mohammad salem - Academia.edu (original) (raw)

Papers by mohammad salem

Sea Urchin Diadema Setosum as a Possible Bioindicator for Trace Metal Pollution in the Gulf of Aq... more Sea Urchin Diadema Setosum as a Possible Bioindicator for Trace Metal Pollution in the Gulf of Aqaba , Red Sea، للحصول على النص الكامل يرجى زيارة مكتبة الحسين بن طلال في جامعة اليرموك او زيارة موقعها الالكتروني

Objective: This study sought to determine the impact of educational intervention on the caregiver... more Objective: This study sought to determine the impact of educational intervention on the caregivers’ understanding of the SBAR tool used during the patients’ handover practices by utilizing a quasi-experimental design. Methods: This quantitative study was conducted within the Transfer Center of a tertiary care hospital in Abu Dhabi. In a quasi-experimental design, the researcher collected data in two separate phases using a borrowed questionnaire. The first phases, pretest, was administered to all the 40 participants within the first week of July, 2018 to assess their knowledge levels regarding the use of SBAR communication tool during patient handover practices. Subsequently, the educational training was offered to all the 40 participants before administering the posttest on the first week of August 2018. Results: Descriptive data analysis showed that majority of the participants had ages of between 30 and 49. 72.5% of the participants had over four years of experience and with a Ba...

This paper provides my reflection and examination of a typical incidence that elucidates the chal... more This paper provides my reflection and examination of a typical incidence that elucidates the challenge of violence against nurses and physicians in the healthcare facilities. Literature records that nurses often come to contact with the outsiders of the cl inic and are at high chances of meeting violence. Hence, it is significant to learn from the past event through a reflection on practice. In my case, I encountered a violence case when I tried to intervene in a case when one of the patient’s visitors came to disagreement with the nurse on duty on how to position a comatose patient. Accordingly, the narrative presented in this article shows my reflection on practice within the confines and guidelines of Gibbs’ model of reflection on practice that runs from the narrative of the event, what was bad, what was good, an evaluation of the event and the action plan. Nevertheless, I noticed that such challenges as violence are inescapable and that I need to inculcate a sober mind and think...

Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine

The objective of our study is to develop extended finite element method models of cancellous bone... more The objective of our study is to develop extended finite element method models of cancellous bone specimens that are capable of accurately predicting the onset and propagation of cracks under mechanical loading. In order to do so, previously published three-point bending test results of a single trabecula were replicated using two different extended finite element method approaches, namely, elastic-plastic-fracture and elastic-fracture that considered different configurations of the elasto-plastic properties of bone from which the best approach to fit the experimental data was identified. The behavior of a single trabecula was then used in 2D extended finite element method models to quantify the strength of the trabecular tissue of the forearm along three perpendicular anatomical axes. The results revealed that the elastic-plastic-fracture model better represented the experimental data in the model of a single trabecula. Considering the 2D trabecular specimens, the elastic fracture ...

JCI insight, Jan 5, 2018

GARP, a cell surface docking receptor for binding and activating latent TGF-β, is highly expresse... more GARP, a cell surface docking receptor for binding and activating latent TGF-β, is highly expressed by platelets and activated Tregs. While GARP is implicated in immune invasion in cancer, the roles of the GARP-TGF-β axis in systemic autoimmune diseases are unknown. Although B cells do not express GARP at baseline, we found that the GARP-TGF-β complex is induced on activated human and mouse B cells by ligands for multiple TLRs, including TLR4, TLR7, and TLR9. GARP overexpression on B cells inhibited their proliferation, induced IgA class-switching, and dampened T cell-independent antibody production. In contrast, B cell-specific deletion of GARP-encoding gene Lrrc32 in mice led to development of systemic autoimmune diseases spontaneously as well as worsening of pristane-induced lupus-like disease. Canonical TGF-β signaling more readily upregulates GARP in Peyer patch B cells than in splenic B cells. Furthermore, we demonstrated that B cells are required for the induction of oral tole...

