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Papers by vu huynh

Proceedings of the 10th International Conference on Cloud Computing and Services Science, 2020

Community network edge-clouds have been attracting significant interests over the recent years wi... more Community network edge-clouds have been attracting significant interests over the recent years with the emergence of ubiquitous networked devices embedded in our daily activities and increasingly widespread fully-distributed heterogeneous networks of smart edges offering various applications and services in real time. This paper proposes EdgeCNC, a novel joint multilayer adaptive opportunistic network-coding algorithm integrated with adaptive opportunistic content caching service. EdgeCNC exploits the multilayer spatial-temporal locality of users' mobility and interests in community network edge-clouds in order to select highly suitable set of contents to forward, cache and network code to highly suitable set of nodes in order to enhance QoS, reduce data transmissions and improve energy efficiency. We perform a multi-criteria evaluation of EdgeCNC performance in realistic Foursquare New York scenario of mobile community edgeclouds against the benchmark and competitive protocols in the face of dynamically changing users' publishsubscribe and mobility patterns. We show that EdgeCNC achieves higher success ratio and data transmission efficiency while keeping lower delays, packet loss and energy consumption compared to the competitive and benchmark protocols.

Proceedings of the 9th International Conference on Pervasive and Embedded Computing and Communication Systems, 2019

The emergence and rapid worldwide spread of SARS-CoV-2 has accelerated research and development f... more The emergence and rapid worldwide spread of SARS-CoV-2 has accelerated research and development for controlling the pandemic. A multi-coronavirus protein microarray was created containing full-length proteins, overlapping protein fragments of varying lengths and peptide libraries from SARS-CoV-2 and four other human coronaviruses. Sera from confirmed COVID-19 patients as well as unexposed individuals were applied to multi-coronavirus arrays to identify specific antibody reactivity. High level IgG, IgM and IgA reactivity to structural proteins S, M and N, as well as accessory proteins, of SARS-CoV-2 were observed that was specific to COVID-19 patients. Overlapping 100, 50 and 30 amino acid fragments of SARS-CoV-2 proteins identified antigenic regions. Numerous proteins of SARS-CoV, MERS-CoV and the endemic human coronaviruses, HCoV-NL63 and HCoV-OC43 were also more reactive with IgG, IgM and IgA in COVID-19 patient sera than in unexposed control sera, providing further evidence of im...

Science and Technology Development Journal - Natural Sciences, 2019

Colorectal cancer is one of the most prevalent cancers and a leading cause of death nowadays. The... more Colorectal cancer is one of the most prevalent cancers and a leading cause of death nowadays. The main method to treat colorectal cancer is the surgery. However, more than 50 % of patients relapse after surgery and die from metastatic cancer. Therefore, it is important to do research on the molecular mechanism of this disease and consequently develop effective therapies. In these studies, the colorectal cancer cell is the indispensable research model. However, cancer cell lines lose the oncogenic characteristics after prolonged culture compared to those in the body of patients. To solve this problem, the study is aimed to obtain, to primarily culture, and to maintain the colorectal cancer cells from Vietnamese patients serving as cancer research model. Colorectal cancer cells were separated from 40 tumor samples and primarily cultured in vitro. 4 of 40 populations of cancer cells were cultured successfully. These cell populations were grafted into immuno-deficient SCID mice and 2 ce...

