially available yeast strains. Gas chromatography-mass spectrometry was employed to assess the differences in volatile composition between the samples. Out of the variables analyzed in this work, apple variety turned out to be the primary attribute influencing the quality and aroma properties of apple cider. The effect of yeast strain and the maturity of the fruit was variety-specific where the volatile profiles of ciders made with Melba variety were the least influenced by the ripening stage of apples and yeast strains used for the fermentation.

Research paper thumbnail of FERMEXPERT" - An Expert System for Studies and Optimization of Processes of Microbial Synthesis

IFAC Proceedings Volumes, Mar 1, 1992

FennExpert"-a general purpose fennentation program with expert system features running in the Mic... more FennExpert"-a general purpose fennentation program with expert system features running in the Microsoft Windows environment was developed for real time on-line and off-line data acquisition and fennentation process control. It has a special user definable installation module for coupling different fennentors to the PC. "FennExpert" has built in editor and library of equations for the analysis of data for batch, fed-batch and continuous cultivation procedures. Cubic spline interpolation of data is used throughout for carrying out calculations which can be activated just by One click. Practically all the functions are accessible from the main window (screen) of the program through the mouse driven graphical interface. "FennExpert" has special utilities for the exchange of data files with other fennentation and spreadsheet programs. Graphical data can be printed out in publishable fonn.

Research paper thumbnail of A New Method of Continuous Cultivation with Computer-controlled Change of Dilution Rate

IFAC Proceedings Volumes, Mar 1, 1992

A new method of continuous cultivation of cells with computer controlled (smooth) change of dilut... more A new method of continuous cultivation of cells with computer controlled (smooth) change of dilution rate (A-stat) was developed and introduced into laboratory practice. The A-stat was used for determination of growth parameters of Escherichia coli KI2, Saccharomyces cerevisiae and Pseudomonas putida. It has been shown that the maximum values of specific respiration rates on different substrates investigated vary in E. coli and Ps. putida only little. The results obtained suggest that the maximum values of growth rates are limited by the capacity of the respiratory chain. It was shown that appearence of substrates in the culture media at high growth rates was "coupled" to the increase of growth yield YX02 value. The idea of two "life strategies" one for growth in conditions of limitation by a substrate and another for conditions of abundance of substrates is proposed.

Research paper thumbnail of Rye sourdough fermentation and bread stability. Rukkitaigna hapendamine ja leiva vananemine

kokkuvõte vii list of publications xi list of conference presentations xiii acknowledgments xiv a... more kokkuvõte vii list of publications xi list of conference presentations xiii acknowledgments xiv acronyms xv chemicals and enzymes xvi thesis 17

Research paper thumbnail of Rye sourdough fermentation and bread stability

kokkuvõte vii list of publications xi list of conference presentations xiii acknowledgments xiv a... more kokkuvõte vii list of publications xi list of conference presentations xiii acknowledgments xiv acronyms xv chemicals and enzymes xvi thesis 17

Research paper thumbnail of Effect of changing environmental conditions on the fermentative growth of Saccharomyces cerevisiae S288C: Auxo-accelerostat study

Research paper thumbnail of Production of labelled recombinant proteins in fed-batch systems in Escherichia coli.Märgistatud rekombinantsete valkude tootmine Escherichia coli fed-batch süsteemides

Research paper thumbnail of Study of the Metabolism of the Photosynthetic Bacteria Chlorobium Thiosulfatophilum by 13C NMR

Magnetic Resonance and Related Phenomena, 1979

13C NMR spectra of selectively enriched glucose, glutamic acid, aspartic acid, alanine, uridine a... more 13C NMR spectra of selectively enriched glucose, glutamic acid, aspartic acid, alanine, uridine and guanosine, synthesized by the photosynthetic bacteria Chlorobium thiosulfatophilum were studied. Several 13C-13C spin-spin coupling constants were measured in the tightly coupled systems. Labelling patterns of the compounds were analyzed to identify the metabolic pathways functioning in the cells.