Aesthetic Plastic Surgery, 2015

Background This study aimed to compare the average amounts of facial skin and muscle lifting in t... more Background This study aimed to compare the average amounts of facial skin and muscle lifting in two different face-lift methods, superficial musculo-aponeurotic system (SMAS) plication and minimal access cranial suspension (MACS), to evaluate the effectiveness of each method in facial excursion. Methods Thirty-six face-lift surgeries were performed on nine cadavers between October and December 2010. Both SMAS and MACS surgeries were done on each side of the cadaver faces. The average amounts of skin and muscle lifting up and out in three defined anatomical landmarks were compared between the two methods, SMAS plication and MACS lift procedure. Results Nine fresh cadavers with the mean age of 53 ± 6.7 years entered the study. Seven (77.8 %) were males and two (22.2 %) were females. The average amounts of lifting of the anatomical landmarks up and out were significantly greater in the SMAS plication method compared to the MACS lift procedure (P values \0.05), whereas facial symmetry was not significantly different between the two methods. Conclusion The overall amounts of facial skin and muscle lifting by the SMAS plication method were greater than the MACS lift procedure. However, it does not justify ignoring the benefits of the MACS lift procedure in terms of less invasiveness and quicker recovery. No Level Evidence This journal requires that authors assign a level of evidence to each submission to which Evidence-Based Medicine rankings are applicable. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.

Egyptian Journal of Medical Human Genetics, 2013

Journal of Neuroinflammation, 2011

Background Multiple sclerosis (MS) is an inflammatory disease of the central nervous system (CNS)... more Background Multiple sclerosis (MS) is an inflammatory disease of the central nervous system (CNS) with unknown etiology. Interferon-β (IFN-β), a member of the type I IFN family, is used as a therapeutic for MS and the IFN signaling pathway is implicated in MS susceptibility. Interferon regulatory factor 7 (IRF7) is critical for the induction and positive feedback regulation of type I IFN. To establish whether and how endogenous type I IFN signaling contributes to disease modulation and to better understand the underlying mechanism, we examined the role of IRF7 in the development of MS-like disease in mice. Methods The role of IRF7 in development of EAE was studied by immunizing IRF7-KO and C57BL/6 (WT) mice with myelin oligodendrocyte glycoprotein using a standard protocol for the induction of EAE. We measured leukocyte infiltration and localization in the CNS using flow cytometric analysis and immunohistochemical procedures. We determined levels of CD3 and selected chemokine and cy...

The European Physical Journal Applied Physics, 2013

This paper concentrates on the effect of the AC and DC magnetic fields on plant growth. The effec... more This paper concentrates on the effect of the AC and DC magnetic fields on plant growth. The effect of AC magnetic field with intensities of 2.25, 1.66 and 1.49 mT and DC magnetic field with intensities of 3.6, 2.41 and 2.05 mT in exposure durations of 2, 4, 6, 8, 10 and 12 min on two groups of dry and wet Pisum sativum seedlings was studied. In each experiment 10 seeds were used; the experiments were repeated three times for each group and there was a sham exposed group for comparison purposes. The light cycle was 12 h light/12 h darkness and the temperature was 25 ± 1° C. The index of growth is considered to be the root and stem elongation on the sixth day. It was observed that AC magnetic field has a positive effect on the growth in all durations and intensities. Moreover, it is highlighted that during the experiments, the mean growth of dry seedlings significantly increased by a factor of 11 in AC magnetic field with the lowest intensity of 1.49 mT ( p 0.05). It was also shown that AC magnetic fields had a more positive effect on the growth of plants in comparison to DC magnetic fields.

Cellular and Molecular Life Sciences, 2013

Crohn's disease (CD) is one of main disease entities under the umbrella term chronic inflammatory... more Crohn's disease (CD) is one of main disease entities under the umbrella term chronic inflammatory bowel disease. The etiology of CD involves alterations in genetic, microbiological, and immunological factors. This review is devoted to the role of the bacterial wall compound muramyl dipeptide (MDP) for the activation of inflammatory pathways involved in the pathogenesis of CD. The importance of this molecule is underscored by the fact that (1) MDP, which is found in most Gram-negative and-positive bacteria, is able to trigger several immunological responses in the intestinal system, and (2) that alterations in several mediators of the MDP response including-but not restricted to-nucleotide oligomerization domain 2 (NOD2) are associated with CD. The normalization of MDP signaling is one of several important factors that influence the intestinal inflammatory response, a fact which emphasizes the pathogenic importance of MDP signaling for the pathogenesis of CD. The important aspects of NOD2 and non-NOD2 mediated effects of MDP for the development of CD are highlighted, as well as how alterations in these pathways might translate into the development of new therapeutic strategies.

