Ndidi C. Offonry | Institute of Technology, Sligo (original) (raw)
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Papers by Ndidi C. Offonry
The African Journal of Pharmacology and Therapeutics, 2018
Background: Musa paradisiaca peel is used in folklore for the treatment of inflammation and pains... more Background: Musa paradisiaca peel is used in folklore for the treatment of inflammation and pains without any scientific evidence. Objective: The present study, therefore, evaluated the safety, anti-inflammatory and analgesic effects of the methanolic extract of M. paradisiaca peel. Methods: The methanolic extract of M. paradisiaca was administered orally in three different doses; 100, 200 and 400 mg/kg to Sprague Dawley rats. The anti-inflammatory effect of M. paradisiaca peel was tested in egg albumin-induced paw edema and compared to ibuprofen (25 mg/kg). The analgesic effect was evaluated using formalin-induced paw licking and acetic acid-induced writhing and compared to indomethacin (10 mg/kg). Also, after 21 days of extract administration rats were sacrificed serum was extracted from blood and evaluated for liver, renal function indices and lipid profile. Kidney and liver were excised and weighed. Results: The methanolic extract of M. paradisiaca produced analgesia and decreas...
The African Journal of Pharmacology and Therapeutics, 2018
Background: Musa paradisiaca peel is used in folklore for the treatment of inflammation and pains... more Background: Musa paradisiaca peel is used in folklore for the treatment of inflammation and pains without any scientific evidence. Objective: The present study, therefore, evaluated the safety, anti-inflammatory and analgesic effects of the methanolic extract of M. paradisiaca peel. Methods: The methanolic extract of M. paradisiaca was administered orally in three different doses; 100, 200 and 400 mg/kg to Sprague Dawley rats. The anti-inflammatory effect of M. paradisiaca peel was tested in egg albumin-induced paw edema and compared to ibuprofen (25 mg/kg). The analgesic effect was evaluated using formalin-induced paw licking and acetic acid-induced writhing and compared to indomethacin (10 mg/kg). Also, after 21 days of extract administration rats were sacrificed serum was extracted from blood and evaluated for liver, renal function indices and lipid profile. Kidney and liver were excised and weighed. Results: The methanolic extract of M. paradisiaca produced analgesia and decreas...