Brain regional correlation of amyloid-β with synapses and apolipoprotein E in non-demented individuals: potential mechanisms underlying regional vulnerability to amyloid-β accumulation (original) (raw)
Akiyama H, Kondo H, Ikeda K, Kato M, McGeer PL (2001) Immunohistochemical localization of neprilysin in the human cerebral cortex: inverse association with vulnerability to amyloid beta-protein (Abeta) deposition. Brain Res 902:277–281 ArticlePubMedCAS Google Scholar
Arold S, Sullivan P, Bilousova T et al (2012) Apolipoprotein E level and cholesterol are associated with reduced synaptic amyloid beta in Alzheimer’s disease and apoE TR mouse cortex. Acta Neuropathol 123:39–52 ArticlePubMedCAS Google Scholar
Benkovic SA, McGowan EM, Rothwell NJ, Hutton M, Morgan DG, Gordon MN (1997) Regional and cellular localization of presenilin-2 RNA in rat and human brain. Exp Neurol 145:555–564. doi:10.1006/exnr.1997.6487 ArticlePubMedCAS Google Scholar
Bernstein HG, Ansorge S, Riederer P, Reiser M, Frolich L, Bogerts B (1999) Insulin-degrading enzyme in the Alzheimer’s disease brain: prominent localization in neurons and senile plaques. Neurosci Lett 263:161–164 ArticlePubMedCAS Google Scholar
Bero AW, Yan P, Roh JH et al (2011) Neuronal activity regulates the regional vulnerability to amyloid-beta deposition. Nat Neurosci 14:750–756. doi:10.1038/nn.2801 ArticlePubMedCAS Google Scholar
Braak H, Braak E (1991) Neuropathological staging of Alzheimer-related changes. Acta Neuropathol 82:239–259 ArticlePubMedCAS Google Scholar
Bramanti V, Tomassoni D, Avitabile M, Amenta F, Avola R (2010) Biomarkers of glial cell proliferation and differentiation in culture. Front Biosci 2:558–570 Article Google Scholar
Bu G (2009) Apolipoprotein E and its receptors in Alzheimer’s disease: pathways, pathogenesis and therapy. Nat Rev Neurosci 10:333–344. doi:10.1038/nrn2620 ArticlePubMedCAS Google Scholar
Buckner RL, Snyder AZ, Shannon BJ et al (2005) Molecular, structural, and functional characterization of Alzheimer’s disease: evidence for a relationship between default activity, amyloid, and memory. J Neurosci 25:7709–7717. doi:10.1523/jneurosci.2177-05.2005 ArticlePubMedCAS Google Scholar
Camus MC, Chapman MJ, Forgez P, Laplaud PM (1983) Distribution and characterization of the serum lipoproteins and apoproteins in the mouse, Mus musculus. J Lipid Res 24:1210–1228 PubMedCAS Google Scholar
Chakrabarty P, Jansen-West K, Beccard A et al (2010) Massive gliosis induced by interleukin-6 suppresses Abeta deposition in vivo: evidence against inflammation as a driving force for amyloid deposition. FASEB J 24:548–559. doi:10.1096/fj.09-141754 ArticlePubMedCAS Google Scholar
De Strooper B, Vassar R, Golde T (2010) The secretases: enzymes with therapeutic potential in Alzheimer disease. Nat Rev Neurol 6:99–107 ArticlePubMed Google Scholar
Delledonne A, Kouri N, Reinstatler L et al (2009) Development of monoclonal antibodies and quantitative ELISAs targeting insulin-degrading enzyme. Mol Neurodegener 4:39. doi:10.1186/1750-1326-4-39 ArticlePubMed Google Scholar
Dickson DW, Crystal HA, Mattiace LA et al (1992) Identification of normal and pathological aging in prospectively studied nondemented elderly humans. Neurobiol Aging 13:179–189 ArticlePubMedCAS Google Scholar
