Urmilesh Jha - Academia.edu (original) (raw)
Address: Pune, Maharashtra, India
less
Uploads
Papers by Urmilesh Jha
The objective of the present study was to evaluate the skeletal muscle relaxant activity of metha... more The objective of the present study was to evaluate the skeletal muscle relaxant activity of methanolic extract of the leaves of Parthenium hysterophorus L (MEPH) using Rota-Rod method and traction test . ME PH was administered orally at dose of 3mg/kg and 6 mg/kg p.o to Swiss A lbino mice. The methanolic extract significantly re duces the fall off time (motor coordination), and highly significa nt (**P<0.01) at 30 min of duration. It also shows significant muscle relaxant effect in traction test. Thus, the result suggested that the MEPH possess skeletal mu scle relaxantactivity may be due to presence of differen t chemical compounds present in the extract. Key-Words: Parthenium hysterophorus , methanolic extract, Skeletal muscle relaxant acti vity Introduction Parthenium hysterophorus L., belongs to the dicot family of flowering plants (Asteraceae) to which otherwise ornamentals like dahlia and chrysanthemum and oilseed crop plants like sunflower and safflowe r belong. It was acc...
The Pharma Innovation Journal, 2020
Coronavirus (COVID-19) is an enveloped RNA virus that is diversely found in humans and wild life.... more Coronavirus (COVID-19) is an enveloped RNA virus that is diversely found in humans and wild life. A total of six species have been identified to cause disease in humans. They are known to infect the neurological, respiratory, enteric, and hepatic systems. The past few decades have seen endemic outbreaks in the form of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) and Severe Acute Respiratory Syndrome Related Coronavirus (SARS-CoV). Yet again, we see the emergence of another outbreak due to a new strain called the SARS-CoV-2 virus. The most recent outbreak initially presented as pneumonia of unknown etiology in a cluster of patients in Wuhan, China. The epicenter of infection was linked to seafood and exotic animal wholesale markets in the city. SARS-CoV-2 is highly contagious and has resulted in a rapid pandemic of COVID-19. As the number of cases continues to rise, it is clear that these viruses pose a threat to public health. This review will introduce a general overview...
In-Vitro Antilithiatic Effect of Ethanolic Extract of Codiaeum Variegatum (L.
Journal of Ethnopharmacology, 2010
Ethnopharmacological relevance: The aerial parts of Coccinia cordifolia L. are used to treat fema... more Ethnopharmacological relevance: The aerial parts of Coccinia cordifolia L. are used to treat female infertility in West Bengal state of India. Aim of the study: The present study was undertaken to evaluate the fertility inducing effect of aerial parts of Coccinia cordifolia L. in female rats. Materials and methods: The effect of aqueous extract of Coccinia cordifolia L. on hyperprolactinemia induced infertility, endometriosis induced infertility and androgen-induced infertility was studied. The effect on serum estrogen level, serum progesterone level and reproductive tract was also evaluated in normal healthy female rats. The extract was administered orally at two different doses of 500 mg/kg and 1000 mg/kg. Results: In hyperprolactinemia induced infertility model, the numbers of uterine implants were almost 10 times more in the extract treated groups as compared to control. The high dose of extract also produced a significant increase in serum estrogen levels (p < 0.01) and number of corpus luteum (p < 0.05) in healthy female rats. The extract at both doses was effective in reducing the weight of endometrial implants by 70-80%, but failed to induce fertility in rats with endometriosis. The extract was ineffective in inducing fertility in androgen-induced infertility model. Conclusions: The aqueous extract of Coccinia cordifolia L. induces fertility in hyperprolactinemia induced infertility model in female rats.
The objective of the present study was to evaluate the skeletal muscle relaxant activity of metha... more The objective of the present study was to evaluate the skeletal muscle relaxant activity of methanolic extract of the leaves of Parthenium hysterophorus L (MEPH) using Rota-Rod method and traction test . ME PH was administered orally at dose of 3mg/kg and 6 mg/kg p.o to Swiss A lbino mice. The methanolic extract significantly re duces the fall off time (motor coordination), and highly significa nt (**P<0.01) at 30 min of duration. It also shows significant muscle relaxant effect in traction test. Thus, the result suggested that the MEPH possess skeletal mu scle relaxantactivity may be due to presence of differen t chemical compounds present in the extract. Key-Words: Parthenium hysterophorus , methanolic extract, Skeletal muscle relaxant acti vity Introduction Parthenium hysterophorus L., belongs to the dicot family of flowering plants (Asteraceae) to which otherwise ornamentals like dahlia and chrysanthemum and oilseed crop plants like sunflower and safflowe r belong. It was acc...
The Pharma Innovation Journal, 2020
Coronavirus (COVID-19) is an enveloped RNA virus that is diversely found in humans and wild life.... more Coronavirus (COVID-19) is an enveloped RNA virus that is diversely found in humans and wild life. A total of six species have been identified to cause disease in humans. They are known to infect the neurological, respiratory, enteric, and hepatic systems. The past few decades have seen endemic outbreaks in the form of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) and Severe Acute Respiratory Syndrome Related Coronavirus (SARS-CoV). Yet again, we see the emergence of another outbreak due to a new strain called the SARS-CoV-2 virus. The most recent outbreak initially presented as pneumonia of unknown etiology in a cluster of patients in Wuhan, China. The epicenter of infection was linked to seafood and exotic animal wholesale markets in the city. SARS-CoV-2 is highly contagious and has resulted in a rapid pandemic of COVID-19. As the number of cases continues to rise, it is clear that these viruses pose a threat to public health. This review will introduce a general overview...
In-Vitro Antilithiatic Effect of Ethanolic Extract of Codiaeum Variegatum (L.
Journal of Ethnopharmacology, 2010
Ethnopharmacological relevance: The aerial parts of Coccinia cordifolia L. are used to treat fema... more Ethnopharmacological relevance: The aerial parts of Coccinia cordifolia L. are used to treat female infertility in West Bengal state of India. Aim of the study: The present study was undertaken to evaluate the fertility inducing effect of aerial parts of Coccinia cordifolia L. in female rats. Materials and methods: The effect of aqueous extract of Coccinia cordifolia L. on hyperprolactinemia induced infertility, endometriosis induced infertility and androgen-induced infertility was studied. The effect on serum estrogen level, serum progesterone level and reproductive tract was also evaluated in normal healthy female rats. The extract was administered orally at two different doses of 500 mg/kg and 1000 mg/kg. Results: In hyperprolactinemia induced infertility model, the numbers of uterine implants were almost 10 times more in the extract treated groups as compared to control. The high dose of extract also produced a significant increase in serum estrogen levels (p < 0.01) and number of corpus luteum (p < 0.05) in healthy female rats. The extract at both doses was effective in reducing the weight of endometrial implants by 70-80%, but failed to induce fertility in rats with endometriosis. The extract was ineffective in inducing fertility in androgen-induced infertility model. Conclusions: The aqueous extract of Coccinia cordifolia L. induces fertility in hyperprolactinemia induced infertility model in female rats.