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Papers by Vanina Guntero
The 24th International Electronic Conference on Synthetic Organic Chemistry, 2020
Bovine casein is a family of milk proteins with hydrophilic and hydrophobic regions that show blo... more Bovine casein is a family of milk proteins with hydrophilic and hydrophobic regions that show block distribution within the protein chain. These amphiphilic properties offer great potential as a material for use as a matrix for transporting active materials such as tocopherol. In this work, we aimed to evaluate the interaction of α1-casein, the main fraction of casein, with vitamin E by docking calculations. Docking studies were conducted using SwissDock and DockThor servers. Using specific scoring functions based on energy terms, the best protein-ligand binding models were obtained. The observed interactions between vitamin E and amino acid residues consisted of several hydrophobic interactions (e.g., with Tyr119, Ala144, Trp179, Met211, Pro212). A few hydrogen bonds were observed between the phenyl group of vitamin E and the carboxylate group of the glutamic acid residue (e.g., with Glu85, Glu148). In conclusion, the results suggest that there is a major interaction of vitamin E with random coil structure and interaction with segments formed by α-helix and β-sheet. This implies that in random coil segments there is a predominance of hydrophobic domains.
World Journal of Chemical Education
The main aim of this work is to teach chemistry through a practical application. In it is describ... more The main aim of this work is to teach chemistry through a practical application. In it is described a chemical experiment for high school students. They learn fundamental concepts through the preparation of gel alcohol flavored. The experiment has four stages: search information, cultivation of aromatic plants, extraction of essential oils, and elaboration of gel alcohol. The hydro distillation technique was applied in order to obtain the corresponding essential oil. The aromatic plants used were cloves, lavender, rosemary, salvia and cedron. The essential oils were analyzed by gas chromatography. The experiment demonstrated to the students the application of chemistry for the preparation of personal care products making concepts more tangible than a simple reading.
The 24th International Electronic Conference on Synthetic Organic Chemistry, 2020
Bovine casein is a family of milk proteins with hydrophilic and hydrophobic regions that show blo... more Bovine casein is a family of milk proteins with hydrophilic and hydrophobic regions that show block distribution within the protein chain. These amphiphilic properties offer great potential as a material for use as a matrix for transporting active materials such as tocopherol. In this work, we aimed to evaluate the interaction of α1-casein, the main fraction of casein, with vitamin E by docking calculations. Docking studies were conducted using SwissDock and DockThor servers. Using specific scoring functions based on energy terms, the best protein-ligand binding models were obtained. The observed interactions between vitamin E and amino acid residues consisted of several hydrophobic interactions (e.g., with Tyr119, Ala144, Trp179, Met211, Pro212). A few hydrogen bonds were observed between the phenyl group of vitamin E and the carboxylate group of the glutamic acid residue (e.g., with Glu85, Glu148). In conclusion, the results suggest that there is a major interaction of vitamin E with random coil structure and interaction with segments formed by α-helix and β-sheet. This implies that in random coil segments there is a predominance of hydrophobic domains.
World Journal of Chemical Education
The main aim of this work is to teach chemistry through a practical application. In it is describ... more The main aim of this work is to teach chemistry through a practical application. In it is described a chemical experiment for high school students. They learn fundamental concepts through the preparation of gel alcohol flavored. The experiment has four stages: search information, cultivation of aromatic plants, extraction of essential oils, and elaboration of gel alcohol. The hydro distillation technique was applied in order to obtain the corresponding essential oil. The aromatic plants used were cloves, lavender, rosemary, salvia and cedron. The essential oils were analyzed by gas chromatography. The experiment demonstrated to the students the application of chemistry for the preparation of personal care products making concepts more tangible than a simple reading.