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Papers by chandni chandarana

International journal of biological macromolecules, May 1, 2024

Journal of chromatographic science, Mar 28, 2024

Current Drug Therapy

Background: The link between autophagy and lysosomal function has been well-recognised in recent ... more Background: The link between autophagy and lysosomal function has been well-recognised in recent dec-ades; defective autophagy and lysosomal function lead to various disorders, notably Lysoso-mal Storage Disorders (LSDs). The malfunction of multiple mechanistic pathways influences the contribution of LSDs. Different ways are employed in such situations, but one novel ap-proach could resolve the problem by inducing the autophagic pathway, which aids in main-taining proper autophagy and lysosomal degradation function. Method: Autophagic Inducer functions on the activation of Transcriptional factor EB (TFEB) and its mechanism; mTOR Complex Inhibition dependently or independently may repair the mal-function of the entire mechanism. Finding a potential autophagic inducer is still a work in progress, but targeting TFEB and mTOR could redefine LSD treatment. The development of experimentally available TFEB modulators could enhance autophagic flux promote lysosomal function and increase lys...

Reviews on Recent Clinical Trials, Nov 9, 2023

International journal of pharmaceutical sciences review and research, May 15, 2022

Meniere's disease (MD) is a type of peripheral vestibular disease and affects the inner ear. It i... more Meniere's disease (MD) is a type of peripheral vestibular disease and affects the inner ear. It is characterised by a combination of classic symptoms, including vertigo (spinning sensation), sensorineural hearing loss (SNHL), tinnitus (ear ringing), nausea, and vomiting. The most important histological marker of the Meniere's disease (MD) is endolymphatic hydrops (EH). Different subgroups of patients have different aetiologies, including trauma, viral infection, autoimmunity, allergy, otitis media, and genetic predisposition. MD is most prevalent in European descendants with higher women to men ratio. Recent diagnostic criteria classify MD into definite and probable MD. The treatment consists of non-invasive approaches to surgically destructive methods. The review focuses on epidemiology, aetiology, diagnostic criteria, recent imaging techniques, diagnostic tools, and various treatment regimens.

International Journal of Pharmaceutical Sciences Review and Research, 2021

Inflammatory bowel disease is a chronic disease of the gastrointestinal tract, which is character... more Inflammatory bowel disease is a chronic disease of the gastrointestinal tract, which is characterized by serious events of inflammation in either specifically colon (ulcerative colitis) or the whole length of the gut (Crohn’s disease). IBD affects people greatly all over the globe. It is observed that it is more prevalent in the urbanized countries. Both the etiology and pathogenesis of IBD are complex to understand. Yet many researchers have taken great efforts to figure out the etiopathogenesis. Diagnosis of IBD is also difficult thus it is required to differentiate between UC and CD. Thus, we have shed some light on the diagnostic tools too. Since the cure for IBD is difficult, treatment is the only option, hence various recent treatments are also explained with the help of this review. This review gives a brief overview of the disease also highlights the various etiopathogenesis involved.

Global Translational Medicine

Acute myocardial infarction (AMI) is the most prevalent condition that results in sickness and de... more Acute myocardial infarction (AMI) is the most prevalent condition that results in sickness and death worldwide. An early and accurate diagnosis of AMI is critical for prompt and appropriate treatment. Cardiac biomarkers, including myoglobin, creatinine phosphokinase (CK), and cardiac troponins, have been widely used for AMI diagnosis. More recently, new biomarkers such as heart-type fatty acid-binding protein and matrix metalloproteinases have shown promise in improving AMI diagnosis. At present, cardiac biomarkers and biosensors are used in the diagnosis and prognosis of AMI. This review article gives information on cardiac biomarkers specific to AMI and its diagnostic methods. These biomarkers have several advantages, including their high specificity for cardiac injury and their sensitivity to even small extent of cardiac damage. In addition, cardiac biomarkers can be used to assess the severity of AMI and predict the risk of complications or mortality. Recently, biosensors that c...

Indian Journal of Pharmaceutical Education and Research

Brazilian Journal of Analytical Chemistry, 2020

An eco-friendly method for quantification of Aspirin and Omeprazole in pharmaceutical solid dosag... more An eco-friendly method for quantification of Aspirin and Omeprazole in pharmaceutical solid dosage form has been developed using Fourier transform infrared spectrophotometry. The proposed method avoids the use of solvents which are commonly used for other methods of quantification e.g. Liquid Chromatography, UV spectrophotometry, etc. The developed method has been validated for the quantification of Aspirin and Omeprazole in a marketed formulation as per ICH Topic Q 2 (R1) guidelines. The method is based on Beer-Lamberts' law. For the proposed method C=O stretch at 1754 cm −1 was selected for Aspirin between 1750-1730 cm-1 and C=N stretch at 1627 cm −1 was selected for Omeprazole in the range of 1690-1620 cm-1. Linearity was obtained in the concentration range of 10-50 mg g-1 and 5-25 mg g-1 with an R 2 value of 0.999 and 0.997 for Aspirin and Omeprazole respectively. The % recovery was calculated with intra and inter day precision study.

International Journal of Ayurvedic Medicine

This review article encompasses the various evaluation parameters of standardization of different... more This review article encompasses the various evaluation parameters of standardization of different medicinal plants and its constituents. In today’s life, more and more people of the world are turning towards the use of natural or herbal products as these have very less or negligible side effects. As the use of herbal medicinal products is increasing day by day, the questions regarding their quality are also arising. This is due to lack of parameters for the standardization of these products. There is a need to set different parameters or methods that can help to standardize the herbal medicinal plant materials. Various methods like physical, chemical, biological is used for standardization and quality evaluation of herbal medicinal plants. These methods can act as a basic tool for the quality evaluation of herbal plant materials. Different parameters of standardization are the fundamental tool for evaluating and assuring the quality of the herbal plant material and its products. Thi...