British Journal of Haematology, 2008

CSF, G-CSF. M-CSF and Epo to induce maturation in human AML cells in vitro were investigated usin... more CSF, G-CSF. M-CSF and Epo to induce maturation in human AML cells in vitro were investigated using cell specimens from 25 AML patients. The experiments were carried out under exactly defined serum-free culture conditions. In the absence of CSFs, monocytic and/or granulocytic maturation was detected in 14/25 cases. IL-3, GM-CSF. G-CSF and M-CSF elevated the proportions of monocyte/macrophages in 3/2 5, 2/25, 1/25 and 6/25 cases respectively, and increased the percentages ofmature granulocytes in 2/25, 1/25,1/25 and 0/25 cases, and if so only to a limited extent (values below 50%). The 'H-thymidine ('H-TdR) uptake studies revealed that IL-3, GM-CSF, G-CSF and M-CSF were efficient stiniulators of DNA synthesis of AML cells in 19, 15, 13 and four of those cases, respectively. Thus, although the cells in most Colony stimulating factors (CSFs) and erythropoietin (Epo) are known to regulate the expansion and cell lineage commitment of the haematopoietic progenitor cells. Multi-CSF (IL-3) and granulocyte-macrophage CSlF (GM-CSF) exert stimulative effects on the more primitive pi-ogenitors in the marrow, and granulocyte CSF (G-CSF), macrophage CSF (M-CSF) and Epo act particularly on maturation and functional activities of the more differentiated cells (Metcalf, 1984;

Journal of fusion energy, 2010

... S. Saadat (&amp;) Á MK Salem Á M. Goranneviss Plasma Physics Research Center, Islamic... more ... S. Saadat (&amp;) Á MK Salem Á M. Goranneviss Plasma Physics Research Center, Islamic Azad University, Tehran Science &amp; Research Campus, Punak Ave, POBox 14665-678, Tehran, Iran e-mail: shnst577@yahoo.com MK Salem e-mail: mkssalem@gmail.com ...

International journal of …, 2004

A cross-sectional study was conducted in a randomly selected factory producing Portland cement in... more A cross-sectional study was conducted in a randomly selected factory producing Portland cement in eastern Saudi Arabia to determine the prevalence of respiratory symptoms and diseases and chest x-ray changes consistent with pneumoconiosis in the employees. A sample of 150 ...

Intermittent fasting and caloric restriction have been shown to extend life expectancy and reduce... more Intermittent fasting and caloric restriction have been shown to extend life expectancy and reduce inflammation and cancer promotion in animal models. It was hypothesized that intermittent prolonged fasting practiced during the month of Ramadan (RIF) could positively affect the inflammatory state. To investigate this hypothesis, a cross-sectional study was designed to investigate the impact of RIF on selected inflammatory cytokines and immune biomarkers in healthy subjects. Fifty (21 men and 29 women) healthy volunteers who practiced Ramadan fasting were recruited for the investigation of circulating proinflammatory cytokines (interleukin [IL]-1β, IL-6, and tumor necrosis factor α), immune cells (total leukocytes, monocytes, granulocytes, and lymphocytes), and anthropometric and dietary assessments. The investigations were conducted 1 week before Ramadan fasting, at the end of the third week of Ramadan, and 1 month after the cessation of Ramadan month. The proinflammatory cytokines IL-1β, IL-6, and tumor necrosis factor α; systolic and diastolic blood pressures; body weight; and body fat percentage were significantly lower (P < .05) during Ramadan as compared with before Ramadan or after the cessation of Ramadan fasting. Immune cells significantly decreased during Ramadan but still remained within the reference ranges. These results indicate that RIF attenuates inflammatory status of the body by suppressing proinflammatory cytokine expression and decreasing body fat and circulating levels of leukocytes.