Journal of Cellular Physiology, 2019

The ErbB3-binding protein 1 (Ebp1) has been reported as either an oncogenic regulator or a tumor ... more The ErbB3-binding protein 1 (Ebp1) has been reported as either an oncogenic regulator or a tumor suppressor in a variety of cancers. Here, we show that Ebp1 p48, a predominant expression isoform, is highly expressed in the majority of human colon tumor cells compared with normal adjacent tissues and its expression is required for the oncogenic activities of these cells. Depletion of Ebp1 expression in primary colon cancer cells inhibits cell proliferation, colony forming, and invasion in vitro as well as tumor formation in vivo and enhances cell sensitivity to irradiation. We further demonstrated that Ebp1 interacts with TIF-90, a splice variant of transcription initiation factor IA (TIF-IA) of the RNA polymerase I complex, allowing for regulation of ribosomal RNA (rRNA) synthesis and oncogenesis in human colon cancer cells. Moreover, Ebp1 expression is essential for Akt protected TIF-90 stability by preventing TIF-90's ubiquitination by Mdm2 and hence, its proteasomal degradation. The results of the present study support a mechanism of underlying oncogenic activities by means of Ebp1 through regulation of TIF-90-mediated rRNA synthesis and suggest the potential therapeutic treatment of colon cancer by targeting Ebp1 and its signaling.

PLOS ONE, 2019

The rubber hand illusion describes a phenomenon in which participants experience a rubber hand as... more The rubber hand illusion describes a phenomenon in which participants experience a rubber hand as being part of their body by the synchronous application of visuotactile stimulation to the real and the artificial limb. In the recently introduced robotic hand illusion (RobHI), a robotic hand is incorporated into one's body representation due to the integration of synchronous visuomotor information. However, there are no setups so far that combine visuotactile and visuomotor feedback, which is expected to unravel mechanisms that cannot be detected in experimental designs applying this information in isolation. We developed a robotic hand, controlled by a sensor glove and equipped with pressure sensors, and varied systematically and separately the synchrony for motor feedback (MF) and tactile feedback (TF). In Experiment 1, we implemented a ball-grasping task and assessed the perceived proprioceptive drift of one's own hand as a behavioral measure of the spatial calibration of body coordinates as well as explicit embodiment experiences by a questionnaire. Results revealed significant main effects of both MF and TF for proprioceptive drift data, but we only observed main effects for MF on perceived embodiment. Furthermore, for the proprioceptive drift we found that synchronous feedback in one factor compensates for asynchronous feedback in the other. In Experiment 2, including a new sample of naïve participants, we further explored this finding by adding unimodal conditions, in which we manipulated the presence or absence of MF and/or TF. These findings replicated the results from Experiment 1 and we further found evidence for a supper-additive multisensory effect on spatial body representation caused by the presence of both factors. Results on conscious body perception were less consistent across both experiments. The findings indicate that sensory and motor input equally contribute to the representation of spatial body coordinates which for their part are subject to multisensory enhancing effects. The results outline the potential of

Journal of Global Oncology, 2018

The United Nations Sustainable Development Goals 2015 to 2030 includes a specific goal for health... more The United Nations Sustainable Development Goals 2015 to 2030 includes a specific goal for health (Sustainable Development Goal [SDG] 3) with 13 targets, including SDG3.4 for the control and treatment of noncommunicable diseases (NCDs), namely, cardiovascular diseases, cancer, diabetes, and chronic lung disease. There is considerable concern that SDG3.4 may not be achieved. The WHO Best Buys for NCDs has emphasized prevention, and although crucial, it alone will not achieve the 30% reduction in NCDs by 2030. Likewise, a strengthened health system is required as all NCDs are likely to require hospital facilities and community services for optimal management. This is a major problem for low-resource countries (LRCs) —that is, low-income countries and lower-middle-income countries—as most currently have a poorly developed health system, including cancer services, in need of upgrading. This is a result of the extreme poverty of LRCs, where 40% to 80% of the population live on less than ...

ACM SIGPLAN Notices, 2018

Journal of cellular physiology, Jan 4, 2018

ErbB3, a member of the epidermal growth factor receptor family, reportedly plays an essential rol... more ErbB3, a member of the epidermal growth factor receptor family, reportedly plays an essential role in the regulation of cancer progression and therapeutic resistance. Numerous studies have indicated that ErbB3 binding protein 1 (Ebp1), a binding partner for ErbB3, plays an important regulatory role in the expression and function of ErbB3, but there is no agreement as to whether Ebp1 also has an ErbB3-independent function in cancer and how it might contribute to tumorigenesis. In this review, we will discuss the different functions of the two Ebp1 isoforms, p48 and p42, that may be responsible for the potentially dual role of Ebp1 in cancer growth.