Research paper thumbnail of Stochastic control of growth in fed batch cultivation of bacteria

Research paper thumbnail of Multilevel Control of GSH Accumulation in Mutant and Wild-Type Strains of S. Cerevisiae Under Conditions of Smooth Cysteine Addition

Chemical Engineering Transactions, 2010

preview not available - see full-text PDF article.

Research paper thumbnail of Application of Gas Chromatography-Olfactometry (GC-O) and Correlation with Sensory Analysis. Gaaskromatograaf-olfaktomeetri (GC-O) rakendusvõimalused ja korreleerimine sensoorse analüüsiga

Research paper thumbnail of Identification and Characterization of Bioactive Peptides with Antimicrobial and Immunoregulating Properties Derived from Bovine Colostrum and Milk. Antimikroobsete ja immuunsüsteemi stimuleerivate omadustega bioaktiivsete peptiidide identifitseerimine ja karakteriseerimine lehma piimast ja kolostru

Research paper thumbnail of Dimetüülsulfiidi kontsentratsiooni sõltuvus õlles virde aurustumisprotsendist. Effect of wort boiling on dimethyl sulfide concentration in beer

Research paper thumbnail of Applications of 15N-labeled Yeast Hydrolysates in Metabolic Studies of Lactococcus lactis and Saccharomyces cerevisiae. 15N-märgistatud pärmihüdrolüsaatide rakendused Lactococcus lactis'e ja Saccharomyces cerevisiae ainevahetuse uurimisel

Research paper thumbnail of Simultaneous utilization of ammonia, free amino acids and peptides during fermentative growth ofSaccharomyces cerevisiae

Journal of the Institute of Brewing, 2016

The efficiency of nitrogen use by yeast is one of the key determinants of the successful completi... more The efficiency of nitrogen use by yeast is one of the key determinants of the successful completion of alcoholic fermentations. In this work the growth of Saccharomyces cerevisiae S288c in a synthetic medium containing ammonia and free amino acids, supplemented with yeast hydrolysate, was studied. Experiments with 15 NH 4 Cl and 15 N-labelled yeast hydrolysate were carried out to gain insight into which of these three classes of assimilable nitrogen sources yeast cells prefer. Co-consumption of all three sources was observed; approximately 40% of the total nitrogen in the yeast protein fraction originated from yeast hydrolysate, while free amino acids and ammonia contributed 40 and 20%, respectively. The results indicate that several amino acids are more readily obtained from peptides, most likely when the uptake of their free forms is competitively inhibited and/or repressed. During the second half of each fermentation, a decrease in the incorporation of yeast hydrolysate-derived nitrogen was observed. These results highlight the nutritional role of peptides in various yeast fermentations.

Research paper thumbnail of Stochastic Control of Growth in Fed-Batch Culture of Bacteria

Eesti NSV Teaduste Akadeemia toimetised, 1988

STOCHASTIC CONTROL OF GROWTH IN FED-BATCH CULTURE OF BACTERIA (Presented by E. Lippmaa) Using the... more STOCHASTIC CONTROL OF GROWTH IN FED-BATCH CULTURE OF BACTERIA (Presented by E. Lippmaa) Using the stoichiometric equation of growth and Monod type kinetic equation, a deterministic model of growth of microorganisms in fed-batch culture was built. A stochastic model of the process was developed on the basis of the deterministic description. A stochastic control algorithm which is using filtered data was developed.

Research paper thumbnail of Metabolic Flux Analysis of Compartmentalized Systems using Dynamic Isotopologue Modeling. Isotopoloogilise modelleerimise rakendamine heterogeensete bioloogiliste süsteemide ainevahetusvoo analüüsis

Research paper thumbnail of Identification and Characterization of Bioactive Peptides with Antimicrobial and Immunoregulating Properties Derived from Bovine Colostrum and Milk. Antimikroobsete ja immuunsüsteemi stimuleerivate omadustega bioaktiivsete peptiidide identifitseerimine ja karakteriseerimine lehma piimast ja kolos...