Research journal of pharmacy and technology, Aug 30, 2022

International Journal of Pharmaceutical Sciences Review and Research, 2022

Bioanalysis is most widely used for drug discovery and development. Bioanalytical methods have be... more Bioanalysis is most widely used for drug discovery and development. Bioanalytical methods have been working for the quantitative estimation of drugs, or its metabolites and biomarkers in its biological samples. The steps involved in bioanalysis comprise of many steps that are from sample collection to sample analysis and then data reporting. The first step involves sample collection from clinical or preclinical studies. After that, the analysis of the sample is done in the laboratory. The second step involves the sample cleanup the cleanup process should be carried out carefully to eliminate the interferences present in the sample matrix. And it increases the performance of the analytical system. The last step involves sample analysis and detection of a separated compound and detection techniques used are HPLC and Liquid chromatography coupled with double mass spectrometry (LCMS-MS) and are used in the bioanalysis of drugs in the body. Each one of these has its advantage and disadva...

International Journal of Pharmaceutical Chemistry and Analysis, 2016

For determination of Spironolactone in pharmaceutical formulation, Simple, fast and reliable firs... more For determination of Spironolactone in pharmaceutical formulation, Simple, fast and reliable first and second order derivative UV spectrophotometric methods were developed. Spectrophotometrically, Spironolactone was determined by measuring the 1D and 2D-values at 226 nm and 262 nm using methanol as background solvent. The Calibration curves were shown linear within a concentration range from 5-35 μg/ml. The developed and validated method was easily applied to the analysis of the pharmaceutical tablet preparations. The percentage recoveries were found to be 100% for given methods. The excipients did not interfere in the analysis. The results showed that this method can be used for rapid determination of Spironolactone in pharmaceutical tablet with specificity and accuracy.

Vibrational Spectroscopy, 2018

A simple, specific, sensitive, accurate, precise and economical Fourier transform infrared spectr... more A simple, specific, sensitive, accurate, precise and economical Fourier transform infrared spectrophotometric method was developed for the quantitation of Spironolactone in bulk and tablet dosage form. The method was based on the determination of Spironolactone by the measurement of absorption of radiation at absorption band corresponding to C]O stretch of cyclic ester centered at 1768 cm −1 , which is typically in the range of 1802-1748 cm −1 because those absorption bands did not occur in excipients present inpharmaceutical preparation. The proposed method was validated as per ICH guidelines. The linearity of spironolactone was obtained in the concentration range of 1-7 mg/g with correlation coefficient value (R 2) 0.995. The recovery studies confirmed by the accuracy of the proposed method and low values of standard deviation confirmed precision of the method.

Reference Series in Phytochemistry

Journal of the Egyptian Public Health Association

Background In the global health emergency caused by COVID-19, multiple experts have mandated the ... more Background In the global health emergency caused by COVID-19, multiple experts have mandated the use of hand sanitizers as a safety measure from COVID-19. The sale of hand sanitizers has increased many folds. Therefore, when there is such large use of hand sanitizers, it becomes extremely important to study and understand hand sanitizers in a comprehensive manner. Main body of the abstract This article starts with the importance of sanitizers as a defence mechanism that is employed by the hand to fight against the coronavirus. This article provides information about history, types, composition, various dosage forms, and marketed formulations of hand sanitizers. The article sheds a detailed light on industrial production techniques for hand sanitizers and also outlines new innovative techniques that were employed by the industry to mass produce hand sanitizers in the wake of the pandemic. The article further dives into a comparison between hand sanitizers and soaps so as to give pros...

Journal of Pharmaceutical Research International

Aims: To study force degradation of aspirin and omeprazole simultaneously by RP-HPLC method Study... more Aims: To study force degradation of aspirin and omeprazole simultaneously by RP-HPLC method Study design: RP-HPLC method was used to measure % degradation. Place and Duration of Study: Study was carried out at center of excellence, G.I.D.C., vapi-396195, Gujarat, India between June 2019 to march 2020. Methodology: A force degradation study of aspirin and omeprazole was carried out simultaneously. The drugs were subjected to various degradation conditions like hydrolysis by acid and base, Oxidative degradation, and thermal degradation study. Results: For acidic condition, the degradation was found to be 32.63 % for aspirin and 61.64 % for omeprazole. For basic condition, the degradation was found to be 10.17 % for aspirin and 4.29 % for omeprazole. By oxidative hydrolysis, the aspirin was degraded by 15.48 % and omeprazole was degraded by 26.38 %. By thermal degradation, 0.37 % degradation was observed for aspirin and 4.32 % degradation for omeprazole. Conclusion: In this proposed me...

Current Biotechnology

Online analysis of bioprocesses by analytical spectroscopic methods is used to produce fast sampl... more Online analysis of bioprocesses by analytical spectroscopic methods is used to produce fast sample analysis. Bio-transformations are directly controlled by continuous process It improves management of Quality. Various methods for online analysis have been reported. This review article majorly covers applications for infrared [NIR and MIR]; Fluorescence; Ultraviolet [UV] Spectroscopy and Raman Spectroscopy for online monitoring of bioprocesses. The use of Uv- Vis spectroscopy in bioprocess monitoring to measure different chemicals compound present in sample. The measurement of proteins and other large molecule, where light is absorbed by functional group of molecules, resulting in non-specific uv-vis spectra. Raman spectroscopy is supportive to MIR, yielding different intensities and selectivity. Raman measures inelastic scattering from a monochromatic radiation source. Fluorescence spectroscopy monitoring and automation of fluorescence can be improved by using in combination with ch...