Transfusion, 2016

BACKGROUND-Babesia microti is a protozoan parasite responsible for the majority of reported cases... more BACKGROUND-Babesia microti is a protozoan parasite responsible for the majority of reported cases of human babesiosis and a major risk to the blood supply. Laboratory screening of blood donors may help prevent transfusion-transmitted babesiosis but there is no Food and Drug Administration-approved screening method yet available. Development of a sensitive, specific, and highly automated B. microti antibody assay for diagnosis of acute babesiosis and blood screening could have an important impact on decreasing the health burden of B. microti infection. STUDY DESIGN AND METHODS-Herein, we take advantage of recent advances in B. microti genomic analyses, field surveys of the reservoir host, and human studies in endemic areas to apply a targeted immunomic approach to the discovery of B. microti antigens that serve as signatures of active or past babesiosis infections. Of 19 glycosylphosphatidylinositol (GPI)anchored protein candidates (BmGPI1-19) identified in the B. microti proteome, 17 were

This paper proposes a general framework for a low-cost mobile wireless geographical information s... more This paper proposes a general framework for a low-cost mobile wireless geographical information system to facilitate dynamic near real-time server access from remote locations. For instance, one targeted application is the monitoring of environmental and natural disasters. While current systems are based on dedicated hardware and/or utilise high-quality imagery, the depicted solution targets a more cost effective solution. This does not render estab-lished systems redundant, but rather extends the application range. In particular, a system was developed which integrates the retrieval of satellite image data available free-of-charge on the Internet with remote access from resource limited handheld devices.

Indiana University Mathematics Journal, 2015

We confirm the AJ conjecture [Ga2] that relates the A-polynomial and the colored Jones polynomial... more We confirm the AJ conjecture [Ga2] that relates the A-polynomial and the colored Jones polynomial for hyperbolic knots satisfying certain conditions. In particular, we show that the conjecture holds true for some classes of two-bridge knots and pretzel knots. This extends the result of the first author in [Le2], who established the AJ conjecture for a large class of two-bridge knots, including all twist knots. Along the way, we explicitly calculate the universal SL 2 (C)-character ring of the knot group of the (−2, 3, 2n + 1)-pretzel knot, and show it is reduced for all integers n.

Avian Diseases, 2015

This study was performed to investigate the prevalence and to characterize the genetic diversity ... more This study was performed to investigate the prevalence and to characterize the genetic diversity of Histomonas meleagridis isolates in chickens in southern Vietnam. A total of 194 chickens, randomly selected from 18 backyard and 18 commercial flocks, were screened for H. meleagridis infection using both macroscopic diagnosis and an 18S rRNA gene-based PCR method. Overall, 12.9% of birds, representing 19 flocks, showed gross lesions typical for histomonosis whereas 25.3% of the birds from 29 flocks were positive by PCR assay. Following initial diagnostic approaches, H. meleagridis-positive samples were further analyzed by sequencing three different genomic loci; the 18S rRNA, alpha-actinin1, and rpb1. Thirteen samples from 12 flocks were genetically identified as H. meleagridis, demonstrating a flock and sample prevalence of 33.3% and 6.7%, respectively. There was no significant difference in prevalence between different farm types, age groups, and seasonality. Genetic analysis demonstrated minor heterogeneity of Vietnamese isolates with 99% homology to H. meleagridis sequences from the database. This is the first survey of the prevalence and genetic characterization of H. meleagridis in chickens in Vietnam.