Research paper thumbnail of Spice-Cured Sprats Ripening, Sensory Parameters Development, and Quality Indicators. Vürtsikilu valmimine, sensoorsete omaduste kujunemine ja kvaliteediindikaatorid

kokkuvõte vii list of publications xi list of conference presentations xii additional publication... more kokkuvõte vii list of publications xi list of conference presentations xii additional publications & conference presentations xiii acknowledgments xiv acronyms xv chemicals and enzymes xvi thesis 19

Research paper thumbnail of Application of isothermic calorymetry and dynamic viscosimetry in studies of rye bread staling

Research paper thumbnail of The effects of apple variety, ripening stage, and yeast strain on the volatile composition of apple cider

Heliyon, Jun 1, 2019

This work examined the degree of influence of apple variety, apple ripening stage, and yeast stra... more This work examined the degree of influence of apple variety, apple ripening stage, and yeast strain on the volatile composition of apple cider. Four apple varieties grown in Estonia were selected for the study-Antei, Melba, Kulikovskoye, and Orlovski Sinap. The must from the apples at various stages of ripening (unripe, ripe, overripe) underwent alcoholic fermentation using commercially available yeast strains. Gas chromatography-mass spectrometry was employed to assess the differences in volatile composition between the samples. Out of the variables analyzed in this work, apple variety turned out to be the primary attribute influencing the quality and aroma properties of apple cider. The effect of yeast strain and the maturity of the fruit was variety-specific where the volatile profiles of ciders made with Melba variety were the least influenced by the ripening stage of apples and yeast strains used for the fermentation.

Research paper thumbnail of FERMEXPERT" - An Expert System for Studies and Optimization of Processes of Microbial Synthesis

IFAC Proceedings Volumes, Mar 1, 1992

FennExpert"-a general purpose fennentation program with expert system features running in the Mic... more FennExpert"-a general purpose fennentation program with expert system features running in the Microsoft Windows environment was developed for real time on-line and off-line data acquisition and fennentation process control. It has a special user definable installation module for coupling different fennentors to the PC. "FennExpert" has built in editor and library of equations for the analysis of data for batch, fed-batch and continuous cultivation procedures. Cubic spline interpolation of data is used throughout for carrying out calculations which can be activated just by One click. Practically all the functions are accessible from the main window (screen) of the program through the mouse driven graphical interface. "FennExpert" has special utilities for the exchange of data files with other fennentation and spreadsheet programs. Graphical data can be printed out in publishable fonn.

Research paper thumbnail of A New Method of Continuous Cultivation with Computer-controlled Change of Dilution Rate

IFAC Proceedings Volumes, Mar 1, 1992

A new method of continuous cultivation of cells with computer controlled (smooth) change of dilut... more A new method of continuous cultivation of cells with computer controlled (smooth) change of dilution rate (A-stat) was developed and introduced into laboratory practice. The A-stat was used for determination of growth parameters of Escherichia coli KI2, Saccharomyces cerevisiae and Pseudomonas putida. It has been shown that the maximum values of specific respiration rates on different substrates investigated vary in E. coli and Ps. putida only little. The results obtained suggest that the maximum values of growth rates are limited by the capacity of the respiratory chain. It was shown that appearence of substrates in the culture media at high growth rates was "coupled" to the increase of growth yield YX02 value. The idea of two "life strategies" one for growth in conditions of limitation by a substrate and another for conditions of abundance of substrates is proposed.