Eckman EA, Adams SK, Troendle FJ et al (2006) Regulation of steady-state beta-amyloid levels in the brain by neprilysin and endothelin-converting enzyme but not angiotensin-converting enzyme. J Biol Chem 281:30471–30478. doi:10.1074/jbc.M605827200 ArticlePubMedCAS Google Scholar
Fuentealba RA, Liu Q, Zhang J et al (2010) Low-density lipoprotein receptor-related protein 1 (LRP1) mediates neuronal Abeta42 uptake and lysosomal trafficking. PLoS One 5:e11884. doi:10.1371/journal.pone.0011884 ArticlePubMed Google Scholar
Goedert M (1987) Neuronal localization of amyloid beta protein precursor mRNA in normal human brain and in Alzheimer’s disease. EMBO J 6:3627–3632 PubMedCAS Google Scholar
Goulinet S, Chapman MJ (1993) Plasma lipoproteins in the golden Syrian hamster (Mesocricetus auratus): heterogeneity of apoB- and apoA-I-containing particles. J Lipid Res 34:943–959 PubMedCAS Google Scholar
Gupta VB, Laws SM, Villemagne VL et al (2011) Plasma apolipoprotein E and Alzheimer disease risk: the AIBL study of aging. Neurology 76:1091–1098 ArticlePubMedCAS Google Scholar
Haddy N, De Bacquer D, Chemaly MM et al (2002) The importance of plasma apolipoprotein E concentration in addition to its common polymorphism on inter-individual variation in lipid levels: results from Apo Europe. Eur J Hum Genet 10:841–850 ArticlePubMedCAS Google Scholar
Holtzman DM, Fagan AM, Mackey B et al (2000) Apolipoprotein E facilitates neuritic and cerebrovascular plaque formation in an Alzheimer’s disease model. Ann Neurol 47:739–747 ArticlePubMedCAS Google Scholar
Jack CR Jr, Lowe VJ, Weigand SD et al (2009) Serial PIB and MRI in normal, mild cognitive impairment and Alzheimer’s disease: implications for sequence of pathological events in Alzheimer’s disease. Brain 132:1355–1365. doi:10.1093/brain/awp062 ArticlePubMed Google Scholar
Jack CR Jr, Wiste HJ, Vemuri P et al (2010) Brain beta-amyloid measures and magnetic resonance imaging atrophy both predict time-to-progression from mild cognitive impairment to Alzheimer’s disease. Brain 133:3336–3348 ArticlePubMed Google Scholar
Kanekiyo T, Zhang J, Liu Q, Liu CC, Zhang L, Bu G (2011) Heparan sulphate proteoglycan and the low-density lipoprotein receptor-related protein 1 constitute major pathways for neuronal amyloid-beta uptake. J Neurosci 31:1644–1651. doi:10.1523/jneurosci.5491-10.2011 ArticlePubMedCAS Google Scholar
Koffie R, Hyman B, Spires-Jones T (2011) Alzheimer’s disease: synapses gone cold. Molecular Neurodegeneration 6:63 ArticlePubMed Google Scholar
Koffie RM, Hashimoto T, Tai HC et al (2012) Apolipoprotein E4 effects in Alzheimer’s disease are mediated by synaptotoxic oligomeric amyloid-beta. Brain 135:2155–2168 ArticlePubMed Google Scholar
Koffie RM, Meyer-Luehmann M, Hashimoto T et al (2009) Oligomeric amyloid beta associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques. Proc Natl Acad Sci USA 106:4012–4017. doi:10.1073/pnas.0811698106 ArticlePubMedCAS Google Scholar
Koistinaho M, Lin S, Wu X et al (2004) Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-beta peptides. Nat Med 10:719–726. doi:10.1038/nm1058 ArticlePubMedCAS Google Scholar
Lazarov O, Lee M, Peterson DA, Sisodia SS (2002) Evidence that synaptically released beta-amyloid accumulates as extracellular deposits in the hippocampus of transgenic mice. J Neurosci 22:9785–9793 PubMedCAS Google Scholar