We show,that the A-polynomial A(L; M) of a 2-bridge knot b(p; q) is irreducible if p is prime, an... more We show,that the A-polynomial A(L; M) of a 2-bridge knot b(p; q) is irreducible if p is prime, and if (p 1)=2 is also prime and q , 1 then the L-degree of A(L; M) is (p,1)=2. This shows that the AJ conjecture relating the A-polynomial and the colored Jones polynomial holds true for these knots, according to work of the second author. We also study relationships between the A-polynomial of a 2-bridge knot and a twisted Alexander polynomial associated with the adjoint representation of the fundamental,group of the knot complement. We show that for twist knots the A-polynomial is a factor of the twisted Alexander polynomial. 1. Background,and conventions

53rd IEEE Conference on Decision and Control, 2014

In this paper, we consider a class of stochastic optimal control problems with risk constraints t... more In this paper, we consider a class of stochastic optimal control problems with risk constraints that are expressed as bounded probabilities of failure for particular initial states. We present here a martingale approach that diffuses a risk constraint into a martingale to construct timeconsistent control policies. The martingale stands for the level of risk tolerance that is contingent on available information over time. By augmenting the system dynamics with the controlled martingale, the original risk-constrained problem is transformed into a stochastic target problem. We extend the incremental Markov Decision Process (iMDP) algorithm to approximate arbitrarily well an optimal feedback policy of the original problem by sampling in the augmented state space and computing proper boundary conditions for the reformulated problem. We show that the algorithm is both probabilistically sound and asymptotically optimal. The performance of the proposed algorithm is demonstrated on motion planning and control problems subject to bounded probability of collision in uncertain cluttered environments.

2009 Sixth International Conference on Information Technology: New Generations, 2009

In-flight entertainment systems are prone to many restrictions such as non-interference with airc... more In-flight entertainment systems are prone to many restrictions such as non-interference with aircraft control and navigation systems, bandwidth bottleneck, space and weight limitation. Based on light transmission, infrared technologies are excellent options of cabin wireless communication as they are lightweight, safe and interference-free. With the development of infrared and peer-to-peer networking technologies, there is a feasibility of setting up an in-flight wireless peer-to-peer network for streaming of media content with high level of quality and reliability. This paper provides an extensive review of state-of-the-art technologies that are relevant in setting up a new generation of aircraft media streaming networks using infrared communication and decentralized decision making.

2009 IEEE International Conference on Robotics and Automation, 2009

When a mobile robot does not have perfect knowledge of its position, conventional controllers can... more When a mobile robot does not have perfect knowledge of its position, conventional controllers can experience failures such as collisions because the uncertainty of the position is not considered in choosing control actions. In this paper, we show how global planning and local feedback control can be combined to generate control laws in the space of distributions over position, that is, in information space. We give a novel algorithm for computing "information-constrained" linear quadratic Gaussian (icLQG) policies for controlling a robot with imperfect state information. The icLQG algorithm uses the belief roadmap algorithm to efficiently search for a trajectory that approximates the globally-optimal motion plan in information space, and then iteratively computes a feedback control law to locally optimize the global approximation. The icLQG algorithm is not only robust to imperfect state information but also scalable to high-dimensional systems and environments. In addition, icLQG is capable of answering multiple queries efficiently. We demonstrate performance results for controlling a vehicle on the plane and a helicopter in three dimensions.

2012 IEEE 51st IEEE Conference on Decision and Control (CDC), 2012

In this paper, we consider a class of stochastic optimal control problems with trajectory constra... more In this paper, we consider a class of stochastic optimal control problems with trajectory constraints. As a special case, we can constrain the probability that a system enters undesirable regions to remain below a certain threshold. We extend the incremental Markov Decision Process (iMDP) algorithm, which is a new computationally-efficient and asymptotically-optimal sampling-based tool for stochastic optimal control, to approximate arbitrarily well an optimal feedback policy of the constrained problem. We show that with probability one, in the presence of trajectory constraints, the sequence of policies returned from the algorithm is both probabilistically sound and asymptotically optimal. We demonstrate the proposed algorithm on motion planning and control problems subject to bounded collision probability in uncertain cluttered environments.