Research paper thumbnail of Rye sourdough fermentation and bread stability. Rukkitaigna hapendamine ja leiva vananemine

kokkuvõte vii list of publications xi list of conference presentations xiii acknowledgments xiv a... more kokkuvõte vii list of publications xi list of conference presentations xiii acknowledgments xiv acronyms xv chemicals and enzymes xvi thesis 17

Research paper thumbnail of Rye sourdough fermentation and bread stability

kokkuvõte vii list of publications xi list of conference presentations xiii acknowledgments xiv a... more kokkuvõte vii list of publications xi list of conference presentations xiii acknowledgments xiv acronyms xv chemicals and enzymes xvi thesis 17

Research paper thumbnail of Effect of changing environmental conditions on the fermentative growth of Saccharomyces cerevisiae S288C: Auxo-accelerostat study

Research paper thumbnail of Production of labelled recombinant proteins in fed-batch systems in Escherichia coli.Märgistatud rekombinantsete valkude tootmine Escherichia coli fed-batch süsteemides

Research paper thumbnail of Study of the Metabolism of the Photosynthetic Bacteria Chlorobium Thiosulfatophilum by 13C NMR

Magnetic Resonance and Related Phenomena, 1979

13C NMR spectra of selectively enriched glucose, glutamic acid, aspartic acid, alanine, uridine a... more 13C NMR spectra of selectively enriched glucose, glutamic acid, aspartic acid, alanine, uridine and guanosine, synthesized by the photosynthetic bacteria Chlorobium thiosulfatophilum were studied. Several 13C-13C spin-spin coupling constants were measured in the tightly coupled systems. Labelling patterns of the compounds were analyzed to identify the metabolic pathways functioning in the cells.

Research paper thumbnail of Stochastic control of growth in fed batch cultivation of bacteria

Research paper thumbnail of Multilevel Control of GSH Accumulation in Mutant and Wild-Type Strains of S. Cerevisiae Under Conditions of Smooth Cysteine Addition

Chemical Engineering Transactions, 2010

preview not available - see full-text PDF article.

Research paper thumbnail of Application of Gas Chromatography-Olfactometry (GC-O) and Correlation with Sensory Analysis. Gaaskromatograaf-olfaktomeetri (GC-O) rakendusvõimalused ja korreleerimine sensoorse analüüsiga

Research paper thumbnail of Identification and Characterization of Bioactive Peptides with Antimicrobial and Immunoregulating Properties Derived from Bovine Colostrum and Milk. Antimikroobsete ja immuunsüsteemi stimuleerivate omadustega bioaktiivsete peptiidide identifitseerimine ja karakteriseerimine lehma piimast ja kolostru

Research paper thumbnail of Dimetüülsulfiidi kontsentratsiooni sõltuvus õlles virde aurustumisprotsendist. Effect of wort boiling on dimethyl sulfide concentration in beer

Research paper thumbnail of Applications of 15N-labeled Yeast Hydrolysates in Metabolic Studies of Lactococcus lactis and Saccharomyces cerevisiae. 15N-märgistatud pärmihüdrolüsaatide rakendused Lactococcus lactis'e ja Saccharomyces cerevisiae ainevahetuse uurimisel

Research paper thumbnail of Simultaneous utilization of ammonia, free amino acids and peptides during fermentative growth ofSaccharomyces cerevisiae

Journal of the Institute of Brewing, 2016

The efficiency of nitrogen use by yeast is one of the key determinants of the successful completi... more The efficiency of nitrogen use by yeast is one of the key determinants of the successful completion of alcoholic fermentations. In this work the growth of Saccharomyces cerevisiae S288c in a synthetic medium containing ammonia and free amino acids, supplemented with yeast hydrolysate, was studied. Experiments with 15 NH 4 Cl and 15 N-labelled yeast hydrolysate were carried out to gain insight into which of these three classes of assimilable nitrogen sources yeast cells prefer. Co-consumption of all three sources was observed; approximately 40% of the total nitrogen in the yeast protein fraction originated from yeast hydrolysate, while free amino acids and ammonia contributed 40 and 20%, respectively. The results indicate that several amino acids are more readily obtained from peptides, most likely when the uptake of their free forms is competitively inhibited and/or repressed. During the second half of each fermentation, a decrease in the incorporation of yeast hydrolysate-derived nitrogen was observed. These results highlight the nutritional role of peptides in various yeast fermentations.

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