Leissring MA, Farris W, Chang AY et al (2003) Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death. Neuron 40:1087–1093 ArticlePubMedCAS Google Scholar
Marquez-Sterling NR, Lo AC, Sisodia SS, Koo EH (1997) Trafficking of cell-surface beta-amyloid precursor protein: evidence that a sorting intermediate participates in synaptic vesicle recycling. J Neurosci 17:140–151 PubMedCAS Google Scholar
May P, Rohlmann A, Bock HH et al (2004) Neuronal LRP1 functionally associates with postsynaptic proteins and is required for normal motor function in mice. Mol Cell Biol 24:8872–8883. doi:10.1128/mcb.24.20.8872-8883.2004 ArticlePubMedCAS Google Scholar
Meilandt WJ, Cisse M, Ho K et al (2009) Neprilysin overexpression inhibits plaque formation but fails to reduce pathogenic Abeta oligomers and associated cognitive deficits in human amyloid precursor protein transgenic mice. J Neurosci 29:1977–1986. doi:10.1523/jneurosci.2984-08.2009 ArticlePubMedCAS Google Scholar
Miller BC, Eckman EA, Sambamurti K et al (2003) Amyloid-beta peptide levels in brain are inversely correlated with insulysin activity levels in vivo. Proc Natl Acad Sci USA 100:6221–6226. doi:10.1073/pnas.1031520100 ArticlePubMedCAS Google Scholar
Mooijaart SP, Berbee JF, van Heemst D et al (2006) ApoE plasma levels and risk of cardiovascular mortality in old age. PLoS Med 3:9 Article Google Scholar
Moore AH, O’Banion MK (2002) Neuroinflammation and anti-inflammatory therapy for Alzheimer’s disease. Adv Drug Deliv Rev 54:1627–1656 ArticlePubMedCAS Google Scholar
Moore BD, Chakrabarty P, Levites Y et al (2012) Overlapping profiles of Abeta peptides in the Alzheimer’s disease and pathological aging brains. Alzheimers Res Ther 4(3):18 ArticlePubMedCAS Google Scholar
Morris JC, Roe CM, Xiong C et al (2010) APOE predicts amyloid-beta but not tau Alzheimer pathology in cognitively normal aging. Ann Neurol 67:122–131. doi:10.1002/ana.21843 ArticlePubMedCAS Google Scholar
Nalivaeva NN, Beckett C, Belyaev ND, Turner AJ (2012) Are amyloid-degrading enzymes viable therapeutic targets in Alzheimer’s disease? J Neurochem 1:167–185 Article Google Scholar
Okello A, Koivunen J, Edison P et al (2009) Conversion of amyloid positive and negative MCI to AD over 3 years: an 11C-PIB PET study. Neurology 73:754–760 ArticlePubMedCAS Google Scholar
Page K, Hollister R, Tanzi RE, Hyman BT (1996) In situ hybridization analysis of presenilin 1 mRNA in Alzheimer disease and in lesioned rat brain. Proc Natl Acad Sci USA 93:14020–14024 ArticlePubMedCAS Google Scholar
Pellerin L, Magistretti PJ (1994) Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization. Proc Natl Acad Sci USA 91:10625–10629 ArticlePubMedCAS Google Scholar
Pocivavsek A, Burns MP, Rebeck GW (2009) Low-density lipoprotein receptors regulate microglial inflammation through c-Jun N-terminal kinase. Glia 57:444–453. doi:10.1002/glia.20772 ArticlePubMed Google Scholar
Reiman EM, Chen K, Liu X et al (2009) Fibrillar amyloid-beta burden in cognitively normal people at 3 levels of genetic risk for Alzheimer’s disease. Proc Natl Acad Sci USA 106:6820–6825. doi:10.1073/pnas.0900345106 ArticlePubMedCAS Google Scholar
Riddell DR, Zhou H, Atchison K et al (2008) Impact of apolipoprotein E (ApoE) polymorphism on brain ApoE levels. J Neurosci 28:11445–11453 ArticlePubMedCAS Google Scholar
Shankar GM, Li S, Mehta TH et al (2008) Amyloid-beta protein dimers isolated directly from Alzheimer’s brains impair synaptic plasticity and memory. Nat Med 14:837–842. doi:10.1038/nm1782 ArticlePubMedCAS Google Scholar
Shibata M, Yamada S, Kumar SR et al (2000) Clearance of Alzheimer’s amyloid-ss(1–40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier. J Clin Invest 106:1489–1499. doi:10.1172/jci10498 ArticlePubMedCAS Google Scholar
Shigematsu K, McGeer PL, McGeer EG (1992) Localization of amyloid precursor protein in selective postsynaptic densities of rat cortical neurons. Brain Res 592:353–357 ArticlePubMedCAS Google Scholar
Sokolow S, Luu SH, Nandy K et al (2012) Preferential accumulation of amyloid-beta in presynaptic glutamatergic terminals (VGluT1 and VGluT2) in Alzheimer’s disease cortex. Neurobiol Dis 45:381–387 ArticlePubMedCAS Google Scholar
Suh J, Lyckman A, Wang L, Eckman EA, Guenette SY (2011) FE65 proteins regulate NMDA receptor activation-induced amyloid precursor protein processing. J Neurochem 119:377–388 ArticlePubMedCAS Google Scholar
Sullivan PM, Han B, Liu F et al (2011) Reduced levels of human apoE4 protein in an animal model of cognitive impairment. Neurobiol Aging 32:791–801 ArticlePubMedCAS Google Scholar
Takahashi RH, Milner TA, Li F et al (2002) Intraneuronal Alzheimer abeta42 accumulates in multivesicular bodies and is associated with synaptic pathology. Am J Pathol 161:1869–1879 ArticlePubMedCAS Google Scholar
Takami K, Terai K, Matsuo A, Walker DG, McGeer PL (1997) Expression of presenilin-1 and -2 mRNAs in rat and Alzheimer’s disease brains. Brain Res 748:122–130 ArticlePubMedCAS Google Scholar
Thal DR (2012) The role of astrocytes in amyloid beta-protein toxicity and clearance. Exp Neurol 236:1–5 ArticlePubMedCAS Google Scholar
Thal DR, Rub U, Orantes M, Braak H (2002) Phases of A beta-deposition in the human brain and its relevance for the development of AD. Neurology 58:1791–1800 ArticlePubMed Google Scholar
Vassar R, Bennett BD, Babu-Khan S et al (1999) Beta-secretase cleavage of Alzheimer’s amyloid precursor protein by the transmembrane aspartic protease BACE. Science 286:735–741 ArticlePubMedCAS Google Scholar
Verges DK, Restivo JL, Goebel WD, Holtzman DM, Cirrito JR (2011) Opposing synaptic regulation of amyloid-beta metabolism by NMDA receptors in vivo. J Neurosci 31:11328–11337 ArticlePubMedCAS Google Scholar
Villemagne VL, Ataka S, Mizuno T et al (2009) High striatal amyloid beta-peptide deposition across different autosomal Alzheimer disease mutation types. Arch Neurol 66:1537–1544. doi:10.1001/archneurol.2009.285 ArticlePubMed Google Scholar
Villemagne VL, Pike KE, Chetelat G et al (2011) Longitudinal assessment of Abeta and cognition in aging and Alzheimer disease. Ann Neurol 69:181–192 ArticlePubMedCAS Google Scholar
Vlassenko AG, Vaishnavi SN, Couture L et al (2010) Spatial correlation between brain aerobic glycolysis and amyloid-beta (Abeta) deposition. Proc Natl Acad Sci USA 107:17763–17767. doi:10.1073/pnas.1010461107 ArticlePubMedCAS Google Scholar
Wenk GL (2003) Neuropathologic changes in Alzheimer’s disease. J Clin Psychiatry 9:7–10 Google Scholar